Researcher:
Ulusu, Nuriye Nuray

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Nuriye Nuray

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Ulusu

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Ulusu, Nuriye Nuray

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2014 - 2019332020 - 202336

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    Effects of alprazolam and haloperidol on thyroglobulin, antithyroglobulin, anti thyroid peroxidase and TSH in Rat
    (Walter De Gruyter Gmbh, 2018) Samadi, Afshin; Ansari, Mohammad Hassan Khadem; Ulusu, Nuriye Nuray; Faculty Member; School of Medicine; 6807
    Background: A large number of psychotropic drugs can interfere with the thyroid physiology, function and autoimmunity. Objective: The aim of the present study was to investigate the effects of alprazolam and haloperidol on thyroglobulin, antithyroglobulin (aTg), antithyroid peroxidase, and thyroid stimulating hormone levels on rats. Materials and Methods: First group of adult male Wistar rats was the control, second group received 0.5 mg kg(-1) haloperidol in physiological saline and the third group received 0.5 mg kg(-1) alprazolam, via gastric gavage once daily for 28 days. Plasma levels of all thyroid function tests were measured with chemiluminescent assay. Results: We have investigated a decrease in aTg amounts of control group (5.461 +/- 0.718) compared with drug treated rats with alprazolam (1.433 +/- 0.225) and haloperidol (1.21 +/- 0.228). (P-aTg = 0.00([ALP]), P-aTg = 0.01([HAL])). Although there were not any change in thyroglobulin levels in the haloperidol treated groups (0.9583 +/- 0.014) relative to control group (0.975 +/- 0.015); but in opposition Tg levels decreased significantly in response to alprazolam (0.36 +/- 0.16) compared with the control group (0.975 +/- 0.015), p-values are (P-Tg = 0. 001([ALP])), (P-Tg = 0. 021([HAL])). Conclusion: We found that these two drugs may interfere with the thyroid physiology and metabolism.
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    Impact of COVID-19 pandemic on academic research and being demotivated
    (AVES, 2020) N/A; Aydemir, Duygu; Ulusu, Nuriye Nuray; PhD Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; N/A; 6807
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    Synthesis and characterization of a triple enzyme-inorganic hybrid nanoflower (TrpE@ihNF) as a combination of three pancreatic digestive enzymes amylase, protease and lipase
    (Society for Bioscience and Bioengineering Japan, 2020) Gecili, Firdevs; Ozdemir, Nalan; N/A; Aydemir, Duygu; Ulusu, Nuriye Nuray; PhD Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; N/A; 6807
    Nanoflowers are recently developed flower-shaped nanoparticles consisting of several layers of petals to improve surface reaction and stability. Among them organic-inorganic hybrid nanoflowers have been spotlighted, since they can overcome enzyme-related limitations, including low stability, high production cost, substrate/product inhibition and difficult recovery. In this study, triple enzyme-inorganic hybrid nanoflowers (TrpE@ihNFs) were synthesized using a mixture of three enzymes (alpha-amylase, lipase and protease) and Cu2+ ions. TrpE@ihNFs were characterized by their morphology and chemical point of view by using different techniques including SEM, FTIR, EDX, and XRD. Afterwards we compared the enzyme activity and stability of TrpE@ihNFs with the free enzymes, including lipase, amylase and protease at the different pH and temperatures spectrophotometrically. Our data reveal that enzyme activities and stability of TrpE@ihNFs were significantly higher compared to the each free enzyme. In conclusion, we showed TrpE@ihNFs which can be used for the treatment of wastewater, biosensors, biocatalysts, and bio-related devices in the future.
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    Evolution of enzyme kinetic mechanisms
    (Springer, 2015) Ulusu, Nuriye Nuray; Faculty Member; School of Medicine; 6807
    This review paper discusses the reciprocal kinetic behaviours of enzymes and the evolution of structure-function dichotomy. Kinetic mechanisms have evolved in response to alterations in ecological and metabolic conditions. The kinetic mechanisms of single-substrate mono-substrate enzyme reactions are easier to understand and much simpler than those of bi-bi substrate enzyme reactions. The increasing complexities of kinetic mechanisms, as well as the increasing number of enzyme subunits, can be used to shed light on the evolution of kinetic mechanisms. Enzymes with heterogeneous kinetic mechanisms attempt to achieve specific products to subsist. In many organisms, kinetic mechanisms have evolved to aid survival in response to changing environmental factors. Enzyme promiscuity is defined as adaptation to changing environmental conditions, such as the introduction of a toxin or a new carbon source. Enzyme promiscuity is defined as adaptation to changing environmental conditions, such as the introduction of a toxin or a new carbon source. Enzymes with broad substrate specificity and promiscuous properties are believed to be more evolved than single-substrate enzymes. This group of enzymes can adapt to changing environmental substrate conditions and adjust catalysing mechanisms according to the substrate's properties, and their kinetic mechanisms have evolved in response to substrate variability.
