Researcher:
Büyüktiryaki, Ayşe Betül

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Ayşe Betül

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Büyüktiryaki

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Büyüktiryaki, Ayşe Betül

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2020 - 202311

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    Clinical characteristics and prognosis of legume allergy in children
    (Bilimsel Tıp Yayınevi) Brohi, Zeliha Yanginlar; Guvenir, Hakan; Celik, Ilknur Kulhas; Toyran, Muge; Civelek, Ersoy; Ginis, Tayfur; Kocabas, Can Naci; Misirlioglu, Emine Dibek; Büyüktiryaki, Ayşe Betül; Faculty Member; School of Medicine; 195944
    Objective: The knowledge concerning allergy to legumes is limited. We aimed to evaluate the clinical features and prognosis of legume allergy in children.Materials and Methods: We evaluated patients with legume allergy who were followed up from 2010 to 2017 at the Division of Pediatrics Allergy and Immunology, with their clinical features, laboratory findings, and prognosis.Results: The median age of the enrolled 37 patients in our study was 7 (interquartile range, 4.3-9.2) years. Twenty-nine (78.3%) were male. Thirteen (35.1%) patients were found to have an allergic reaction against more than one legume. The distribution of legume allergies was as follows: peanut (n=21, 56.8%), lentil (n=16, 43.2%), chickpea (n=13, 35.1%), pea (n=6,16.2%), bean (n=5, 13.5%), lupine (n=2, 5.4%), and kidney bean (n=1, 2.7%), with a total of 64 allergic reactions. The distribution of these different legume allergy reactions was as follows: urticaria and angioedema (n=31, 48.4%), anaphylaxis (n=23, 35.9%), atopic dermatitis (n=6, 9.3%), eosinophilic esophagitis (n=3, 7.8%), and food protein-induced enterocolitis syndrome (n=1, 1.5%). Thirty-two (86.5%) of 37 patients had an allergy to a non-legume food. Tolerance to 50 legume allergies affecting 27 patients being followed up for more than 12 months were given. Eight of the 18 patients with a single legume allergy and 1 of the 9 patients who were allergic to multiple legumes developed tolerance.Conclusion: Peanut and lentil were the most frequent legumes that caused allergic reactions in our study. The rate of allergies to non-legume foods was high. In patients who were allergic to a single legume, the tolerance rate was 44.4%.
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    The common triggers of urticaria in children admitted to the pediatric emergency room
    (Wiley, 2022) Bezirganoğlu, Handan; Yılmaz, Ebru Arık; Şahiner, Ümit M.; Soyer, Özge; Şekerel, Bülent E.; Tekşam, Özlem; Büyüktiryaki, Ayşe Betül; Saçkesen, Cansın; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 195944; 182537
    Background Urticaria frequently causes pediatric emergency department (PED) admissions. Children with urticaria may unnecessarily avoid suspected allergens. We aimed to investigate the possible and exact triggers of urticaria in children admitted to the PED. Methods Medical records of children admitted to the PED within a 1-year period were evaluated for the International Classification of Diseases 10 (ICD-10) L50 urticaria code, noting symptoms, and possible triggers of urticaria. We performed telephone interviews to complete the missing data and further diagnostic tests for IgE-mediated allergies to identify the exact triggers of urticaria. Results Among 60,142 children, 462 (0.8%) with the L50 code were evaluated. Possible triggers based on the history and physical examination could be identified in 46%: infections (18%), drugs (11%), foods (8%), infections and drugs (3%), insects (3%), pollen (1%), blood products (0.4%), and vaccines (0.4%). The most frequent infections related to urticaria were upper respiratory tract infections (74.5%), urinary tract infections (13.2%), gastroenteritis (8.2%), and otitis media (4.1%). After a diagnostic workup, IgE-mediated allergic diseases were diagnosed in 6% of patients. Twenty-two percent of the patients had multiple PED admission for the same urticaria flare. Urticaria severity was found to be the most important risk factor for readmissions to the PED (odds ratio: 3.86; 95% confidence interval: 2.39-6.23; p < .001). No relationship between urticaria severity, duration, and the triggers was present. Conclusions Despite detailed diagnostic tests, IgE-mediated allergic triggers were rarely the cause of urticaria in children admitted to the PED. Infections are the most frequent trigger. Severe urticaria causes more frequent readmissions to the PED.
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    Development of a new hypoallergenic casein product for use in milk immunotherapy
    (Wiley, 2021) Büyüktiryaki, Ayşe Betül; Saçkesen, Cansın; N/A; Doctor; Faculty Member;  Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; N/A; School of Medicine; Koç University Hospital; N/A; 195944; 182537
    N/A
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    Food allergy severity predictions based on cellular in vitro tests
    (Taylor & Francis, 2020) Buyuktiryaki, Betul; Santos, Alexandra F.; Büyüktiryaki, Ayşe Betül; Faculty Member; School of Medicine; 195944
