Researcher: Dinçer, Neris
Loading...
Name Variants
Dinçer, Neris
Email Address
Birth Date
9 results
Search Results
Now showing 1 - 9 of 9
Publication Metadata only Validity and reliability of the Turkish version of Snaith-Hamilton pleasure scale(Association for Cognitive and Behavioral Psychotherapies, 2020) Aydemir, Ömer; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Küçüker, Mehmet Utku; Kılçıksız, Can Mişel; Yılmaz, Sezen Güçlü; Dinçer, Neris; Kılıç, Özge; Ercan, Alaattin Cenk; Faculty Member; Doctor; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Doctor; Doctor; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; 134359; N/A; N/A; N/A; N/A; 349025; N/A; N/AAnhedonia is a core feature of many psychiatric disorders and its reliable evaluation is needed for the dimensional understanding of psychiatric disorders. Snaith-Hamilton Pleasure Scale (SHAPS) is one of the most widely used scales to assess anhedonia. Here, we aimed to search the validity and reliability of the Turkish version of SHAPS. Translation of the original scale was completed in a two-step procedure. 188 healthy controls, 56 patients with a depressive disorder (F32-F34, excluding F34.0 cyclothymic disorder, according to ICD-10), and 52 patients with anxiety, stress-related or somatoform disorder diagnoses (F40-49 diagnosis according to ICD-10) were recruited, and evaluated with the Turkish version of SHAPS, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Symptom Checklist-90-R (SCL-90-R). For the Turkish version of SHAPS, Cronbach’s alpha coefficient was found 0.87. The item-total item correlation indices ranged from 0.39 to 0.64. Principal components analysis extracted two factors and explained 46.57 % of total variance. The most significant correlation of SHAPS was found with BDI and depression subscale of SCL-90-R scores. SHAPS also weakly but significantly correlated with obsessive compulsive and anxiety subscales of SCL-90-R, and weakly but non-significantly with BAI and somatization, interpersonal sensitivity, hostility and psychoticism subscales of SCL-90-R. Depressive group had significantly higher SHAPS scores compared to controls and anxious group. Anxious group and control group were not significantly different for SHAPS scores. The current study shows that the Turkish version of the SHAPS has good psychometric properties. SHAPS scores may correlate with depression, somatization, and interpersonal sensitivity scores, and it may help to differentiate depressive patients from anxious patients and controls. /Öz: Anhedoni, birçok psikiyatrik bozukluğun temel bir özelliğidir ve psikiyatrik bozuklukların boyutsal olarak anlaşılması için güvenilir bir şekilde değerlendirilmesi gerekir. Snaith-Hamilton Keyif Alma Ölçeği (SHKÖ), anhedoniyi değerlendirmek için en yaygın kullanılan ölçeklerden biridir. Burada, SHKÖ’nün Türkçe versiyonunun geçerliliği ve güvenilirliğinin araştırılması amaçlanmıştır. Orijinal ölçeğin çevirisi iki aşamalı bir prosedürle tamamlanmıştır. 188 sağlıklı kontrol, 56 depresif bozukluk (ICD-10’a göre F34.0 (siklotimi) dışında F32-F34 tanıları almış kişiler) ve 52 anksiyete, stres ilişkili veya somatoform bozukluk tanısı almış olan anksiyöz hasta (ICD-10’a göre F40-49 tanıları almış kişiler) çalışmaya alınmıştır. Katılımcılar SHKÖ’nün Türkçe versiyonu, Beck Depresyon Envanteri (BDE), Beck Anksiyete Envanteri (BAE) ve Belirti Kontrol Listesi-90-Gözden Geçirilmiş Form (SCL-90-R) ile değerlendirilmiştir. SHKÖ’nün Türkçe versiyonu için Cronbach alfa katsayısı 0,87 olarak bulunmuştur. Madde-toplam madde korelasyon endeksleri 0,39 ile 0,64 arasında değişmiştir. Temel bileşenler analizi iki faktörü ortaya çıkarmış ve toplam varyansın % 46,57‘ sini açıklamıştır. En yüksek SHKÖ korelasyonu BDE ve SCL-90-R‘nin depresyon alt ölçeği skorları ile bulunmuştur. SHKÖ ayrıca SCL-90-R‘nin obsesif kompulsif ve anksiyete alt ölçekleri ile zayıf fakat istatiksel olarak anlamlı bir korelasyon gösterirken, SCL-90- R‘nin somatizasyon, kişilerarası duyarlılık, hostilite ve psikotisizm alt ölçekleri ile zayıf fakat istatistiksel