Researcher:
Nazlı, Caner

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PhD Student

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Caner

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Nazlı

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Nazlı, Caner

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2011 - 20175

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Researcher Of Publications: search.filters.isAuthorOfPublication.8d082602-06da-407c-bc4a-6b0072ae3788

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    Design of bioartificial pancreas with functional micro/nano-based encapsulation of islets
    (Bentham Science Publ Ltd, 2014) N/A; N/A; N/A; N/A; Department of Chemical and Biological Engineering; Kepsütlü, Burcu; Nazlı, Caner; Bal, Tuğba; Kızılel, Seda; Master Student; PhD Student; PhD Student; Faculty Member; Department of Chemical and Biological Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; N/A; 353534; 28376
    Type I diabetes mellitus (TIDM), a devastating health issue in all over the world, has been treated by successful transplantation of insulin secreting pancreatic islets. However, serious limitations such as the requirement of immunosuppressive drugs for recipient patients, side effects as a result of long-term use of drugs, and reduced functionality of islets at the transplantation site remain. Bioartificial pancreas that includes islets encapsulated within semi-permeable membrane has been considered as a promising approach to address these requirements. Many studies have focused on micro or nano-based islet immunoisolation systems and tested the efficacy of encapsulated islets using in vitro and in vivo platforms. In this review, we address current progress and obstacles for the development of a bioartificial pancreas using micro/nano-based systems for encapsulation of islets.
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    Mesenchymal stem cells and ligand incorporation in biomimetic poly(ethylene glycol) hydrogels significantly improve insulin secretion from pancreatic islets
    (Wiley, 2017) Okçu, Alparslan; Duruksu, Gökhan; Karaöz, Erdal; N/A; N/A; Department of Chemical and Biological Engineering; Bal, Tuğba; Nazlı, Caner; Kızılel, Seda; PhD Student; PhD Student; Faculty Member; Department of Chemical and Biological Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; 353534; N/A; 28376
    The main goal of this study was to investigate pancreatic islet function with mesenchymal stem cells (MSCs) in a ligand-functionalized poly(ethylene glycol) (PEG) hydrogel for the treatment of type 1 diabetes (T1D). Rat bone marrow-derived MSCs (rBM-MSCs) were encapsulated within synthetic PEG hydrogel, and cell viability and apoptosis within this 3D environment was examined in detail. ATP content and caspase-3 activity of encapsulated MSCs showed that fibronectin-derived RGDS, laminin-derived IKVAV and/or insulinotropic glucagon-like peptide (GLP-1) were required to maintain MSC survival. Incorporation of these peptides into the hydrogel environment also improved pancreatic islet viability, where combinations of peptides had altered effects on islet survival. GLP-1 alone was the leading stimulator for insulin secretion. Cell adhesion peptides RGDS and IKVAV improved insulin secretion only when theywere used in combination, but could not surpass the effect of GLP-1.Further, when pancreatic islets were co-encapsulated with MSCs within synthetic PEG hydrogel, a two- fold increase in the stimulation index wasmeasured. Synergistic effects ofMSCs and peptideswere observed, with a seven-fold increase in the stimulation index. The results are promising and suggest that simultaneous incorporation ofMSCs and ECM-derived peptides and/or GLP-1 can improve pancreatic islet function in response to altered glucose levels in the physiological environment. Copyright (C) 2014 John Wiley & Sons, Ltd.
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    Targeted delivery of doxorubicin into tumor cells via MMP-sensitive PEG hydrogel-coated magnetic iron oxide nanoparticles (mionps)
