Researcher: Topaloğlu, Mahir
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Topaloğlu, Mahir
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Publication Metadata only Effect of kinesio tape applied to supraspinatus muscle on shoulder scaption strength and upper extremity stability in healthy women aged 20 to 30 years: a double blind randomized controlled trial(EDRA SPA, 2024) Sokucu, Sami; Taşkıran, Özden Özyemişçi; Topaloğlu, Mahir; Albayrak, Havvanur; School of Medicine; Koç University HospitalObjective. To investigate the effect of kinesio tape applied to the supraspinatus muscle on shoulder scaption muscle strength and upper extremity stability in healthy women. Methods. 26 healthy female volunteers aged 20-30 years were included in the study. Individuals were randomized into two groups, kinesio taping (n = 13) and sham taping (n = 13). In the kinesio taping group a Y-shaped tape was applied to the supraspinatus muscle in the direction of facilitation while in the sham group an I tape was applied on the scapula. Before taping and 20 minutes after taping the shoulder scaption strength was measured with a dynamometer and functional evaluations were performed by the closed kinetic chain upper extremity stability test. Results. In the kinesio tape group, median scaption strength decreased after taping (p = 0.016). The median contact, normalized, and power scores increased significantly (respectively, p = 0.001, p = 0.001, and p = 0.001). In the sham group there was no significant difference in the median scaption strength after taping; the median contact, normalized and power scores increased significantly (p = 0.004, p = 0.004, and p = 0.006, respectively). There was no significant difference in scaption strength and upper extremity stability test scores between groups. After taping the changes were categorized as "no change", "increase" and "decrease" according to the minimal clinically significant difference value, the number of individuals with increased scaption strength was higher in the kinesio tape group compared to the sham group, although not statistically significant. Conclusions. The significance of kinesio taping applied to healthy women was not observed compared to sham taping on shoulder scaption muscle strength and upper extremity stability.Publication Metadata only Effect of platelet-rich plasma injections versus placebo on pain and quality of life in patients with hip osteoarthritis: a double-blind, randomized clinical trial(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2024) Sen, Ekin Ilke; Diracoglu, Demirhan; N/A; Topaloğlu, Mahir; Sarıkaya, Deniz; School of Medicine; Koç University HospitalObjectives: This study aims to compare the efficacy of intra-articular platelet -rich plasma (PRP) injections over a saline placebo in terms of reduction of pain and impact on quality of life among patients with hip osteoarthritis. Patients and methods: A total of 60 patients (29 males, 31 females, mean age: 57.9 +/- 7.3 years; range, 47 to 69 years) with known hip osteoarthritis of Kellgren-Lawrance (KL) Grades 2/3 were randomized into placebo (n=30) and PRP groups (n=30) between June 2014 and June 2015. Both groups received intra-articular injections into the hip joint under ultrasound guidance for three consecutive weeks. The patients were followed for six months, and pain reduction was assessed using the Visual Analog Scale (VAS), Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire, and Short Form Health Survey -36 (SF -36). Results: Intra-articular PRP treatment showed no advantage over a saline placebo in terms of VAS scores during activity. Both groups showed a significant improvement in VAS activity scores at one and six months. The placebo group showed improvements in VAS resting scores, whereas the PRP group did not. Both groups showed no improvement in WOMAC-total scores. Both groups showed no significant improvement across most SF -36 domains with the exception of improved physical role functioning at one month and general health at one and six months in the placebo group. Conclusion: Intra-articular injections of PRP show no significant difference compared to a saline placebo over a period of six months on pain, function, and quality of life scores in patients with hip osteoarthritis.Publication Metadata only Effect of ultrasound-guided rhomboid interfascial plane block on pain severity, disability, and quality of life in myofascial pain syndrome - a case series with one-year follow-up(American Society of Interventional Pain Physicians, 2023) ; Taşkıran, Özden Özyemişçi; Albayrak, Havvanur; Topaloğlu, Mahir; Manici, Mete; Ketenci, Ayşegül; Gürkan, Yavuz; ; School of Medicine; Koç University HospitalBackground: Myofascial pain syndrome (MPS) is a condition characterized by trigger points in the taut bands of skeletal muscles, commonly affecting the trapezius, rhomboid, and supraspinatus muscles. Rhomboid intercostal block (RIB), an interfascial plane block used to assist perioperative analgesia might be a potential treatment option in MPS. Objectives: To investigate the short and long-term effects of ultrasound-guided RIB in reducing the