Researcher:
Cengiz, Duygu

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Doctor

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Duygu

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Cengiz

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Cengiz, Duygu

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2020 - 20249

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Researcher Of Publications: search.filters.isAuthorOfPublication.7c79445f-ae38-4892-85a7-b0a939a26802

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Now showing 1 - 9 of 9
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    Superior scapular location: an overlooked albeit frequent finding in elastofibroma dorsi
    (Elsevier Inc., 2024) N/A; Atalay, Hande Özen; Cengiz, Duygu; Atasoy, Kayhan Çetin; School of Medicine; Koç University Hospital
    Purpose: To explore the frequency of superior scapular elastofibroma dorsi in a large patient series with elastofibroma dorsi. Methods: 136 chest CTs from January 2016 to July 2022 reporting elastofibroma dorsi were retrospectively analyzed. Three radiologists assessed the number, size, and location of elastofibroma dorsi. Continuous variables underwent two-tailed t-tests with p < 0.05. Inter-observer agreement was assessed by using Cohen's Kappa values. Results: In 136 patients (mean age, 75.9 +/− 9.8 years; 117 female), 330 elastofibroma dorsi were found. Six (4.4 %) patients had single, 87 (64 %) double, 22 (16.2 %) triple and 21 (15.4 %) quadruple lesions. All single and double lesions were in the inferior scapular regions. 43 (31.6 %) patients had superior scapular lesions in addition to inferior scapular elastofibroma dorsi. Inferior scapular elastofibroma dorsi was significantly larger than superior scapular elastofibroma dorsi. The probability of a right superior lesion was significantly higher in patients with a larger right inferior lesion. Inter-observer agreement was very good for experienced radiologist (κ = 94.1) and good for other radiologists (κ = 79.4 and κ = 78). Conclusion: In contrast to current belief, superior scapular elastofibroma dorsi accompanying the typical inferior scapular lesions is not uncommon and can even manifest bilaterally. To the best of our knowledge, this is the first case series reporting prevalence of quadruple elastofibroma dorsi.
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    Intra-ampullary papillary tubular neoplasm (IAPN): clinicopathologic analysis of 72 cases highlights the distinctive characteristics
    (Elsevier Science Inc, 2023) Tarcan, Zeynep; Akar, Kadriye; Bagci, Pelin; Bozkurtlar, Emine; Ozkan, Hulya Sahin; Ozcan, Kerem; Balci, Serdar; Yilmaz, Serpil; Bilge, Orhan; Basturk, Olca; Esmer, Rohat; Saka, Burcu; Armutlu, Ayşe; Kapran, Yersu; Meriçöz, Çisel Aydın; Cengiz, Duygu; Gürses, Bengi; Alper, Emrah; Tellioğlu, Gürkan; Bozkurt, Emre; Adsay, Nazmi Volkan; School of Medicine; Koç University Hospital
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    Metaplastic (centrally-necrotic demarcated) carcinomas of the pancreas immunohistochemically classify as basal type, further warranting their classification as a separate category (ICD-O:8575/3) as in the breast
    (Elsevier Science Inc, 2023) Bagci, Pelin; Pehlivanoglu, Burcin; Bozkurtlar, Emine; Reid, Michelle; Bilge, Orhan; Cheng, Jeanette; Luchini, Claudio; Scarpa, Aldo; Cengiz, Duygu; Meriçöz, Çisel Aydın; Esmer, Rohat; Saka, Burcu; Armutlu, Ayşe; Alper, Emrah; Tellioğlu, Gürkan; Gürses, Bengi; Adsay, Nazmi Volkan; School of Medicine; Koç University Hospital
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    Sagittal (duct-centric) grossing of whipple specimens as a novel approach that combines the benefits of the axial and bivalving methods and provides more detailed documentation of anatomic variations and pathologic conditions: radiologic-pathologic correlative analysis of 61 cases
    (Elsevier Science Inc, 2023) Kurt, Ozgur; Kayim, Hatice Goksu; Bilge, Orhan; Basturk, Olca; Tezcan, Nuray; Cengiz, Duygu; Esmer, Rohat; Aktaş, Berk Kaan; Armutlu, Ayşe; Saka, Burcu; Kapran, Yersu; Karakaya, Afak Durur; Bozkurt, Emre; Tellioğlu, Gürkan; Alper, Emrah; Gürses, Bengi; School of Medicine; Koç University Hospital
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    Intra-ampullary papillary tubular neoplasm (IAPN): clinicopathologic analysis of 72 cases highlights the distinctive characteristics of a poorly recognized entity
