Researcher:
Taşkın, Ali Cihan

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Ali Cihan

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Taşkın

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Taşkın, Ali Cihan

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2015 - 2019102020 - 20229

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Now showing 1 - 10 of 19
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    Treatment with melatonin enhances the embryo quality and the development of vitrified/warmed eight cell mouse embryos by solid surface vitrification (SSV)
    (Cryo Letters, 2020) Caglar, Kubra; Arat, Sezen; N/A; N/A; Kocabay, Ahmet; Taşkın, Ali Cihan; Other; Other; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; N/A; 291296; N/A
    BACKGROUND: Melatonin is an endocrine hormone secreted from the pineal gland located outside the blood-brain barrier. OBJECTIVE: In this study, in vitro propagated eight-cell mouse embryos were vitrified by the Solid Surface Vitrification (SSV) method and after thawing, their in vitro development and embryo qualities in melatonin added media were investigated. METHODS: Pronuclear stage embryos obtained from super ovulated B6CBAF1/J strain mice, were cultured until the eight-cell stage. Then these eight-cell embryos were vitrified by the SSV method and after thawing, cultured in melatonin added media at 37 degrees C and 5 %CO2 conditions until the blastocyst stage. RESULT: In the experimental period, in vitro embryo development rates of the control, SSV and +10(-12) M melatonin groups were observed as 97%, 86% and 93%, respectively. CONCLUSION: Our results indicated that melatonin addition slightly increased the development rates and total cell numbers of embryos vitrified by the SSV method.
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    Construction of gel based 3D endometrial co -culture systems: can human mesenchymal stem cells be an alternative?
    (Oxford Univ Press, 2017) Yücel, D.; N/A; Karahüseyinoğlu, Serçin; Şahin, Gizem Nur; Şevgin, Kübra; Kocabay, Ahmet; Taşkın, Ali Cihan; Faculty Member; Master Student; PhD Student; Other; Other; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; N/A; N/A; 110772; N/A; N/A; N/A; 291296
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    Polymeric and collagen biomaterials enhance implantation of mouse blastocysts in three-dimensional culture models
    (Elsevier, 2021) Başoz, Deniz; Yücel, Deniz; N/A; N/A; N/A; N/A; N/A; Department of Industrial Engineering; N/A; Ergün, Yağmur; Şahin, Gizem Nur; Şevgin, Kübra; Kocabay, Ahmet; Taşkın, Ali Cihan; Gönen, Mehmet; Karahüseyinoğlu, Serçin; PhD Student; PhD Student; PhD Student; Other; Other; Faculty Member; Faculty Member; Department of Industrial Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Health Sciences; N/A; N/A; College of Engineering; School of Medicine; N/A; N/A; N/A; N/A; 291296; 237468; 110772
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    Celcular and molecular dynamics of in-vitro 2D and 3D cultured blastocysts throughout the implantation process
    (Amer Soc Cell Biology, 2016) Yucel, D.; N/A; Karahüseyinoğlu, Serçin; Şahin, Gizem Nur; Kocabay, Ahmet; Taşkın, Ali Cihan; Faculty Member; PhD Student; Other; Other; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health Sciences; N/A; N/A; N/A; N/A; N/A; Koç University Hospital; 110772; N/A; N/A; 291296
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    In vitro blastocyst implantation model by the use of synthetic polymer foam scaffolds
    (Mary Ann Liebert, Inc, 2022) Başöz, Deniz; Yücel, Deniz; N/A; Ergün, Yağmur; Kocabay, Ahmet; Taşkın, Ali Cihan; Karahüseyinoğlu, Serçin; Master Student; Other; Other; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; N/A; N/A; School of Medicine; N/A; N/A; 291296; 110772
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    Comparison of the development of mouse embryos manipulatedwith different biopsy techniques
    (Scientific and Technological Research Council of Turkey, 2016) Sağırkaya, Hakan; Arat, Sezen; Bağış, Haydar; Akkoç, Tolga; Taşkın, Ali Cihan; Other; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); 291296