severity of pain, disability, and improving quality of life in MPS patients with trigger points in the rhomboid muscle. Study Design: Retrospective study. Setting: Physical medicine and rehabilitation outpatient clinic in a university hospital. Methods: Patients with a diagnosis of MPS who received ultrasound (US)-guided RIB between November 2021 and January 2022 were enrolled in this study. All patients reported pain lasting ≥ 3 months and severity ≥ 4/10 on numeric rating scale (NRS), without any comorbidities affecting the neuromuscular system. Trigger points in the rhomboid muscle were treated with US-guided RIB. Pain intensity was evaluated using a NRS at pre-treatment and one week, one month and one year after the injection. At pre-treatment, one month, and one year after treatment, self-administered neck pain and disability scale and Nottingham Health Profile were evaluated. Results: A total of 23 patients were included in this study (5 men and 18 women, with an average age of 45). Pain severity was statistically significantly reduced in approximately 90%, 60-70%, and 50% of the chronic MPS patients at the first week, first month, and first year following injection, respectively. Disability scores improved significantly in 70% and 56% of those patients at the first month and first-year follow-up. Improvement in the quality of life was observed at the first month and maintained at the first-year follow-up. Limitations: The retrospective design of this study is a limitation. Due to the lack of a control group, this treatment option could not be compared with other treatments. Conclusions: Our study demonstrated that RIB might be an effective long-term treatment option for MPS in the reduction of pain and disability, improvement of quality of life and overall patient satisfaction. © 2023, American Society of Interventional Pain Physicians. All rights reserved.Publication Open Access Differentiation of post-polio syndrome from prior poliomyelitis sequela by assessing paraspinal muscle involvement in magnetic resonance imaging(MDPI, 2024) Terlemez, Rana; Cetin, Burak Ugur; Topaloğlu, Mahir; Sarıkaya, Deniz; Peker, Ahmet; Şentürk, Yunus Emre; Öğe, Ali Emre; Ketenci, Ayşegül; School of Medicine; Koç University HospitalBackground/Objectives: Post-polio syndrome (PPS) affects former polio patients, manifesting decades after initial infection with progressive symptoms like pain, fatigue, and muscle weakness. Diagnosis relies on the clinical criteria and exclusion of other probable causes. The purpose of this study is to determine the scope and new diagnostic value of magnetic resonance imaging (MRI) in identifying muscle involvement in PPS and distinguishing it from prior poliomyelitis (PPM). Methods: This study was approved by the Koç University Ethics Committee with Approval No. 2023.409.IRB2.090. Electronic medical archives from two academic institutions were searched for records tagged with ICD code B-91 for poliomyelitis sequalae. The resulting search query of 291 records was manually sorted for PPS and PPM, medical history, clinical examination findings, and lumbar MR images down to 32 patients. Two independent radiologists evaluated the paraspinal musculature in the MRIs using the Mercuri scale. Inter-rater agreement, comparison of the paraspinal musculatures between groups, and their relationship to leg involvement were assessed with the resulting data. Results: Inter-rater agreement was found to be almost perfect across all muscles, except for the multifidus muscle. When clinical examination findings were included for these muscles, quadratus lumborum (QL) degradation was found in both right-side (p = 0.017) and left-side (p = 0.002) leg involvement. Conclusions: QL muscle deterioration may serve as a diagnostic marker for PPS, potentially guiding lumbar pain treatment through rehabilitation. © 2024 by the authors.Publication Metadata only The effect of blood flow restricted aerobic exercise training on pain, functional status, quality of life and hormonal response to exercise in fibromyalgia patients(Clinical and Exper Rheumatology, 2023) Zure, Mert; Arman, Sina; Topaloğlu, Mahir; Ketenci, Ayşegül; School of Medicine; Koç University HospitalPublication Metadata only Is poliomyelitis sequelae a disadvantage for recovery from Covid-19 ARDS: a case report(Turkish Neuropsychiatry assoc-Turk Noropsikiyatri Dernegi, 2022) N/A; N/A; N/A; N/A; Topaloğlu, Mahir; Turan, Zeynep; Tekin, Süda; Şentürk, Evren; Taşkıran, Özden Özyemişçi; Doctor; Doctor; Faculty Member; Faculty Member; Faculty Member; N/A; N/A; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; 42146; 48359; 133091We present a case with acute respiratory distress syndrome due to COVID-19 who had poliomyelitis sequelae. He was hospitalized in the intensive care unit and supported by non-invasive mechanical ventilation for 7 days. IL-6 inhibitor was administered due to cytokine storm. No steroid or sedative agents were administered. Early mobilization was performed in the intensive care unit. one month after discharge, physical examination revealed COVID-19 infection did not cause significant changes in muscle strength