Researcher:
Gündüz, Hande

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Hande

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Gündüz

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Gündüz, Hande

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2021 - 20236

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Researcher Of Publications: search.filters.isAuthorOfPublication.9a5b66f2-9034-44b1-a44a-3379d7923ec8

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Now showing 1 - 6 of 6
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    Directing chemiluminescent dioxetanes to mitochondria: a cationic luminophore enables in vitro and in vivo detection of cancer cells upon enzymatic activation
    (Elsevier B.V., 2023) Department of Chemistry; N/A; N/A; Department of Chemistry; N/A; N/A; N/A; N/A; N/A; Department of Chemistry; Gündüz, Hande; Acari, Alperen; Çetin, Sultan; Almammadov, Toghrul; Değirmenci, Nareg Pınarbaşı; Dırak, Musa; Cingöz, Ahmet; Kılıç, Eda; Önder, Tuğba Bağcı; Kölemen, Safacan; Researcher; Master Student; PhD Student; Researcher; PhD Student; PhD Student; Researcher; Master Student; Faculty Member; Faculty Member; Department of Chemistry; N/A; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; N/A; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; N/A; N/A; College of Sciences; Graduate School of Health Sciences; Graduate School of Sciences and Engineering; College of Sciences; Graduate School of Health Sciences; Graduate School of Sciences and Engineering; N/A; Graduate School of Sciences and Engineering; School of Medicine; College of Sciences; 224496; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 184359; 272051
    A mitochondrion targeted and leucine aminopeptidase (LAP) activatable 1,2-dioxatane based chemiluminescent probe (MCL) for detection of LAP activity in living cancer cells and tumor bearing mice was reported. MCL displayed a selective and sensitive turn-on response in aqueous solutions upon reacting with the LAP enzyme. In cell culture studies, a selective luminescence intensity increase was observed in cancer cell lines, suggesting that MCL can differentiate between cancer and normal cells and allows detection of varying endogenous LAP concentrations. Using fluorescence imaging with a commercial Mitotracker dye, MCL was also shown to localize mitochondria in cancer cell lines. Furthermore, MCL was used to image tumors in mice models. MCL marks not only the first ever example of a mitochondria targeted chemiluminescent probe, but also the first ever example of an organelle targeted 1,2-dioxetane derivative. © 2023 Elsevier B.V.
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    A novel anthracene functionalized dibenzoxanthene fluorophore for copper (II) sensing
    (Elsevier, 2021) Özükanar, Özge; Ünlü, Caner; Kumbaracı, Volkan; Department of Chemistry; Gündüz, Hande; Researcher; Department of Chemistry; College of Sciences; 224496
    Dibenzoxanthene derivatives are widely used in metal ion sensing applications. Especially, fluorescent dibenzoxanthene derivatives are potential candidate to sense metal ions in various solvent systems. However, most of the studies are focused on either metal sensing in aqueous solutions, or sensing of the extremely toxic metal ions, such as Pb2+ and Hg2+. In this study, a novel benzyl functionalized dibenzoxanthene derivative and a novel fluorescent anthracene functionalized dibenzoxanthene derivative were synthesized to sense metal ions in polar aprotic solvent systems by using UV-Vis spectroscopy and Fluorescence spectroscopy. As benzyldibenzoxanthene was sensitive to multiple metal ions (Pb2+, CO2+, and Cu2+), novel anthracenyldibenzoxanthene was only sensitive to Cu2+ with the binding capacity of one anthracenyl-dibenzoxanthene to three Cu2+ ions, thus the copper sensitivity was increased. The binding affinity of dibenzoxanthene derivatives with Cu2+ has been analyzed by H-1 NMR and High-resolution XPS.
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    Singlet oxygen probes: diversity in signal generation mechanisms yields a larger color palette
    (Elsevier Science Sa, 2021) Akkaya, Engin Umut; Department of Chemistry; Department of Chemistry; Gündüz, Hande; Kölemen, Safacan; Researcher; Faculty Member; Department of Chemistry; Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM), Koç University Boron and Advanced Materials Application and Research Center (KUBAM) / Koç Üniversitesi Bor ve İleri Malzemeler Uygulama ve Araştırma Merkezi (KUBAM), Koç University Tüpraş Energy Center (KUTEM) / Koç Üniversitesi Tüpraş Enerji Merkezi (KÜTEM); N/A; College of Sciences; College of Sciences; 224496; 272051
    The detection and imaging of singlet oxygen produced by natural processes, or by photochemical and chemical reactions has become an important goal in probe design. The short half-life and solvent sensitive nature of the singlet oxygen makes this detection highly challenging. At the same time, since singlet oxygen can be the precursor of other reactive oxygen species (ROS), it is crucial to have a selective probe for singlet oxygen in the presence of other oxidizing species. The challenge is immense, yet there are already brilliant examples of smart probe design. This review mechanistically classifies and discusses what is being done in order to obtain a selective response and at the same time, push the signalling events towards longer wavelengths of the visible spectrum. (C) 2020 Elsevier B.V. All rights reserved.
