Researcher: Öztürk, Ayşe Bilge
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Öztürk, Ayşe Bilge
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Publication Metadata only Prevalence of apis, vespula and polistes sensitivity in venom allergic patients in Turkey(Wiley, 2020) Dursun, A. B.; Sonmez, H.; Gelincik, A.; Yigit, O. O.; Albayrak, O.; Celebioglu, E.; Sahiner, U. M.; Buyuktiryaki, B.; Erdogan, T.; Firtina, S.; Taylan, D.; Soyer, O.; Karakaya, G.; Kalyoncu, A. F.; Sekerel, B.; N/A; Hela, Francesko; Öztürk, Ayşe Bilge; Saçkesen, Cansın; Albayrak, Özgür; Other; Faculty Member; Faculty Member; Researcher; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; N/A; School of Medicine; N/A; N/A; 147629; 182537; N/AN/APublication Metadata only A case of mediterranean spotted fever misdiagnosed as drug allergy(National Society of Allergy and Clinical Immunology, 2018) Gözaydın, Ayhan; Tekin, Süda; Öztürk, Ayşe Bilge; Faculty Member; Faculty Member; School of Medicine; School of Medicine; Koç University Hospital; 42146; 147629Skin rashes are observed in about 2-3% of patients taking medication for any reason. Since the cutaneous manifestations are also common in viral exanthemas, rickettsial-bacterial infections and rheumatologic diseases, it is important to exclude other conditions that may mimic drug-induced allergic reactions in patients having skin rashes. Here, we report a patient of Mediterranean Spotted Fever (MSF) who was initially misdiagnosed as a drug eruption. The clinician should take into account the skin manifestations that can also be seen in the course of infectious diseases and they should consider the possibility of various infections in the diagnosis of drug allergy such as a Mediterranean Spotted Fever. / Deri döküntüleri herhangi bir nedenle ilaç kullanan hastaların yaklaşık %2-3’ünde gözlenmektedir. Cilt bulguları aynı zamanda viral döküntüler, riketsiyal-bakteriyel enfeksiyonlar ve romatizmal hastalıklarda da sık görülen bir bulgu olduğundan, deri döküntüsü olan hastalarda ilacın neden olduğu allerjik reaksiyonları taklit eden diğer durumları dışlamak önemlidir. Burada, başlangıçta yanlış ilaç allerjisi tanısı almış bir Akdeniz Benekli Ateşi olgusu sunulmuştur. Klinisyenler enfeksiyon hastalıklarının seyrinde de görülebilen cilt bulguları konusunda dikkatli olmalı ve ilaç allerjisi ayırıcı tanısında Akdeniz Benekli Ateşi gibi çeşitli enfeksiyonların olasılığını düşünmelidir.Publication Metadata only The impact of dietary salicylate on asthma control in acetylsalicylic acid-exacerbated respiratory disease(Wiley, 2021) Gumusburun, R; Göksel, O.; N/A; İncir, Sevil; Sönmez, Sadi Can; Kısakürek, Zeynep Büşra; Öztürk, Ayşe Bilge; Saçkesen, Cansın; Doctor; Other; Undergraduate Student; Faculty Member; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 147629; 182537N/APublication Metadata only Pros and cons of nebulizer treatment in asthma exacerbation during the COVID-19 pandemic(Bilimsel Tıp Yayınevi, 2021) Baccioglu, Ayse; Uysal Soyer, Ozge; Civelek, Ersoy; Sekerel, Bulent Enis; Bavbek, Sevim; N/A; Öztürk, Ayşe Bilge; Faculty Member; School of Medicine; 147629Nebulizers generate aerosols and may potentially transmit respiratory viral particles including SARS-CoV-2. There is a great concern about the use of a nebulizer in the treatment of asthma exacerbations in the hospital or home setting during the COVID-19 pandemic and its use is not recommended unless essential. However, aerosol therapy should not be avoided in obligatory indications. Therefore, indications of nebulizer use during the pandemic should be evaluated on an individual basis in case of a severe asthma attack, and infection control recommendations should be followed by clinicians while using nebulizers. In this article, we aimed to assess the safety in addition to the "pro" and "con" sides of nebulizer treatment in asthma exacerbation during the COVID-19 pandemic.Publication Metadata only Clinical and allergic