Researcher:
Gürsoy, Erol

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Doctor

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Erol

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Gürsoy

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Gürsoy, Erol

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2021 - 20236

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    Relationship between the triglyceride-glucose index and the SYNTAX score 2 in patients with non-ST elevation myocardial infarction
    (Lippincott Williams and Wilkins (LWW), 2023) N/A; Baydar, Onur; Kılıç, Alparslan; Gürsoy, Erol; Doctor; Doctor; Doctor; N/A; N/A; N/A; Koç University Hospital; N/A; N/A; N/A
    Objective: We evaluated if admissiontriglyceride-glucose index (TyG index) correlated with the anatomical synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score 2 in non-ST elevation myocardial infarction (NSTEMI), nondiabetic patients. Methods: SYNTAX score 2 (SSII) was retrospectively evaluated in 260 nondiabetic patients hospitalized with NSTEMI who underwent coronary angiography. The TyG index was calculated using the following equation: log [fasting triglycerides (mg/dl) × fasting glucose (mg/dl)/2]. We stratified patients according to tertiles of SSII (≤21.5, 21.5-30.6, and ≥30.6). These score ranges were defined as SSII low, SSII mid, and SSII high, respectively. Results: the average age of the patients was 57.2 ± 10.9 years; 135 patients (52.2%) were males. The average TyG index was 8.68 ± 0.12, and SSII was 18.9 ± 9.9. A moderate correlation was found between TyG index and SSII (r = 0.347; P < 0.001) and TyG index was independent risk factors for SSII high [odds ratio (OR), 6.0; 95% CI, 2.7-17.0; P < 0.001]. Conclusion: in nondiabetic patients with NSTEMI, TyG index correlated with the SSII.
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    Impact of gender and diabetes on the relationship between lipoprotein (a) and coronary artery disease
    (Elsevier Ireland Ltd, 2021) Yurtseven, Ece; Ural, Dilek; Cünedioğlu, Berkay Ömer; Gürsoy, Erol; Güler, Orhan Ulaş; Aytekin, Saide; Aytekin, Vedat; Baysal, Kemal; Teaching Faculty; Faculty Member; Undergraduate Student; Doctor; Undergraduate Student; Doctor; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; N/A; School of Medicine; School of Medicine; 176021; 1057; N/A; N/A; N/A; N/A; 140946; 119184
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    Relationship between lipoprotein (a) and coronary artery disease in patients with very high ldl level
    (Elsevier Ireland Ltd, 2022) Yurtseven, Ece; Ural, Dilek; Cünedioğlu, Berkay Ömer; Gürsoy, Erol; Aytekin, Saide; Aytekin, Vedat; Baysal, Kemal; Teaching Faculty; Faculty Member; Undergraduate Student; Doctor; Doctor; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; School of Medicine; 176021; 1057; N/A; N/A; N/A; 140946; 119184
    Background and Aims : Adults who have low density lipoprotein (LDL) cholesterol levels of more than 190 mg/dl are classified in very high-risk group for major cardiovascular events. The data about the impact of Lp(a) on coronary artery disease (CAD) in patients with very high LDL levels is insufficient. We aimed to investigate the relationship of Lp(a) level with CAD in patients with very high LDL levels. Methods: We retrospectively analyzed the data of 247 patients whose LDL levels were equal to or higher than 190mg/dl and who had Lp(a) measurements. Lipid profile, co-morbidities, cardiovascular diseases, blood pressure, body mass index, eGFR and smoking status were assessed. The relationship between Lp(a) levels and CAD was analyzed. Results: A total of 247 patients whose 50.4% were female, 22.6% diabetic and 36.7% hypertensive, 19% had coronary artery disease were included in the analysis. Patients with CAD had higher levels of Lp (a) (median 16 mg/dl vs 23 mg/dl p= 0.024). Age [odds ratio (OR), 1.060; 95% confidence interval (CI): 1.020-1.101; p = 0.003], sex (OR, 6.29; 95% CI:2.604-15.198; p = 0.000) and Lp(a) level (OR, 1.011; 95% CI: 1.001-1.021; p = 0.035) were independently related with CAD. ROC curve analyses demonstrated that Lp(a) level of 19.5mg/dl was the cut-off value for CAD in patients with very high LDL level (AUC:0.6, p=0.023). Conclusions: In our study, we found increased Lp(a) level as a risk factor for CAD in patients with very high LDL levels. Furthermore, our results demonstrate that Lp(a) is the independent predictor of CAD in this patient group.
