Researcher:
Şenol, Kazım

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Doctor

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Kazım

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Şenol

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Şenol, Kazım

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2018 - 20196

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Researcher Of Publications: search.filters.isAuthorOfPublication.6dddc0dd-0cd6-439a-89e4-cea410796603

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    Clinicopathologic and prognostic features in appendiceal malignancies: tumor invasiveness matters
    (Turkish Surgical Association/ Türk Cerrahi Derneği, 2018) Ferhatoğlu, Murat Ferhat; Tihan, Deniz; N/A; Şenol, Kazım; Doctor; N/A; Koç University Hospital; N/A
    Objective: Appendiceal tumors are rare and mostly present as acute appendicitis. Its estimated lifetime prevalence has been reported as 8%, and the annual incidence is approximately 0.1% in Western countries. The only treatment approach is still surgery, but surgical management still remains unclear in appendiceal malignancy. Material and Methods: Histopathological examination of 2840 specimens obtained from patients who underwent appendectomy between January 2012 and December 2015 was investigated. Data from 23 patients diagnosed with the malignancy had been analyzed in terms of age, gender, and preoperative and postoperative clinical parameters. The overall survival rates of the patients and prognostic parameters affecting survival were also evaluated. Statistical analyses were performed using the SPSS software. The study was performed according to the Declaration of Helsinki. Results: The overall median age of the patients was 28 years with a male/female ratio of 1.55. Pediatric group between 1 and 6 years, late pediatric group between 7 and 11 years, and adolescent group between 12 and 17 years did not present appendix tumors. Carcinoid tumors were reported in 17 patients. Adenocarcinoma of the appendix was reported in 6 patients. Patients with carcinoid tumors were significantly younger than those with adenocancer (p=0.01). The mean tumor size of the carcinoid group was significantly smaller than that of the adenocancer group (p=0.02). Patients with adenocancer were significantly more likely to have tumor extension beyond the appendix (p=0.05). All patients in the adenocancer group and 4 patients in the carcinoid group with mesoappendix invasion underwent right hemicolectomy. Univariate analyses demonstrated that serosal invasion, advanced tumor stage, and tumor invasion depth were associated with poor survival rates. Conclusion: Tumor subtype and tumor invasiveness are important risk factors for survival in appendiceal malignancies. Appendectomy alone presents satisfactory results, but complete staging of the tumor should always be considered. In addition, surgical choice is not presented as an effective factor for improved clinical outcomes and survival rates. Further prospective studies are needed to evaluate the proper staging of the tumors.
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    Importance of neutrophil/ lymphocyte ratio is important in helicobacter pylori eradication treatment follow-up
    (Ankara Eğitim ve Araştırma Hastanesi, 2019) Ferhatoğlu, Murat Ferhat; Kartal, Abdulcabbar; Kıvılcım, Taner; Filiz, Ali İlker; N/A; Şenol, Kazım; Doctor; N/A; Koç University Hospital; N/A
    Introduction: Helicobacter pylori is the most common chronic bacterial infection in humans, which plays a role in the etiopathogenesis of many upper gastrointestinal diseases. The prevalence varies according to the sociocultural and geographical regions, and this pathogen affects 30% to 50% of the world population. Due to increased antibiotic use and changes in sanitary conditions over the years, the pattern of behavior of this widespread infection has also changed. In this study, we aimed to investigate the relationship of HP infection with gastritis and gastric adenocarcinoma and inflammation indicator findings in complete blood count. Material and Method: In this study, we retrospectively analyzed the complete blood count and pathology data of 2939 patients who underwent upper gastrointestinal system endoscopy between January 2016 and December 2016. Results: There was a statistically significant