Researcher: Yalçınay-İnan, Merve
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Publication Metadata only Validity and reliability of the Turkish version of Snaith-Hamilton pleasure scale(Association for Cognitive and Behavioral Psychotherapies, 2020) Aydemir, Ömer; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Küçüker, Mehmet Utku; Kılçıksız, Can Mişel; Yılmaz, Sezen Güçlü; Dinçer, Neris; Kılıç, Özge; Ercan, Alaattin Cenk; Faculty Member; Doctor; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Doctor; Doctor; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; 134359; N/A; N/A; N/A; N/A; 349025; N/A; N/AAnhedonia is a core feature of many psychiatric disorders and its reliable evaluation is needed for the dimensional understanding of psychiatric disorders. Snaith-Hamilton Pleasure Scale (SHAPS) is one of the most widely used scales to assess anhedonia. Here, we aimed to search the validity and reliability of the Turkish version of SHAPS. Translation of the original scale was completed in a two-step procedure. 188 healthy controls, 56 patients with a depressive disorder (F32-F34, excluding F34.0 cyclothymic disorder, according to ICD-10), and 52 patients with anxiety, stress-related or somatoform disorder diagnoses (F40-49 diagnosis according to ICD-10) were recruited, and evaluated with the Turkish version of SHAPS, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Symptom Checklist-90-R (SCL-90-R). For the Turkish version of SHAPS, Cronbach’s alpha coefficient was found 0.87. The item-total item correlation indices ranged from 0.39 to 0.64. Principal components analysis extracted two factors and explained 46.57 % of total variance. The most significant correlation of SHAPS was found with BDI and depression subscale of SCL-90-R scores. SHAPS also weakly but significantly correlated with obsessive compulsive and anxiety subscales of SCL-90-R, and weakly but non-significantly with BAI and somatization, interpersonal sensitivity, hostility and psychoticism subscales of SCL-90-R. Depressive group had significantly higher SHAPS scores compared to controls and anxious group. Anxious group and control group were not significantly different for SHAPS scores. The current study shows that the Turkish version of the SHAPS has good psychometric properties. SHAPS scores may correlate with depression, somatization, and interpersonal sensitivity scores, and it may help to differentiate depressive patients from anxious patients and controls. /Öz: Anhedoni, birçok psikiyatrik bozukluğun temel bir özelliğidir ve psikiyatrik bozuklukların boyutsal olarak anlaşılması için güvenilir bir şekilde değerlendirilmesi gerekir. Snaith-Hamilton Keyif Alma Ölçeği (SHKÖ), anhedoniyi değerlendirmek için en yaygın kullanılan ölçeklerden biridir. Burada, SHKÖ’nün Türkçe versiyonunun geçerliliği ve güvenilirliğinin araştırılması amaçlanmıştır. Orijinal ölçeğin çevirisi iki aşamalı bir prosedürle tamamlanmıştır. 188 sağlıklı kontrol, 56 depresif bozukluk (ICD-10’a göre F34.0 (siklotimi) dışında F32-F34 tanıları almış kişiler) ve 52 anksiyete, stres ilişkili veya somatoform bozukluk tanısı almış olan anksiyöz hasta (ICD-10’a göre F40-49 tanıları almış kişiler) çalışmaya alınmıştır. Katılımcılar SHKÖ’nün Türkçe versiyonu, Beck Depresyon Envanteri (BDE), Beck Anksiyete Envanteri (BAE) ve Belirti Kontrol Listesi-90-Gözden Geçirilmiş Form (SCL-90-R) ile değerlendirilmiştir. SHKÖ’nün Türkçe versiyonu için Cronbach alfa katsayısı 0,87 olarak bulunmuştur. Madde-toplam madde korelasyon endeksleri 0,39 ile 0,64 arasında değişmiştir. Temel bileşenler analizi iki faktörü ortaya çıkarmış ve toplam varyansın % 46,57‘ sini açıklamıştır. En yüksek SHKÖ korelasyonu BDE ve SCL-90-R‘nin depresyon alt ölçeği skorları ile bulunmuştur. SHKÖ ayrıca SCL-90-R‘nin obsesif kompulsif ve anksiyete alt ölçekleri ile zayıf fakat istatiksel olarak anlamlı bir korelasyon gösterirken, SCL-90- R‘nin somatizasyon, kişilerarası duyarlılık, hostilite ve psikotisizm alt ölçekleri ile zayıf fakat istatistiksel olarak anlamlı olmayan bir ilişki göstermiştir. Depresif