sensitization characteristics of allergic rhinitis among the elderly population in Istanbul, Turkey(Springer, 2015) Olmez, Merve Ozata; N/A; Öztürk, Ayşe Bilge; Özyiğit, Sabiha Leyla Pur; Faculty Member; Doctor; School of Medicine; School of Medicine; N/A; Koç University Hospital; 147629; 214687Prevalence of allergic rhinitis (AR) in elderly population in Turkey is not known. Studies on the prevalence and features of allergy in older adults are needed to identify safe and effective diagnostic/therapeutic methods for elderly AR patients. We aimed to identify the clinical and allergic characteristics of sensitization to aeroallergens among individuals aged a parts per thousand yen60 years with allergic rhinitis admitted to an allergy outpatient clinic in Istanbul. Of 109 patients, 33.9 % were atopic. Sixty-five percent of subjects were sensitized to Dermatophagoides pteronyssinus, 17 % to a grass-pollen mixture, 8 % to Aspergillus fumigatus, and 8 % to Blattella germanica. There was no difference between mono- and polysensitized patients in terms of the duration of rhinitis and symptom severity. No significant difference was observed between the two groups according to age, sex, smoking status, AR onset (< 40 or a parts per thousand yen40 years), or duration/severity of disease. There was no significant difference between the two groups in the prevalence of asthma and conjunctivitis, (p = 0.256). Atopic dermatitis/eczema was more prevalent in those with AR (p = 0.046). Clinical characteristics of AR in the elderly could be different from those in non-allergic patients, and the prevalence of allergy may be higher than expected.Publication Metadata only Quality of management in drug-induced anaphylaxis: an analysis of yearlong data in a tertiary care setting(Wiley, 2021) N/A; N/A; N/A; N/A; Kısakürek, Zeynep Büşra; Sönmez, Sadi Can; Öztürk, Ayşe Bilge; Undergraduate Student; Other; Faculty Member; School of Medicine; Koç University Hospital; School of Medicine; N/A; N/A; 147629N/APublication Metadata only A rare case of right sided pulmonary artery agenesis associated with congenital mitral valve prolapse(Turkish Assoc Tuberculosis & Thorax, 2016) N/A; N/A; İliaz, Sinem; Aslan, Gamze; Öztürk, Ayşe Bilge; Özyiğit, Sabiha Leyla Pur; Tabak, Levent; Doctor; Doctor; Faculty Member; Doctor; Faculty Member; N/A; N/A; School of Medicine; N/A; School of Medicine; Koç University Hospital; Koç University Hospital; N/A; Koç University Hospital; N/A; N/A; N/A; 147629; 214687; N/AN/APublication Metadata only Allergic asthma: differences in characteristics between younger and older patients(Elsevier Masson, Corporation Office, 2015) Keskin, Havva; N/A; Özyiğit, Sabiha Leyla Pur; Öztürk, Ayşe Bilge; Doctor; Faculty Member; School of Medicine; School of Medicine; N/A; Koç University Hospital; 214687; 147629Allergic asthma is generally more severe in older than in younger individuals. To assess the reasons for severity, the clinical characteristics of younger (16-55 years; n = 57) and older (> 55 years; n=23) adults with allergic asthma were compared. Although their allergy profiles were similar, the older group had a lower level of education and worse asthma control. Older asthmatics of our population were less familiar to Internet-based asthma education compared to younger group and the Internet education does not seem achievable and/or suitable for them.Publication Metadata only Rituximab desensitization in three patients with severe rituximab allergy(Mosby-Elsevier, 2017) N/A; N/A; Öztürk, Erman; Özyiğit, Sabiha Leyla Pur; Öztürk, Ayşe Bilge; Akay, Olga Meltem; Çetiner, Mustafa; Ferhanoğlu, Ahmet Burhan; Doctor; Doctor; Faculty Member; Faculty Member; Faculty Member; Faculty Member; N/A; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; 214687; 147629; 170966; N/A; 18320Rituximab is a chimeric monoclonal antibody that targets CD20 positive B cells and has a positive effect on both overall and progression-free survival