Researcher:
Deveci, Mehmet Ali

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Mehmet Ali

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Deveci

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Deveci, Mehmet Ali

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2020 - 202211

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    Recurrent cervical cancer case with sacral metastasis
    (BMJ Publishing Group, 2022) N/A; Taşkıran, Çağatay; Vatansever, Doğan; Giray, Burak; Dönmez, Emin Erhan; Deveci, Mehmet Ali; Oktar, Tayfun; Arvas, Macit; Faculty Member; Faculty Member; Faculty Member; Researcher; Faculty Member; Doctor; Doctor; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Koç University Hospital; Koç University Hospital; 134190; 193687; 316087; 334646; 206311; N/A; N/A
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    Reconstruction of critical size segmental femoral diaphyseal defects of new zealand rabbits by using combined titanium mesh cage and induced membrane technique
    (Springernature) Kaya, Onur; Mirioglu, Akif; Ozkan, Cenk; Bicer, Omer Sunkar; Tekin, Mustafa; Ates, Kivilcim Eren; Deveci, Mehmet Ali; Faculty Member; School of Medicine; 206311
    Purpose Long bone defects due to fractures resulting from high-energy trauma, infections and tumor resections are problems that orthopedic surgeons commonly face. We investigated the effects of a titanium mesh cage on bone healing with an induced membrane technique. Methods Three groups, each composed of eight rabbits, were formed. Extraarticular diaphyseal bone defects were created. Femora of the first group were fixed with an empty titanium mesh cage and two K-wires. After formation of the defect, polymethylmethacrylate was inserted and fixed with a K-wire in the second group. At the third week, the cement was removed, a sterilized cancellous graft-filled titanium mesh cage was placed into the defect, and the membrane that was previously formed over the cement was placed on the cage and repaired. In the third group, sterilized cancellous grafts were filled into the titanium mesh cage, and the titanium mesh cage was fitted into the bone defect area. Results At the end of the third month, all subjects were killed. Radiological data revealed that the healing of the bone in the second and third groups was significantly better than that in the first group. There was no difference between the second and third groups. A histological evaluation of the healing status, such as fibrous tissue, cartilage tissue and mature or immature bone formation, was performed. Histological healing in the second and third groups was also significantly better than that in the first group. Conclusion We concluded that the combination of membrane-induced bone healing and graft-filled titanium mesh cages expedites osteogenesis in extraarticular bone defects.
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    PublicationOpen Access
    Clinicalopathological evaluation of soft tissue myxofibrosarcoma
    (Çukurova Üniversitesi, 2021) Erdoğan, Kıvılcım; Karabağ, Sevil; Gamlı, Alper; Gönlüşen, Gülfiliz; Özbarlas, Hilmi Serdar; Deveci, Mehmet Ali; Faculty Member; School of Medicine; 206311
    Purpose: the aim of this study is to evaluate the relationship between the clinical course of these tumors by emphasizing the epidemiological data as well as the pathological features of different myxofibrosarcoma cases. Materials and methods: 22 cases of myxofibrosarcoma were included in the single center study. Age, gender, tumor location, size, histopathological features as well as treatment modalities and clinical follow-up of the cases were also evaluated. Additional immunohistochemical studies were applied for the differential diagnosis in pathological evaluation. Results: the mean age of the patients was 54 years old and there is no sex predilection. The extremities are the most common location. Deep located myxofibrosarcoma were highly aggressive unlike superficial counterparts. The grade given as a result of pathological examination is closely related to the clinical course. Since the mean recurrence period is 16 months, long term follow up is required. Recurrence is present in all metastatic cases. Death from the disease occurred only in those with a higher grade. Conclusion: myxofibrosarcomas are rarely seen but diagnostically challenging. Accurate diagnosis is essential to differentiate myxofibrosarcoma from other pleomorphic sarcomas, and to manage the treatment of patients since it may mimic even reactive lesions by histop athologic ally. Superficial and low grade myxofibrosarcoma of present study showed excellent prognosis and it has been presented as a contribution to the literature that these patients may have a good prognosis with correct diagnosis and treatment. / Amaç: bu çalışmada amaç, farklı mikzofibrosarkom vakalarının epidemiyolojik verileri yanı sıra patolojik özelliklerini vurgulayarak bu tümörlerin klinik gidişi ile ilişkisini değerlendirmektir. Gereç ve Yöntem: tek merkezli çalışmaya 22 mikzofibrosarkom olgusu dahil edilmiştir. Olguların yaş, cinsiyet, tümör yerleşimi, çapı, histopatolojik özellikleri yanı sıra tedavi yöntemleri, klinik takibi de araştırılmıştır. Patoloji değerlendirmesinde ayırıcı tanıya yönelik ek immünohistokimyasal çalışmalar yapılmıştır. Bulgular: bu seride ortalama yaş 54 olup kadın-erkek oranı eşittir. Ekstremiteler en sık yerleşim yeridir. Yüzeyel yerleşmiş tümörler, derin yerleşim gösterenlere kıyasla belirgin olarak iyi seyretmektedir. Patolojik değerlendirme sonucu verilen grade ile klinik gidiş yakın ilişkilidir. Ortalama rekürrens süresi 16 ay olduğu için olguların uzun dönem takibi gereklidir. Metastaz görülen tüm olgularda öncesinde rekürrens mevcuttur. Hastalıktan ölüm sadece yüksek dereceli olanlarda gerçekleşmiştir. Sonuç: sonuçta bu tümörler çok nadir görülmekle birlikte tanıda zorluk yaratması bakımından önem teşkil etmektedir. Histopatolojik olarak reaktif lezyonlarla bile karışabilmesi nedeniyle doğru tanı koymak hasta yönetiminde şarttır. Bu tümör grubunda bizim serimizde yüzeyel olanlar ve derecesi düşük olanlar çok iyi seyirli olup, doğru tanı ve tedavi ile bu hastaların iyi prognozlu da olabileceği literatüre katkı olarak sunulmuştur.
