Researcher:
Şimşek, Sezai Aykın

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Sezai Aykın

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Şimşek

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Şimşek, Sezai Aykın

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2016 - 201922020 - 20213

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    PublicationMetadata only
    Comparison of effectiveness of kyphoplasty and vertebroplasty in patients with osteoporotic vertebra fractures
    (Turkish Association of Orthopaedics and Traumatology (TOTDER), 2016) Ateş, Ahmet; Gemalmaz, Halil Can; Deveci, Mehmet Ali; Çetin, Engin; Şenköylü, Alpaslan; N/A; Şimşek, Sezai Aykın; Faculty Member; School of Medicine; 133305
    Objective: The aim of this study was to compare the functional and radiological outcomes of vertebroplasty and kyphoplasty in patients with osteoporotic vertebra fractures. Methods: The files of the patients who underwent vertebroplasty or kyphoplasty for osteoporotic vertebrae fractures were retrieved from the archives. Forty-three patients with complete follow-up data were included in the study group. The patients were evaluated for radiological outcomes in terms of local kyphosis angle, wedging index, compression ratio, visual analog pain scale (VAS) and Oswestry Disability Index (ODI). Results: In the study group, kyphoplasty was performed on 24 vertebrae of 22 patients (17 females, 5 males; mean age: 73 years) whereas vertebroplasty was applied on 24 vertebrae of 21 (16 females, 5 males; mean age: 74.7 years) patients. The mean follow-up time was 26 months. When the VAS and ODI values of the groups were analyzed, both groups showed statistically significant progress after the operation. Radiological data showed that the kyphoplasty group showed statistically significant improvement in the sagittal index values whereas the vertebroplasty group did not. The overall complication ratio was 4%. Conclusion: Both vertebroplasty and kyphoplasty are effective treatment methods for functional recovery and pain relief in osteoporotic fractures of the vertebra. Although radiological outcomes of the kyphoplasty seem to be better, this does not have any clinical relevance. We suggest vertebroplasty over kyphoplasty since it is an easier method to manage. (C) 2016 Turkish Association of Orthopaedics and Traumatology. Publishing services by Elsevier B. V. This is an open access article under the CC BY-NC-ND license.
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    PublicationOpen Access
    Cross-cultural adaptation and validation of the Turkish version of the Musculoskeletal Tumor Society scoring system in patients with musculoskeletal tumors
    (Aves, 2021) Ocaktan, Bahadır; Tokgöz, Mehmet Ali; Yapar, Aliekber; Deveci, Mehmet Ali; Şimşek, Sezai Aykın; Faculty Member; Faculty Member; School of Medicine; Koç University Hospital; 206311; 133305
    Objective: this study aimed to translate and cross-culturally adapt the musculoskeletal tumor society (MSTS) scoring system into Turkish and to determine the reliability and validity of the translated version for the functional evaluation of patients with musculoskeletal tumors. Methods: a total of 36 patients (16 women, 20 men; mean age=36.6; age range=13-75 years) who underwent limb-salvage surgery owing to benign aggressive or malignant musculoskeletal tumors were included in the study. Translation and back translations of the MSTS were performed according to the published guidelines. Short form (SF) 36 physical component, Western Ontario and McMaster Universities Arthritis Index (WOMAC), disabilities of the arm, shoulder, and hand (DASH), and range of motion scale (ROMS) that were previously analyzed for Turkish validation were used for validity. Reliability of MSTS Turkish version was evaluated by calculating test-retest reliability and internal consistency. Intraclass correlation coefficient (ICC) was used to evaluate the inter-observer consistency and test-retest reliability. Alpha coefficient (Cronbach's alpha) was used to evaluate the internal consistency. Results: it was observed that total MSTS score has a strong negative correlation with DASH (r=-0.689; p<0.001) and WOMAC scores (r=-0.634; p<0.001) and moderate correlation with the ROMS score (r=0.521; p<0.001). Total MSTS score also had a statistically significant strong correlation with SF-36 scores (r values ranging from 0.425 to 0.609, p<0.001). Inter and intra-observer reliability of the MSTS scale was found to be excellent (Cronbach's alpha=0.97 p<0.001; ICC: 0.97 (0.96-0.99; p<0.001). Unlike other subscales, statistical correlation between dexterity and hand-positioning subscales of MSTS with DASH scores was found to be insignificant (r=-0.533, p =0.061 and r=-0.336, p=0.261, respectively). Conclusion: the Turkish version of the MSTS scoring system seems to be a valid and reliable scale that measures the correct and desired values in the evaluation of health-related quality of life in orthopedic oncology. Reliability coefficients of the Turkish version of MSTS were determined to be strong.