in B-cell lymphoid malignancies. Combination rituximab with chemotherapy treatment provide survival improvement. Although rituximab is an important treatment option in hematological malignancies, the risk of allergic reactions is high. These reactions are usually IgE-mediated and can be varied in regard of severity from urticaria to anaphylaxis. It is an option to interrupt the treatment and ommit rituximab therapy who had allergic reactions. Drug desensitization is another option and successful results have been reported by applying desensitization to such reactions. Drug desensitization alters the immune response to induce a state of temporary clinical tolerance to the allergic drug by giving gradual increasing of doses of drug at fixed time intervals. Herein, we present 3 cases successfully treated with rituximab desensitization. The cases were using rituximab with the diagnosis of Burkitt lymphoma, follicular lymphoma, and marginal zone lymphoma, respectively. Two cases had grade 2 and 1 case had grade 3 systemic allergic reaction with rituximab. There was no known allergy history in all 3 cases. All patients tolerated the desensitization protocol. The subsequent treatments of the patients were also given by desensitization protocol. A total of 12 desensitizations were administered to 3 cases. No severe or life-threating reactions were observed in subsequent applications. To date applying desensitization protocols ensure rituximab treatment safely. Rituximab desensitization can be performed at trained allergy centers, and it may be an appropriate option for rituximab allergic patients.Publication Metadata only Functionality of natural killer cells in obese asthma phenotypes(Wiley, 2022) Pur Ozyigit, Leyla; Aktas, Esin Cetin; Gelmez, Yusuf Metin; Gemicioglu, Bilun; Deniz, Gunnur; N/A; Öztürk, Ayşe Bilge; Faculty Member; School of Medicine; 147629Background Obesity-associated asthma (OA) is a difficult to treat asthma phenotype due to its severity and poor response to inhaled steroids. Early-onset allergic (EoOA) and late-onset non-allergic (LoOA) OA are suggested subtypes of this phenotype. Natural Killer (NK) cells are key elements of innate immunity involved in cytotoxicity and immune regulation, with uncertain role in OA pathogenesis. Methods Early-onset allergic and LoOA patients together with obese non-asthmatic (ONA) controls have been enrolled in the study. Peripheral blood samples have been collected for analysis. Percentages of total NK cells, CD3(-)CD56(dim) and CD3(-)CD56(bright) NK cell subsets, cytotoxic activity, intracellular interferon-gamma, interleukin (IL)-10, IL-13, IL-17 secretion and activatory receptors (NKG2D, NKp46i and NKp44) have been investigated by flow cytometry. The effect of IL-12 and IL-23 stimulation on NK cells and intracellular cytokines in different groups have also been analysed and compared with unstimulated conditions. Results Results of ONA (n = 5, age 42 +/- 8), EoOA (n = 5, age 42 +/- 10) and LoOA (n = 8, age 46 +/- 8) patients have analysed. Body Mass Index has been found to be negatively correlated with CD69 (p = .022, r = -0.534). NKG2D receptor has been significantly low in CD56(dim) cells of asthma population (p = .046). NKp44 receptor expression has increased after IL-12 stimulation in EoOA and control group (p = .02). Intracellular IL-10 content has increased in LoOA and control subjects (p = .018, p = .03) but not in the EoOA group. Intracellular IL-17 level has found be higher in allergic OA group. LoOA patients showed a decreased NK cytotoxicity compared with the early-onset asthma group (p = .05). Conclusion Our study suggests an impaired NK receptor expression, activation and reduced cytotoxicity in OA patients together with variances between different subtypes of this phenotype. This data would be beneficial for tailoring a more personalized treatment strategy combatting steroid resistance and frequent exacerbations in this group of patients.