Researcher:
Celayir, Özde Melisa

Profile Picture
ORCID

Job Title

Doctor

First Name

Özde Melisa

Last Name

Celayir

Name

Name Variants

Celayir, Özde Melisa

Email Address

Birth Date

Filters

20212

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.a0aba954-3aa7-47fb-84b4-11f6117f9c62

Search Results

Now showing 1 - 3 of 3
  • Placeholder
    PublicationMetadata only
    Immune checkpoints inhibitors and its link to acute kidney injury and renal prognosis
    (Springer) Siriopol, Dimitrie; Covic, Adrian; Perazella, Mark A.; N/A; Kanbay, Mehmet; Yıldız, Abdullah Burak; Vehbi, Sezan; Hasbal, Nuri Barış; Kesgin, Yavuz Erkam; Celayir, Özde Melisa; Selçukbiricik, Fatih; Faculty Member; Undergraduate Student; Undergraduate Student; Faculty Member; Researcher; Other; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; Koç University Hospital; 110580; N/A; N/A; 143778; 327622; N/A; 202015
    Background Immunotherapy with immune checkpoint inhibitors (ICPi) may cause acute kidney injury (AKI) and their use is increasing. Materials and methods This is a single-center retrospective cohort study of patients receiving ICPi drugs for solid organ malignancies. ICPi-related AKI, the need for renal replacement therapy during or following ICPi treatment, and the associated mortality was studied. Results Two hundred thirty five patients were included in the final analysis. Patients with (N = 40) and without (n = 195) AKI had similar age, sex, type of ICPi, baseline serum creatinine levels, comorbidities and mortality; while patients with AKI were more likely to be receiving a nephrotoxic agent or be treated for genitourinary malignancy. 18 patients had ICPi-related AKI; 7 of these patients underwent kidney biopsy, which showed acute interstitial nephritis while the remaining 11 were diagnosed on clinical parameters. 18 (45%) patients recovered kidney function after AKI. No differences were observed between patients with and without kidney function recovery, although patients without recovery had a numerical, but not statistically significant, higher mortality. Patients with biopsy-confirmed ICPi-induced AKI had an increased risk of mortality, as compared with the rest of the population-HR 1.83, 95% CI 1.22-2.74, p = 0.003. Conclusion Use of nephrotoxic drugs and the location of malignancy appear to be common drivers of AKI in patients receiving ICPis for solid organ malignancy. Whether nephrotoxic agents or urinary tract obstruction may favor ICPi-related autoimmunity should be further studied.
  • Placeholder
    PublicationMetadata only
    Association between high initial CEA, CA 19-9 levels and HER-2 status and their prognostic values on overall survival in metastatic gastric cancer
    (Zerbinis Publications, 2021) Tural, Deniz; Selçukbiricik, Fatih; Ertürk, Kayhan; Balık, Emre; Kuvvet, Fadime Buket Bayram; Celayir, Özde Melisa; Babashov, Farid; Şentürk, Begüm Güler; Mandel, Nil Molinas; Faculty Member; Faculty Member; Faculty Member; Doctor; Doctor; Doctor; Researcher; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 202015; N/A; 18758; 176242; 329382; N/A; 327593; 194197
    Purpose: This study aimed to investigate the correlations between baseline levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) and immunohistochemical (IHC), Human epidermal growth factor receptor (HER-2) expressions; and question their prognostic values in patients with metastatic gastric cancer. Methods: Gastric cancer patients were retrospectively analyzed. Demographic information, clinical stages, immunohistochemical HER-2 expressions and serum CEA, serum CA 19-9 levels were evaluated at the time of diagnosis. The correlations between HER-2 IHC expressions and the initial marker levels were assessed, and survival analyses were performed. Results: A total of 411 patients were included in the study. Median age of patients was 58 years (range: 22-90); males: 297 (72.3%); females: 114 (27.7%). Median overall survival (OS) was 24 months (range: 19-29). Patient HER-2 IHC expression 0, 1, 2, 3 ratios were 43, 22, 16, and 19%, respectively. At the time of diagnosis, the median value of CEA was 4 (range: 3-5), and the median value of CA 19-9 was 18 (range: 14-22). The increase in CEA and CA 19-9 levels were correlated with the increase of IHC levels (p=0.0001). OS of patients with high initial CEA levels (>5 ng/mL) were significantly shorter than those with low initial CEA levels (<5 ng/mL). Conclusion: Significant positive correlations were shown between HER-2 IHC expressions and CEA, CA 19-9 levels. Baseline CEA, CA 19-9 levels predicted HER-2 positivity and this directly affected treatment and OS.