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    PublicationOpen Access
    Cross-cultural adaptation and validation of the Turkish version of the Musculoskeletal Tumor Society scoring system in patients with musculoskeletal tumors
    (Aves, 2021) Ocaktan, Bahadır; Tokgöz, Mehmet Ali; Yapar, Aliekber; Deveci, Mehmet Ali; Şimşek, Sezai Aykın; Faculty Member; Faculty Member; School of Medicine; Koç University Hospital; 206311; 133305
    Objective: this study aimed to translate and cross-culturally adapt the musculoskeletal tumor society (MSTS) scoring system into Turkish and to determine the reliability and validity of the translated version for the functional evaluation of patients with musculoskeletal tumors. Methods: a total of 36 patients (16 women, 20 men; mean age=36.6; age range=13-75 years) who underwent limb-salvage surgery owing to benign aggressive or malignant musculoskeletal tumors were included in the study. Translation and back translations of the MSTS were performed according to the published guidelines. Short form (SF) 36 physical component, Western Ontario and McMaster Universities Arthritis Index (WOMAC), disabilities of the arm, shoulder, and hand (DASH), and range of motion scale (ROMS) that were previously analyzed for Turkish validation were used for validity. Reliability of MSTS Turkish version was evaluated by calculating test-retest reliability and internal consistency. Intraclass correlation coefficient (ICC) was used to evaluate the inter-observer consistency and test-retest reliability. Alpha coefficient (Cronbach's alpha) was used to evaluate the internal consistency. Results: it was observed that total MSTS score has a strong negative correlation with DASH (r=-0.689; p<0.001) and WOMAC scores (r=-0.634; p<0.001) and moderate correlation with the ROMS score (r=0.521; p<0.001). Total MSTS score also had a statistically significant strong correlation with SF-36 scores (r values ranging from 0.425 to 0.609, p<0.001). Inter and intra-observer reliability of the MSTS scale was found to be excellent (Cronbach's alpha=0.97 p<0.001; ICC: 0.97 (0.96-0.99; p<0.001). Unlike other subscales, statistical correlation between dexterity and hand-positioning subscales of MSTS with DASH scores was found to be insignificant (r=-0.533, p =0.061 and r=-0.336, p=0.261, respectively). Conclusion: the Turkish version of the MSTS scoring system seems to be a valid and reliable scale that measures the correct and desired values in the evaluation of health-related quality of life in orthopedic oncology. Reliability coefficients of the Turkish version of MSTS were determined to be strong.
