Researcher:
Özdemir, Yasemin Gürsoy

Profile Picture
ORCID

Job Title

Faculty Member

First Name

Yasemin Gürsoy

Last Name

Özdemir

Name

Name Variants

Özdemir, Yasemin Gürsoy
Gürsoy-Özdemir, Yasemin

Email Address

Birth Date

Filters

2015 - 2019272020 - 202316

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.69accf1f-9fc5-4724-8e15-e958e97e9da0

Search Results

Now showing 1 - 10 of 43
  • Placeholder
    PublicationMetadata only
    A multidisciplinary clinical approach to facioscapulohumeral muscular dystrophy orthopedic surgery in facioscapulohumeral dystrophy
    (Literatura Medica, 2018) N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Çakmak, Özgür Öztop; Eren, İlker; Aslanger, Ayça Dilruba; Günerbüyük, Caner; Kayserili, Hülya; Oflazer, Piraye; Şar, Cüneyt; Demirhan, Mehmet; Özdemir, Yasemin Gürsoy; Faculty Member; Faculty Member; Doctor; Teaching Faculty; Faculty Member; Faculty Member; Doctor; Faculty Member; Faculty Member; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koc University Hospital; 107818; 168021; N/A; 380939; 7945; N/A; N/A; 9882; 170592
    Background - Impaired shoulder function is the most disabling problem for daily life of Fascioscapulohumeral muscular dystrophy (FSHD) patients. Scapulothoracic arthrodesis can give a high impact to the functionality of patients. Here we report our experience with scapulothoracic arthrodesis and spinal stenosis surgery in FSHD patients. Patients and methods - 32 FSHD patients were collected between 2015-2016. Demographical and clinical features were documented. All the patients were neurologically examined. The Medical Research Council (MRC) and the FSHD evaluation scale was used to assess muscle involvement(1). Scapulothoracic arthrodesis and spinal stenosis surgeries were performed in eligible patients. Results - There were 16 male and 16 female (mean age 34.4 years; range 12-73) patients. 6 shoulders of 4 patients aged between 2132 years underwent scapulothoracic arthrodesis (two bilateral, one left and one right sided). Only one 63 years old female patient with severe hyperlordosis had spinal fusion surgery. All of the patients undergoing these corrective surgeries have better functionality in daily life, as well as superior shoulder elevation. Conclusion - Until the emergence and clinical use of novel therapeutics, surgical interventions are indicated in carefully selected patients with FSHD to improve arm movements, the posture and the quality of life of patients in general. Scapulothorosic arthrodesis is a management with good clinical results and patient satisfaction. In selected cases other corrective orthopedic surgeries like spinal fusion may also be considered.
  • Placeholder
    PublicationMetadata only
    Reversible transverse sinus collapse in a patient with idiopathic intracranial hypertension
    (BMJ Publishing Group, 2015) Önder, Halil; Göçmen, Rahşan; N/A; Özdemir, Yasemin Gürsoy; Faculty Member; School of Medicine; 170592
    The association of idiopathic intracranial hypertension (IIH) with stenosis or narrowing of the transverse sinuses (TSs) is well known. However, there is debate as to whether the stenosis is a cause or consequence. Here we describe a case of IIH and narrowing of the TSs, with four relapses and recoveries after repeated CSF diversions with lumbar puncture (LP) over 2 months. Subsequently, implantation of a lumboperitoneal shunt (LPrS) ensured recovery. MR venography 20 months after LPrS showed normally calibrated TSs. We show repeated MR venography findings before and after the LPs, and discuss the pathogenesis of IIH in terms of the cause and effect relationship between IIH and sinus collapse.
  • Placeholder
    PublicationMetadata only
    Nose-to-brain delivery of farnesylthiosalicylic acid loaded hybrid nanoparticles in the treatment of glioblastoma
    (Elsevier Science Bv, 2017) Lüle, Sevda; Pehlivan, Sibel Bozdag; Kara, Aslı; Özturk, Naile; Kaffashi, Abbas; Vural, Imran; Yavuz, Burçin; Oğuz, Kader Karlı; Söylemezoğlu, Figen; Mut, Melike; Şekerdağ, Emine; Özdemir, Yasemin Gürsoy; PhD Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; N/A; 170592
