Researcher:
Aydemir, Duygu

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Researcher

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Duygu

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Aydemir

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Aydemir, Duygu

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2018 - 201982020 - 202335

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Researcher Of Publications: search.filters.isAuthorOfPublication.751f58d0-8814-48e6-8943-ae3c6d2a7064

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Now showing 1 - 10 of 43
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    Impact of COVID-19 pandemic on academic research and being demotivated
    (AVES, 2020) N/A; Aydemir, Duygu; Ulusu, Nuriye Nuray; PhD Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; N/A; 6807
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    Synthesis and characterization of a triple enzyme-inorganic hybrid nanoflower (TrpE@ihNF) as a combination of three pancreatic digestive enzymes amylase, protease and lipase
    (Society for Bioscience and Bioengineering Japan, 2020) Gecili, Firdevs; Ozdemir, Nalan; N/A; Aydemir, Duygu; Ulusu, Nuriye Nuray; PhD Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; N/A; 6807
    Nanoflowers are recently developed flower-shaped nanoparticles consisting of several layers of petals to improve surface reaction and stability. Among them organic-inorganic hybrid nanoflowers have been spotlighted, since they can overcome enzyme-related limitations, including low stability, high production cost, substrate/product inhibition and difficult recovery. In this study, triple enzyme-inorganic hybrid nanoflowers (TrpE@ihNFs) were synthesized using a mixture of three enzymes (alpha-amylase, lipase and protease) and Cu2+ ions. TrpE@ihNFs were characterized by their morphology and chemical point of view by using different techniques including SEM, FTIR, EDX, and XRD. Afterwards we compared the enzyme activity and stability of TrpE@ihNFs with the free enzymes, including lipase, amylase and protease at the different pH and temperatures spectrophotometrically. Our data reveal that enzyme activities and stability of TrpE@ihNFs were significantly higher compared to the each free enzyme. In conclusion, we showed TrpE@ihNFs which can be used for the treatment of wastewater, biosensors, biocatalysts, and bio-related devices in the future.
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    A new substrate for glutathione reductase: glutathione coated Ag2S quantum dots
    (Elsevier, 2019) N/A; N/A; N/A; Department of Chemistry; N/A; Aydemir, Duygu; Hashemkhani, Mahshid; Durmuşoğlu, Emek Göksu; Acar, Havva Funda Yağcı; Ulusu, Nuriye Nuray; PhD Student; PhD Student; PhD Student; Faculty Member; Faculty Member; Department of Chemistry; Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM); Graduate School of Health Sciences; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Sciences; School of Medicine; N/A, N/A; N/A; 178902; 6807
    Glutathione (GSH), a key player in various cellular processes including detoxification, anti-oxidant defense system and cell proliferation is also a potentially good coating material for luminescent quantum dots. GSH is oxidized to oxidized glutathione (GSSG) under oxidative stress and then reduced back by glutathione reductase (GR) enzyme to maintain the balance of GSH/GSSG ratio. In this frame, GSH stabilized quantum dots (QDs) have never been evaluated as GR substrate. Here, GSH coated Ag2S QDs, luminescent in the medical window, were prepared and their GR activity were tested. We have shown by spectrophotometric methods that GSH-Ag2S acted as a substrate-analog for GR enzyme that had lower activity compared to the original substrate GSSG. These results provide a new perspective in the evaluation of QDs in medical applications, enzyme activity or level detection as well as possible means to study enzymes.
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    Impact of COVID-19 pandemic on academic research and being demotivated
    (Cukurova University, Faculty of Medicine, 2020) N/A; Aydemir, Duygu; Ulusu, Nuriye Nuray; PhD Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; N/A; 6807
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    People with blood disorders can be more vulnerable during COVID-19 pandemic: a hypothesis paper
    (Pergamon-Elsevier Science Ltd, 2021) N/A; N/A; Aydemir, Duygu; Ulusu, Nuriye Nuray; PhD Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; N/A; 6807
