Researcher:
Gönenli, Mehmet Gökhan

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Mehmet Gökhan

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Gönenli

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Gönenli, Mehmet Gökhan

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2018 - 201912020 - 20238

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    The role of reactive nitrogen species as biomarkers of disease severity in COVID-19
    (European Respiratory Society (ERS), 2022) Akyil, F. Tokgoz; Altin, S.; N/A; N/A; N/A; N/A; Department of Molecular Biology and Genetics; N/A; N/A; Konyalılar, Nur; Kayalar, Özgecan; Mortazavi, Deniz; Rajabi, Hadi; Korkunç, Seval Kübra; Erkan, Selim; Gönenli, Mehmet Gökhan; Bayram, Hasan; PhD Student; Researcher; PhD Student; PhD Student; Master Student; Other; Other; Teaching Faculty; Faculty Member; Department of Molecular Biology and Genetics; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; N/A; Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Sciences and Engineering; N/A; N/A; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; 350445; 4890
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    Pregnancy in Takayasu's arteritis has a high risk of hypertension-related fetomaternal complications: a retrospective study of a Turkish cohort
    (Wiley, 2022) Tahra, Sema Kaymaz; Kara, Mete; Keser, Gokhan; Yazici, Ayten; Erden, Abdulsamet; Omma, Ahmet; Gercik, Onay; Akar, Servet; Aksu, Kenan; Kenar, Gokce; Kocaer, Sinem Burcu; Onen, Fatos; Ersozlu, Duygu; Alibaz-Oner, Fatma; Bayramlar, Osman Faruk; Direskeneli, Haner; N/A; Gönenli, Mehmet Gökhan; Kanıtez, Nilüfer Alpay; Teaching Faculty; Faculty Member; School of Medicine; School of Medicine; 350445; 239432
    Background This study aimed to examine fetomaternal outcomes in pregnant women in a large Turkish Takayasu arteritis (TAK) cohort and to evaluate the effects of pregnancy on the disease in those patients. Methods This is a cohort study involving 296 pregnancies of 112 TAK patients from 8 tertiary rheumatology centers in Turkey. Pregnancies were divided into 2 groups as pre-d (before disease onset) and post-d (after disease onset). In addition, post-d pregnancies were further divided into 2 subgroups according to fetomaternal complications (FMC) development status. Finally, patients were grouped into those with and without a history of pregnancy after disease onset. Results In post-d pregnancies, rates of worsening hypertension, new-onset hypertension, and preeclampsia were higher than in pre-d pregnancies (0.9% vs 16%, P < .001, 0.5% vs 5.3%, P = .012, and 0% vs 4%, P = .013, respectively). Patients with FMC were more likely to have renal artery involvement (65% vs 21%, P = .003). The patients who had post-d were younger, had longer disease duration, and had more relapses number than other patients (P < .001, P = .028, P = .016, respectively). Vasculitis Damage Index (VDI) results were similar in patients with or without post-d pregnancies. Conclusion Pregnancies after disease onset were found to be associated with HT and preeclampsia/eclampsia. HT-related FMCs are increased in TAK, and patients with renal artery involvement are at higher risk. The number of relapses increases in patients who become pregnant after disease onset, but pregnancy was not an independent risk factor for relapse. Pregnancy after the onset of disease had no negative effect on VDI.
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    Cyclin-D1 positive B cell lymphoma with intravascular and interstitial involvement of kidney and bone marrow
    (Springer, 2023) Altinkaynak, Mustafa; Goksoy, Yagmur; Yegen, Gulcin; Erten, Sebile Nilgun; Saka, Bulent; Akpinar, Timur Selcuk; N/A; Gönenli, Mehmet Gökhan; Teaching Faculty; School of Medicine; Koç University Hospital; 350445
    Kidney involvement is rare in non-Hodgkin's lymphomas (NHL), and can be caused by direct lymphoid infiltration, paraneoplastic glomerulonephritis (GN), or both. Herein, we present a case of acute kidney injury (AKI) due to renal cyclin-D1 positive B cell lymphoma infiltration. To our knowledge, this is the first case where a renal biopsy revealed intravascular neoplastic cells along with parenchymal infiltration.
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    Warfarin-induced skin necrosis due to protein C deficiency in a dialysis patient
    (Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2018) Ozkok, Abdullah; Ozportakal, Hande; Asik, Murat; Ozkok, Sercin; Alkan, Ozlem; Boyraz, Memduha; Yildiz, Banu Sahin; Bahat, Kubra Aydin; Odabas, Ali Riza; Gönenli, Mehmet Gökhan; Teaching Faculty; School of Medicine; 350445