and physical performance in this patient with poliomyelitis sequelae. It is important to promote early mobilization in the intensive care unit to prevent post-intensive care syndrome in COVID-19 acute respiratory distress syndrome.Publication Metadata only Physical rehabilitation in intensive care unit in acute respiratory distress syndrome patients with COVID-19(Edizioni Minerva Medica, 2021) N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Taşkıran, Özden Özyemişçi; Turan, Zeynep; Tekin, Süda; Şentürk, Evren; Topaloğlu, Mahir; Yurdakul, Fatma; Ergönül, Önder; Çakar, Nahit; Faculty Member; Doctor; Faculty Member; Faculty Member; Doctor; Doctor; Faculty Member; Faculty Member; School of Medicine; N/A; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; School of Medicine; KUH Hospital; 133091; N/A; 42146; 48359; N/A; N/A; 110398; 198906Background: The risk of muscle weakness is high in the survivors of acute respiratory distress syndrome with COVID-19 following discharge from intensive care unit. AIM: To evaluate the effects of early rehabilitation program in intensive care unit in patients with acute respiratory distress syndrome secondary to COVID-19. Design: The design of the study is observational. SETTING: The setting of the study is inpatient Population: Thirty-five patients with acute respiratory distress syndrome secondary to COVID-19 were enrolled. Methods: This study was performed in an intensive care unit of a university hospital. Early rehabilitation program consisting of passive or active range of motion exercises and neuromuscular electrical stimulation in addition to standard intensive care (N.=18) compared to standard intensive care (N.=17). Primary outcome was hand grip strength following discharge. RESULTS : Rehab group had higher prevalence of chronic pulmonary diseases and neurologic diseases. There was no difference in hand grip or manual muscle strength following discharge between rehab and non-rehab groups. No adverse event was noted. Conclusions: The results did not support the beneficial effects of early rehabilitation in intensive care unit on improving muscle strength. More patients with pulmonary and neurologic diseases in rehab group might impede the impact of rehabilitation on outcomes. On the other hand, these comorbidities underline the role and need of rehabilitation. It is safe both for the patients and the health care workers when necessary precautions are taken. Clinical Rehabilitation Impact: This study guide how to rehabilitate patients with acute respiratory distress syndrome with COVID-19 during intensive care unit in a safe way.Publication Metadata only Musculoskeletal complaints and associated factors in school children aged between 6 and 13 years in Istanbul during the COVID-19 pandemic: a cross-sectional study(IOS Press BV, 2023) Giray, Esra; Yilmaz Yalcinkaya, Ebru; Taşkıran, Özden Özyemişçi; Topaloğlu, Mahir; Turan, Zeynep; Sakarya, Sibel; Faculty Member; Doctor; Doctor; Faculty Member; School of Medicine; N/A; N/A; School of Medicine; Koç University Hospital; 133091; N/A; N/A; 172028Background: Following the first COVID-19 cases in Turkey, face-to-face education was ceased after March 16, 2020 until the end of the educational year (i.e. June 19, 2020) and education was substituted remotely due to confinement. Objective: This study aims to investigate the frequency of musculoskeletal complaints in school-age children and associated risk factors including reduced physical activity, increased screen time and poor ergonomics conditions in school-age children during the pandemic. Methods: This cross-sectional study included parents or guardians of 960 students aged between 6-13 years old with a non-randomized sampling. A survey was administered consisting of 65 items related with sociodemographic characteristics of the children and family, online education hours, technological device(s) used, screen time, type of physical activity, presence of musculoskeletal problems and poor ergonomics conditions such as incorrect sitting posture. Results: Logistic regression results demonstrated that age, excess weight gain, total daily screen time, smartphone use, incorrect sitting posture were associated with musculoskeletal complaints. Conclusion: The long-term closure of schools due to the pandemic may have led to an increase in musculoskeletal complaints in 6-13 years old children, based on the factors identified in this study, which were excess weight gain, increased screen time and incorrect sitting posture. These findings might help education and health authorities to develop strategies to improve musculoskeletal health of children especially in emergencies such as the pandemic.Publication Metadata only Suprascapular nerve block in hemiplegic shoulder pain: comparison of the effectiveness of placebo, local anesthetic, and corticosteroid injections-a randomized controlled study(Springer-Verlag Italia Srl, 2020) Terlemez, Rana; Çiftçi, Selda; Doğu, Beril; Yılmaz, Figen; Kuran, Banu; N/A; Topaloğlu, Mahir; Doctor; N/A; Koç University Hospital; N/ABackground: Shoulder pain is a common complication of hemiplegic patients that can interrupt