Researcher:
Yunisova, Gulshan

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Doctor

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Gulshan

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Yunisova

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Yunisova, Gulshan

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20223

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Researcher Of Publications: search.filters.isAuthorOfPublication.6bc2ca03-6a52-49c4-ba5c-c183e0d64545

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    The clinical use of impulse oscillometry in neuromuscular diseases
    (W. B. Saunders, 2022) Bayraktaroglu, Mesut; N/A; İliaz, Sinem; Yunisova, Gulshan; Çakmak, Özgür Öztop; Çelebi, Özlem; Buluş, Eser; Duman, Arda; Oflazer, Piraye; Doktor; Doktor; Faculty Member; Doktor; Doktor; Doktor; Faculty Member; N/A; N/A; School of Medicine; N/A; N/A; N/A; School of Medicine; Koç University Hospital; Koç University Hospital; N/A; Koç University Hospital; Koç University Hospital; Koç University Hospital; N/A; N/A; N/A; 299358; N/A; N/A; N/A; N/A
    Background: The patients with neuromuscular diseases (NMD) are very fragile and it is hard to evaluate respiratory involvement of the primary disease in this group. Therefore, our study aimed to reveal the relationship between pulmonary function tests (PFT) and impulse oscillometry (IOS) and their correlation with respiratory clinical findings in NMD. Material and methods: A total of 86 consecutive patients with NMD were included. The clinical findings of respiratory involvement, PFT, and IOS results of the patients were analyzed. Results: Forty patients out of 86 were female. There were 29 patients with amyotrophic lateral sclerosis, four patients with myasthenia gravis, and 53 patients with muscular dystrophies/myopathies. According to the PFT results, 47 patients had restrictive PFT. However, there was no difference in IOS parameters when we compared the patients according to restrictions in PFT. A positive correlation was found with FVC %pred and X-5. PEF % pred values were positively correlated with X-10, X-15, and X-20, and negatively correlated with A(X) and R5-20. The patients with worse swallowing capability had increased R-rs levels, and more negative X-rs levels. The shortness of breath led to lower FEV1 %pred., higher R-5, A(X) and R5-20, and also more negative X-10, X-15, and X-35. Conclusion: Clinically reported dysphagia, a decreased capability of coughing, and shortness of breath in patients with NMD make R-rs increase in general, but X-rs parameters, which mainly express rib cage elasticity, turn more negative. In patients with NMD, IOS monitoring may help in evaluating the regression in respiratory functions, however, future studies are needed to understand more.
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    Sorbitol-dehydrogenase (SORD) gene mutation as a curable cause of charcot-marie-tooth 2 (CMT-2) and distal hereditary motor neuronopathy (D-HMN)
    (Wiley, 2022) N/A; N/A; N/A; N/A; N/A; Yunisova, Gulshan; Avcı, Şahin; Akçay, Ayfer Arduç; Kayserili, Hülya; Oflazer, Piraye; Doctor; Faculty Member; Faculty Member; Faculty Member; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; 162811; 7945; N/A
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    Facial nerve involvement in amyotrophic lateral sclerosis: two case reports
    (Wiley, 2022) Yunisova, Gulshan; Oflazer, Piraye; Doctor; Faculty Member; N/A; School of Medicine; Koç University Hospital; N/A; N/A
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