hasta grubunda kontrol grubuna ve anksiyöz hasta grubuna göre anlamlı derecede yüksek SHKÖ skorları saptanmıştır. Anksiyöz hasta grubu ve kontrol grubu, SHKÖ skorları için farklı bulunmamıştır. Bu çalışma, SHKÖ’nün Türkçe versiyonunun iyi psikometrik özellikleri olduğunu göstermektedir. SHKÖ puanları depresyon, somatizasyon ve kişilerarası duyarlılık puanları ile ilişkili olabilir ve depresif hastaları anksiyöz hastalardan ve kontrollerden ayırmada yardımcı olabilir.Publication Metadata only Anxiety disorders comorbidity in pediatric bipolar disorder: a meta-analysis and meta-regression study(Wiley, 2020) Morey Özcan, Aslıhan; Ongur, Dost; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Eser, Hale Yapıcı; Taşkıran, Ali Sarper; Ertınmaz, Beliz; Mutluer, Tuba; Kılıç, Özge; Necef, Işıl; Yalçınay-İnan, Merve; Faculty Member; Teaching Faculty; Undergraduate Student; Faculty Member; Doctor; Doctor; Koç University Hospital; N/A; N/A; Koç University Hospital; N/A; Koç University Hospital; N/A; Koç University Hospital; 134359; 195168; N/A; 305311; 167890; N/A; N/A; N/AObjective Anxiety disorders (AD) are known for its comorbidity and negative impact on the course of adult bipolar disorder (BD). However, there is limited research on AD comorbidity in pediatric BD (PBD). Here, we aimed to conduct a meta-analysis and meta-regression study about the comorbidity and covariates of AD and PBD. Method We systematically searched relevant articles published until May 2019, as defined in PRISMA guidelines. Variables for associated features and prevalence of AD were extracted. Results Thirty-seven articles represented data for the analysis. Lifetime any AD comorbidity was 44.7%; panic disorder (PD) was 12.7%; generalized anxiety disorder (GAD) was 27.4%; social phobia was 20.1%; separation anxiety disorder (SAD) was 26.1%; and obsessive-compulsive disorder (OCD) was 16.7%. Childhood-onset studies reported higher GAD and SAD comorbidity, while adolescent-onset studies reported higher PD, OCD, and social phobia. Age of onset, gender, comorbidity of ADHD, substance use, oppositional defiant disorder and conduct disorder affected each anxiety disorders' comorbidity with PBD differently. Conclusion Anxiety disorders are highly comorbid with PBD. Early-onset PBD increases the risk of AD. Biopsychosocial aspects of this comorbidity and its course needs to be evaluated further.Publication Metadata only Development, validity and reliability of the 4-point likert Turkish version of cognitive failures questionnaire(İnönü Üniversitesi Tıp Fakültesi, 2020) Aydemir, Ömer; N/A; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Küçüker, Mehmet Utku; Kılçıksız, Can Mişel; Yılmaz, Sezen Güçlü; Dinçer, Neris; Kılıç, Özge; Ercan, Alaattin Cenk; Faculty Member; Doctor; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Doctor; Doctor; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; 134359; N/A; N/A; N/A; N/A; 349025; N/A; N/AAim: Cognitive failures are suggested to be a transdiagnostic endophenotype that increases the vulnerability for psychiatric disorders. Broadbent’s Cognitive Failures Questionnaire (CFQ), is among the most widely used scales to assess cognitive function observed in an ecological manner. Despite its wide use in research and correlation with biological markers, CFQ is criticized for its unstable factorial structure among studies and 5-Likert structure that may lead to bias for neutral answers. Here we aimed to develop a 4-Likert Turkish version of CFQ, search its validity, reliability and factorial structure. Material and Methods: CFQ has been translated to Turkish in two steps. CFQ, Perceived Deficit Questionnaire-D (PDQ-D), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were applied to 272 participants (187 healthy controls, 55 patients diagnosed with depression, 30 patients diagnosed with anxiety disorder). Results: The Cronbach’s alpha coefficient of 4-Likert Turkish version of CFQ was found as 0.91. Principal component analysis extracted five factors and explained 53.7 % of total variance. CFQ scores were