Researcher:
Dora, Begüm

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PhD Student

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Begüm

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Dora

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Dora, Begüm

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2015 - 20202

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Researcher Of Publications: search.filters.isAuthorOfPublication.904db203-6541-460e-814f-e2e421812031

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    Transactional associations of maternal depressive symptoms with child externalizing behaviors are small after age 3
    (Cambridge Univ Press, 2020) Department of Psychology; Department of Psychology; Dora, Begüm; Baydar, Nazlı; PhD Student; Faculty Member; Department of Psychology; College of Social Sciences and Humanities; College of Social Sciences and Humanities; N/A; 50769
    A large and growing body of research suggests that maternal depressive symptoms and child externalizing behaviors are strongly associated. theoretical arguments supported by these findings led to the question of whether maternal depressive symptoms are transactionally associated with child externalizing behaviors. Using 5-year nationally representative longitudinal data from Turkey (N = 1,052), we estimated a transactional bivariate autoregressive latent trajectory model addressing this question. This model disaggregated the association of the two processes into two components: (a) the association of the interindividual differences in the trajectories; and (b) the intradyad association of the changes in maternal depressive symptoms with the changes in child externalizing behaviors. although maternal depressive symptoms were robustly associated with child externalizing behaviors at age 3, the transactional associations of the two processes were small prior to age 5 and absent at ages 5 to 7. Furthermore, maternal harsh parenting did not have a mediating role in the limited transactional association of maternal depressive symptoms with child externalizing behaviors.
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    Abnormal high-energy phosphate molecule metabolism during regional brain activation in patients with bipolar disorder
    (Nature Publishing Group (NPG), 2015) Yuksel, C.; Du, F.; Ravichandran, C.; Goldbach, J. R.; Thida, T.; Lin, P.; Gelda, J.; O'Connor, L.; Sehovic, S.; Gruber, S.; Ongur, D.; Cohen, B. M.; Department of Psychology; Dora, Begüm; PhD Student; Department of Psychology; College of Social Sciences and Humanities; N/A
    Converging evidence suggests bioenergetic abnormalities in bipolar disorder (BD). In the brain, phosphocreatine (PCr) acts a reservoir of high-energy phosphate (HEP) bonds, and creatine kinases (CK) catalyze the transfer of HEP from adenosine triphosphate (ATP) to PCr and from PCr back to ATP, at times of increased need. This study examined the activity of this mechanism in BD by measuring the levels of HEP molecules during a stimulus paradigm that increased local energy demand. Twenty-three patients diagnosed with BD-I and 22 healthy controls (HC) were included. Levels of phosphorus metabolites were measured at baseline and during visual stimulation in the occipital lobe using P-31 magnetic resonance spectroscopy at 4T. Changes in metabolite levels showed different patterns between the groups. During stimulation, HC had significant reductions in PCr but not in ATP, as expected. In contrast, BD patients had significant reductions in ATP but not in PCr. In addition, PCr/ATP ratio was lower at baseline in patients, and there was a higher change in this measure during stimulation. This pattern suggests a disease-related failure to replenish ATP from PCr through CK enzyme catalysis during tissue activation. Further studies measuring the CK flux in BD are required to confirm and extend this finding.