Researcher:
Şengün, Berke

Profile Picture
ORCID

Job Title

Undergraduate Student

First Name

Berke

Last Name

Şengün

Name

Name Variants

Şengün, Berke

Email Address

Birth Date

Filters

2016 - 201972020 - 20212

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.a02eefa1-0b48-47f3-b619-a0cc6863987f

Search Results

Now showing 1 - 9 of 9
  • Placeholder
    PublicationMetadata only
    Should we perform routine prophylactic central neck dissection in patients with thyroid papillary microcarcinoma?
    (Edizioni Luigi Pozzi, 2018) Bilgiç, Cağrı; Karabay, Önder; Ağcaoğlu, Orhan; Şengün, Berke; Özoran, Emre; Taşkın, Orhun Çığ; Dereli, Dilek Yazıcı; Tezelman, Tevfik Serdar; Faculty Member; Undergraduate Student; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 175476; N/A; N/A; 166686; 179659; 114860
    PURPOSE: Cervical lymph node (LN) metastases in papillary thyroid cancer (PTC) are common in tumors especially that are larger than 1cm. Ipsilateral central neck dissection (CND) is usually preferred even in the absence of a palpable LN. This study aims to clarify the incidence and predictive factors for occult ipsilateral central LN metastasis in these patients, and the management of patients without clinical evidence of metastasis. METHODS: 204 PTC patients were studied. The patients were divided into two according to the tumor size of <= 5mm or larger. Patient demographics, tumor properties, LN metastasis, preoperative neck ultrasonography findings and surgical outcomes were analyzed. RESULTS: There were 152 patients in study group-1 (nodule > 5 mm) and 52 patients in group-2 (nodule 5 mm). The mean tumor size was 11.9 mm. Overall, preoperative neck ultrasonography showed central neck LN in 25 (12.3%) patients, however, final pathology revealed metastatic LN at central compartment in 59 (28.9%) patients. There were 56 (27.5%) patients with metastasis in group-1 compared to 3 (1.4%) patients in group-2. CONCLUSIONS: Prophylactic CND is advised in PTC for the reduction of recurrence in central compartment. According to our results, in patients with tumors smaller than 5 mm and without evidence of nodal metastasis in preoperative neck ultrasonography, we do not recommend prophylactic CND.
  • Placeholder
    PublicationMetadata only
    Robotic complete mesocolic excision for transverse colon cancer can be performed with a morbidity profile similar to that of conventional laparoscopic colectomy
    (Springer, 2020) Özben, Volkan; De Muijnck, Cansu; Zenger, Serkan; Aytac, Erman; Bilgin, İsmail Ahmet; Baca, Bilgi; Hamzaoğlu, İsmail; Karahasanoğlu, Tayfun; N/A; N/A; N/A; N/A; Şengün, Berke; Ağcaoğlu, Orhan; Balık, Emre; Buğra, Dursun; Undergraduate Student; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 309087; 175476; 18758; 1758
    Background: In minimally invasive surgery, complete mesocolic excision (CME) for transverse colon cancer is challenging; thus, non-CME resections are commonly preferred when laparoscopy is used. Robotic technology has been developed to reduce the limitations of laparoscopy. The aim of our study was to evaluate whether robotic CME for transverse colon cancer can be performed with short-term outcomes similar to those of laparoscopic conventional colectomy (CC). Methods: A retrospective review of 118 consecutive patients having robotic CME or laparoscopic CC for transverse colon cancer in two specialized centers between May 2011 and September 2018 was performed. Perioperative 30-day outcomes of the two procedures were compared. Results: There were 38 and 80 patients in the robotic CME group and laparoscopic CC group, respectively. The groups were comparable regarding preoperative characteristics. Intraoperative results were similar, including blood loss (median 50 vs 25 ml), complications (5.3% vs 3.8%), and conversions (none vs 7.5%). The rate of intracorporeal anastomosis was significantly higher (86.8% vs 20.0%), mean operative time was longer (325.0 +/- 123.2 vs 159.3 +/- 56.1 min (p < 0.001), and the mean number of harvested lymph nodes was higher in the robotic CME group (46.1 +/- 22.2 vs 39.1 +/- 17.8, p = 0.047). There were only minor differences in length of hospital stay (7.2 +/- 3.1 vs 7.9 +/- 4.0 days), anastomotic leak (none vs 2.6%), bleeding (none vs 1.3%), surgical site infections (10.5% vs 12.5%), and reoperations (2.6% vs 6.3%). Conclusions: Robotic CME can be performed with a similar morbidity profile as laparoscopic CC for transverse colon cancer along with a higher rate of intracorporeal anastomosis, and higher number of lymph nodes retrieved, but longer operative times.