significantly different among groups. Both depressive and anxious groups reported higher CFQ scores compared to controls. CFQ significantly and strongly correlated with PDQ-D and showed a moderate correlation with BDI and BAI. Conclusion: 4-Likert Turkish version of CFQ is a valid and reliable tool to assess cognitive failures in non-demented groups. Our analysis revealed a five factorial structure for CFQ, however previous literature with the 5-Likert version shows different factor structures and does not indicate a dimensional stability.Publication Metadata only The aggression level of the parents of patients with substance use disorder: the relationship between aggression and the level of depression, and anxiety(ANP Yayıncılık, 2016) Ekinci, Suat; Kural, Hanife Uğur; Kandemir, Hasan; Yalçınay-İnan, Merve; Doctor; Koç University Hospital; N/AThe aim of this study is to research the aggression level in parents of patients with substance use disorder and to examine the relationship between aggression and the level of depression and anxiety. Methods: 40 parents of patients with substance use disorder are included in substance use parents group. 40 participants who were equalized with the substance use parents group in terms of age and gender and do not have an Axis I diagnosis are considered as the control group. Parents who accepted to participate to the study and signed informed consent form included in the study. With the aim of collecting the data, a Sociodemographic Data Form, Buss-Perry Aggression Questionnaire, Beck Depression Inventory, and Beck Anxiety Inventory were given to the participants. In order to determine DSM-IVTR Axis I diagnoses, The Structured Clinical Interview for DSM-IV-TR was used. Results: As we compared two groups in terms of scale scores, it was found that the scores of Buss-Perry Aggression Questionnaire, Beck Anxiety Inventory, and Beck Depression Inventory was higher in substance use parents group than the control group. It was revealed that 18 participants in substance use parents group (45%) had Axis I diagnosis comorbidity. Regarding the relationship between scales, there was a positive relationship between aggression and the level of depression and anxiety. Cocnclusion: In this study, it could be suggested that the aggression level was higher in the families of patients with substance use disorder and that there was a relationship between aggression and the level of depression and anxiety. In substance use parents group, high prevalence of Axis I diagnosis comorbidity was observed. We think that it is essential to handle the aggression problems of parents in the process of treatment of patients with substance use disorder. / Madde bağımlılığı olan hastaların ebeveynlerinde öfke düzeyinin araştırılması, öfkenin, depresyon ve anksiyete düzeyi ile ilişkisinin incelenmesi amaçlanmaktadır. Gereç ve Yöntem: Madde bağımlılığı olan hastaların 40 ebeveyni, madde bağımlılığı ebeveyn grubunu, madde bağımlılığı grubu ile yaş ve cinsiyet bakımından denkleştirilmiş, DSM IV TR tanı ölçütlerine göre eksen 1 tanısı almamış 40 kişi, kontrol grubunu oluşturmuştur. Çalışmaya katılmayı kabul etmiş ve bilgilendirilmiş onam formunu imzalamış olan kişiler çalışmaya dahil edilmiştir. Çalışmaya katılanlara, Sosyo-demografik Veri Formu, Buss-Perry Saldırganlık Ölçeği, Beck Depresyon Envanteri, Beck Anksiyete Ölçeği uygulanmıştır. DSM IV TR eksen I tanıları belirlemek için, yapılandırılmış klinik tanı görüşmesi kullanılmıştır. Bulgular: Iki grubu ölçek puanları açısından karşılaştırdığımızda, MBE grubunda, BussPerry Saldırganlık Ölçeği, Beck Anksiyete Ölçeği ve Beck Depresyon Envanteri puanlarının daha yüksek olduğu görülmüştür. MBE grubunda 18 kişide (%45) eksen I eş tanı tespit edilmiştir. Ölçekler arasındaki ilişki incelendiğinde, MBE grubunda, öfke ile anksiyete ve depresyon arasında pozitif bir ilişki olduğu görülmüştür. Sonuç: Bu çalışmada madde bağımlılığı olan kişilerin ailelerinde öfke düzeyinin yüksek olduğu, öfke ile depresyon ve anksiyete düzeyleri arasında bir ilişki olduğu görülmektedir. MBE