    Protein-C (PC) is a vitamin-K-dependent anticoagulant proenzyme produced by the liver. PC deficiency may cause both venous and arterial thromboses. In patients with PC deficiency, warfarin further decreases PC activity and causes thrombosis of skin arterioles leading to skin necrosis. A 59-year-old female was admitted with dyspnea, cough, hoarseness and edema in her neck and arms. She had chronic kidney disease for 20 years. She had been on hemodialysis for 8 years but had been switched to peritoneal dialysis due to vascular access problems caused by multiple venous thromboses. With a pre-diagnosis of Superior Vena Cava (SVC) syndrome, cavography was performed and near-total occlusion of the SVC was detected. Balloon dilatation was performed and warfarin 5 mg and enoxoparin 40 mg were started. Within a day, necrotic and well-demarcated lesions 4x5 cm in size appeared on the arm. Warfarin was stopped and enoxoparin was continued. After 2 weeks, plasma PC activity was found to be significantly low (40% of normal). The diagnosis of "warfarin-induced skin necrosis in a patient with PC deficiency" was established. Skin lesions promptly and completely recovered after the treatment. PC deficiency should be considered in dialysis patients with multiple thromboses, vascular access problems and warfarin-induced skin necrosis.
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    The frequency of acceptance of oral glucose tolerance test in Turkish pregnant women: a single tertiary center results
    (Kare Publ, 2022) Yerlikaya, Aslıhan; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Sezer, Havva; Dereli, Dilek Yazıcı; Canbaz, Hande Bulut; Gönenli, Mehmet Gökhan; Ata, Mustafa Barış; Bekdemir, Bahar; Nalbantoğlu, Emine Ayça; Teaching Faculty; Faculty Member; Master Student; Teaching Faculty; Faculty Member; Nurse; Faculty Member; School of Medicine; School of Medicine; School of Nursing; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; Koç University Hospital Nurse; 154807; 179659; N/A; 350445; 182910; N/A; 327621
    Objective: It is thought that there is not enough data about the frequency of acceptance of oral glucose tolerance test (OGTT) in Turkish pregnant women. The aim of this study was to investigate the frequency of acceptance of OGTT among participants in our single tertiary center. Methods: The data of non-diabetic 344 pregnant women seen at the Obstetrics Clinic of our hospital between September 2016 and September 2017 were obtained from the hospital records. Women who did not have regular follow-up during pregnancy were excluded. One of the two or one-step approaches was used in the diagnosis of gestational diabetes mellitus (GDM) depending on the choice of the physician following the patient. Results: There were 223 subjects eligible for the study. One hundred seventy-seven pregnant women (79.4%) accepted to do OGTT. We determined that 46 women (20.6%) did not complete at least one OGTT, of whom 74% (n=34) never completed the recommended screening test in this cohort. The overall frequency of GDM was approximately 15.2% (n=34). OGTT acceptability was higher among pregnant women with university graduates (p=0.02). Adverse pregnancy outcomes were similar between the accepted and rejected groups. Among the reasons for OGTT rejection, the media had a significant influence (n=35). Conclusion: Our results show that a significant percentage of patients refused to do OGTT. Therefore the actual frequency of pregnant women with GDM could not be determined. One way to increase compliance may be recommending only the one-step test for pregnant women in countries with a high rejection rate of OGTT.
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    PublicationOpen Access
    Rotational thromboelastometry reveals distinct coagulation profiles for patients with COVID-19 depending on disease severity
    (Sage, 2021) Gönenli, Mehmet Gökhan; Komesli, Zeynep; İncir, Said; Yalçın, Özlem; Akay, Olga Meltem; Teaching Faculty; Faculty Member; Faculty Member; School of Medicine; Koç University Hospital; 350445; N/A; N/A; 218440; 170966
    Identifying a hypercoagulable state in patients with COVID-19 may help identify those at risk for virus–induced thromboembolic events and improve clinical outcomes using personalized therapeutic approaches. Herein, we aimed to perform a global assessment of the patients’ hemostatic system with COVID-19 using rotational thromboelastometry (ROTEM) and to describe whether patients with different disease severities present different coagulation profiles. Together with 37 healthy volunteers, a total of 65 patients were included and then classified as having mild, moderate, and severe disease depending on clinical severity. Peripheral blood samples were collected and analyzed using a ROTEM Coagulation Analyzer. Also, complete blood count and coagulation parameters including prothrombin time, activated partial thromboplastin time, fibrinogen levels, and D-dimer levels were measured at admission. EXTEM and INTEM MCF (P < 0.001) values were significantly higher and the EXTEM CFT (P = 0.002) value was significantly lower in patients with COVID-19 when compared with controls. In particular, patients with the severe disease showed a significant decrease in CFT (P < 0.001) and an increase in MCF (P < 0.001) in both INTEM and EXTEM assays compared with patients with the non-severe disease. Correlation analysis revealed significant correlations between ROTEM parameters and other coagulation parameters. There were significant positive correlations between fibrinogen, D-dimer, platelet count, and MCF in both EXTEM and INTEM assays. Our data demonstrate thromboelastographic signs of hypercoagulability in patients with COVID-19, which is more pronounced in patients with increased disease severity. Therefore, ROTEM analysis can classify subsets of patients with COVID-19 at significant thrombotic risk and assist in clinical decisions.
