Researcher:
Yerlikaya, Aslıhan

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Undergraduate Student

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Aslıhan

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Yerlikaya

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Yerlikaya, Aslıhan

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2015 - 201992020 - 20211

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Researcher Of Publications: search.filters.isAuthorOfPublication.7fb18ce4-7d44-4c90-a9d9-079dbfa858af

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    The crosstalk of gut microbiota and chronic kidney disease: role of inflammation, proteinuria, hypertension, and diabetes mellitus
    (Springer, 2018) Covic, Adrian; Vaziri, Nosratola D.; Afsar, Baris; N/A; Kanbay, Mehmet; Önal, Emine Meltem; Dağel, Tuncay; Yerlikaya, Aslıhan; Faculty Member; Undergraduate Student; Doctor; Undergraduate Student; School of Medicine; School of Medicine; N/A; School of Medicine; N/A; N/A; Koç University Hospital; N/A; 110580; N/A, N/A; N/A
    Chronic kidney disease (CKD) has been shown to result in profound changes in the composition and functions of the gut microbial flora which by disrupting intestinal epithelial barrier and generating toxic by-products contributes to systemic inflammation and the associated complications. On the other hand, emerging evidence points to the role of the gut microbiota in the development and progression of CKD by provoking inflammation, proteinuria, hypertension, and diabetes. These observations demonstrate the causal interconnection between the gut microbial dysbiosis and CKD. The gut microbiota closely interacts with the inflammatory, renal, cardiovascular, and endocrine systems via metabolic, humoral, and neural signaling pathways, events which can lead to chronic systemic inflammation, proteinuria, hypertension, diabetes, and kidney disease. Given the established role of the gut microbiota in the development and progression of CKD and its complications, favorable modification of the composition and function of the gut microbiome represents an appealing therapeutic target for prevention and treatment of CKD. This review provides an overview of the role of the gut microbial dysbiosis in the pathogenesis of the common causes of CKD including hypertension, diabetes, and proteinuria as well as progression of CKD.
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    Iron in kidney and heart failure: from theory to practice
    (Springer, 2018) Afsar, Baris; Voroneanu, Luminita; Siriopol, Dimitire; Covic, Adrian; N/A; N/A; N/A; N/A; N/A; Yerlikaya, Aslıhan; Bülbül, Mustafa Cem; Dağel, Tuncay; Aslan, Gamze; Kanbay, Mehmet; Undergraduate Student; Researcher; Doctor; Doctor; Faculty Member; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; N/A; N/A; Koç University Hospital; School of Medicine; N/A; N/A; 327626; N/A; N/A; 110580
    There is evidence that serum iron levels, regardless of the presence of anemia, directly impact outcomes in congestive heart failure (CHF) including quality of life, hospitalization rate and overall survival. Despite modern medical treatments, the prognosis of CHF remains grim. Ironically, simple iron replenishment may serve as a powerful tool in the armamentarium. This review will start from fundamental concepts of iron in oxygen delivery and analyze evidence-based outcomes in CHF iron-directed therapeutic trials. Imaging rationale that dovetails with this pathophysiology will also be detailed in a clinician-directed fashion.
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    Salt intake and immunity
    (Lippincott Williams and Wilkins (LWW), 2018) Afsar, Baris; Kuwabara, Masanari; Ortiz, Alberto; Siriopol, Dimitrie; Covic, Adrian; Rodriguez-Iturbe, Bernardo; Johnson, Richard J.; N/A; Yerlikaya, Aslıhan; Kanbay, Mehmet; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; N/A; 110580
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    Reply to: hemodynamic and arterial stiffness parameters in ambulatory blood pressure phenotypes and the clinical scenario of polypharmacy and comorbidities
    (Wiley-Blackwell, 2015) Afşar, Barış; N/A; Kanbay, Mehmet; Yerlikaya, Aslıhan; Faculty Member; Undergraduate Student; School of Medicine; School of Medicine; 110580; N/A
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    Erythropoietin mediates brain-vascular-kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertension
    (Taylor & Francis, 2017) Afsar, Baris; N/A; Kanbay, Mehmet; Önal, Emine Meltem; Sağ, Alan Alper; Şal, Oğuzhan; Yerlikaya, Aslıhan; Faculty Member; Undergraduate Student; Faculty Member; Undergraduate Student; Undergraduate Student; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 110580; N/A; N/A; 341966; N/A
    Organ crosstalk pathways represent the next frontier for target-mining in molecular medicine for existing syndromes. Pulmonary hypertension and resistant essential hypertension are syndromes that have been proven elusive in etiology, and frequently refractory to first-line management. Underlying crosstalk mechanisms, not yet considered in these treatments, may hinder outcomes or unlock novel treatments. This review focuses systematically on erythropoietin, a synthesizable molecule, as a mediator of brain-kidney crosstalk. Insights gained from this review will be applied to cardiovascular diseases in a clinician-directed fashion.
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    Erratum to: Dietary and commercialized fructose: sweet or sour?
    (Springer, 2017) King, Christopher; Kuwabara, Masanari; Lanaspa, Miguel A.; Andres-Hernando, Ana; Covic, Adrian; Manitius, Jacek; N/A; Kanbay, Mehmet; Yerlikaya, Aslıhan; Sağ, Alan Alper; Dağel, Tuncay; Faculty Member; Undergraduate Student; Faculty Member; Doctor; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; Koç University Hospital; 110580; N/A; N/A; N/A
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    Dietary and commercialized fructose: sweet or sour?