grubunda yüksek oranda eksen I eş tanı görülmektedir. Madde bağımlılığı olan hastaların ebeveynlerine yönelik psikiyatrik değerlendirmelerin ve tedaviye yönelik müdahalelerin göz ardı edilmemesi gerektiğini düşünmekteyiz.Publication Metadata only Experience of grief by patients with cancer in relation to perceptions of illness: the mediating roles of identity centrality, stigma-induced discrimination, and hopefulness(Routledge Journals, Taylor & Francis Ltd, 2017) Gokler-Danisman, Ilgin; Yigit, Ibrahim; Yalçınay-İnan, Merve; Doctor; Koç University Hospital; N/ADiagnosis of cancer leads to multiple losses, all with the potential to initiate grief reactions in patients. The present study aims to contribute to the understanding of the experience of grief by patients with cancer in relation to perceptions of illness, with a focus on the mediating roles of identity centrality, stigma-induced discrimination, and hopefulness. The analyses indicated that these factors functioned as significant partial mediators. The results have implications in terms of supporting patients through the grieving process by working on the meaning of the illness for their identity and improving psychosocial environments to minimize discrimination and facilitate hope.Publication Metadata only A meta-analysis of anxiety disorder comorbidity in pediatric bipolar disorder(Elsevier Science Inc, 2016) Taşkıran, Ali Sarper; Eser, Hale Yapıcı; Mutluer, Tuba; Kılıç, Özge; Özcan, Aslıhan; Necef, Işıl; Yalçınay-İnan, Merve; Öngür, Dost; Other; Faculty Member; Faculty Member; Doctor; Other; Doctor; Doctor; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; N/A; N/A College of Engineering; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; N/A; N/A; Koç University Hospital; 195168; 134359; 305311; N/A; N/A; N/A; N/A; N/AObjectives: AD are among the most prevalent comorbid conditions in pediatric bipolar disorder (PBD). There are conflicting results in the literature regarding prevalence of AD subtypes, and significant discrepancy with PBD course of illness (episodic or chronic) or diagnostic criteria (narrow or broad). Our aim in conducting meta-analysis is to investigate the prevalence of subtypes of comorbid anxiety disorders and its relations with the onset (childhood or adolescent) and course (episodic or chronic) of PBD. Methods: We have conducted a systematic research of Pubmed by using “bipolar disorder, affective psychosis, generalized anxiety disorder, panic, social phobia, obsessive compulsive disorder and anxiety disorder” as keywords to search in title/abstract until September 2015. Among 3202 articles, a total of 430 abstracts were found to be related; 82 were conducted in pediatric population, which were read in full text by at least two authors and data was extracted for outcome measures. Articles that include the data from the same population sample were excluded. Data was analyzed with random effects model using R statistical program package. Results: Data from 33 studies were included in the final analysis. The prevalence of any AD in PBD was 44 percent (95% CI 0.38–0.50), prevalence of AD subtypes were GAD 25 percent (95% CI 0.18–0.36); Separation Anxiety Disorder (SAD) 22 percent (95% CI 0.14–0.33); OCD 17 percent (95% CI 0.11–0.23); Social Phobia (SP) 15 percent (95% CI 0.08–0.27); Panic Disorder (PD) 10 percent (95% CI 0.05–0.19). When only episodic PBD were concerned, prevalence rates differed, with any AD 38 percent (95% CI 0.28–0.48); GAD 19 percent (95% CI 0.08–0.41); SAD 21 percent (95% CI 0.10–0.40); OCD 11 percent (95% CI 0.03–0.29); SP 11 percent (95% CI 0.04–0.27); PD 9 percent (95% CI 0.03–0.23). Prevalence of any AD (34% (95% CI 0.23-0.48), GAD and SAD were found as lower and OCD, SP and PD were slightly higher in adolescent onset compared to childhood onset PBD. Conclusions: Youth with BD are at increased risk of AD; nearly one in two has an AD. GAD and SAD are among the most prevalent comorbidities. AD are seen less with episodic and adolescent onset PBD. AD should be carefully investigated alongside the