    The world has been encountered with COVID-19 pandemic since at the beginning of 2020 and the number of infected people by COVID-19 is increasing every day. Despite various studies conducted by researchers and doctors, no treatment has been developed until now, therefore self-protection and isolation are strongly recommended to stop the spread of the virus. The elderly population and people with chronic diseases such as hypertension, cardiovascular diseases, diabetes, and cancer are categorized as risk groups, however, we suggest that people with hemoglobinopathies or porphyria can be described as risk groups as well. Current in silico studies have revealed that the COVID-19 virus can attack heme and hemoglobin metabolisms which are responsible for the oxygen transport to the tissues, iron metabolism, elevated levels of oxidative stress, and tissue damage. Data of the in silico study have been supported with the biochemistry and hemogram results of the COVID-19 patients, for instance hemoglobin levels decreased and serum ferritin and C-reactive protein levels increased. Indicated biochemistry biomarkers are tightly associated with inflammation, iron overload, and oxidative stress. In conclusion, since people with hemoglobinopathies or porphyria have already impaired heme and hemoglobin metabolism, COVID-19 infection can enhance the adverse effects of impaired hemoglobin metabolism and accelerate the progression of severe symptoms in patients with hemoglobinopathies or porphyria compared to the normal individuals. Thus those people can be considered as a risk group and extra precautions should be applied for them to protect them.
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    Identifying and solving scientific problems in the medicine: key to become a competent scientist
    (Walter De Gruyter Gmbh, 2020) N/A; Aydemir, Duygu; Ulusu, Nuriye Nuray; PhD Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; N/A; 6807
    The scientific method can be described as a multistep and detailed process, in which finding the best question is the first and most crucial step. Thus, scientific problem should be examined thoroughly in different ways and perspectives. The amount and diversity of scientific data are enormously increasing and becoming more specific day by day, therefore traditional observational biology is not sufficient on an individual basis to understand and treat multifactorial diseases. Moreover, protocols, documentations, information, outcomes, precisions, and considerations of evidence should be improved to answer scientific questions correctly during the scientific research. Because of the diversity of the data and the methods, statisticians and methodologists should be involved and contribute to the all stages of research. Besides that, all scientific data should be certainly reproducible and repeatable. Scientific knowledge is in a state of flux and becomes more complex day by day. Thus, becoming a competent scientist needs, abilities and skills such as creativity, hardworking and self-discipline that all requires lifelong learning, searching, and widening scientific horizons consistently. / Bilimsel yöntem, en iyi soruyu bulmanın ilk ve en önemli adım olduğu çok aşamalı ve ayrıntılı bir süreç olarak tanımlanabilir. Bu nedenle, bilimsel problem farklı şekillerde ve bakış açılarıyla ayrıntılı olarak incelenmelidir. Bilimsel verilerin sayısı ve çeşitliliği gün geçtikçe son derece hızlı bir biçimde artmakta ve daha belirgin hale gelmektedir, bu nedenle gelenekseli, gözlemsel biyoloji, çok faktörlü hastalıkları anlamak ve tedavi etmek için tek başına yeterli değildir. Ayrıca, bilimsel araştırma sırasında bilimsel sorulara doğru cevap verebilmek için protokoller, belgeler, bilgiler, sonuçlar, kesinlikler ve kanıtlar iyileştirilmelidir. Verilerin çeşitliliği ve yöntemlerden dolayı, istatistikçiler ve metod geliştirenler araştırmaya katılmalı ve araştırmanın her aşamasına katkıda bulunmalıdır. Bunun yanı sıra, tüm bilimsel veriler kesinlikle tekrarlanabilir olmalıdır. Bilimsel bilgi bir akış halindedir ve gün geçtikçe daha karmaşık hale gelir. Böylece, yetkin bir bilim insanının yaratıcılık, çalışkanlık ve öz disiplin gibi ihtiyaçları, yetenekleri ve becerileri herkesin yaşam boyu öğrenmeyi, aramayı ve bilimsel ufukları tutarlı bir şekilde genişletmeyi gerektiren bir hale gelir.
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    People having hematological disorders and hypercoagulability state need extra precautions because of the increased risk of thrombosis after COVID-19 vaccination
    (Frontiers, 2023) Aydemir, Duygu; Ulusu, Nuriye Nuray; N/A; Aydemir, Duygu; Ulusu, Nuriye Nuray; Researcher; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; School of Medicine; N/A; 6807