    (LIPPINCOTT WILLIAMS & WILKINS, 2024) Tarcan, Zeynep C.; Akar, Kadriye E.; Bağcı, Pelin; Bozkurtlar, Emine; Özkan, Hülya Şahin; Özcan, Kerem; Balcı, Serdar; Yılmaz, Serpil; Bilge, Orhan; Cheng, Jeanette D.; Baştürk, Olca; Esmer, Rohat; Saka, Burcu; Armutlu, Ayşe; Taşkın, Orhun Çığ; Kapran, Yersu; Meriçöz, Çisel Aydın; Cengiz, Duygu; Gürses, Bengi; Alper, Emrah; Tellioğlu, Gürkan; Bozkurt, Emre; Adsay, Nazmi Volkan; School of Medicine; Koç University Hospital
    The guidelines recently recognized the intra-ampullary papillary tubular neoplasm (IAPN) as a distinct tumor entity. However, the data on IAPN and its distinction from other ampullary tumors remain limited. A detailed clinicopathologic analysis of 72 previously unpublished IAPNs was performed. The patients were: male/female=1.8;mean age=67 years (range: 42 to 86 y);mean size=2.3 cm. Gross-microscopic correlation was crucial. From the duodenal perspective, the ampulla was typically raised symmetrically, with a patulous orifice, and was otherwise covered by stretched normal duodenal mucosa. However, in 6 cases, the protrusion of the intra-ampullary tumor to the duodenal surface gave the impression of an "ampullary-duodenal tumor," with the accurate diagnosis of IAPN established only by microscopic correlation illustrating the abrupt ending of the lesion at the edge of the ampulla. Microscopically, the preinvasive component often revealed mixed phenotypes (44.4% predominantly nonintestinal). The invasion was common (94%), typically small (mean=1.2 cm), primarily pancreatobiliary-type (75%), and showed aggressive features (lymphovascular invasion in 66%, perineural invasion in 41%, high budding in 30%). In 6 cases, the preinvasive component was pure intestinal, but the invasive component was pancreatobiliary. LN metastasis was identified in 42% (32% in those with <= 1 cm invasion). The prognosis was significantly better than ampullary-ductal carcinomas (median: 69 vs. 41 months;3-year: 68% vs. 55%;and 5-year: 51% vs. 35%, P=0.047). In conclusion, unlike ampullary-duodenal carcinomas, IAPNs are often (44.4%) predominantly nonintestinal and commonly (94%) invasive, displaying aggressive features and LN metastasis even when minimally invasive, all of which render them less amenable to ampullectomy. However, their prognosis is still better than that of the "ampullary-ductal" carcinomas, with which IAPNs are currently grouped in CAP protocols (while IAPNs are kindreds of intraductal tumors of the pancreatobiliary tract, the latter represents the ampullary counterpart of pancreatic adenocarcinoma/cholangiocarcinoma).
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    Feasibility and results of the stentectomy procedure performed as rescue treatment for acute thrombosis of self-expandable intracranial stents: a case series
    (Lippincott Williams & Wilkins, 2022) Onal, Yılmaz; Velioğlu, Murat; Barburoğlu Mehmet; Aydın, Kubilay; Cengiz, Duygu; Doctor; Other; N/A; N/A; Koç University Hospital; N/A; N/A
    Background: Self-expandable stents have been increasingly used for endovascular treatment of intracranial aneurysms. Because the usage of intracranial stents has increased overall, total numbers of complications associated with these devices have increased. Thrombosis, distortion, or incomplete opening of stents are potential complications that may result in occlusion of the parent artery. In such cases, removal of the stent (stentectomy) may be the only solution to avoid serious clinical consequences. Objective: To investigate the feasibility and efficacy of a novel stentectomy technique for removal of thrombosed self-expandable stents. Methods: A retrospective review was performed of patients who underwent the stentectomy procedure. Initial and follow-up imaging and clinical outcomes were assessed. Immediate postprocedural and follow-up clinical statuses were assessed using the modified Rankin scale. Results: Seven patients were included in this study (mean age: 54.1 years). The stentectomy was successful in 6 of 7 patients (85.7%). Seven stents in 6 patients were successfully removed to treat the acute in-stent thrombosis that was resistant to alternative bail-out treatments. The removed stents were self-expandable braided in 2 patients, flow diverters in 2 patients, and laser cut open-cell stents in 2 patients. Stentectomy failed to retrieve a thrombosed braided stent in 1 patient. The modified Rankin scale score of all patients who underwent a success stentectomy was <= 1. Conclusion: The stentectomy procedure using the defined technique is feasible to retrieve thrombosed stents and effective to restore the blood flow. It can be considered a last resort option to treat acute in-stent thrombosis resistant to alternative bail-out treatments.
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    In-bore MRI-guided prostate biopsy in a patient group with PI-RADS 4 and 5 targets: a single center experience