mood symptoms in PBD, as comorbidity may change course, treatment and subtyping of the disorder.Publication Metadata only Role of emotion regulation and fear of compassion on depression and anxiety in patients with colorectal cancer(Kartal Eğitim ve Araştırma Hastanesi, 2022) Kılıç, Özge; Dikmen, Yasemin; N/A; Özata, İbrahim Halil; Yalçınay-İnan, Merve; Tüfekçi, Tutku; Ağcaoğlu, Orhan; Kuşçu, Kemal; Balık, Emre; Teaching Faculty; Doctor; Researcher; Faculty Member; Faculty Member; Faculty Member; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; N/A; N/A; N/A; 177151; N/A; 327608; 175476; N/A; 18758INTRODUCTION: Maladaptive emotion regulation (ER) styles act as transdiagnostic mechanisms that underlie many psychiatric symptoms linked to cancer. ER and fear of compassion (FC) were studied in breast cancer, but their effects on psychiatric symptoms of colorectal cancer (CRC) patients are not studied. We aim to examine the role of ER and FC on depression and anxiety in Turkish CRC patients. METHODS: This observational, cross-sectional study recruited 38 patients with CRC who were being followed up by the general surgery department of a university hospital. Emotion Regulation Questionnaire, Fear of Compassion Scale, the Exercise of Self-care Agency Scale, Hospital Anxiety and Depression Scale, Distress Thermometer, Numeric Pain Intensity Scale, and Ostomy Adjustment Inventory were applied. Multiple regression analyses were performed to identify factors affecting depression and anxiety levels. RESULTS: Twenty-nine men and 9 women (median age=56.5, 28–69), most of whom were married and highly educated, were recruited. Expressive suppression (p=0.013) and pain (p=0.010) positively (Model, R2=0.42, p<0.001) and self-care agency (p=0.021) negatively influenced anxiety levels. Expressive suppression (p=0.017) and male gender (p=0.020) positively influenced depression levels (Model, R2=0.28, p=0.003). There was no association between cognitive reappraisal and levels of depression and anxiety. Among ostomates (n=17), 11 patients had low and 6 patients had medium adaptation to an active ostomy. No patient exhibited high adjustment to an ostomy. DISCUSSION AND CONCLUSION: Findings indicate that in CRC patients, expressive suppression affects levels of anxiety and depression while cognitive reappraisal does not. FC was not found to be related to anxiety and depression. Physicians should carefully observe the patients’ and the caregivers’ ER strategies and the dynamic and interactive psychological states to understand which patients need psychological and psychiatric interventions. We suggest future studies explore the interventions that target expressive suppression patterns to prevent anxiety and depression in CRC patients. / GİRİŞ ve AMAÇ: Uyumsal olmayan emosyon düzenleme biçimleri, kanserle ilişkili psikiyatrik belirtilerin altında yatan tanılar üstü mekanizmalar olarak rol oynar. Emosyon düzenleme ve şefkat korkusu meme kanseri hastalarında incelenmiştir ancak kolorektal kanser hastalarında psikiyatrik belirtiler üzerine etkileri araştırılmamıştır. Emosyon düzenleme ve şefkat korkusunun depresyon ve anksiyete üzerindeki rolünü Türk kolorektal kanser hastalarında incelemeyi amaçladık. YÖNTEM ve GEREÇLER: Bu gözlemsel, kesitsel çalışmaya, bir üniversite hastanesinin genel cerrahi bölümü tarafından takip edilen 38 kolorektal kanser hastası alındı. Emosyon Düzenleme Ölçeği, Şefkat Korkusu Ölçeği, Özbakım Gücü Ölçeği, Hastane Anksiyete ve Depresyon Ölçeği, Distres Termometresi, Sayısal Ağrı Derecelendirme Ölçeği, ve Stomaya Uyum Envanteri uygulandı. Depresyon ve anksiyeteyi etkileyen faktörleri belirlemek için çoklu regresyon analizleri yapıldı. BULGULAR: Çalışmaya çoğu evli ve yüksek eğitimli (medyan yaş= 56.5, 28–69) olan 29 erkek, 9 kadın alındı. Anksiyete düzeyleri üzerine dışavurumu bastırma (p=0.013) ve ağrının (p=0.010) etkisi pozitif, özbakım gücünün (p=0.02) etkisi negatifti (Model, R2=0.42, p<0.001). Depresyon düzeyleri üzerineyse dışavurumu bastırma (p=0.017) ve erkek cinsiyet (p=0.020) pozitif yönde etki