    Introduction Food allergy is increasing in prevalence and the severity of allergic reactions is unpredictable. Identifying food-allergic patients at high risk of severe reactions would allow us to offer a personalized and improved management for these patients. Areas covered We review the evidence for using the levels of specific IgE, the nature of the allergen, and cellular tests to identify patients at high risk of developing severe allergic reactions to foods. Expert opinion The evidence about whether the quantity of allergen-specific IgE reflects the severity of allergic reactions to foods is conflicting, with some positive and some negative studies. For some foods, specific IgE to individual components (e.g. Ara h 2 in peanut) can provide additional information. However, more important than the quantity of IgE is possibly the quality of IgE, which can be captured by individual measurements of affinity/avidity, diversity, and specific activity, but is best measured overall using the basophil and mast cell activation tests, which assess the function of IgE in its ability to induce cell activation, degranulation, and mediator release. Biomarkers look at a single aspect of the allergic response and should be interpreted in the broader clinical context for each individual patient assessed.
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    IgE-mediated Anisakis allergy in children
    (Codon Publications, 2023) Pontone Matteo; Giovannini Mattia; Barni Simona; Mori Francesca; Venturini Elisabetta; Galli Luisa; Valleriani Claudia; De las Vecillas Leticia; Lopata Andres Ludwig; Saçkesen, Cansın; Büyüktiryaki, Ayşe Betül; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 182537; 195944
    Anisakids are nematodes responsible for different clinical patterns in humans. The well-known human-infecting Anisakis species include members of the Anisakis simplex (AS) complex. Humans usually contract anisakiasis through ingestion of raw or undercooked seafood containing Anisakis larvae. Once Anisakis has been ingested, patients may develop disease driven directly by Anisakis larvae and/or by allergic reaction due to this nematode. The capability of inducing allergic reactions depends on the expression of specific antigens by nematodes and host factors. This study aims to resume actual knowledge about AS and Anisakiasis with regard to epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment. Particular attention is paid to Anisakis allergens and their cross-reactivity on available diagnostic methods, and defining a diagnostic pathway for Anisakis allergy. Because only a few data are available in the literature about pediatric population, we focus on this group of patients specifically © 2023 Codon Publications. Published by Codon Publications
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    PublicationOpen Access
    Allergic contact dermatitis to temporary black henna tattoo due to sensitization to para-phenylenediamine
    (Buluş Design, 2021) Dibek Mısırlıoğlu, Emine; Tanıdır, Merve; Kanık Yüksek, Saliha; Şahiner, Neriman; Güvenir, Hakan; Azkur, Dilek; Kocabaş, Can Naci; Büyüktiryaki, Ayşe Betül; Faculty Member; School of Medicine
    The fashion for temporary ""black henna tattoo"" is becoming increasingly more common among young adults and teens. An adolescent case with itching, erythema, edema, and inflammatory discharge on the right forearm two days after a temporary tattoo application is presented in this report. To determine the contact sensitizer, a patch test was performed one month after the end of the treatment. A bullous strong positive reaction (3+) was observed against para-phenylenediamine at the 48th and 72nd hours of evaluation after the application. Despite the common belief that henna tattoo application is harmless, the ingredients used in henna tattoo especially paraphenylenediamine can lead to allergenic reactions that can even be severe.
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    PublicationOpen Access
    Ige-mediated fish allergy in children
    (Multidisciplinary Digital Publishing Institute (MDPI), 2021) Masini, M.; Mori, F.; Barni, S.; Liccioli, G.; Sarti, L.; Lodi, L.; Giovannini, M.; du Toit, G.; Lopata, A.L.; Marques-Mejias, M.A.; Büyüktiryaki, Ayşe Betül; Faculty Member; Koç University Hospital
    Fish allergy constitutes a severe problem worldwide. Its prevalence has been calculated as high as 7% in paediatric populations, and in many cases, it persists into adulthood with life-threatening signs and symptoms. The following review focuses on the epidemiology of Immunoglobulin E (IgE)-mediated fish allergy, its pathogenesis, clinical manifestations, and a thorough approach to diagnosis and management in the paediatric population. The traditional approach for managing fish allergy is avoidance and rescue medication for accidental exposures. Food avoidance poses many obstacles and is not easily maintained. In the specific case of fish, food is also not the only source of allergens; aerosolisation of fish proteins when cooking is a common source of highly allergenic parvalbumin, and elimination diets cannot prevent these contacts. Novel management approaches based on immunomodulation are a promising strategy for the future of these patients.