difference between neutrophil/lymphocyte ratio according to presence of Helicobacter pylori and neutrophil/lymphocyte ratio values of helicobacter pylori (+) cases were found higher than helicobacter pylori (-) cases. Conclusion: In our study, the neutrophil/lymphocyte ratio obtained from the parameters found in the complete blood count was higher in HP (+) cases. We believe that neutrophil/lymphocyte ratio, which can be tested in many health institutions and which is an inexpensive laboratory test, may be useful for monitoring HP eradication treatment process. / Amaç: Üst sindirim sistemine ait birçok hastalığın etyopatogenezinde rol oynayan helicobacter pylori insanlarda en sık görülen kronik bakteriyel enfeksiyondur. Prevalansı sosyokültürel ve coğrafi bölgelere göre değişkenlik gösteren bu patojen dünya nüfusunun %30−%50'sini etkilemektedir. Yıllar içerisinde artan antibiyotik kullanımı ve sanitasyon koşullarındaki değişiklikler nedeniyle bu yaygın enfeksiyonun davranış şekli de değişiklik göstermiştir. Bu çalışmada helicobacter pylori enfeksiyonunun gastrit ve gastrik adenokanser ve tam kan sayımında bulunan inflamasyon göstergesi tetkikler ile olan ilişkisini incelemeyi amaçladık. Gereç ve Yöntem: Bu çalışmamızda Ocak 2016-Aralık 2016 arasında üst gastrointestinal sistem endoskopisi yapılan 2939 hastanın tam kan sayımı ve patoloji verilerini retrospektif olarak inceledik. Bulgular: Helicobacter pylori varlığına göre nötrofil/lenfosit oranı arasında istatistiksel olarak anlamlı farklılık saptanmış ve helicobacter pylori (+) olguların nötrofil/ lenfosit oranı değerleri helicobacter pylori (-) olgulara göre yüksek bulunmuştur. Sonuç: Çalışmamızda, tam kan sayımında bulunan parametrelerden elde edilen nötrofil/ lenfosit oranı HP (+) olgularda daha yüksek bulunmuştur. Birçok sağlık kuruluşunda çalışılabilen ve ucuz bir tetkik olan nötrofil/lenfosit oranının HP eradikasyonu tedavi sürecini takip etmek için yararlı olabileceğini düşünmekteyiz.
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    Comparison of technical details and short-term outcomes of single-incision versus multiport laparoscopic adrenalectomy
    (Lippincott Williams and Wilkins (LWW), 2019) Gurbuz, Bulent; Carilli, Senol; N/A; N/A; N/A; N/A; N/A; Ağcaoğlu, Orhan; Şengün, Berke; Şenol, Kazım; Özoran, Emre; Tezelman, Tevfik Serdar; Faculty Member; Undergraduate Student; Doctor; Teaching Faculty; Faculty Member; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; N/A; N/A; Koç University Hospital; N/A; N/A; 175476; 309087; N/A; 307296; 114860
    To date, the single-incision laparoscopic surgery (SILS) technique has been applied to a wide range of general surgical procedures; however, there are still scant data and debates on adrenal procedures. The aim of this study was to compare surgical outcomes of single-incision versus laparoscopic multiport adrenalectomy. The patients were divided into 2 study groups on the basis of the surgical approach: SILS (group 1) and multiport laparoscopic surgery (group 2). Patient demographics and their perioperative and postoperative results were evaluated retrospectively from the medical records. A total of 80 patients were included in the study. There were 44 patients in group 1 and 36 patients in group 2. The average operative time, estimated blood loss, and tumor size were similar between the study groups. There were no mortalities in both groups and the mean duration of hospital stay was 3 days for both groups. Without using any single-incision access trocars and articulated instrumentation, we achieved the same surgical outcomes in our SILS adrenalectomy series compared with conventional multiport laparoscopy series in terms of postoperative short-term outcomes and cost-effectivity.
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    Skin metastasis of renal cell carcinoma: a case report
    (Cureus Inc, 2018) Ferhatoğlu, Murat Ferhat; Filiz, Ali İlker; N/A; Şenol, Kazım; Doctor; N/A; Koç University Hospital; N/A