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    PublicationOpen Access
    Does dynamic contrast enhanced magnetic resonance imaging contribute to differantion of benign and malignant bone tumors?
    (Gazi Üniversitesi, 2019) Şendur, Halit Nahit; Tokgöz, Nil; Şendur, Aylin Billur; Cerit, Mahinur; Cindil, Emetullah; Uçar, Murat; Şimşek, Sezai Aykın; Koç University Hospital
    Objectives: we aimed to evaluate the efficacy of the dynamic contrast enhanced magnetic resonance imaging (DCE MRI) in the differantiation of benign and malignant bone tumors. Methods: thirty seven patients consisted of 18 men and 19 women (mean age 33,3; age range:11-69) with bone tumors were included in this study. Because of one patient has two lesions, a total of 38 bone tumors (29 benign, 9 malignant) were evaluated with DCE-MRI. Signal intensity - time (SIT) curves that divided into two categories were obtained from dynamic images. Relative contrast enhancement ratio within the first minute (K1) and slope of signal intensity - time curves were calculated. Results: according to SIT curves, 24 (82.8%) of 29 benign bone tumors, showed category 1, and 5 (17,2%) of them showed category 2 contrast enhancement pattern. All malignant bone tumors (100%) revealed category 2 enhancement pattern. 85% cut off value for K1 had sensitivity and spesificity, 100% and 86,2%, respectively. 84,1% cut off value for slope of SIT curves had sensitivity and spesificity, 100% and 82,8%, respectively. (p<0,001). Conclusion: the data obtained from DCE MRI revealed that malignant bone tumors show faster and more contrast enhancement than benign lesions. K1 and slope of SIT curves provided similar results that indicate the first minute of DCE MRI presents the most important information for differantiation of benign and malignant bone tumors. / Amaç: kemik tümörlerinde benign ve malign lezyon ayrımında dinamik kontrastlı manyetik rezonans görüntülemenin (DK MRG) etkinliğinin değerlendirilmesi. Yöntem: direkt grafide kemik tümörü bulunan 18 erkek ve 19 kadından oluşan 37 hasta (ort. yaş: 33,3; yaş aralığı:11-69) çalışmaya dahil edildi. Bir hastada iki farklı kemik tümörü olduğundan, toplam 38 lezyona (29 benign, 9 malign) DK MRG gerçekleştirildi. DK MRG’de sinyal intensitesi–zaman (SİZ) eğrilerine göre 2 kategori tanımlandı. SİZ eğrilerinde birinci dakikada göreceli kontrastlanma oranı (K1) ve eğrilerin eğimleri ölçüldü. Bulgular: SİZ eğrilerine göre; 29 benign kemik tümöründen 24’ü (%82,8) kategori 1, 5’i (%17,2) kategori 2 ile uyumlu kontrastlanma gösterdi. Dokuz malign kemik tümörünün tamamı (%100) kategori 2 kontrastlanma ile uyumlu olarak değerlendirildi. Benign ve malign lezyonları ayırt etmede K1 için %85’lik eşik değerinin duyarlılığı %100, özgüllüğü %86,2 bulundu (p<0,001). SİZ eğrilerinin eğiminde %84,1’lik eşik değerinin duyarlılığı %100, özgüllüğü %82,8 bulundu (p<0,001). Sonuç: DK MRG’de benign lezyonlarda daha yavaş ve daha az, malign lezyonlarda ise daha hızlı ve daha yüksek oranda kontrast tutulumu izlenmektedir. K1 değerleri ile SİZ eğri eğimleri tanısal doğruluk yönünden benzer sonuçlar vermekte olup, benign ve malign lezyonların ayrımında DK MRG’nin ilk dakikası en önemli verileri sağlamaktadır.
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    PublicationOpen Access
    Cross-cultural adaptation and validation of the Turkish version of the Toronto Extremity Salvage Score in patients with musculoskeletal tumors
    (Aves, 2021) Ocaktan, Bahadır; Yapar, Aliekber; Tokgöz, Mehmet Ali; Deveci, Mehmet Ali; Şimşek, Sezai Aykın; Faculty Member; Faculty Member; School of Medicine; 206311; 133305