    Background: Effective treatments for gliomas are highly needed in research and clinical area in order to reach a high antineoplastic drug concentration at the target site without damaging healthy tissues. Intranasal (IN) administration, an alternative route for non-invasive drug delivery to the brain, bypasses the blood-brain-barrier (BBB) and eliminates systemic side effects. Objective: This study evaluated the antitumor efficacy of the RAS/MAPK inhibitor, farnesylthiosalicylic acid (FTA), loaded (lipid-cationic lipid-PEG-PLGA hybrid nanoparticles (HNPs) after IN versus IV application in tumor bearing rats. Patients and Methods / Material and Methods: FTA loaded HNPs were prepared, characterized and evaluated for their anticancer activity in vitro and in vivo and a biodistribution profile in rats was investigated. Results: Rat glioma bearing rats received either no treatment, a single dose or repeated treatments of 500 μM FTA loaded HNPs (~ 163.9 nm) via IN or IV application. After both single dose, and repeated treatments of IV and IN applied FTA loaded HNPs, significant tumor reduction was achieved. The biodistribution study of the same administration routes in healthy rats showed successful brain accumulation of FTA loaded HNPs with even higher presence in the olfactory bulb after nasal application. Furthermore, a lower accumulation was observed in the kidney and liver for nasal application compared to IV application. Conclusion: Herewith, we showed the potential and safer utility of IN application of FTA loaded HNPs as a non-invasive approach in glioblastoma treatment that bypasses both systemic toxicity and the BBB limitation by a direct transport route via the olfactory bulb to the brain.
  • Placeholder
    PublicationMetadata only
    MTBR-243 in the early diagnoses of AD and the role of microglia/carbenoxolone as localized therapeutic interventions in AD rats
    (Wiley, 2022) Anwar, Mai M.; N/A; Özkan, Esra; Özdemir, Yasemin Gürsoy; Researcher; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; N/A; School of Medicine; N/A; 170592
    N/A
  • Placeholder
    PublicationMetadata only
    The role of pericytes in neurovascular unit: Emphasis on stroke
    (Bentham Science Publ Ltd, 2017) N/A; N/A; Çakmak, Özgür Öztop; Solaroğlu, İhsan; Özdemir, Yasemin Gürsoy; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; 299358; 102059; 170592
    Background: Among the central nervous system (CNS) disorders, diseases like ischemic and hemorrhagic stroke which are important health care problems as well as leading causes for emergency admissions, primarily affect neurovascular structure. Despite their high rate of mortality and morbidity, very few efficient treatment targets have been established until now. Objective: Blood-brain barrier (BBB) is the mostly effected structure in stroke as detected in both clinical studies and experimental settings. BBB is composed of endothelia, astrocyte end-foot, pericytes and basal lamina. Neurovascular unit, pericytes and BBB forming endothelia play significant pathophysiological roles in both ischemic and hemorrhagic stroke. Discussion: In this mini-review, the role of microcirculation and cells of blood-brain barrier in stroke pathophysiology will be discussed with a special emphasis based on pericytes. Pericytes are especially important for providing adequate microcirculatory supply according to needs of neuronal tissue and form one of the functionally important part of BBB and take role in neurovascular coupling. Understanding the role and disease producing mechanisms of neurovascular unit elements in different neurological conditions will provide novel targets for future treatments.
  • Placeholder
    PublicationMetadata only
    Spreading depolarization waves in neurological diseases: a short review about its pathophysiology and clinical relevance
    (Bentham Science Publ Ltd, 2019) Taş, Yağmur Çetin; Solaroğlu, İhsan; Özdemir, Yasemin Gürsoy; Researcher; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; School of Medicine; School of Medicine; N/A; 102059; 170592
    Lesion growth following acutely injured brain tissue after stroke, subarachnoid hemorrhage and traumatic brain injury is an important issue and a new target area for promising therapeutic interventions. Spreading depolarization or peri-lesion depolarization waves were demonstrated as one of the significant contributors of continued lesion growth. In this short review, we discuss the pathophysiology for SD forming events and try to list findings detected in neurological disorders like migraine, stroke, subarachnoid hemorrhage and traumatic brain injury in both human as well as experimental studies. Pharmacological and non-pharmacological treatment strategies are highlighted and future directions and research limitations are discussed.