    Metastasis of renal cell carcinoma is seen in approximately 25% of all cases. Rarely, they can appear in unusual sites. Herein, we present a 40-year-old female patient with an itching scalp mass. The mass appeared one year after the nephrectomy performed for a right renal cell carcinoma. Computed tomography scans have not identified any metastasis during the postoperative evolution of the disease. We excised the mass with a large surgical margin under local anesthesia. Pathological examination of the lesion diagnosed metastasis of clear cell carcinoma. Our case is not just the rare metastatic site but also the fact that the tumor appeared despite its low grade (T2N0MO). Unfortunately, the prognosis of metastatic renal cell carcinoma (RCC) with skin metastasis is in most cases unfavorable. We believe that our case could add more information to the following measures, complete the frame of rare oncologic cases and consolidate the data published on the topic so far. Although skin metastases are a poor sign of progression, disease-free follow-up is possible after appropriate surgical excision.
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    A comparison of logistic regression and artificial neural networks in predicting central lymph node metastases in papillary thyroid microcarcinoma
    (2018) Er, Sadettin; Saylam, Barış; Tez, Mesut; Şenol, Kazım; Doctor; School of Medicine; Koç University Hospital; N/A
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    PublicationOpen Access
    Clinicopathologic and prognostic features in gallbladder malignancies: retrospective analysis of 5206 cases
    (Galenos Yayınevi, 2019) Ferhatoglu, Murat Ferhat; Kıvılcım, Taner; Kartal, Abdulcabbar; Gürkan, Alp; N/A; Şenol, Kazım; Doctor; School of Medicine
    Aim: Gallbladder cancer is the sixth most common cancer of the gastrointestinal system. Clinical presentation may not be distinguished from cholelithiasis or cholecystitis and most patients are diagnosed intraoperatively or in the postoperative histologic examination. In this study, we aimed to investigate the association of incidentally detected gallbladder cancer with gallbladder premalignant lesions, age, gender, ultrasonography features and gallbladder stones. Methods: demographic and clinical characteristics and pathology results of 5206 patients who underwent cholecystectomy between January 2012 and December 2015 were evaluated retrospectively. Results: three thousand eight hundred and eighty four (74.6%) patients were female. Pathologic reports showed pre-malignant and malignant lesions in 102 (1.95%) cases. Metaplasia was significantly more common in females, while no significant difference was found in development of dysplasia and cancer between genders. Gallbladder stone was found to be a risk factor for the development of metaplasia. Gallbladder wall thickening and advanced age are the most important risk factors for gallbladder cancer. Conclusion: female gender and gallstone are important risk factors for the development of metaplasia. Advanced age, gallstone and gallbladder wall thickening on ultrasonography are the most important factors in the development cancer. Cholecystectomy should be kept in mind as the most effective method to prevent cancer development in elderly patients with gallbladder stones. / Amaç: safra kesesi kanseri, gastrointestinal sistemin en yaygın altıncı kanseridir. Klinik prezentasyon safra kesesi taşı veya kolesistitden ayırt edilemez ve çoğu hasta intraoperatif veya postoperatif histolojik incelemede tanı alır. Bu çalışmada, insidental olarak tespit edilmiş safra kesesi kanserli olguların safra kesesi pre-malign lezyonları, yaş, cinsiyet, ultrasonografi özellikleri ve safra kesesi taşı ile ilişkisi araştırılmıştır. Yöntemler: Ocak 2012-Aralık 2015 tarihleri arasında kolesistektomi uygulanan 5206 hastanın demografik ve klinik özellikleri, patoloji sonuçları retrospektif olarak değerlendirildi. Bulgular: hastaların 3884’ü (%74,6) kadındı. Patoloji raporlarında 102 (%1,95) olguda pre-malign ve malign lezyonlar olduğu tespit edildi. Metaplazi kadınlarda anlamlı olarak daha fazla iken, displazi ve kanser gelişimi arasında cinsiyete göre anlamlı bir fark bulunamadı. Safra kesesi taşı metaplazi gelişiminde bir risk faktörü olarak bulundu. Safra kesesi duvar kalınlaşmasının ve ileri yaşın safra kesesi kanseri gelişimi için en önemli risk faktörleri olduğu tespit edildi. Sonuç: metaplazi gelişiminde kadın cinsiyet ve taş varlığı önemli faktörlerdir. Ultrasonografide safra kesesi duvar kalınlaşması, ileri yaş, safra kesesinde taşı varlığı kanser gelişiminde en önemli faktörlerdir. Kolesistektomi, ileri yaşta safra kesesi taşı olan hastalarda kanser gelişimini önlemek için en etkili yöntem olarak akılda tutulmalıdır.