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    The possible role of the endocrine disrupting chemicals on the premature and early menopause associated with the altered oxidative stress metabolism
    (Frontiers, 2023) N/A; Aydemir, Duygu; Ulusu, Nuriye Nuray; Researcher; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; School of Medicine; N/A; 6807
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    Importance of the serum biochemical parameters as potential biomarkers for rapid diagnosis and evaluating preclinical stage of ALS
    (Churchill Livingstone, 2020) N/A; Aydemir, Duygu; Ulusu, Nuriye Nuray; PHD Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; N/A; 6807
    Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder affected by both genetic and environmental factors. Since ALS is a heterogenic disease, symptoms vary among patients and there are no prognostic biomarkers, 18 months of delay occur from the onset of symptoms to confirmation of the diagnosis. Additionally, there are only two FDA-approved drugs, riluzole and edaravone, which are more effective at the early stages of ALS. Therefore, establishing biomarkers for ALS patients are vital for rapid and accurate diagnosis. Several biomarkers including genetic, biochemical, neurophysiological, cerebrospinal fluid (CSF) and imaging data have been reported for the diagnosis and evaluating progression of ALS, however none of them have been studied in the preclinical stage of ALS and superiority of different biomarkers have not been evaluated until now. We hypothesized that serum biochemical parameters can be used as potential biomarkers for diagnosis and evaluation of ALS progression even at the preclinical stages. Because, serum biochemical parameters are widely used, easy to measure, routine and cheaper approach to measure certain serum biochemistry parameters helping diagnosis and progression of several diseases. Moreover ALS causes hypermetabolic state which leads to malnutrion, losing weight and muscle mass in patients. Thus protein, lipid and carbohydrate metabolisms are impaired in the ALS patients. These impairments can be observed via serum biochemical parameters indicating nutrient metabolism and muscle destruction. Additionally, pathological changes in ALS have been started before disease symptoms manifesting. Therefore we hypothesized serum biochemical parameters can be used to prognosis and evaluate preclinical stages of ALS.
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    Evaluation of the effects of aging on the aorta stiffness in relation with mineral and trace element levels: an optimized method via custom-built stretcher device
    (Springernature, 2021) Turan, Belma; N/A; Department of Mechanical Engineering; N/A; Department of Mechanical Engineering; N/A; Aydemir, Duygu; Salman, Naveed; Karimzadehkhouei, Mehrdad; Alaca, Burhanettin Erdem; Ulusu, Nuriye Nuray; Faculty Member; Other; Researcher; Faculty Member; Faculty Member; Department of Mechanical Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM); School of Medicine; College of Engineering; N/A; College of Engineering; School of Medicine; N/A; N/A; N/A; 115108; 6807
    Aortic stiffness represents the major cause of aging and tightly associated with hypertension, atherosclerosis, cardiovascular diseases, and increased mortality. Mechanical characteristics of the aorta play a vital role in the blood flow, circulation, systolic pressure, and aortic stiffness; however, the correlation of trace element and mineral levels with aortic stiffness has not been studied before. Balance in the trace elements and minerals is vital for the biological functions; however, natural aging may alter this balance. Thus, after measuring aortic stiffness of aged and young rat aortas by a custom-built stretcher device, trace element and mineral levels were evaluated via ICP-MS. Also, biomarkers of aging including blood pressure, arterial pressure glucose, insulin levels, and histochemical parameters were investigated as well. Aortic stiffness, blood glucose, plasma insulin, systolic, diastolic, and mean arterial pressure significantly increased by aging in the aorta of aged rats compared with the young ones. Also, Fe, Al, Co, Ni, Zn, Sr, Na, Mg, and K levels increased in the aged aorta samples compared with the young aorta samples of rats. Increased levels of the indicated elements may be correlated with the development and progression of aortic stiffness and vascular complications. Thus, possible mechanisms correlating aortic stiffness with the imbalance in the trace element and mineral levels should be further investigated.