Researcher: Nargül, Sezin
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Nargül, Sezin
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Publication Metadata only Magnetic actuated moems resonant biosensor array(IEEE, 2010) Department of Electrical and Electronics Engineering; N/A; Department of Chemical and Biological Engineering; N/A; Ürey, Hakan; Timurdoğan, Erman; Kavaklı, İbrahim Halil; Alaca, Burhanettin Erdem; Nargül, Sezin; Faculty Member; Undergraduate Student; Faculty Member; Faculty Member; PhD Student; Department of Electrical and Electronics Engineering; Department of Chemical and Biological Engineering; College of Engineering; College of Engineering; College of Engineering; College of Engineering; Graduate School of Sciences and Engineering; 8579; N/A; 40319; 115108; N/AA biosensor platform is utilized in liquid for detection of His protein. T-shaped thin film nickel cantilevers are actuated magnetically using self-oscillation principle and the sensing is based on embedded diffraction gratings on the cantilevers with interferometric sensitivity. Experiments are performed in a custom 1ml liquid chamber and 5.7ng/ml detection sensitivity is demonstrated. Method is label-free, robust and allows mu ltip lexing. It also doesn't require any electrical connections to the MEMS sensor chip. Therefore, it is suitable for real-time multi analyte screening using a disposable chip in a portable device.Publication Metadata only Detection of human kappa-opioid antibody using microresonators with integrated optical readout(Elsevier advanced Technology, 2010) N/A; N/A; N/A; N/A; Department of Mechanical Engineering; Department of Chemical and Biological Engineering; Department of Electrical and Electronics Engineering; Department of Mechanical Engineering; Timurdoğan, Erman; Özber, Natali; Nargül, Sezin; Yavuz, Serhat; Kılıç, M. Salih; Kavaklı, İbrahim Halil; Ürey, Hakan; Alaca, Burhanettin Erdem; PhD Student; Master Student; PhD Student; Master Student; Resercher; Faculty Member; Faculty Member; Faculty Member; Department of Chemical and Biological Engineering; Department of Electrical and Electronics Engineering; Department of Mechanical Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; College of Engineering; College of Engineering; College of Engineering; N/A; N/A; N/A; N/A; N/A; 40319; 8579; 115108Label-free detection of the interaction between hexahistidine-tagged human kappa-opioid receptor membrane protein and anti-His antibody is demonstrated in liquid by an optical microelectromechanical system utilizing electromagnetically actuated microresonators Shift in resonance frequency due to accretion of mass on the sensitive surface of microresonators is monitored via an integrated optical readout a frequency resolution of 2 Hz is obtained Together with a sensitivity of 7 ppm/(ng/ml)) this leads to a minimum detectable antibody concentration of 57 ng/ml for a 50-kHz device the measurement principle is shown to impart immunity to environmental noise, facilitate operation in liquid media and bring about the prospect for further miniaturization of actuator and readout leading to a portable biochemical sensor.