    (Elsevier Ireland Ltd, 2021) Vural, M.; Coskun, B.; Kilic, M.; Durmaz, S.; Onay, A.; Saglican, Y.; Colakoglu, B.; Akpek, S.; Yildirim, H.; Esen, T.; Rozanes, I.; Gümüş, Terman; Cengiz, Duygu; Doctor; Doctor; N/A; N/A; Koç University Hospital; N/A; N/A
    Purpose: To determine the diagnostic yield of magnetic resonance imaging (MRI) guided in-bore biopsy in patients with high likelihood multiparametric MRI (mpMRI) findings, regarding overall and clinically significant prostate cancer (csPCa) detection rates and concordance of biopsy and radical prostatectomy (RP) Gleason scores (GS). Methods: This retrospective study consisted of 277 Prostate Imaging Reporting and Data System (PI-RADS) assessment category 4 and 5 targets in 246 patients (mean age, 65.7 years; median prostate specific antigen value, 7.75 ng/mL) who had undergone in-bore biopsy at our institution between 2012 and 2020. Eighty-one patients who underwent RP were eligible for the concordance analysis of biopsy and RP specimen GS. Results: Overall PCa detection rates were 80.5 % per patient (198/246) and 78 % per target (216/277) and 83.5 % and 67.4 % in primary (biopsy naive) and secondary (at least one negative prior biopsy) settings. csPCa was found in 63 % overall, 66 % of patients (132/200) in the primary, and 50 % of patients (23/46) in the secondary biopsy settings (p < 0.001). The prostate cancer detection rate was 68 % and 92 % in PI-RADS 4 and 5, respectively (p < 0.001). In the radical prostatectomy subcohort, 27.2 % of patients were upgraded, 8.6 % of patients were downgraded from needle biopsy. Significant complications occurred in 1.2 % of patients. Conclusions: MRI-guided in-bore prostate biopsy has a high detection rate of csPCa in primary and secondary biopsy cohorts. Biopsy results were satisfactory in terms of the number of positive cores, cancer percentage in positive cores, and concordance of GS in needle biopsy and RP specimen. © 2021 Elsevier B.V.
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    Centrally-necrotic/hyalinizing demarcated (CND) carcinomas of the pancreas: a clinico-pathologically distinct group with divergent metaplastic patterns and high-grade characteristics
    (Elsevier, 2022) Bagci, Pelin; Altinmakas, Emre; Pehlivanoglu, Burcin; Bozkurtlar, Emine; Reid, Michelle; Cheng, Jeanette; Luchini, Claudio; Scarpa, Aldo; Basturk, Olca; N/A; Cengiz, Duygu; Saka, Burcu; Bozkurt, Emre; Armutlu, Ayşe; Meriçöz, Çisel Aydın; Alper, Emrah; Tellioğlu, Gürkan; Gürses, Bengi; Adsay, Nazmi Volkan; Other; Faculty Member; Doctor; Teaching Faculty; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; 296729; 222921; N/A; 133567; 162418; 220444; 230736; 113169; 286248
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    PublicationOpen Access
    Changes in computed tomography findings of COVID-19 pneumonia: less extensive lung involvement with decreasing disease prevalence
    (Wiley, 2020) Gümüş, Terman; Cengiz, Duygu; Kartal, Furkan; Atçeken, Zeynep; Tekin, Süda; Atasoy, Kayhan Çetin; Doctor; Faculty Member; School of Medicine
    It has been observed that the degree of pulmonary involvement shown in chest computed tomography (CT) scans tended to decrease as the prevalence of coronavirus disease 2019 (COVID-19) infection decreased in the Turkish population. The purpose of this study was to investigate the relationship between the disease severity based on chest CT scans and the temporal evolution of the epidemic. This study recruited 179 patients with confirmed COVID-19 disease who had received a chest CT scan between March 14 and April 28, 2020. The participants were divided into three successive temporal groups based on their date of CT examination. The early (March 14-29), mid (March 30-April 13), and late (April 14-28) groups were compared regarding the presence and extent of pulmonary involvement and CT characteristics of lesions. COVID-19 pneumonia was less extensive in participants under 45 years of age and patients presenting late in the course of epidemic (i.e., the late group) compared those presenting earlier. When each group was subcategorized on the basis of age, older patients in the late group had less extensive lung involvement than older patients in the early group. However, there was no significant difference in the extent of lung involvement in younger patients between the late and early groups. The severity of COVID-19 pneumonia appears to be variable at different temporal windows of the epidemic curve and decreases in patients presenting in the later weeks compared to the earlier weeks, particularly in older patients.