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    Evaluation of pulmonary arterial stiffness and comparison with right ventricular functions in patients with cirrhosis preparing for liver transplantation
    (Wiley, 2022) Elçioğlu, Betül Cengiz; Baydar, Onur; Helvacı, Füsun; Karataş, Cihan; Aslan, Gamze; Kılıç, Alparslan; Tefik, Nihal; Demir, Barış; Gürsoy, Erol; Demirci, Yasemin; Ural, Dilek; Kanmaz, Turan; Aytekin, Vedat; Aytekin, Saide; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Faculty Member; Faculty Member; Faculty Member; Doctor; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; NA; N/A; N/A; 1057; 275799; 140946; N/A
    Objective Pulmonary complications are common in patients with liver cirrhosis. Devolopment of pulmonary hypertension (PH) is associated with a poor prognosis in these patients. Pulmonary arterial stiffness (PAS) is considered an early sign of pulmonary vascular remodeling. The aim of this study is to investigate PAS and compare it with right ventricular (RV) functions in patients with cirrhosis who are scheduled for liver transplantation. Methods The study included 52 cirrhosis patients (mean age 51.01 +/- 12.18 years, male gender 76.9%) who were prepared for liver transplantation and 59 age and sex matched (mean age 51.28 +/- 13.63 years, male gender 62.7%) healthy individuals. Patients with left ventricular ejection fraction (LVEF) less than 55%, ischemic heart disease, more than mild valvular heart disease, chronic pulmonary disease, congenital heart disease, rheumatic disease, moderate to high echocardiographic PH probability, rhythm or conduction disorders on electrocardiography were excluded from the study. In addition to conventional echocardiographic parameters, PAS value, pulmonary vascular resistance (PVR) and RV ejection efficiency was calculated by the related formulas with transthoracic echocardiography (TTE). Results Demographic characteristics and cardiovascular risk factors of the groups were similar. PAS, PVR, and sPAP values were found to be significantly higher in the patient group (20.52 +/- 6.52 and 13.73 +/- 2.05; 1.43 +/- 0.15 and 1.27 +/- 0.14; 27.69 +/- 3.91 and 23.37 +/- 3.81 p < 0.001, respectively). RV FAC and RV Ee were significantly lower and RV MPI was significantly higher in the patient group (45.31 +/- 3.85 and 49.66 +/- 3.62, p < 0.001; 1.69 +/- 0.35 and 1.85 +/- 0.23, p = 0.005; 0.39 +/- 0.07 and 0.33 +/- 0.09, p = 0.001, respectively). PAS was significantly correlated with RV FAC and MPI (r = -0.423, p < 0.001; r = 0.301, p = 0.001, respectively). Conclusions Increased PAS in cirrhosis patients may be associated with early pulmonary vascular involvement. Evaluation of RV functions is important to determine the prognosis in these patients. FAC, MPI, and RV Ee measurements instead of TAPSE or RV S ' may be more useful in demonstrating subclinical dysfunction. The correlation of PAS with RV FAC and MPI may indicate that RV subclinical dysfunction is associated with early pulmonary vascular remodeling in patients with liver cirrhosis.
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    The triglyceride-glucose index and contrast-induced nephropathy in non-ST elevation myocardial infarction patients undergoing percutaneous coronary intervention
    (Lippincott Williams and Wilkins (LWW), 2023) N/A; N/A; Gürsoy, Erol; Baydar, Onur; Doctor; Doctor; N/A; N/A; Koç University Hospital; Koç University Hospital; N/A; N/A