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    PublicationOpen Access
    Carotid atherosclerosis and lectin-like oxidized low density lipoprotein receptor-1 levels in hemodialysis patients
    (Prusa Medical Publishing, 2022) Kahvecioğlu, Serdar; Dağel, Tuncay; Gönenli, Mehmet Gökhan; Doctor; School of Medicine; N/A; 237468
    Objectives: atherosclerotic cardiovascular disease risk is increased in hemodialysis patients. Oxidized low density lipoprotein has an important role in atherosclerotic process and it exerts this effect via lectin like oxidized low density lipoprotein-1 (LOX-1). Carotid artery intima-media thickness (CIMT) is accepted as a god indicator of subclinical atherosclerosis. In this study, we aimed to investigate LOX-1 and CIMT levels in hemodialysis patients. Methods: twenty-eight patients treated with hemodialysis at least 6 months and 19 healthy subjects were enrolled in this study. Serum LOX-1 levels and simultaneously with CIMT were measured in hemodialysis patients and healthy control group. Results: CIMT value was found to be statistically significantly higher in the hemodialysis group compared to control group (0.9 mm in hemodialysis group vs. 0.7 mm in control group, p < 0.001). There was no statistically significant difference between groups in terms of LOX-1 levels. (0.172 ng/ml in hemodialysis group vs. 0.213 ng/ml in healthy control group, p > 0.05). Conclusions: although cardiovascular risk markers like CIMT, CRP were higher in hemodialysis group as expected, increase in LOX-1 levels was not detected.
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    Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients
    (EMBO Press, 2021) Altay, O.; Arif, M.; Li, X.; Yang, H.; Fredolini, C.; Kim, W.; Schwenk, J.M.; Zhang, C.; Shoaie, S.; Nielsen, J.; Uhlen, M.; Boren, J.; Mardinoğlu, A.; Zeybel, Müjdat; Ural, Dilek; Gönenli, Mehmet Gökhan; Akyıldız, Murat; Kurtoğlu, Burçin Sağlam; Faculty Member; Faculty Member; Teaching Faculty; Faculty Member; School of Medicine; Koç University Hospital; 214694; 1057; 350445; 123080; N/A
    Nonalcoholic fatty liver disease (NAFLD) refers to excess fat accumulation in the liver. In animal experiments and human kinetic study, we found that administration of combined metabolic activators (CMAs) promotes the oxidation of fat, attenuates the resulting oxidative stress, activates mitochondria, and eventually removes excess fat from the liver. Here, we tested the safety and efficacy of CMA in NAFLD patients in a placebo-controlled 10-week study. We found that CMA significantly decreased hepatic steatosis and levels of aspartate aminotransferase, alanine aminotransferase, uric acid, and creatinine, whereas found no differences on these variables in the placebo group after adjustment for weight loss. By integrating clinical data with plasma metabolomics and inflammatory proteomics as well as oral and gut metagenomic data, we revealed the underlying molecular mechanisms associated with the reduced hepatic fat and inflammation in NAFLD patients and identified the key players involved in the host-microbiome interactions. In conclusion, we showed that CMA can be used to develop a pharmacological treatment strategy in NAFLD patients.
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    PublicationOpen Access
    Multiomics analysis reveals the impact of microbiota on host metabolism in hepatic steatosis
    (Wiley, 2022) Arif, Muhammad; Li, Xiangyu; Altay, Özlem; Shi, Mengnan; Shoaie, Saeed; Türkez, Hasan; Nielsen, Jens; Zhang, Cheng; Uhlen, Mathias; Boren, Jan; Mardinoğlu, Adil; Yang, Hong; Ural, Dilek; Akyıldız, Murat; Gönenli, Mehmet Gökhan; Kurtoğlu, Burçin Sağlam; Yiğit Alpdoğan, Buket; Ulukan, Bürge; Zeybel, Müjdat; Faculty Member; Faculty Member; Teaching Faculty; Faculty Member; Graduate School of Health Sciences; School of Medicine; 1057; 123080; 350445; N/A; N/A; N/A; N/A
    Metabolic dysfunction-associated fatty liver disease (MAFLD) is a complex disease involving alterations in multiple biological processes regulated by the interactions between obesity, genetic background, and environmental factors including the microbiome. To decipher hepatic steatosis (HS) pathogenesis by excluding critical confounding factors including genetic variants and diabetes, 56 heterogenous MAFLD patients are characterized by generating multiomics data including oral and gut metagenomics as well as plasma metabolomics and inflammatory proteomics data. The dysbiosis in the oral and gut microbiome is explored and the host-microbiome interactions based on global metabolic and inflammatory processes are revealed. These multiomics data are integrated using the biological network and HS's key features are identified using multiomics data. HS is finally predicted using these key features and findings are validated in a follow-up cohort, where 22 subjects with varying degree of HS are characterized.