Researcher:
Erman, Baran

Profile Picture
ORCID

Job Title

Researcher

First Name

Baran

Last Name

Erman

Name

Name Variants

Erman, Baran

Email Address

Birth Date

Filters

2017 - 20204

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.6edcbd18-b77c-4867-bf6c-f4985137c861

Search Results

Now showing 1 - 4 of 4
  • Placeholder
    PublicationMetadata only
    Two siblings with PRKDC defect who presented with cutaneous granulomas and review of the literature
    (Academic Press Inc Elsevier Science, 2018) Esenboğa, Saliha; Akal, Can; Karaatmaca, Betül; Doğan, Sibel; Orhan, Diclehan; Boztuğ, Kaan; Ayvaz, Deniz; Tezcan, İlhan; N/A; Erman, Baran; Researcher; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; 268521
    V(D)J recombination, during which recognition and repair of broken DNA chains are accomplished by non-homologous end joining pathway, is a critical process in B and T cell development.Null mutations of each enzyme or protein of this pathway result in T- B- NK + severe combined immunodeficiency whereas hypomorphic mutations result in atypical(leaky)severe combined immunodeficiency forms. We present two siblings with PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide) mutation who presented with granulomatous skin lesions and recurrent lung infections. Primary immune deficiencies may initially present with skin findings. Disruption in central and peripheral B-cell tolerance and impaired intrathymic T-cell maturation,a central player in T-cell tolerance, have been identified as the mechanism of autoimmunity and granuloma seen in patients. The variation in clinical phenotypes of patients with PRKDC mutation suggests that additional factors such as modifying genes, epigenetic and environmental factors may affect the severity and clinical phenotype of the disease. Functional studies during the follow-up and evaluation before and after hematopoeitic stem cell transplantation will hopefully increase our knowledge about the autoimmune and inflammatory process of the disease spectrum.
  • Placeholder
    PublicationMetadata only
    IgE and IgG4 binding to lentil epitopes in children with red and green lentil allergy
    (Wiley, 2020) Gimenez, Gustavo; Grishina, Galina; Yavuz, Süleyman T.; Şahiner, Ümit Murat; Büyüktiryaki, Betül; Yılmaz, Ebru Arık; Cavkaytar, Özlem; Sampson, Hugh A.; N/A; N/A; N/A; Saçkesen, Cansın; Erman, Baran; Yılmaz, Özlem; Faculty Member; Researcher; Doctor; School of Medicine; School of Medicine; School of Medicine; 182537; 268521; 140706
    Background: The consumption of lentil is common in the Mediterranean area and is one of the causes of IgE-mediated food allergy in many countries. Len c 1 is a well-defined allergen of lentil and approximately 80% of the patients with lentil allergy recognize the purified Len c 1 protein. We sought to identify IgE and IgG4 sequential epitopes of Len c 1 in patients with red and/or green lentil allergy. We also aimed to determine IgE and IgG4 binding differences between those patients who had outgrown or remained reactive to lentil. Methods: Children with IgE-mediated lentil allergy were included in the study. We applied a microarray immunoassay to determine the characterization of positive IgE and IgG4 binding to Len c 1 epitopes in the patients' sera. Results The peptides specifically recognized by IgE and IgG4 antibodies were mainly detected between peptides 107 and 135 of Len c 1. The signal intensities of positive epitopes were significantly greater in reactive patients than tolerant ones (P = .008 for IgE and P = .002 for IgG4). Moreover, IgE and IgG4 antibodies bound largely the same sequential epitopes in patients who remained reactive or outgrew their allergy. Conclusion: IgG4-binding epitopes in lentil allergy were identified and IgE and IgG4 binding to epitopes in both red and green lentils was compared. Our data regarding signal intensity differences between reactive and outgrown patients and overlap binding of IgE and IgG4 antibodies may be important for the development of more accurate diagnostic tests and understanding of natural tolerance development.
  • Placeholder
    PublicationMetadata only
    Defective pneumococcal antibody response in patients with recurrent respiratory tract infections
    (Turkish J Pediatrics, 2017) Demirtaş, Duygu; Bildik, Hacer Neslihan; Cağdas Ayvaz, Deniz; Sanal, Özden; Tezcan, İlhan; N/A; Erman, Baran; Researcher; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; 268521
    Streptococcus pneumoniae is a common pathogen responsible for pulmonary infections and the leading cause of mortality and morbidity in patients with particularly B cell immunodeficiencies. Antibody production is the principal protective immune response against S. pneumoniae and measurement of the production of antipolysaccharide antibodies is important in the evaluation of B cell deficiencies. We quantified serotype-specific immunoglobulin G antibodies against seven common pneumococcal serotypes before and three weeks after unconjugated vaccine in 416 patients with recurrent respiratory tract infections; fifty-five (13%) of whom showed impaired antibody response. We could evaluate 41 of these 55 patients for their particular clinical features. Specific antibody deficiency, was diagnosed in 10 of these patients, common variable immunodeficiency in 18, ataxia telangiectasia in 10 and other antibody deficiencies in 7 (transient hypogammaglobulinemia in 4, IgG subclass deficiency in 1, partial and selective IgA deficiency in 1) patients. Evaluation of the antibody response to polysaccharide antigens should be considered early on in patients with recurrent respiratory infections and required particularly for the diagnosis of specific antibody deficiency and the decision of the appropriate treatment approaches.
  • Thumbnail Image
    PublicationOpen Access
    Role of natural killer cells in lung cancer
    (Springer, 2018) Aktaş, Özge Nur; Erman, Baran; Erus, Suat; Tanju, Serhan; Dilege, Şükrü; Öztürk, Ayşe Bilge; Faculty Member; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Koç University Hospital; N/A; N/A; N/A; N/A; 147629
    Purpose: One of the key immune cells involved in the pathogenesis of lung cancer is natural killer (NK) cells and these cells are novel targets for therapeutic applications in lung cancer. The purpose of this review is to summarize the current literature on lung cancer pathogenesis with a focus on the interaction between NK cells and smoking, how these factors are related to the pathogenesis of lung cancer and how NK cell-based immunotherapy effect lung cancer survival. Methods: The relevant literature from PubMed and Medline databases is reviewed in this article. Results: The cytolytic potential of NK cells are reduced in lung cancer and increasing evidence suggests that improving NK cell functioning may induce tumor regression. Recent clinical trials on NK cell-based novel therapies such as cytokines including interleukin (IL)-15, IL-12 and IL-2, NK-92 cell lines and allogenic NK cell immunotherapy showed promising results with less adverse effects on the lung cancer survival. Conclusions: The NK cell targeting strategy has not yet been approved for lung cancer treatment. More clinical studies focusing on the role of NK cells in lung cancer pathogenesis are warranted to develop novel NK cell-based therapeutic approaches for the treatment of lung cancer.