    The triglyceride glucose (TyG) index is an indicator of insulin resistance and associated with increased risk of diabetes mellitus and cardiovascular events. Our study investigates the correlation between TyG index and contrast induced nephropathy (CIN) in non-diabetic patients with non-ST elevation myocardial infarction (NSTEMI) undergoing percutaneous coronary intervention (PCI). 350 non-diabetic NSTEMI patients (183, 52.3% male) undergoing PCI were retrospectively enrolled. The enrolled cohort was divided into 2 groups based on the calculated TyG index, namely values < 8.65 or higher. CIN was defined as an increase in serum creatinine > 25% or 0.5 mg/dL from baseline in the first 48 to 72 hours after PCI. A total of 56 (16%) cases of CIN were diagnosed. In contrast to patients with lower TyG indexes, patients with higher TyG indexes (>= 8.65) had a higher frequency of CIN, 9.5%. versus 20.8% respectively (P .004). Patients with CIN also had higher TyG indexes (8.74 +/- 0.12 vs 8.67 +/- 0.11, P < .001). In addition, TyG index, age, and glomerular filtration rate were identified as independent risk factors for CIN in logistic regression model (OR: 2.5 CI: 1.3-4.6, P .006, OR: 1.0 CI: 1.0-1.1, P < .001, OR: 1.0 KI: 1.03-1.06, P .025). In the ROC analysis, the area under the curve predictive of CIN was 0.666 (P < .001, 95% [CI] 0.58-0.75) with a cutoff value of 8.69 (sensitivity 71,4%, specificity 55.1%) TyG index. Higher TyG indexes are associated with an increased risk of CIN in non-diabetic patients with NSTEMI.
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    PublicationOpen Access
    Effects of iron deficiency on left ventricular functions in young women regardless of anemia: a speckle tracking echocardiography study
    (TÜBİTAK, 2022) Elçioğlu, Betül Cengiz; Baydar, Onur; Kılıç, Alparslan; Tefik, Nihal; Helvacı, Füsun; Gürsoy, Erol; Demirci, Yasemin; Ural, Dilek; Aytekin, Vedat; Aytekin, Saide; Doctor; Doctor; Doctor; Faculty Member; Faculty Member; Doctor; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 1057; N/A; N/A
    Background/aim: iron deficiency is one of the most common metabolic disorders worldwide and affects multiple organs and systems including the cardiovascular (CV) system. Iron deficiency can cause structural and functional changes in the myocardium. The aim of the study is to evaluate left ventricular (LV) functions in patients with low ferritin levels without anemia by two-dimensional ???speckle tracking??? echocardiography (2D STE). Materials and methods: we studied 90 participants (all female) that were divided into two groups according to ferritin levels (49 patients with ferritin levels 30 ng/mL, 41 age-matched controls with 55%), active infection, high ferritin levels ( 200 ng/mL) were excluded. All patients were evaluated by transthoracic echocardiography. In addition to conventional echocardiographic parameters and Doppler measurements, LV global longitudinal strain (GLS) and strain rate (GLSR) were obtained by 2D STE. Results: mean ferritin level was 18.96 ?? 7.29 ng/mL in low ferritin group, and was 61.22 ?? 26.14 ng/mL in control group. There were no significant differences according to conventional and Doppler echocardiographic parameters between the groups. LV GLS and GLSR values were significantly lower in low ferritin group comparing with control group (17.31% ?? 1.56 and 18.96% ?? 1.53, p < 0.001; 0.64 ?? 0.13 1/s and 0.81 ?? 0.13 1/s, p < 0.001, respectively). There was a significant positive correlation between ferritin levels and LV GLS and GLSR values in study group (r = 0.482, p < 0.001; r = 0.387, p < 0.001, respectively). Ferritin level was also detected as an independent risk factor for GLS value < ???18% in logistic regression analysis. In ROC curve analysis, the area under the curve for predicting GLS < ???18% was 0.801 (p < 0.001, 95% CI 0.70???0.89) and the threshold of ferritin value was 28.5 ng/mL (sensitivity 76.1%, specificity 77.3%). Conclusion: low ferritin levels can cause subclinical LV systolic dysfunction in patients without anemia. STE provides detailed information about LV functions. With larger studies, these patients should be followed more closely and considered for iron replacement treatment before developing anemia.