olarak anlamlı olmayan bir ilişki göstermiştir. Depresif hasta grubunda kontrol grubuna ve anksiyöz hasta grubuna göre anlamlı derecede yüksek SHKÖ skorları saptanmıştır. Anksiyöz hasta grubu ve kontrol grubu, SHKÖ skorları için farklı bulunmamıştır. Bu çalışma, SHKÖ’nün Türkçe versiyonunun iyi psikometrik özellikleri olduğunu göstermektedir. SHKÖ puanları depresyon, somatizasyon ve kişilerarası duyarlılık puanları ile ilişkili olabilir ve depresif hastaları anksiyöz hastalardan ve kontrollerden ayırmada yardımcı olabilir.Publication Metadata only Noninvasive optical coherence tomography imaging correlates with anatomic and physiologic end-organ changes in healthy normotensives with systemic blood pressure variability(Lippincott Williams & Wilkins, 2020) Afşar, Barış; Sağ, Alan A.; N/A; Dağel, Tuncay; Derin, Gözde; Kesim, Cem; Taş, Ayşe Yıldız; Şahin, Afsun; Dinçer, Neris; Kanbay, Mehmet; Doctor; Undergraduate Student; Teaching Faculty; Faculty Member; Faculty Member; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; 387367; 200905; 171267; 349025; 110580Objective: Blood pressure variability (BPV) is considered as a novel risk factor for cardiovascular disease including left ventricular hypertrophy, vascular stiffness, and renal dysfunction. In this study, we aimed to determine the relationship between ambulatory BPV with subclinical organ damage and vascular stiffness parameters in normotensive healthy subjects. Methods: A total of 100 healthy subjects over 18 years of age were included in this cross-sectional study. We divided the participants into two groups according to the median value of the SD of mean 24-h blood pressure (BP) (Group 1: SD of mean 24-h BP 10.15). BPs of these subjects were recorded over a 24-h period using ambulatory BP monitoring. Mobil-O-Graph device was used to estimate the augmentation index (AIx), pulse wave velocity (PWV), and ambulatory BP measurement. The choroidal thickness was measured by using optical coherence tomography device. Results: The mean age of the patients was 25.4 +/- 5.0 years. Choroidal thickness was correlated with PWV, AIx, protein excretion, and SD of systolic and diastolic BP (P < 0.05). Additionally, participants with higher BP variability have lower choroidal thickness and higher AIx. Conclusion: We showed that even in normotensive subjects, BPV correlates with choroid thickness. Thus, BPV can be an early prognostic parameter for pathologic vascular changes.Publication Metadata only Development, validity and reliability of the 4-point likert Turkish version of cognitive failures questionnaire(İnönü Üniversitesi Tıp Fakültesi, 2020) Aydemir, Ömer; N/A; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Küçüker, Mehmet Utku; Kılçıksız, Can Mişel; Yılmaz, Sezen Güçlü; Dinçer, Neris; Kılıç, Özge; Ercan, Alaattin Cenk; Faculty Member; Doctor; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Doctor; Doctor; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; 134359; N/A; N/A; N/A; N/A; 349025; N/A; N/AAim: Cognitive failures are suggested to be a transdiagnostic endophenotype that increases the vulnerability for psychiatric disorders. Broadbent’s Cognitive Failures Questionnaire (CFQ), is among the most widely used scales to assess cognitive function observed in an ecological manner. Despite its wide use in research and correlation with biological markers, CFQ is criticized for its unstable factorial structure among studies and 5-Likert structure that may lead to bias for neutral answers. Here we aimed to develop a 4-Likert Turkish version of CFQ, search its validity, reliability and factorial structure. Material and Methods: CFQ has been translated to Turkish in two steps. CFQ, Perceived Deficit Questionnaire-D (PDQ-D), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were applied to 272 participants (187 healthy controls, 55 patients diagnosed with depression, 30 patients diagnosed with anxiety disorder). Results: The Cronbach’s alpha coefficient of 4-Likert Turkish version of CFQ was found as 0.91. Principal component analysis extracted five