    Objective: the aim of the study was to translate the Toronto Extremity Salvage Score (TESS) into Turkish and perform across cultural adaptation for patients with musculoskeletal tumors. Methods: thirty-six patients (20 male, 16 female; mean age = 36.6 ± 15.4 years) who were diagnosed with malignant bone and soft tissue sarcoma or benign aggressive bone tumors between the years 2007 and 2012 were included in the study. TESS was translated into Turkish and back translated to determine language validity. To test convergent validity, the Turkish versions of the Short Form-36 (SF-36), Western Ontario and McMaster Universities Arthritis Index (WOMAC), and Disabilities of the Arm, Shoulder, and Hand (DASH) were used. SF-36 was used on all patients while WOMAC and DASH were used on patients with lower extremity tumors and upper extremity tumors respectively. The tests were repeated 15 days later and the intraclass correlation coefficient (ICC) was used to determine test-retest reliability. Results: the Turkish version of TESS was found to have a strong negative correlation with WOMAC (r = -0.702; P < 0.001) and DASH (r = -0.774; P < 0.001) as well as a strong negative correlation with ROMS (r = 0.601; P < 0.001). Turkish TESS also had a statistically significant correlation with SF-36–Physical functioning, SF-36–Role Physical, SF-36–Bodily Pain, and SF36–General Health at levels ranging from 0.326 to 0.669 (r values ranging from 0.326 to 0.669, P < 0.001). The internal consistency (Cronbach’s ?:0.96 for lower extremity and Cronbach’s ?:0.94 for upper extremity) and test-retest reliability of Turkish TESS were found to be excellent (ICC lower extremity: 0.96 [0.935-0.983]; P < 0.001 and ICC upper extremity: 0.99 [0.967-0.997]; P < 001). ICC values varied between 0.674 and 0.987 for each item of the scale for both extremities. Conlusion: the Turkish version of TESS seems to be a valid and reliable patient-reported outcome measure to evaluate physical function after musculoskeletal tumor surgery in Turkish patients. Level of Evidence: level II, diagnostic study
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    PublicationOpen Access
    Is elective cancer surgery feasible during the lock-down period of the COVID-19 pandemic? Analysis of a single institutional experience of 404 consecutive patients
    (Wiley, 2021) Cesur, Ezgi; Kırış, Talat; Giray, Burak; Kulle, Cemil Burak; Azamat, İbrahim Fethi; Ağcaoğlu, Orhan; Dilege, Ece; Erkan, Murat Mert; Balık, Emre; Bilge, Orhan; Buğra, Dursun; Vatansever, Doğan; Taşkıran, Çağatay; Erus, Suat; Yavuz, Ömer; Tanju, Serhan; Dilege, Şükrü; Tarım, Kayhan; Kiremit, Murat Can; Kılıç, Mert; Canda, Abdullah Erdem; Kordan, Yakup; Akyoldaş, Göktuğ; Solaroğlu, İhsan; Sasani, Mehdi; Gökler, Ozan; Ünsaler, Selin; Altuntaş, Muzaffer Ozan; Hafız, Ayşenur Meriç; Şimşek, Sezai Aykın; Deveci, Mehmet Ali; Korkmaz, Murat; Çakar, Nahit; Ergönül, Önder; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Teaching Faculty; Faculty Member; Researcher; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Teaching Faculty; Teaching Faculty; Teaching Faculty; Faculty Member; Faculty Member; Doctor; Faculty Member; Faculty Member; School of Medicine; Koç University Hospital; N/A; N/A; 175476; 218050; 214689; 18758; 176833; 1758; 193687; 134190; 175565; N/A; 214690; 122573; 327605; N/A; N/A; 116202; 157552; N/A; 102059; N/A; 311179; 167909; 169795; 53676; N/A; 206311; N/A; 198906; 110398
    Background: we aimed to assess the feasibility and short-term clinical outcomes of surgical procedures for cancer at an institution using a coronavirus disease 2019 (COVID-19)-free surgical pathway during the peak phase of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Materials and methods: this was a single-center study, including cancer patients from all surgical departments, who underwent elective surgical procedures during the first peak phase between March 10 and June 30, 2020. The primary outcomes were the rate of postoperative SARS-CoV-2 infection and 30-day pulmonary or non-pulmonary related morbidity and mortality associated with SARS-CoV-2 disease. Results: four hundred and four cancer patients fulfilling inclusion criteria were analyzed. The rate of patients who underwent open and minimally invasive procedures was 61.9% and 38.1%, respectively. Only one (0.2%) patient died during the study period due to postoperative SARS-CoV2 infection because of acute respiratory distress syndrome. The overall non-SARS-CoV2 related 30-day morbidity and mortality rates were 19.3% and 1.7%, respectively; whereas the overall SARS-CoV2 related 30-day morbidity and mortality rates were 0.2% and 0.2%, respectively. Conclusions: under strict institutional policies and measures to establish a COVID-19-free surgical pathway, elective and emergency cancer operations can be performed with acceptable perioperative and postoperative morbidity and mortality.