  • Placeholder
    PublicationMetadata only
    Re: "report of dramatic improvement after a lumboperitoneal shunt procedure in a case of anticoagulation therapy-resistant cerebral venous thrombosis"
    (Elsevier, 2016) Önder, Halil; Özdemir, Yasemin Gürsoy; Faculty Member; School of Medicine; 170592
    N/A
  • Placeholder
    PublicationMetadata only
    Poloxamer-188 and citicoline provide neuronal membrane integrity and protect membrane stability in cortical spreading depression
    (Taylor & Francis Ltd, 2015) Yildirim, Timur; Eylen, Alpaslan; Lule, Sevda; Erdener, Sefik Evren; Vural, Atay; Karatas, Hulya; Ozveren, Mehmet Faik; Dalkara, Turgay; N/A; Özdemir, Yasemin Gürsoy; Faculty Member; School of Medicine; 170592
    Under pathological conditions such as brain trauma, subarachnoid hemorrhage and stroke, cortical spreading depression (CSD) or peri-infarct depolarizations contribute to brain damage in animal models of neurological disorders as well as in human neurological diseases. CSD causes transient megachannel opening on the neuronal membrane, which may compromise neuronal survival under pathological conditions. Poloxamer-188 (P-188) and citicoline are neuroprotectants with membrane sealing properties. The aim of this study is to investigate the effect of P-188 and citicoline on the neuronal megachannel opening induced by CSD in the mouse brain. We have monitored megachannel opening with propidium iodide, a membrane impermeable fluorescent dye and, demonstrate that P-188 and citicoline strikingly decreased CSD-induced neuronal PI influx in cortex and hippocampal dentate gyrus. Therefore, these agents may be providing neuroprotection by blocking megachannel opening, which may be related to their membrane sealing action and warrant further investigation for treatment of traumatic brain injury and ischemic stroke.
  • Placeholder
    PublicationMetadata only
    Stroke
    (Academic Press Inc Elsevier Science, 2017) N/A; N/A; Çakmak, Özgür Öztop; Vanlı-Yavuz, Ebru Nur; Özdemir, Yasemin Gürsoy; Faculty Member; Doctor; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; N/A; 299358; 251177; 170592
    Stroke is a devastating neurological disease with a few therapeutic approaches. Despite the acute and prophylactic treatment options, novel effective treatments are required. The main limitation for effective treatment strategies to be developed is the presence of the blood–brain barrier. Targeted nanoparticulate treatment options may help to overcome this issue. This chapter deals with novel studies performed for targeted drug delivery technologies for stroke.
  • Placeholder
    PublicationMetadata only
    Cell death mechanisms in stroke and novel molecular and cellular treatment options
    (Bentham Science Publ Ltd, 2018) Şekerdağ, Emine; Solaroğlu, İhsan; Özdemir, Yasemin Gürsoy; PhD Student; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; School of Medicine; N/A; 102059; 170592
    As a result of ischemia or hemorrhage, blood supply to neurons is disrupted which subsequently promotes a cascade of pathophysiological responses resulting in cell loss. Many mechanisms are involved solely or in combination in this disorder including excitotoxicity, mitochondrial death pathways, and the release of free radicals, protein misfolding, apoptosis, necrosis, autophagy and inflammation. Besides neuronal cell loss, damage to and loss of astrocytes as well as injury to white matter contributes also to cerebral injury. The core problem in stroke is the loss of neuronal cells which makes recovery difficult or even not possible in the late states. Acute treatment options that can be applied for stroke are mainly targeting re-establishment of blood flow and hence, their use is limited due to the effective time window of thrombolytic agents. However, if the acute time window is exceeded, neuronal loss starts due to the activation of cell death pathways. This review will explore the most updated cellular death mechanisms leading to neuronal loss in stroke. Ischemic and hemorrhagic stroke as well as subarachnoid hemorrhage will be debated in the light of cell death mechanisms and possible novel molecular and cellular treatment options will be discussed.