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    PublicationOpen Access
    Detection of ibuprofen levels by high performance liquid chromatography after phonophoresis in the tissues of patients with knee osteoarthritis: a controlled preliminary study
    (Türkiye Klinikleri, 2021) Kelle, Bayram; Türk, Murat; Tekin, Mustafa; Giray, Sultan; Kozanoğlu, Erkan; Deveci, Mehmet Ali; Faculty Member; School of Medicine; 206311
    Objective: this study is aimed to detect the drug concentration in articular tissues after phonophoresis application in patients with knee osteoarthritis who were planned to undergo total knee arthroplasty. Material and methods: seventeen patients with grade 4 knee OA were allocated to 6 groups according to ultrasound parameters and three sessions of ibuprofen phonophoresis were applied before surgery. Six groups were divided into as follows: Group 1; 5 minutes, frequency 0 MHz, power 0 W/cm2 , continuous mode; Group 2; 5 minutes, frequency 1 MHz, power 1 W/cm2 , continuous mode; Group 3; 5 minutes, frequency 1 MHz, power 1.5 W/cm2 , continuous mode; Group 4; 5 minutes, frequency 1 MHz, power 1.5 W/cm2 , pulse mode; Group 5; 8 minutes, frequency 1 MHz, power 1.5 W/cm2 , continuous mode; Group 6; 5 minutes, frequency 1 MHz, power 2 W/cm2 , continuous mode. Bone, synovial fluid and synovial tissue samples were obtained from patients during the surgery. A high-performance liquid chromatographic method was used for the determination of ibuprofen levels from isolated human synovial fluid, synovial tissue and bone. Results: ibuprofen was detected to the articular tissues of patients. The highest concentrations of ibuprofen in synovial fluid were detected in Group 3 and 5. The highest concentrations in bone were obtained in Group 2 and in synovial tissue were obtained in Group 2 and Group 3. Conclusion: optimal penetration of ibuprofen to articular tissues was obtained with 1 MHz and 1-1.5 W/cm2 , and continuous ultrasound mode. Phonophoresis is seemed as an effective treatment modality in patients with OA. / Amaç: bu çalışmada total diz artroplastisi planlanan diz osteoartritli hastalarda fonoforez uygulaması sonrası eklem dokularındaki ilaç konsantrasyonunun saptanması amaçlanmıştır. Gereç ve yöntemler: Evre 4 diz osteoartritli (OA) 17 hasta, ultrason parametrelerine göre 6 gruba ayrıldı ve ameliyat öncesi 3 seans ibuprofen fonoforezi uygulandı. Altı grup aşağıdaki gibi ayrılmıştır: Grup 1; 5 dakika, frekans 0 MHz, güç 0 W/cm2 , sürekli mod; Grup 2; 5 dakika, frekans 1 MHz, güç 1 W/cm2 , sürekli mod; Grup 3; 5 dakika, frekans 1 MHz, güç 1,5 W/cm2, sürekli mod; Grup 4; 5 dakika, frekans 1 MHz, güç 1,5 W/cm2 , darbe modu; Grup 5; 8 dakika, frekans 1 MHz, güç 1,5 W/cm2 , sürekli mod; Grup 6; 5 dakika, frekans 1 MHz, güç 2 W/cm2 , sürekli mod. Ameliyat sırasında hastalardan kemik, eklem sıvısı ve eklem dokusu örnekleri alındı. Yüksek performanslı sıvı kromatografik yöntemi, izole edilmiş insan eklem sıvısı, eklem dokusu ve kemikten ibuprofen seviyelerinin belirlenmesi için kullanıldı. Bulgular: hastaların eklem dokularında ibuprofen tespit edildi. Sinovyal sıvıda en yüksek ibuprofen konsantrasyonları Grup 3 ve 5’te tespit edildi. Kemikte en yüksek konsantrasyonlar Grup 2’de elde edildi ve sinovyal dokuda Grup 2 ve Grup 3’te elde edildi. Sonuç: ibuprofenin eklem dokularına optimum penetrasyonu, 1 MHz ve 1-1.5 W/cm2 ve sürekli ultrason modu ile elde edildi. OA’lı hastalarda fonoforez etkili bir tedavi yöntemi olarak görülmektedir.
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    PublicationOpen Access
    Preliminary results of a new intercalary modular endoprosthesis for the management of diaphyseal bone metastases
    (Turkish Joint Diseases Foundation, 2021) Göker, Barlas; Tokgözoğlu, Mazhar; İnan, Ulukan; Özkan, Korhan; Çolak, Tahsin Sami; Ayvaz, Mehmet; Büyükdoğan, Kadir; Aslan, Lercan; Deveci, Mehmet Ali; Doctor; Faculty Member; Faculty Member; School of Medicine; Koç University Hospital; N/A; N/A; 206311
    Objectives: this study aims to evaluate functional outcomes of patients and to analyze complication rates of modular intercalary endoprosthetic reconstruction after resection of metastatic diaphyseal bone lesions. Patients and methods: between December 2017 and February 2020, 22 patients (15 males, 7 females; median age: 64.2 years; range, 49 to 91) who underwent reconstruction with modular intercalary endoprostheses for metastatic bone tumors at five different centers were retrospectively analyzed. Age, sex, diagnosis, follow-up duration, previous treatments of patients, and resection lengths were recorded. The Musculoskeletal Tumor Society Scores (MSTS) were used to assess functional status of available patients at the final follow-up. Failures were categorized according to the Henderson classification. Results: locations of the resected tumors included 10 humeri (45.5%), five tibiae (22.7%), and seven femurs (31.8%). The length of the resected tissues ranged from 35 mm to 180 mm. Seven patients (31.8%) died of disease, and one patient died of pneumonia within follow-up period. The functional outcomes of surviving patients were satisfying with a median MSTS score of 86.9% (range, 70 to 100%) at a median follow-up of 17 months (range, 8 to 26). There were two cases of type II (9%), one cases of type IIIa (4.5%), two cases of type IIIb (9%), and one case of type IV (4.5%) failure. Complications were most commonly observed in tibial reconstructions. Conclusion: the good short-term functional results were achieved in surviving patients. Uncomplicated patients were able to perform daily living activities without limitations. The overall rate of complications was relatively low and, among them, mechanical problems were the most commonly encountered problems.