their rehabilitation program and is associated with poorer outcomes. The usefulness of the suprascapular nerve block. (SSNB) in the stroke population has been suggested, but some concerns still remain. Objectives: To investigate the effect of SSNB on pain intensity and passive range ofmotion (PROM) in patients with hemiplegic shoulder pain (HSP). Study Design: A prospective, double blind, randomized controlled trial was conductedin 34 stroke patients with HSP. They were randomly divided into three groups: Localanesthetic (LA) injection into the trapezius muscle (placebo group), LA injection into thesuprascapular notch, and LA and corticosteroid (CS) injections into the suprascapularnotch.The main outcome was visual analog scale (VAS) scores evaluated before andafter administration of the injection at 1 hour, 1 week, and 1 month. Results: There were significant decreases in the VAS scores with all three injections at all follow-up time points (p: 0.001 for the placebo group, p <0.001 for the LA group, and p <0.001 for the LA+CS group). When changes in VAS scores were compared between the groups, the LA+CS group demonstrated a higher decrease in VAS than the placebo group. Improvement in the PROM was seen only in the LA and LA+CS groups. Conclusions: The findings of this study support the use of an SSNB with or without CS, to increase the range of motion in the affected shoulder, especially during the rehabilitation period.Publication Metadata only Validity, inter-rater reliability, and feasibility of the chelsea physical assessment tool for assessing physical function in post-acute covid-19 patients: a cross-sectional study(IOS Press, 2022) Giray, Esra; Öke, Deniz; Curci, Claudio; De Sire, Alessandro; N/A; Turan, Zeynep; Topaloğlu, Mahir; Baygül, Arzu Eden; Taşkıran, Özden Özyemişçi; Doctor; Doctor; Faculty Member; Faculty Member; N/A; N/A; School of Medicine; School of Medicine; Koç University Hospital; Koç University Hospital; N/A; N/A; 272290; 133091Background: Various tools have been created to measure physical function during intensive care unit (ICU) stay and after ICU discharge, but those have not been validated in coronavirus 2019 (COVID-19) patients. There is a need for a reliable, valid and feasible tool to define the rehabilitation needs of post-ICU COVID-19 patients entering the acute wards and then rehabilitation clinics. Objective: this study aims to investigate the validity, inter-rater reliability and feasibility of Chelsea Physical Assessment Tool (CPAx) in assessing the functional status of COVID-19 patients after discharge from the ICU. Methods: Demographic and clinical characteristics of the patients were recorded. Patients were evaluated using the modified Medical Research Council (MRC) dyspnea scale, Functional Oral Intake Scale, Glasgow Coma Scale, CPAx, Barthel Index, Katz Index and MRC sum score, measurements of grip strength obtained by dynamometer, the 5 time sit-to-stand test and 30 seconds and sit-to-stand test. CPAx and the other functional assessment tools were administered to 16 patients within 48 hours following ICU discharge. For inter-rater reliability, another physiatrist independently re-assessed the patients. MRC sum score, Barthel and Katz indexes were used to assess construct validity of CPAx. The discriminative validity of CPAx was determined by its ability to differentiate between patients with and without ICU acquired muscle weakness based on MRC sum score. The intra-class correlation coefficients (ICC) were calculated to determine inter-rater reliability for total scores of the functional assessment tools. Cohen's Kappa (kappa) coefficient and weighed Kappa (kappa(w)) were calculated to determine inter-rater reliability of individual CPAx items. Ceiling and flooring effects were calculated by percentage frequency of lowest or highest possible score achieved. The number and percentages of the patients who were able to complete each tool were calculated to assess feasibility. Results: The CPAx score was strongly correlated with MRC sum score (rho: 0.83), Barthel Index (rho: 0.87) and Katz Index (rho: 0.89) (p < 0.001) showing construct validity. Area under the ROC curve demonstrated that cut off score for CPAx was <= 12 to discriminate patients with MRC sum score < 48, with a sensitivity and a specificity of 100% and 63%, respectively (AUC = 0.859, p < 0.001). ICC was high for CPAx, MRC sum score, Barthel and Katz indexes, Glasgow Coma Scale, and hand grip strength measurement, with the highest value observed for CPAx (ICC, 0.96; 95% confidence interval (CI), 0.71-0.98). kappa and kappa(w) analysis showed good to excellent inter-rater reliability for individual CPAx items. No floor or ceiling effect was observed at CPAx while floor effect was observed at Barthel Index scores (25%) and Katz Index scores (37.5%). All patients could be evaluated using CPAx while less were physically able to complete the 5 time sit-to-stand, 30 seconds sit-to-stand tests (n = 4) and MRC sum score (n = 14). Conclusion: CPAx is a valid, reliable, and feasible tool to assess the physical functional state in COVID-19 patients following discharge from the ICU.