Researcher:
Özler, Oğuz

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Undergraduate Student

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Oğuz

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Özler

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Özler, Oğuz

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2018 - 201922020 - 20213

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    An 8-month-old infant with hypercalcemia and hyperphosphatemia: questions
    (Springer, 2021) N/A; N/A; Özler, Oğuz; Yeşiltepe Mutlu, Rahime Gül; Taşdemir, Mehmet; Avcı, Şahin; Bilge, İlmay; Hatun, Şükrü; Undergraduate Student; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; 153511; 175867; N/A; 198907; 153504
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    Plasma cell-free DNA methylation: a liquid biomarker of hepatic fibrosis
    (BMJ Publishing Group, 2018) Boyle, Marie; Hardy, Timothy; Bergmann, Christina; Distler, Joerg H. W.; Adali, Gupse; Dayangac, Murat; Mann, Derek A.; Mann, Jelena; Yiğit Alpdoğan, Buket; Özler, Oğuz; Erden, Nihan; Tutucu, Faik; Zeybel, Müjdat; Researcher; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; 214694
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    An 8-month-old infant with hypercalcemia and hyperphosphatemia-Answers
    (Springer, 2021) N/A; N/A; Özler, Oğuz; Yeşiltepe Mutlu, Rahime Gül; Taşdemir, Mehmet; Avcı, Şahin; Bilge, İlmay; Hatun, Şükrü; Undergraduate Student; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; 153511; 175867; N/A; 198907; 153504
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    Non-therapeutic circumcision of boys: medical, sociocultural and ethical view
    (İstanbul Üniversitesi, 2021) N/A; N/A; Özler, Oğuz; Undergraduate Student; School of Medicine; N/A
    There is no medical or ethical consensus over the necessity and the ethical statue of nontherapeutic circumcision of boys. From the medical aspect, there are some potential medical benefits like decreased UTI contracture and Human Immunodeficiency Virus (HIV). transmission rates. However, it is an intervention to the child’s bodily integrity and has some surgical complications like bleeding, pain, postoperative infection and inadequate skin removal. Complication rates are low when the surgery is done according to medical standards. When considering the ethical aspects of circumcision, the most important question to be asked is ‘What is the best interest of the child?’ In order to answer this question, all medical, cultural and psychosocial aspects of the circumcision need to be evaluated. It is an important part of sociocultural life especially in Islamic and Jewish societies. Therefore, it is necessary for the child to be integrated to society and to socialize in that environment. Since it is not a fact whether the medical benefits outweigh the risk or vice versa, the right of the parents to raise a child according to their sociocultural and religious beliefs and the right of the child to be a part of the society should not be eliminated. / Erkek çocuklarında terapötik olmayan sünnet uygulamasının gerekliliği konusunda tıbbi ve etik açıdan bir fikir birliğine varılmış değildir. Tıbbi olarak, idrar yolu enfeksiyon sıklığını ve HIV bulaş ihtimalini azaltması gibi potansiyel faydaları mevcuttur. Öte yandan bu işlem çocuğun vücut bütünlüğünü bozmaktadır ve kanama, ağrı, operasyon sonrası enfeksiyon ve yetersiz miktarda cildin alınması gibi komplikasyonları da mevcuttur. Ancak ameliyat tıbbi standartlara uygun yapılırsa komplikasyon ihtimali düşüktür. Sünnetin etik boyutunu tartışırken sorulması gereken en önemli soru ‘Çocuğa en faydalı olan nedir?’ sorusudur. Bu soruyu cevaplandırabilmek için sünnetin tıbbi, kültürel ve psikolojik boyutlarının tamamı ele alınmalıdır. Çünkü erkek çocuklarının sünneti özellikle Müslüman ve Yahudi toplumlarda sosyo-kültürel hayatın önemli bir parçasıdır. Bu yüzden çocuğun topluma entegre olup o çevrede sosyalleşmesi gerekir. Tıbbi faydalarının zararlarına oranla üstün veya düşük olup olmadığı henüz bilimsel bir gerçek halini almadığı için, ailelerin çocuklarını kendi sosyokültürel ve dini inanışlarına göre yetiştirme hakkı ve çocukların da bulunduğu toplumun sosyal anlamda bir üyesi olması hakkı ellerinden alınmamalıdır.
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    Left congenital diaphragmatic hernia‑associated musculoskeletal deformities
    (Springer, 2019) Burns, Patricia; Lim, Foong-Yen; Peiro, Jose Luis; N/A; N/A; Aydın, Emrah; Özler, Oğuz; Faculty Member; Undergraduate Student; School of Medicine; School of Medicine; Koç University Hospital; Koc University Hospital; 32059; N/A
    Aim With the advancement in the treatment strategies of congenital diaphragmatic hernia (CDH), there is an increase in the survival rates. This fact leads to an increase in the morbidity and extrapulmonary complications in the long term such as failure to thrive, hernia recurrence, neurodevelopmental delay, gastrointestinal problems, and musculoskeletal anomalies. Herein, we aim to investigate the association between the long-term musculoskeletal complications in CDH patients regarding the defect size, repair type, and perinatal parameters. Methods After Institutional Review Board approval was obtained (2017-6361), a retrospective chart review was performed on CDH patients from 2003 to 2016. Patients who were operated due to left-sided isolated congenital diaphragmatic hernia and survived to date were included in the study. Data were collected on demographics, preoperative characteristics, operative interventions, and postoperative outcomes. Statistical analysis was performed with IBM SPSS Statistics 20.0.0 (Chicago, IL). Results There were 98 patients with left CDH of whom 33 (33.7%) had primary repair, 25 (25.5%) had patch repair, and 40 (40.8%) had muscle flap repair. The median age of the patients was 6.00 +/- 3.83 years. 45 patients (45.9%) had large diaphragmatic defects, 28 patients (28.6%) had at least one type of musculoskeletal deformities, 2 of which were pectus carinatum, 16 were pectus excavatum, and 18 were scoliosis. CDH patients who had small diaphragmatic defects and repaired with a patch were less likely develop musculoskeletal deformities while who had primary abdominal closure after ventral hernia significantly have more pectus excavatum. Conclusion Although there was a trend towards an increased risk of the pectus deformity and scoliosis in patients repaired with muscle flap, it did not reach statistical significance. There is a correlation between musculoskeletal deformities and the severity of the CDH.