    Preimplantation genetic diagnosis is the detection of inherited diseases and the sex of embryos before implantation in the practice of human medicine as well as in veterinary medicine. The introduction of experimental animal embryo biopsy techniques has been a milestone in the developmental process of preimplantation genetic diagnosis techniques. The aim of the present study was to evaluate in vivo and in vitro development of embryos after biopsy in an experimental mouse model and to perform comparisons across different biopsy techniques (blastomere biopsy and trophectoderm biopsy). At the end of the study, no significant difference was observed between the blastomere biopsy group and the control group in terms of in vitro development, embryo quality, and fetal development, whereas embryo quality and in vivo development were negatively affected in the trophectoderm biopsy group (P< 0.05).
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    Use of polymeric cell carriers supplemented with endometrial co-culture systems to enhance blastocyst implantation
    (Amer Soc Cell Biology, 2015) Yücel, Deniz; Köse, Ayça; N/A; Karahüseyinoğlu, Serçin; Şahin, Gizem Nur; Taşkın, Ali Cihan; Okan, Türkan Pemra; Öktem, Özgür; Faculty Member; PhD Student; Other; N/A; Undergraduate Student; Faculty Member; School of Medicine; Graduate School of Health Sciences; N/A; N/A; School of Medicine; School of Medicine; 110772; N/A; 291296; N/A; N/A; 102627
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    Effect of leptin on derivation rate of mouse embryonic stem (ES) cell line
    (Springer, 2016) N/A; N/A; N/A; N/A; Taşkın, Ali Cihan; Kocabay, Ahmet; Önder, Tamer Tevfik; Ebrahimi, Ayyub A.; Other; Other; Faculty Member; Researcher; N/A; N/A; School of Medicine; School of Medicine; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; N/A; 291296; N/A; 42946; 381072
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    Celcular and molecular dynamics of in-vitro 2D and 3D cultured blastocysts throughout the implantation process
    (Amer Soc Cell Biology, 2016) Yucel, D.; N/A; Karahüseyinoğlu, Serçin; Şahin, Gizem Nur; Kocabay, Ahmet; Taşkın, Ali Cihan; Faculty Member; PhD Student; Other; Other; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health Sciences; N/A; N/A; N/A; N/A; N/A; Koç University Hospital; 110772; N/A; N/A; 291296
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    Effects of different parthenogenetic activation periods on mouse embryo development and quality
    (Afyon Kocatepe Üniversitesi Veterinerlik Fakültesi, 2020) N/A; N/A; N/A; Taşkın, Ali Cihan; Coşkun, Nilhan; Kocabay, Ahmet; Other; Other; Other; Koç University Research Center for Translational Medicine (KUTTAM); Koç University Research Center for Translational Medicine (KUTTAM); Koç University Research Center for Translational Medicine (KUTTAM); N/A; N/A; N/A; 291296; N/A; N/A
    In the present study we investigate the effects of parthenogenetic activation on in vitro embryo development and quality in different activation periods. oocytes were obtained 14 hours after human chorionic gonadotropin (hCG) injection from superovulated B6D2F1 female mice then parthenogenetic activation started 18 hours after hCG injection. The oocytes were activated at different activation periods for 3, 4, 5 or 6 hours in 10 mM strontium chloride (SrCl2)+ 5 μg/mL-1 Cytohalasine B (CB) + 5 nM Trichostatin A (TSA) containing a Ca 2+ free Chatot Ziomek Brinster (CZB) activation medium, followed by further incubation for two hours at 37°C and 5% CO2 in embryo culturing medium + TSA. The results in the present study suggested that the parthenogenetic activation of the 6 hour activation period was found to be higher than at 3, 4 and 5 hours. / Çalışmamızın amacı, partenogenetik aktivasyonda farklı aktivasyon sürelerinin in vitro embriyo gelişimi ve kalitesi üzerindeki etkilerinin araştırılmasıdır. Superovule B6D2F1 ırkı dişi farelere uygulanan insan koryonik gonadotropin (hCG) enjeksiyonundan 14 saat sonra oositler elde edildi ve 18 saat sonra partenogenetik aktivasyona başlandı. Oositler, 10 mM stronsiyum klorür (SrCl2) + 5 μg/mL-1 sitokalazin B (CB) + 5 nM trikostatin A (TSA) Ca 2+ içermeyen Chatot Ziomek Brinster (CZB) medyumu içerisinde 3, 4, 5 ve 6 saat bekletildi. Aktivasyon sonrası, embriyo kültür medyumu + TSA’da inkübatörde 37°C ve %5 CO2 ortamında 2 saat bekletildi. Son olarak, tüm embriyolar 120 saat süre ile kültüre edildi. Bu çalışmadan elde edilen sonuçlar göre, 6 saatlik partenogenetik aktivasyon başarısının, 3, 4 ve 5 saatlik sürelere göre daha yüksek olduğu saptandı.