etmekteydi. (Model, R2=0.28, p=0.003). Bilişsel yeniden değerlendirme ile depresyon ve ve anksiyete arasında ilişki saptanmadı. Stomaya uyum aktif stomalı hastaların (n=17) 11’inde düşük, altısında ortaydı. Stomaya yüksek uyum gözlenmedi. TARTIŞMA ve SONUÇ: Sonuçlar, kolorektal kanser hastalarında dışavurumu bastırmanın anksiyete ve depresyon düzeylerini etkilediğini, bilişsel yeniden değerlendirmenin ise bu düzeyleri etkilemediğini göstermiştir. Şefkat korkusu anksiyete ve depresyonla ilişkili bulunmamıştır. Hekimler, hangi hastaların psikolojik veya psikiyatrik müdahaleye ihtiyaç duyduğunu anlamak için hasta ve bakımverenin emosyon düzenleme biçimlerini ve dinamik ve etkileşimli psikolojik durumlarını dikkatle gözlemelidir. Gelecek çalışmaların kolorektal kanser hastalarında anksiyete ve depresyonu önlemek için dışavurumu bastırma paternini hedef alan müdahaleleri araştırmasını öneririz.Publication Metadata only Subjective cognitive assessments and n-back are not correlated, and they are differentially affected by anxiety and depressionKılıç, Özge; Aydemir, Ömer; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Küçüker, Mehmet Utku; Kılçıksız, Can Mişel; Yılmaz, Sezen Güçlü; Dinçer, Neris; Ercan, Alaattin Cenk; Faculty Member; Doctor; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Doctor; School of Medicine; Koç University Hospital; 134359; N/A; N/A; N/A; 349025; N/ACognitive function (CF) is a core feature related to all psychiatric disorders. However, self-report scales of CF (SRSC) may not always correlate with CF’s objective measures and may have different mediators. Tools to select for evaluating CF in diverse psychiatric populations and their determinants need to be studied. In this study, we aimed to assess the association of SRSC (Perceived Deficit Questionnaire-Depression (PDQ-D), and World Health Organization’s Adult Attention Deficit Hyperactivity Disorder Self-Report Scale (ASRS) and its inattentiveness subscale) with Letter-N-back as an objective measure of CF, and to analyze their association with psychopathology. Two hundred nine (131 nonclinical, and 78 clinical with a psychiatric diagnosis of ICD10 F31-39 [mood disorders excluding Bipolar I] or F40-F49 [neurotic, stress-related or psychosomatic disorder] categories) participants were evaluated with PDQ-D, ASRS, Beck Depression Inventory (BDI), and Beck’s Anxiety Inventory (BAI), and N-back. Both groups’ data were included in the analysis. PDQ-D showed a small correlation with N-back scores, whereas ASRS showed no correlation. PDQ-D and ASRS showed a large correlation. Age and BAI scores significantly predicted both PDQ-D and ASRS, whereas the cognitive subscale of BDI predicted PDQ-D, but not ASRS. Only BAI scores predicted N-back results. The mediation model revealed that 2-back scores of N-back task directly affects PDQ-D scores, independent of BDI scores. However, the cognitive subscale of BDI moderated 2-back and PDQ-D association. On the contrary, BAI scores significantly mediated the association of 2-back scores with PDQ-D. The direct effect of 2-back scores in PDQ-D was insignificant in the mediation of BAI scores. Our study validates the discordance between SRSC and an objective measurement of CF. Anxiety may affect both self-report and objective measurement of CF, whereas depressive thought content may lead to higher cognitive dysfunction reports in nondemented participants.Publication Metadata only Test-retest reliability of the Turkish translation of the Penn Computerized Neurocognitive Battery(Routledge Journals, Taylor & Francis Ltd, 2022) Moore, Tyler M.; Gur, Ruben C.; N/A; İzgi, Büşra; Yalçınay-İnan, Merve; Port, Allison M.; Kuşçu, Kemal; Eser, Hale Yapıcı; PhD Student; Doctor; Other; Other; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM; Graduate School of Health Sciences; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 134359Psychiatric disorders are associated with cognitive dysfunction (CD), and reliable screening and follow-up of CD is essential both for research and clinical practice globally; yet, most