factors and explained 53.7 % of total variance. CFQ scores were significantly different among groups. Both depressive and anxious groups reported higher CFQ scores compared to controls. CFQ significantly and strongly correlated with PDQ-D and showed a moderate correlation with BDI and BAI. Conclusion: 4-Likert Turkish version of CFQ is a valid and reliable tool to assess cognitive failures in non-demented groups. Our analysis revealed a five factorial structure for CFQ, however previous literature with the 5-Likert version shows different factor structures and does not indicate a dimensional stability.Publication Metadata only Antidiuretic hormone and serum osmolarity physiology and related outcomes: what is old, what Is new, and what is unknown?(ENDOCRINE SOC, 2019) Ortiz, Alberto; Sag, Alan A.; Covic, Adrian; Sanchez-Lozada, Laura G.; Lanaspa, Miguel A.; Cherney, David Z. I.; Johnson, Richard J.; Afsar, Baris; N/A; Kanbay, Mehmet; Yılmaz, Sezen Güçlü; Dinçer, Neris; Faculty Member; Undergraduate Student; Undergraduate Student; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; 110580; N/A; N/AContext: Although the physiology of sodium, water, and arginine vasopressin (AVP), also known as antidiuretic hormone, has long been known, accumulating data suggest that this system operates as a more complex network than previously thought. Evidence Acquisition: English-language basic science and clinical studies of AVP and osmolarity on the development of kidney and cardiovascular disease and overall outcomes. Evidence Synthesis: Apart from osmoreceptors and hypovolemia, AVP secretion is modified by novel factors such as tongue acid-sensing taste receptor cells and brain median preoptic nucleus neurons. Moreover, pharyngeal, esophageal, and/or gastric sensors and gut microbiota modulate AVP secretion. Evidence is accumulating that increased osmolarity, AVP, copeptin, and dehydration are all associated with worse outcomes in chronic disease states such as chronic kidney disease (CKD), diabetes, and heart failure. on the basis of these pathophysiological relationships, an AVP receptor 2 blocker is now licensed for CKD related to polycystic kidney disease. Conclusion: From a therapeutic perspective, fluid intake may be associated with increased AVP secretion if it is driven by loss of urine concentration capacity or with suppressed AVP if it is driven by voluntary fluid intake. In the current review, we summarize the literature on the relationship between elevated osmolarity, AVP, copeptin, and dehydration with renal and cardiovascular outcomes and underlying classical and novel pathophysiologic pathways. We also review recent unexpected and contrasting findings regarding AVP physiology in an attempt to explain and understand some of these relationships.Publication Metadata only Effects of volume overload and current techniques for the assessment of fluid status in patients with renal disease(Karger Publishers, 2018) Siriopol, Dimitrie; Covic, Adrian; Ekinci, Can; Karabörk, Merve; Dinçer, Neris; Kanbay, Mehmet; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 323478; 358512; 349025; 110580Volume overload is an important, may be the foremost, independent prognostic factor determining the outcome of hemodialysis patients. Therefore, it is crucial to measure fluid status of these patients and avoid volume overload. This review aims to evaluate volume overload, its effects on patients with renal diseases and current methodologies measuring volume status in the body. These techniques will be first classified as clinical evaluation and non-clinical and/or instrumental techniques, which includes biomarkers, ultrasonography, relative blood volume monitoring, bioimpedance, echocardiography, pulmonary artery catheterization, esophageal and/or suprasternal Doppler, and blood viscosity. Advantages and limitations of these different techniques will be reviewed extensively by comparing each other. At last, insights gained from this review can highlight the future prospects in this active area of research. (C) 2018 S. Karger