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    Cornerstones of biochemistry in stamps
    (Walter De Gruyter Gmbh, 2016) N/A; Ulusu, Nuriye Nuray; Faculty Member; School of Medicine; 6807
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    A comparative study on thyroid function in alzheimer's disease: results from a Turkish multi-centre study
    (Journal Neurological Sciences, 2015) Yılmaz, Gökhan; Erbayraktar, Zübeyde; Evlice, Ahmet; Genç, Metin; Aras, Sevgi; Avcı, Aslıhan; Yener, Görsev; Ulusu, Nuriye Nuray; Faculty Member; School of Medicine; 6807
    Alzheimer's disease is a very severe degenerative disease that affects brain function. Neuronal loss, accumulation of extracellular amyloid beta containing plaques and accumulation of intracellular (tau) neurofibrillary tangles are the hallmarks of this disease. We aim to investigate serum thyroid function tests in Alzheimer's disease, in addition to other dementias, and geriatric Turkish patients. We evaluated patients from Ankara, Dokuz Eylul, Cukurova University Hospitals. 357 female and male geriatric subjects were enrolled. All the cases were selected from three different geographical regions irrespective of sex and socioeconomic status. In this study, we evaluated the results of thyroid functions in Alzheimer disease patients as well as in other dementias and geriatric patients. In patients from Ankara, Central Anatolia region, no significant difference between groups regarding the routine control of biochemical parameters was observed. However, thyroid function results revealed that hypothyroidism in Alzheimer's disease patients from Mediterranean region, Adana and Aegean region, Izmir is a recurrent medical condition and is often an embedded side of the normal aging process. We concluded that currently, routine thyroid functions tests should be a part of all geriatric patients for screening presymptomatic Alzheimer's disease. There might be an interplay between reduced thyroid function and Alzheimer's disease that could be exploited for diagnostic purposes.
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    A comparative study on thyroid function in alzheimer`s disease: results from a Turkish multi-centre study
    (Ege Üniversitesi, 2015) Yılmaz, Gökhan; Erbayraktar, Zübeyde; Evlice, Ahmet; Genç, Metin; Aras, Sevgi; Avcı, Aslıhan; Yener, Görsev; Ulusu, Nuriye Nuray; Faculty Member; School of Medicine; 6807
    Alzheimer's disease is a very severe degenerative disease that affects brain function. Neuronal loss, accumulation of extracellular amyloid β containing plaques and accumulation of intracellular (tau) neurofibrillary tangles are the hallmarks of this disease. We aim to investigate serum thyroid function tests in Alzheimer's disease, in addition to other dementias, and geriatric Turkish patients. We evaluated patients from Ankara, Dokuz Eylul, Cukurova University Hospitals. 357 female and male geriatric subjects were enrolled. All the cases were selected from three different geographical regions irrespective of sex and socioeconomic status. In this study, we evaluated the results of thyroid functions in Alzheimer disease patients as well as in other dementias and geriatric patients. In patients from Ankara, Central Anatolia region, no significant difference between groups regarding the routine control of biochemical parameters was observed. However, thyroid function results revealed that hypothyroidism in Alzheimer's disease patients from Mediterranean region, Adana and Aegean region, İzmir is a recurrent medical condition and is often an embedded side of the normal aging process. We concluded that currently, routine thyroid functions tests should be a part of all geriatric patients for screening presymptomatic Alzheimer`s disease. There might be an interplay between reduced thyroid function and Alzheimer`s disease that could be exploited for diagnostic purposes. / Alzheimer hastalığı, beyin fonksiyonlarını etkileyen çok şiddetli dejeneratif bir hastalıktır. Nöronal kayıp, amiloid β içeren plakların ekstrasellüler birikimi ve intrasellüler nörofibriler yumakların (tau) birikimi, bu hastalığın göstergeleridir. Bu çalışma İzmir Dokuz Eylül, Ankara ve Adana Çukurova Üniversitesi Nöroloji, Biyokimya ve Geriatri Anabilim Dalları tarafından çok merkezli bir çalışma olarak tasarlanmış olup, farklı coğrafi yörelerde yaşayan, geriatri yaş grubundan 357 demans tanısı almış hastalardaki tiroid fonksiyon testlerini karşılaştırmayı amaçlamıştır. Olgular, cinsiyet ve sosyoekonomik durumlarına göre ayırım yapılmadan üç farklı coğrafi bölgeden seçilmiştir. Bu çalışmada, Alzheimer hastalarında, diğer demans tanılı ve geriatrik hastalarda tiroid fonksiyon testleri değerlendirilmiştir. Orta Anadolu Bölgesi'ni temsilen Ankara'daki olguların rutin biyokimyasal parametreleri arasında belirgin bir fark gözlenmemiştir. Ancak Ege Bölgesi'ni temsil eden İzmir ve Akdeniz Bölgesi'ni temsil eden Adana'daki Alzheimer hastalarının tiroid fonksiyonları, genellikle normal yaşlanma süreciyle de ilişkili olan hipotiroidizm ile uyumlu olarak gözlenmiştir. Geriatrik olgularda rutin tiroid fonksiyon testlerinin, presemptomatik Alzheimer taramasının bir parçası olması gerektiği sonucuna varılmıştır. Azalmış tiroid fonksiyonları ile Alzheimer hastalığı arasındaki etkileşim olasılığı, tanısal yaklaşımlarda önemli rol oynayabilecektir.