  • Placeholder
    PublicationMetadata only
    In-vitro modelling of urea cycle liver disorder by using human induced pluripotent stem cells
    (Mary Ann Liebert, Inc, 2016) Akbari, S.; Arslan, N.; Erdal, E.; N/A; N/A; N/A; Sevinç, Gülben Gürhan; Şengün, Berke; Önder, Tamer Tevfik; Phd Student; Undergraduate Student; Faculty Member; Graduate School of Health Sciences; School of Medicine; School of Medicine; N/A; 309087; 42946
    N/A
  • Placeholder
    PublicationMetadata only
    Comparison of technical details and short-term outcomes of single-incision versus multiport laparoscopic adrenalectomy
    (Lippincott Williams and Wilkins (LWW), 2019) Gurbuz, Bulent; Carilli, Senol; N/A; N/A; N/A; N/A; N/A; Ağcaoğlu, Orhan; Şengün, Berke; Şenol, Kazım; Özoran, Emre; Tezelman, Tevfik Serdar; Faculty Member; Undergraduate Student; Doctor; Teaching Faculty; Faculty Member; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; N/A; N/A; Koç University Hospital; N/A; N/A; 175476; 309087; N/A; 307296; 114860
    To date, the single-incision laparoscopic surgery (SILS) technique has been applied to a wide range of general surgical procedures; however, there are still scant data and debates on adrenal procedures. The aim of this study was to compare surgical outcomes of single-incision versus laparoscopic multiport adrenalectomy. The patients were divided into 2 study groups on the basis of the surgical approach: SILS (group 1) and multiport laparoscopic surgery (group 2). Patient demographics and their perioperative and postoperative results were evaluated retrospectively from the medical records. A total of 80 patients were included in the study. There were 44 patients in group 1 and 36 patients in group 2. The average operative time, estimated blood loss, and tumor size were similar between the study groups. There were no mortalities in both groups and the mean duration of hospital stay was 3 days for both groups. Without using any single-incision access trocars and articulated instrumentation, we achieved the same surgical outcomes in our SILS adrenalectomy series compared with conventional multiport laparoscopy series in terms of postoperative short-term outcomes and cost-effectivity.
  • Placeholder
    PublicationMetadata only
    A new technique in treatment of Zenker diverticulum: submucosal tunneling endoscopic septum division (Z-POEM) versus classic endoscopic septomyotomy techniques
    (Mosby-Elsevier, 2019) N/A; Aslan, Fatih; Yılmaz, Onur; Şengün, Berke; Ünlükaplan, Aytekin; Karahan, Salih Nafiz; Koçak, Elif; Faculty Member; Undergraduate Student; Undergraduate Student; Doctor; Researcher; Undergraduate Student; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; Koç University Hospital; 219202; N/A; 309087; N/A; 337050; N/A
    N/A
  • Placeholder
    PublicationMetadata only
    Per-oral endoscopic myotomy (poem) in the treatment of achalasia; clinical outcomes of 430 patients, single center study
    (Mosby-Elsevier, 2019) N/A; Aslan, Fatih; Karahan, Salih Nafiz; Yılmaz, Onur; Şengün, Berke; Koçak, Elif; Darçın, Kamil; Faculty Member; Researcher; Undergraduate Student; Undergraduate Student; Undergraduate Student; Teaching Faculty; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 219202; 337050; N/A; 309087; N/A; 203217
    N/A
  • Thumbnail Image
    PublicationOpen Access
    Robust, long-term culture of endoderm-derived hepatic organoids for disease modeling