AG, Basel.Publication Metadata only Subjective cognitive assessments and n-back are not correlated, and they are differentially affected by anxiety and depressionKılıç, Özge; Aydemir, Ömer; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Küçüker, Mehmet Utku; Kılçıksız, Can Mişel; Yılmaz, Sezen Güçlü; Dinçer, Neris; Ercan, Alaattin Cenk; Faculty Member; Doctor; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Doctor; School of Medicine; Koç University Hospital; 134359; N/A; N/A; N/A; 349025; N/ACognitive function (CF) is a core feature related to all psychiatric disorders. However, self-report scales of CF (SRSC) may not always correlate with CF’s objective measures and may have different mediators. Tools to select for evaluating CF in diverse psychiatric populations and their determinants need to be studied. In this study, we aimed to assess the association of SRSC (Perceived Deficit Questionnaire-Depression (PDQ-D), and World Health Organization’s Adult Attention Deficit Hyperactivity Disorder Self-Report Scale (ASRS) and its inattentiveness subscale) with Letter-N-back as an objective measure of CF, and to analyze their association with psychopathology. Two hundred nine (131 nonclinical, and 78 clinical with a psychiatric diagnosis of ICD10 F31-39 [mood disorders excluding Bipolar I] or F40-F49 [neurotic, stress-related or psychosomatic disorder] categories) participants were evaluated with PDQ-D, ASRS, Beck Depression Inventory (BDI), and Beck’s Anxiety Inventory (BAI), and N-back. Both groups’ data were included in the analysis. PDQ-D showed a small correlation with N-back scores, whereas ASRS showed no correlation. PDQ-D and ASRS showed a large correlation. Age and BAI scores significantly predicted both PDQ-D and ASRS, whereas the cognitive subscale of BDI predicted PDQ-D, but not ASRS. Only BAI scores predicted N-back results. The mediation model revealed that 2-back scores of N-back task directly affects PDQ-D scores, independent of BDI scores. However, the cognitive subscale of BDI moderated 2-back and PDQ-D association. On the contrary, BAI scores significantly mediated the association of 2-back scores with PDQ-D. The direct effect of 2-back scores in PDQ-D was insignificant in the mediation of BAI scores. Our study validates the discordance between SRSC and an objective measurement of CF. Anxiety may affect both self-report and objective measurement of CF, whereas depressive thought content may lead to higher cognitive dysfunction reports in nondemented participants.Publication Metadata only The effect of chronic kidney disease on lipid metabolism(Springer, 2019) Afsar, Baris; Covic, Adrian; Ortiz, Alberto; N/A; Kanbay, Mehmet; Dinçer, Neris; Dağel, Tuncay; Faculty Member; Undergraduate Student; Doctor; School of Medicine; School of Medicine; N/A; N/A; N/A; Koç University Hospital; 110580; 349025; N/AThe major cause of death among chronic kidney disease patients is cardiovascular diseases. Cardiovascular and kidney disease are interrelated and increase the severity of each other. Dyslipidemia is one the major causes of cardiovascular disease among chronic kidney disease patients along with diabetes and hypertension. The relationship between dyslipidemia and chronic kidney disease is reciprocal. Dyslipidemia is known to be a risk factor for chronic kidney disease and chronic kidney disease causes major alterations on lipoprotein profile, defined as the dyslipidemic profile of chronic kidney disease patients. Increased triglyceride, very low density lipoprotein and oxidized low density lipoprotein as well as decreased high density lipoprotein and changes in the composition of lipoproteins contribute to the dyslipidemic profile. Treatment strategies targeting the dyslipidemic profile of chronic kidney disease could contribute to prevent cardiovascular diseases. Current therapy is based on the patient kidney function and consist mainly of statins. This review focuses on the effects of chronic kidney disease on the lipoprotein profile and how this may impact novel therapeutic approaches to cardiovascular risk.Publication Metadata only Unilateral leg edema: is it always vascular?