assessments are in Western languages. We aimed to evaluate the test-retest reliability of the Turkish version of the Penn Computerized Neurocognitive Battery (PennCNB) to guide confident interpretation of results. Fifty-eight healthy individuals completed the PennCNB Turkish version in two sessions. After quality control, reliability analysis was conducted using Intraclass Correlation Coefficients (ICC), corrected for practice effects. Most measures were not significantly different between the sessions and had acceptable ICC values, with several exceptions. Scores were improved considerably for some memory measures, including immediate Facial Memory and Spatial Memory, and for incorrect responses in abstraction and mental flexibility, with correspondingly acceptable ICCs. Test-retest assessment of the Turkish version of the PennCNB shows that it can be used as a reliable real-time measurement of cognitive function in snapshot cross-sectional or longitudinal determinations. Preliminary validity assessment in this normative sample showed expected positive correlations with education level and negative correlations with age. Thus, the Turkish version of the PennCNB can be considered a reliable neuropsychological testing tool in research and clinical practice. Practice effects should be considered, especially when applied in short intervals. Significantly better performances in the retest, beyond practice effect, likely reflect nonlinear improvements in some participants who "learned how to learn" the memory tests or had insight on solving the abstraction and mental flexibility test.Publication Open Access Assessing the validity and reliability of the Turkish versions of craving beliefs and beliefs about substance use questionnaire in patients with heroin use disorder: demonstrating valid tools to assess cognition-emotion interplay(BioMed Central, 2018) Küçükkarapınar, Melike; Kotan, Vahap Ozan; Tarhan, Rıfat; Arıkan, Zehra; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Faculty Member; Doctor; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Koç University Hospital; 134359; N/ABackground: Cognitions associated with craving and substance use are important contributors for the psychological theories of Substance use disorders (SUD), as they may affect the course and treatment. In this study, we aimed to validate Turkish version of two major scales 'Beliefs About Substance Use'(BSU) and 'Craving Beliefs Questionnaire'(CBQ) in patients with heroin use disorder and define the interaction of these beliefs with patient profile, depression and anxiety symptoms, with an aim to use these thoughts as targets for treatment. Methods: One hundred seventy-six inpatients diagnosed with heroin use disorder and 120 participants in the healthy comparison group were evaluated with CBQ, BSU, Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI) and sociodemographic data questionnaire. Patient group was also evaluated with Addiction Profile Index. Reliability and validity analysis for scales were conducted. Linear regression analysis was conducted to evaluate the determinants of BSU and CBQ scores. Results: Cronbach alpha level was 0.93 for BSU and 0.94 for CBQ. Patient group showed significantly higher CBQ, BSU, BAI and BDI scores (p < 0.001). BSU score significantly correlated with API-substance use profile score, API-diagnosis, BAI, BDI and CBQ (p < 0.005), whereas CBQ scores significantly correlated with API-diagnosis, API-impact on life, API-craving, API-total score, BSU, BAI, BDI and amount of cigarette smoking (p < 0.002). Number of previous treatments and age of onset for substance use were not correlated with either BSU or CBQ. BAI and BDI scores significantly predicted BSU score, however only BDI score predicted CBQ score (p < 0.003). Conclusions: Craving beliefs were highly correlated with addiction profile. Anxiety and depression are significant modulators for patients' beliefs about substance use and depression is a modulator for craving and maladaptive beliefs, validating emotion-cognition interplay in addiction.