    (Cell Press, 2019) Akbari, Soheil; Ersoy, Nevin; Başak, Onur; Kaplan, Kübra; Bağrıyanık, Alper; Arslan, Nur; Erdal, Esra; Department of Molecular Biology and Genetics; Önder, Tamer Tevfik; Sevinç, Gülben Gürhan; Özçimen, Burcu; Enüstün, Eray; Şengün, Berke; Özel, Erkin; Sevinç, Kenan; Faculty Member; PhD Student; Undergraduate Student; Department of Molecular Biology and Genetics; School of Medicine; Graduate School of Health Sciences; 42946; N/A; N/A; N/A; N/A; N/A; N/A
    Organoid technologies have become a powerful emerging tool to model liver diseases, for drug screening, and for personalized treatments. These applications are, however, limited in their capacity to generate functional hepatocytes in a reproducible and efficient manner. Here, we generated and characterized the hepatic organoid (eHEPO) culture system using human induced pluripotent stem cell (iPSC)-derived EpCAM-positive endodermal cells as an intermediate. eHEPOs can be produced within 2 weeks and expanded long term (>16 months) without any loss of differentiation capacity to mature hepatocytes. Starting from patient-specific iPSCs, we modeled citrullinemia type 1, a urea cycle disorder caused by mutations in the argininosuccinate synthetase (ASST) enzyme. The disease-related ammonia accumulation phenotype in eHEPOs could be reversed by the overexpression of the wild-type ASS1 gene, which also indicated that this model is amenable to genetic manipulation. Thus, eHEPOs are excellent unlimited cell sources to generate functional hepatic organoids in a fast and efficient manner.
  • Thumbnail Image
    PublicationOpen Access
    Retrograde transcatheter closure of anterior mitral valve leaflet perforation
    (Medknow Publications, 2019) N/A; N/A; Şengün, Berke; Yıldırım, Işıl Şafak; Yıldız, Ömer; Çeliker, Alpay; Undergraduate Student; Other; School of Medicine
    Transcatheter closure of mitral valve leaflet perforation is a very rarely performed and a difficult procedure for repairing the defect. Herein, we are the first to report on both the safety and feasibility of percutaneous retrograde transcatheter closure of anterior mitral valve leaflet perforation with an AMPLATZER (TM) Duct Occluder II (6 mm x 6 mm; ADO II; Abbott Vascular, IL, USA) device in a 19-year-old patient with a severe mitral valve regurgitation following cardiac surgery.
  • Thumbnail Image
    PublicationOpen Access
    Minimally invasive versus open surgery for gastric cancer in Turkish population original article
    (Bilimsel Tıp Yayınevi, 2021) Tarcan, Serim; Aytaç, Erman; Zenger, Serkan; Benlice, Çiğdem; Özben, Volkan; Baca, Bilgi; Hamzaoğlu, İsmail; Karahasanoglu, Tayfun; Ağcaoğlu, Orhan; Şengün, Berke; Bayram, Onur; Balık, Emre; Buğra, Dursun; Faculty Member; Undergraduate Student; Faculty Member; Faculty Member; School of Medicine; Koç University Hospital; 175476; N/A; N/A; 18758; 1758
    Objective: in this study, it was aimed to compare short-term outcomes of minimally invasive and open surgery for gastric cancer in the Turkish population carrying both European and Asian characteristics. Material and Methods: short-term (30-day) outcomes of the patients undergoing minimally invasive and open gastrectomy with D2 lymphadenectomy for gastric adenocarcinoma between January 2013 and December 2017 were compared. Patient demographics, history of previous abdominal surgery, comorbidities, short-term perioperative outcomes and histopathological results were evaluated between the study groups. Results: there were a total of 179 patients. Fifty (28%) patients underwent minimally invasive [laparoscopic (n= 19) and robotic (n= 31)] and 129 (72%) patients underwent open surgery. There were no differences between the two groups in terms of age, sex, body mass index and ASA scores. While operative time was significantly longer in the minimally invasive surgery group (p< 0.0001), length of hospital stay and operative morbidity were comparable between the groups. Conclusion: while both laparoscopic and robotic surgery is safe and feasible in terms of short-term outcomes in selected patients, long operating time and increased cost are the major drawbacks of the robotic technique preventing its widespread use.