    (Springer, 2017) King, Christopher; Kuwabara, Masanari; Lanaspa, Miguel A.; Andres-Hernando, Ana; Covic, Adrian; Manitius, Jacek; N/A; Kanbay, Mehmet; Yerlikaya, Aslıhan; Sağ, Alan Alper; Dağel, Tuncay; Faculty Member; Undergraduate Student; Faculty Member; Doctor; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; Koç University Hospital; 110580; N/A; N/A; N/A
    Metabolic syndrome and diabetes are main health problems of modern life in the twenty-first century. Alarming ratios of global prevalence lead to conduct more and more researches about etiological factors and pathogenesis. Disease mechanism is elementary for advancing more efficient and practicable treatment methods. Concurrent increase in both fructose consumption with Western diet and metabolic syndrome has revealed fructose hypothesis that suggests fructose as one of etiological factor of metabolic syndrome (insulin resistance, central obesity, hypertension, etc.). Recent studies have increasingly lightened the unknowns about role of fructose on pathogenesis. This review discusses fructose hypothesis by exploring current studies and their results in wide perspective. Potential mechanisms covering low-grade inflammation or de novo lipogenesis, etc., in the development of insulin resistance and obesity are explained. Clinical trials have revealed connection of fructose-induced hyperuricemia with insulin resistance and chronic inflammatory state leading to hepatosteatosis or obesity. Further, novel hypothesizes suggesting role of fructose-induced modifications in epigenetics, gut microbiota and oxidative stress on disease pathogenesis are reviewed based on recent clinical trials. More innovative theories including fructose-induced malignancy; decreased satiety feeling, and unfavorable bone health are argued covering fructose-induced neurotransmitter changes in central nervous system, more aggressive malignancy phenotype and impaired calcium absorption.
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    The role of isolation of the patients on hospital admission for prevention of nosocomial infections
    (DOC Design and Informatics, 2021) Madran, Bahar; Akbaba, Gözde; Dönmez, Hanife Ebru; Beşli, Yeşim; N/A; Keske, Şiran; Yerlikaya, Aslıhan; Ergönül, Önder; Faculty Member; Undergraduate Student; Faculty Member; Koç Üniversitesi İş Bankası Enfeksiyon Hastalıkları Uygulama ve Araştırma Merkezi (EHAM) / Koç University İşbank Center for Infectious Diseases (KU-IS CID); School of Medicine; School of Medicine; School of Medicine; 125555; N/A; 110398
    Objective: Contact precautions (CP) for the prevention of multidrug-resistant organisms (MDROs) in endemic countries is a critical element of infection control (IC) practices. In this study, we assessed the effectiveness of empiric CP on admission to the hospital in an MDRO endemic region. Methods: The study was carried out in a 300-bed private hospital from January 2016 to September 2018. The CP indications on the day of hospital admission were decided based on determining risk factors such as long term care patients (Group 1), patients with catheters and/or interventions (Group 2), transferred from another hospital (Group 3), patients with known colonisation with MDRO (Group 4), patients with other risk factors (Group 5). Results: In total, 539 consequent patients were observed. The mean age was 63.4 years, and 57% of the patients were male. Most of the patients were from Turkey (94%); however, the rest were mainly from Middle-Eastern and North-African countries. Among 101 out of 539 (18.7%) patients, at least one pathogen was grown, and among 73 out of 539 patients (13.5%), CP requiring pathogen was isolated. The CP requiring pathogens were detected in group 2 (24%), group 1 (19.4%) and group 3 (13%). The most common pathogens were ESBLproducing Enterobacterales (5.8%), carbapenemase-producing Enterobacterales (3.9%), Pseudomonas spp. (3.53%), Acinetobacter spp. (2.97%), vancomycin-resistant enterococci (2.6%) and methicillin-resistant Staphylococcus (1.86%). Conclusion: Risk assessment-based isolation precautions from the day of hospitalisation in an MDRO endemic country were found to be important among high-risk patients such as patients with catheters and/or interventions, long-term care patients and patients transferred from another medical centre. Implementation of risk-based CP than the culture-based IC strategies might be an effective approach in an MDRO endemic region while pending culture results.
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    PublicationOpen Access
    Effect of social, regional, and education status and season on blood pressure
    (Wiley, 2019) Afşar, Barış; N/A; Yerlikaya, Aslıhan; Kanbay, Mehmet; Undergraduate Student; Faculty Member; School of Medicine; N/A; 110580
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    PublicationOpen Access
    A journey from microenvironment to macroenvironment: the role of metaflammation and epigenetic changes in cardiorenal disease
    (Oxford University Press (OUP), 2019) Sağ, Alan A.; Ortiz, Alberto; Kuwabara, Masanari; Covic, Adrian; Wiecek, Andrzej; Stenvinkel, Peter; Afşar, Barış; N/A; Kanbay, Mehmet; Yerlikaya, Aslıhan; Faculty Member; Undergraduate Student; School of Medicine; 110580; N/A
    Chronic non-communicable diseases have become a pandemic public problem in the 21st century, causing enormous burden on the economy, health and quality of life of societies. The role of a chronic inflammatory state in the pathogenesis of chronic disease has been more comprehensively recognized by recent findings. The new paradigm 'metaflammation' focuses on metabolism-induced (high fat or fructose-based diet or excessive calorie intake) chronic inflammation. There is a close correlation between the increased incidence of chronic kidney disease (CKD) and chronic heart failure with both increased inflammatory marker levels and western-type diet. In this review we describe the concept of metaflammation, its role in the development of CKD and chronic heart disease, the molecular and signalling pathways involved and the therapeutic consequences.