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Öztosun, Çınar

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Undergraduate Student

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Çınar

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Öztosun

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Öztosun, Çınar

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2019 - 201912020 - 20222

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Researcher Of Publications: search.filters.isAuthorOfPublication.9a92b9c8-fd79-46b1-94d7-ef311ea0a04c

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    The role of uric acid in mineral bone disorders in chronic kidney disease
    (Springer, 2019) Afsar, Baris; Sag, Alan A.; Kuwabara, Masanari; Cozzolino, Mario; Covic, Adrian; N/A; Öztosun, Çınar; Kanbay, Mehmet; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; N/A; 110580
    Increasing survival in the chronic kidney disease (CKD) population exposes the bone to the cumulative detrimental sequelae of CKD, now defined physiologically and histopathologically as chronic kidney disease mineral bone disorder (CKD-BMD). This disorder is increasingly recognized as a "nontraditional" driver of morbidity and mortality and presents an opportunity to improve CKD outcomes via research. However, recent advances in the literature on this topic have not yet been collected into a single review. Therefore, this report aims to discuss the disordered renal-bone axis in CKD-BMD, molecular and hormonal drivers, novel treatment strategies, and forthcoming research in a clinician-directed format. A key novel topic will be the unique impact of uric acid on CKD-BMD, which is poised to apply extensive existing research in the uric acid domain to benefit the CKD-BMD population.
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    FKBP5 methylation, psychiatric disorders and stress: a systematic review and synthesis
    (Elsevier Science Inc, 2022) Çiçek, Yusuf; N/A; İzgi, Büşra; Kuvvet, Yasemin; Musaoğlu, Miraç Nur; Öztosun, Çınar; Eser, Hale Yapıcı; PhD Student; Master Student; PhD Student; Undergraduate Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; 134359
    Background FKBP5 methylation levels are among the most studied epigenetic modifications related to psychiatric disorder vulnerability, however there are contradictory findings. We aimed to investigate the role of FKBP5 methylation in psychiatric disorders, in addition to its association with stress exposure (either life adversities, traumatic events or acute stress). Methods In accordance with PRISMA guidelines, ‘FKBP5’ and ‘methylation’ were searched in PubMed and Web of Science in March 2021. 330 studies were identified. Studies on non-psychiatric disorders, animal or cell lines were excluded. Type of study, sample size, sociodemographic properties of the participants, type of stress exposure, type of psychiatric disorder, CPG loci at FKBP5, and other related methods and covariates were extracted from 53 studies found to be eligible based on the inclusion criteria. Results Preliminary analysis showed that 19 studies investigated FKBP5 methylation in psychiatric disorders, 32 studies investigated the effects of stress types on FKBP5 methylation. Among the 197 CpG sites investigated, CpG at chr6:35,590,711 (intron 7), chr6:35,689,425 (promoter region), and chr6:35,590,736 (intron 7/GRE) sites were investigated by 26, 24, and 22 studies, respectively. CpG sites at chr6:35,590,736 and chr6:35,590,711 were reported to be linked to psychiatric disorder; CpG site at chr6:35,590,711, were reported to be linked to types of stress by more than half of the studies that investigated this region. Conclusions The studies on FKBP5 methylation and psychiatric disorder vulnerability are highly heterogeneous and most significant associations are found in intron 7. However, a great percentage of literature report insignificant associations of FKBP5 methylation sites with psychiatric disorder vulnerability.
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    Pharmacologic and interventional paradigms of diuretic resistance in congestive heart failure: a narrative review
    (Springer, 2021) Afsar, Baris; Sag, Alan A.; Kuwabara, Masanari; Covic, Adrian; Ortiz, Alberto; N/A; Acar, Simge; Şanlı, Şüeda; Öztosun, Çınar; Kanbay, Mehmet; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; 110580
    Diuretic volume reduction continues to be the mainstay of congestive heart failure (CHF) management globally. However, diuretic resistance is a critical topic that lacks standardized evidence-based management guidelines accounting for mechanisms of diuretic resistance, renal function, and co-morbidities. Major healthcare utilization consequences result from this. The authors herein reconcile the definition of renal functional decline with emphasis on biomarker-driven assessment. Novel goal-directed treatment approaches are reviewed including hypertonic saline, acetazolamide, sodium-glucose transporter inhibition, sequential nephron blockade and Elabela-APJ axis targeting are reviewed, as well as percutaneous visceral splanchnic sympathectomy (converting a volume-focused to a distribution-focused paradigm).