(Turkish Soc Cardiology, 2018) N/A; N/A; Mutluer, Ferit Onur; İndelen, Cenk; Dinçer, Neris; Aslan, Gamze; Ateş, Mehmet Şanser; Doctor; Doctor; Undergraduate Student; Doctor; Teaching Faculty; N/A; N/A; School of Medicine; N/A; School of Medicine; Koç University Hospital; Koç University Hospital; N/A; Koç University Hospital; N/A; N/A; N/A; 349025; N/A; 230797Unilateral lower extremity edema below the knee commonly results from deep venous thrombosis, venous insufficiency, or lymphedema. The patient history, a physical examination, and lower extremity venous duplex ultrasound often reveal the underlying etiology, which is frequently of vascular origin. Presently described is the case of a 23-year-old patient who underwent a diagnostic workup for unilateral leg swelling and was found to have a relatively uncommon cause of edema: lipedema. Lipedema is a disease characterized by subcutaneous adipose tissue deposition, and although diagnosed very rarely in general cardiology outpatient clinics, it has been demonstrated to be a cause of lower extremity edema in approximately one-fifth of cases in specialized clinics.Publication Open Access Classification of reflux patterns in patients with great saphenous vein insufficiency and correlation with clinical severity(Aves, 2021) Çakır Peköz, Burçak; Yılmaz, Sezen Güçlü; Dinçer, Neris; Deniz, Sinan; Oğuzkurt, Levent; Undergraduate Student; Doctor; Faculty Member; School of Medicine; Koç University Hospital; N/A; N/A; N/A; 13559Purpose: this study aims to establish a clinically applicable classification of reflux patterns in patients with great saphenous vein insufficiency and to evaluate the relationship between this classification, the demographics, and severity of clinical findings. Methods: this is a retrospective study from prospectively collected data of 503 patients who had the complaint of varicose vein. All patients had complete physical examination and their medical history was recorded. Lower limbs of all patients were examined with Doppler ultrasonography. A total of 787 limbs with great saphenous vein insufficiency were included in the analysis. The reflux patterns of great saphenous vein insufficiency were classified into 4 types as: type 1, great saphenous vein reflux without involvement of malleolar region and saphenofemoral junction (SFJ); type 2, reflux involving malleolar region with competent SFJ; type 3, reflux involving SFJ with competent malleolar region; and type 4, reflux involving both the SFJ and the malleolar region. We evaluated the association between the classification of great saphenous vein insufficiency and age, sex, body mass index (BMI), disease duration, clinical, etiological, anatomical and pathophysiological elements (CEAP) classification and venous clinical severity score (VCSS). Results: the mean age of the patients was 45.3±11.7 years, with a male-to-female ratio of 2:3. The most common reflux pattern in patients with great saphenous vein insufficiency was type 3 (48.9%), while 14.8% of patients had type 1, 10.4% had type 2, and 25.7% had type 4. Patients with type I reflux pattern were younger in age (p = 0.002), had lower BMI (p = 0.002), fewer number of children (p = 0.008), as well as milder clinical severity score (p = 0.002) compared to other reflux types. Duration of disease symptoms was not significantly correlated with the reflux patterns, but VCSS increased with the involvement of malleolar region as in type 2 compared to type 1 (2.82±1.67 vs. 2.74±2.31), and further increased with the involvement of SFJ as in type 3 (4.13±2.92 vs. 2.82±1.67). Patients with diffuse reflux pattern (type 4) had the most severe clinical presentation (4.59±2.9). Conclusion: we developed a clinically applicable classification of reflux patterns in patients with great saphenous vein insufficiency based on the involvement of malleolar region and/or SFJ. We showed an association between weight, BMI, VCSS, CEAP classification and the extent of insufficiency.