  • Thumbnail Image
    PublicationOpen Access
    Evaluation of human epidermal growth factor receptor 2 overexpression, clinicopathological characteristics, and factors affecting survival in gastric cancer
    (Kare Yayıncılık, 2021) Tanık, Canan; Altuntaş, Yüksel; Celayir, Özde Melisa; Selçukbiricik, Fatih; Faculty Member; School of Medicine; Koç University Hospital; N/A; 202015
    Objectives: the objective of the study was to evaluate the human epidermal growth factor receptor 2 (HER2) overexpression, clinicopathological features, and factors affecting survival in patients with gastric cancer. Methods: the study is a retrospective study conducted with 128 cases of gastric cancer who were admitted to Sisli Hamidiye Etfal Training and Research Hospital between 2005 and 2012. Patients' demographic characteristics, performance score, tumor localization, information about surgery, HER2 measurements, histopathological characteristics, stage, treatment features, metastasis sites, and overall survival time were obtained from medical records. Immunohistochemical analysis was performed for HER2 scoring. Results: there were 89 (69.5%) men and 39 (30.5%) women in the study group, and the median age of the patients was 64 years. The median survival time of the patients was 24.43 months. The survival rate of the patients was calculated as 35.4 +/- 5.9%. Overall survival time was found to be shorter in the group with higher HER2 levels and also those with advanced-stage cancer. The survival rate was found to be significantly lower in patients with perineural invasion and advanced stage. However, the survival rate was not associated with lymphovascular invasion, surgical margin involvement, and HER2 levels. In the multivariate Cox Regression analysis performed to assess the effects of gender, histological subtype, stage, and surgical margin on overall survival, disease stage was found to be the only factor effective on survival. Gender, histological subtype, and the surgical margin did not affect prognosis. Conclusion: the survival rate in gastric cancers was found to be lower in those with advanced-stage disease. Higher HER2 level and the disease stage were associated with shorter overall survival time. Amaç: Mide kanserli hastalarda aşırı HER2 ekspresyonunun, klinikopatolojik özellikleri ve sağkalımı etkileyen faktörleri değerlendirmek. Yöntemler: çalışma, 2005-2012 yılları arasında hastanemize başvuran 128 mide kanseri (non-lenfoma histolojik tip) olgusu ile yapılan retrospektif bir çalışmadır. Hastaların demografik özellikleri, performans skoru, tümör lokalizasyonu, ameliyat hakkında bilgiler, HER2 ölçümleri, histopatolojik özellikleri, evreleri, tedavi özellikleri, metastaz bölgeleri ve genel sağkalım süresi tıbbi kayıt sisteminden elde edildi. HER2 skorlaması için immüno-histokimyasal analiz yapıldı. Bulgular: çalışma grubunda 89 (% 69,5) erkek ve 39 (% 30,5) kadın vardı ve hastaların ortanca yaşı 64 idi. Medyan sağkalım süresi 24,43 aydı. Hastaların 5 yıllık sağkalım oranı % 35.4 ± 5.9 olarak hesaplandı. Genel sağkalım süresinin daha yüksek HER2 seviyeleri olan grupta ve ayrıca ileri evre kanseri olanlarda daha kısa olduğu bulunmuştur. Perinöral invazyonlu ve ileri evre hastalarda 5 yıllık sağkalım oranı anlamlı olarak daha düşük bulundu. Bununla birlikte, 5 yıllık sağkalım oranı, lenfovasküler invazyon, cerrahi sınır tutulumu ve HER2 seviyeleri ile ilişkili değildi. Cinsiyet, histolojik alt tip, evre ve cerrahi sınırın genel sağkalım üzerindeki etkilerini değerlendirmek için yapılan çok değişkenli Cox Regresyon analizinde hastalık evresinin sağkalım üzerinde etkili tek faktör olduğu bulundu. Cinsiyet, histolojik alt tip ve cerrahi sınırın prognoz üzerine etkisi yoktu. Sonuç: mide kanserlerinde 5 yıllık sağkalım oranı ileri evre hastalığı olanlarda daha düşük bulundu. Daha yüksek HER2 seviyesi ve hastalık evresi, daha kısa genel hayatta kalma süresi ile ilişkilendirildi. (SETB-2020-11-241)