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    Dual laser activatable brominated hemicyanine as a highly efficient and photostable multimodal phototherapy agent
    (Elsevier Science Sa, 2021) Department of Chemistry; N/A; N/A; N/A; Department of Physics; Department of Chemistry; Department of Chemistry; Gündüz, Hande; Bilici, Kübra; Çetin, Sultan; Muti, Abdullah; Sennaroğlu, Alphan; Acar, Havva Funda Yağcı; Kölemen, Safacan; Researcher; PhD Student; PhD Student; PhD Student; Faculty Member; Faculty Member; Faculty Member; Department of Physics; Department of Chemistry; Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM); Koç University Boron and Advanced Materials Application and Research Center (KUBAM) / Koç Üniversitesi Bor ve İleri Malzemeler Uygulama ve Araştırma Merkezi (KUBAM); Koç University Tüpraş Energy Center (KUTEM) / Koç Üniversitesi Tüpraş Enerji Merkezi (KÜTEM); College of Sciences; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Sciences; College of Sciences; College of Sciences; 224496; N/A; N/A; N/A; 23851; 178902; 272051
    Dual phototherapy agents have attracted great interest in recent years as they offer enhanced cytotoxicity on cancer cells due to the synergistic effect of photodynamic and photothermal therapies (PDT/PTT). In this study, we demonstrate a brominated hemicyanine (HC-1), which is previously shown as mitochondria targeting PDT agent, can also serve as an effective photosensitizer for PTT for the first time under a single (640 nm or 808 nm) and dual laser (640 nm + 808 nm) irradiation. Generation of reactive oxygen species and photothermal conversion as a function of irradiation wavelength and power were studied. Both single wavelength irradiations caused significant phototoxicity in colon and cervical cancer cells after 5 min of irradiation. However, coirradiation provided near-complete elimination of cancer cells due to synergistic action. This work introduces an easily accessible small molecule-based synergistic phototherapy agent, which holds a great promise towards the realization of local, rapid and highly efficient treatment modalities against cancer.
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    Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy
    (Elsevier, 2022) Erkısa, Merve; Ulukaya, Engin; N/A; N/A; Department of Chemistry; N/A; N/A; N/A; Department of Physics; Department of Chemistry; Department of Chemistry; Savani, Samira; Onbaşlı, Kübra; Gündüz, Hande; Çelikbaş, Eda; Muti, Abdullah; Khan, Minahil; Sennaroğlu, Alphan; Acar, Havva Funda Yağcı; Kölemen, Safacan; Master Student; PhD Student; Researcher; PhD Student; PhD Student; PhD Student; Faculty Member; Faculty Member; Faculty Member; Department of Physics; Department of Chemistry; Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM); Koç University AKKİM Boron-Based Materials & High-technology Chemicals Research & Application Center (KABAM) / Koç Üniversitesi AKKİM Bor Tabanlı Malzemeler ve İleri Teknoloji Kimyasallar Uygulama ve Araştırma Merkezi (KABAM); Koç University Tüpraş Energy Center (KUTEM) / Koç Üniversitesi Tüpraş Enerji Merkezi (KÜTEM); Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Sciences; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Sciences; College of Sciences; College of Sciences; N/A; 365341; 224496; N/A; N/A; N/A 23851; 178902; 272051
    A cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and activated its singlet oxygen generation as well as photothermal conversion potentials upon reacting with Cys. The laser irradiation of Cl-Cys induced significant cell death in cancer cells with high Cys level, while it stayed deactivated and non-emissive in a healthy cell line. A profound synergistic PDT/PTT effect was observed at high doses. Remarkably, Cl-Cys marks the first ever example of Cys-responsive small organic-based therapeutic agent and holds a great promise to develop new activity-based photosensitizers for dual phototherapy action.
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    PublicationOpen Access
    Balanced intersystem crossing in iodinated silicon-fluoresceins allows new class of red shifted theranostic agents
    (American Chemical Society (ACS), 2021) Elmazoğlu, Zübeyir; Karaman, Osman; Günbaş, Görkem; Department of Chemistry; Çetin, Sultan; Kölemen, Safacan; Gündüz, Hande; PhD Student; Faculty Member; Researcher; Department of Chemistry; Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM); Koç University Tüpraş Energy Center (KUTEM) / Koç Üniversitesi Tüpraş Enerji Merkezi (KÜTEM); Koç University Boron and Advanced Materials Application and Research Center (KUBAM) / Koç Üniversitesi Bor ve İleri Malzemeler Uygulama ve Araştırma Merkezi (KUBAM); Graduate School of Sciences and Engineering; College of Sciences; N/A; 272051; N/A
    Iodination of the silicon-fluorescein core revealed a new class of highly cytotoxic, red-shifted and water-soluble photosensitizer (SF-I) which is also fairly emissive to serve as a theranostic agent. Singlet oxygen generation capacity of SF-I was evaluated chemically, and up to 45% singlet oxygen quantum yield was reported in aqueous solutions. SF-I was further tested in triple negative breast (MDA MB-231) and colon (HCT-116) cancer cell lines, which are known to have limited chemotherapy options as well as very poor prognosis. SF-I induced efficient singlet oxygen generation and consequent photocytotoxicity in both cell lines upon light irradiation with a negligible dark toxicity while allowing cell imaging at the same time. SF-I marks the first ever example of a silicon xanthene-based photosensitizer and holds a lot of promise as a small-molecule-based theranostic scaffold.