    (Elsevier, 2014) N/A; N/A; Department of Chemical and Biological Engineering; N/A; Department of Chemistry; Department of Chemical and Biological Engineering; Nazlı, Caner; Demirer, Gözde Sultan; Yar, Yasemin; Acar, Havva Funda Yağcı; Kızılel, Seda; PhD Student; Undergraduate Student; PhD Student; Faculty Member; Faculty Member; Department of Chemistry; Department of Chemical and Biological Engineering; Graduate School of Sciences and Engineering; College of Engineering; Graduate School of Sciences and Engineering; College of Sciences; College of Engineering; N/A; N/A; N/A; 178902; 28376
    Targeting tumors with nano-scale delivery systems shows promise to improve the therapeutic effects of chemotherapeutic drugs. However, the limited specificity of current nano-scale systems for cancer tissues prevents realization of their full clinical potential. Here, we demonstrate an effective approach to creating as targeted nanocarriers for drug delivery: MIONPs coated with integrin-targeted and matrix-metalloproteinase (MMP) sensitive PEG hydrogel scaffolds. The functional PEG hydrogel coating has been designed for active loading as well as triggered intra-cellular release of the cancer therapeutic agent doxorubicin (DOX). Our study demonstrated that coated nanocarriers could be taken into cancer cells 11 times more efficiently than uncoated ones. Furthermore, confocal laser scanning microscopy images revealed that these targeted nanocarriers could efficiently deliver and release DOX into the nuclei of HeLa cells within 2 h. Coating MIONPs with multifunctional PEG hydrogel could be a promising alternative to existing vehicles for targeted delivery of DOX into tumor tissue.
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    Encapsulation of magnetic nanoparticles within biofunctional poly (ethylene glycol) hydrogel formed via surface initiated photopolymerization
    (AICHE, 2011) Department of Chemistry; Department of Chemical and Biological Engineering; Department of Chemical and Biological Engineering; N/A; Acar, Havva Funda Yağcı; Kızılel, Seda; Ergenç, Tuğba İpek; Nazlı, Caner; Faculty Member; Faculty Member; Undergraduated Student; PhD Student; Department of Chemistry; Department of Chemical and Biological Engineering; College of Sciences; College of Engineering; College of Engineering; Graduate School of Sciences and Engineering; 178902; 28376; N/A; N/A
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    PublicationOpen Access
    RGDS-functionalized polyethylene glycol hydrogel-coated magnetic iron oxide nanoparticles enhance specific intracellular uptake by HeLa cells
    (Dove Medical Press, 2012) N/A; Department of Chemical and Biological Engineering; Department of Chemistry; Nazlı, Caner; Ergenç, Tuğba İpek; Yar, Yasemin; Acar, Havva Funda Yağcı; Kızılel, Seda; PhD Student; Undergraduate Student; Faculty Member; Department of Chemical and Biological Engineering; Department of Chemistry; Graduate School of Sciences and Engineering; College of Sciences; N/A; N/A; N/A; 178902; 28376
    The objective of this study was to develop thin, biocompatible, and biofunctional hydrogel-coated small-sized nanoparticles that exhibit favorable stability, viability, and specific cellular uptake. This article reports the coating of magnetic iron oxide nanoparticles (MIONPs) with covalently cross-linked biofunctional polyethylene glycol (PEG) hydrogel. Silanized MIONPs were derivatized with eosin Y, and the covalently cross-linked biofunctional PEG hydrogel coating was achieved via surface-initiated photopolymerization of PEG diacrylate in aqueous solution. The thickness of the PEG hydrogel coating, between 23 and 126 nm, was tuned with laser exposure time. PEG hydrogel-coated MIONPs were further functionalized with the fibronectin-derived arginine-glycine-aspartic acid-serine (RGDS) sequence, in order to achieve a biofunctional PEG hydrogel layer around the nanoparticles. RGDS-bound PEG hydrogel-coated MIONPs showed a 17-fold higher uptake by the human cervical cancer HeLa cell line than that of amine-coated MIONPs. This novel method allows for the coating of MIONPs with nano-thin biofunctional hydrogel layers that may prevent undesirable cell and protein adhesion and may allow for cellular uptake in target tissues in a specific manner. These findings indicate that the further biofunctional PEG hydrogel coating of MIONPs is a promising platform for enhanced specific cell targeting in biomedical imaging and cancer therapy.