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    Beta-blocker timolol has important beneficial action on diabetes-induced kidney tissue damage by enhancing the activities of some antioxidant enzymes
    (Wiley-Blackwell, 2014) Gökturk, Hilal; Gök, Müslüm; Tuncay, Erkan; Can, Belgin; Turan, Belma; Ulusu, Nuriye Nuray; Faculty Member; School of Medicine; 6807
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    Long-term treatment with a beta-blocker timolol attenuates renal-damage in diabetic rats via enhancing kidney antioxidant-defense system
    (Springer, 2014) Gökturk, Hilal; Gök, Müslüm; Tuncay, Erkan; Can, Belgin; Turan, Belma; Ulusu, Nuriye Nuray; Faculty Member; School of Medicine; 6807
    The factors with increasing diabetes-prevalence lead to significant global increases in chronic kidney disease. Since hyperglycemia generates more ROS and attenuates cellular antioxidant-defense mechanisms, numerous studies demonstrated that hyperglycemia-induced oxidative stress played a major role in the extracellular matrix expansion in tissues. Although no direct relation between activation of beta-adrenergic (beta-AR) system and kidney disease in diabetes and since beta-blockers demonstrate marked beneficial effects due to their scavenging free radicals and/or acting as an antioxidant in diabetic animal studies, the eventual objective of the present study was to determine whether timolol-treatment of streptozotocin-induced diabetic rats (5 mg/kg, daily following diabetes-induction, for 12-week) has advantage to prevent hyperglycemia-induced renal-damage via enhancing the depressed antioxidant defense in the kidney. Light microscopy data and their quantification demonstrated that timolol-treatment prevented basically glomerular hypertrophy, expansion in mesangium cell size, thickening and fibrosis in glomerular basement membrane, and accumulation of glycogen into tubular epithelial cells. Additionally, electron microscopy data demonstrated that timolol-treatment could also prevent diabetes-induced changes in the kidney tissue such as hypertrophy in podocytes, lost of filtration gaps and slit-diaphragms, and vacuolization in the distal tubular cells. Biochemical analysis basically on enzymes of antioxidant-defense system, including glutathione-S-transferase, glutathione reductase, and glucose-6-phosphate dehydrogenase, further supported that diabetes-induced damage in the kidney is mostly dependent on the increased oxidative stress and timolol, having an antioxidant-like action, could protect the kidney against hyperglycemia-induced damage without normalization of high-blood glucose level. Consequently, it can be suggested that although beta-blockers are widely used for the treatment of cardiovascular diseases, beta-blocker therapy of diabetics seems to be a new therapeutic approach against hyperglycemia-induced kidney damage in diabetic patients.
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    A new substrate for glutathione reductase: glutathione coated Ag2S quantum dots
    (Elsevier, 2019) N/A; N/A; N/A; Department of Chemistry; N/A; Aydemir, Duygu; Hashemkhani, Mahshid; Durmuşoğlu, Emek Göksu; Acar, Havva Funda Yağcı; Ulusu, Nuriye Nuray; PhD Student; PhD Student; PhD Student; Faculty Member; Faculty Member; Department of Chemistry; Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM); Graduate School of Health Sciences; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Sciences; School of Medicine; N/A, N/A; N/A; 178902; 6807
    Glutathione (GSH), a key player in various cellular processes including detoxification, anti-oxidant defense system and cell proliferation is also a potentially good coating material for luminescent quantum dots. GSH is oxidized to oxidized glutathione (GSSG) under oxidative stress and then reduced back by glutathione reductase (GR) enzyme to maintain the balance of GSH/GSSG ratio. In this frame, GSH stabilized quantum dots (QDs) have never been evaluated as GR substrate. Here, GSH coated Ag2S QDs, luminescent in the medical window, were prepared and their GR activity were tested. We have shown by spectrophotometric methods that GSH-Ag2S acted as a substrate-analog for GR enzyme that had lower activity compared to the original substrate GSSG. These results provide a new perspective in the evaluation of QDs in medical applications, enzyme activity or level detection as well as possible means to study enzymes.