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    PublicationOpen Access
    Editorial: novel horizons in pediatric food allergy
    (Frontiers, 2022) Barni, S.; Büyüktiryaki, Ayşe Betül; Faculty Member; School of Medicine; 195944
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    PublicationOpen Access
    Over restrictive elimination of foods in children with food allergy
    (Turkish National Pediatric Society, 2021) Melek, Hacer Efnan; Nacaroğlu, Hikmet Tekin; Dut, Raziye; Soyer, Özge; Şahiner, Ümit M.; Yılmaz, Ebru Arık; Akkaya, A. Deniz; Büyüktiryaki, Ayşe Betül; Saçkesen, Cansın; Kızılkan, Nuray Uslu; Undergraduate Student; Faculty Member; Faculty Member; School of Medicine; Koç University Hospital; N/A; N/A; 182537; 221274
    Background: previous studies demonstrated critical deficits in diagnosis and management of childhood food allergy (FA), and recent developments in FA research support adopting a proactive approach in FA management. Our objective was to describe FA knowledge and management patterns of pediatricians. Method: we applied a 24-item survey to 170 general pediatricians, pediatric allergists and pediatric gastroenterologists practicing in Turkey. Results: some IgE-mediated symptoms of FA such as cough, urticaria, wheezing and anaphylaxis were falsely recognized as symptoms of non-IgE-mediated FA by 30%, 29%, 25% and 19% of the participants, respectively. By contrast, 50% of the participants falsely recognized bloody stool, a finding of IgE-mediated FA. Most frequently and least frequently used diagnostic tools were specific IgE (30.5%) and oral food challenge test (1.7%), respectively. Maternal diet restrictions and infant diet restrictions were advised by 82% and 82%, respectively. Percentages of physicians eliminating only 1 food were 21%, 19%; 2 foods were 15%, 11%; 3 foods were 7%, 8%; 4-5 foods were 8%, 11%; 5 to 10 foods were 21%, 26%; and >10 foods were 28%, 25% from the maternal and infant diet, respectively. Cow's milk, cheese, butter, yoghurt, baked milk products and hen's egg were the most commonly restricted items. Conclusion: overall, FA knowledge of pediatricians was fair. Pediatricians utilize an overly restrictive approach when advising diet eliminations in FA. Recent developments favor a more proactive approach to induce immune tolerance and need to be encouraged in pediatric clinical practice. Future educational efforts should focus on emphasizing the deleterious effects of injudicious and extensive eliminations.
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    PublicationOpen Access
    Comparison of tastes of available nutritional integrated or non-integrated formulas for infants older than 1 year of age with cow's milk allergy: a multicenter, prospective, single blind, cross-sectional observational clinical study (contest study)
    (Codon Publications, 2022) Altıntaş, Derya Ufuk; Türktaş, İpek; Arga, Mustafa; Çokuğraş, Haluk Cezmi; Civelek, Ersoy; Keskin, Özlem; Ertem, Deniz; Aydoğan, Metin; Ecevit, Çiğdem Ömür; Öztürk, Yeşim; Tamay, Zeynep; Yücel, Esra; Çaltepe, Gönül; Beşer, Ömer Faruk; Güler, Nermin; Büyüktiryaki, Ayşe Betül; Faculty Member; 195944
    Palatability of the infant formulas lacking cow milk protein formulas is reported by parents to be an important drawback. The purpose of this study is to examine decisions made by mothers of infants having cow milk protein allergy, and physicians concerning the palatability of unflavored extensively hydrolyzed formulas and amino acid-based formulas. We conducted a multi-center, randomized, single-blinded, observational taste study involving 149 pediatricians from gastroenterology and allergy subspecialties at 14 tertiary healthcare units from different regions of Turkey and involving 94 mothers of infants with cow milk protein allergy. Blinding was performed for seven formulas available in the market, which were the most commonly prescribed for feeding: four AAFs (Neocate-Numil((R)), Aptamil Pregomin AS-Numil((R)), Alfamino-Nestle((R)), Comidagen-Mamma((R))), one AAF specifically designed to address the growing nutritional and lifestyle needs of children >1 year (Neocate Junior-Numil((R))), 2 eHFs (Bebelac Pepti Junior-Numil((R)), Similac Alimentum-Abott((R))). Considering all three formula characteristics, Neocate junior-Numil((R)) ranked as the number 1 product among seven products by mothers (63.8%) and physicians (69.8%). The ratings of mothers were significantly higher than the physicians (8.1 points and 6.1 points, respectively; p < 0.001). No difference was found in terms of taste, smell, and appearance for Neocate junior-Numil((R)) between the mothers' and physicians' ratings. Since caregivers have responsibility for careful selection of replacement products for infants with cow milk protein allergy, it is noteworthy that increased awareness and confidence in the palatability characteristics of these products should motivate mothers and physicians to comply with replacement treatment in the long term.