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    PublicationOpen Access
    Ultrasonographic measurement of the dimensions of proximal and distal patellar fragments after Niebauer-King Procedure for the management of congenital dislocation of the knee
    (Aves, 2021) Biçer, Ö. S.; Tekin, M.; Eren, Ö. F.; Mirioğlu, A.; Soyupak, S.; Deveci, Mehmet Ali; Faculty Member; School of Medicine; 206311
    Objective: the aim of this study was to ultrasonographically measure the dimensions of the proximal and distalpatellar fragments to determine whether postoperative growth differences existbetween the fragments in children with congenital dislocation of the kneetreated by Niebauer Kings quadricepsplasty. Methods: this retrospective study included six congenitaldislocated knees of four children with arthrogryposis multiplex congenita (AMC)(3 girls; mean age = 40 months; age range = 9-44 months), presented with severe hyperextension knee contractures,which were treated by Niebauer-King's quadricepsplasty.The transverse, craniocaudal, and anteroposterior dimensions of the patellaewere measured ultrasonographically 20 (range = 6-42) months postoperatively by a singleradiologist. Results: the mean transverse, craniocaudal, and anteroposteriordimensions of proximal and distal halves of the patellae were: 11.46 (7.0-16.9)-10.5 (8.0-14.4); 17.4 (14.0-21.0) -16.68 (14.5-19.3); 6.76 (5.6-7.9) -7.76 (7.0-9.4) mm respectively. There was no significantdifference in craniocaudal and transverse dimensions, but the anteroposteriordimension (thickness) of the distal patellae articulating the knee joint had agreater thickness (P = 0,01). Conclusion: evidence from this study has shown that a bettergrowth can be expected in the distal fragment of the patella compared with theproximal fragment following treatment with Niebauer-King's quadricepsplasty in children with congenital dislocation ofthe knee.
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    PublicationOpen Access
    Minimal invasive percutaneous plate osteosynthesis (MIPPO) in humeral shaft fractures
    (Çukurova Üniversitesi, 2022) Kundakçı, Buğra; Biçer, Ömer; Huri, Gazi; Tekin, Mustafa; Bağır, Melih; Mirioğlu, Akif; Deveci, Mehmet Ali; Faculty Member; School of Medicine; 206311
    Purpose: we aimed to evaluate the radiological and functional results of humeral shaft fractures treated with minimally invasive percutaneous plate osteosynthesis (MIPPO) in our clinic. Material and Methods: data of 21 humeral shaft fractures of 20 patients treated with MIPPO were evaluated retrospectively. Demographic data, type of injury, fracture classification according to AO classification and fracture location, smoking, radial nerve injury were recorded. Radiographically, the union at 6th month and alignment were evaluated. Objective results were evaluated in terms of shoulder and elbow range of motion. Subjective results were assessed by the American Shoulder and Elbow Society Score (ASES), University of California, Los Angles (UCLA) score, Mayo Elbow Performance Index (MEPI), the Disability of The Arm, Shoulder and Hand (DASH) Score and Constant Shoulder Score. Results: the average elbow motion was 131.4 degrees +/- 19.8 degrees. The mean ASES and UCLA scores were 88.5 +/- 16.4 and 32.1 +/- 5.2, respectively. The mean MEPI and DASH scores were 93.1 +/- 11.3 and 11.8 +/- 20.0, respectively, and the Constant score was mean 9.1 +/- 15.3. Nonunion was observed in two patient at 6th month. Conclusion: we believe that MIPPO is a successful technique for the treatment of humeral shaft fractures with minimal soft tissue damage, intact shoulder and elbow motion function. / Amaç: lliniğimizde minimal invaziv perkütan plak osteosentezi (MIPPO) ile tedavi edilen humerus cisim kırıklarının radyolojik ve fonksiyonel sonuçlarının değerlendirilmesi amaçlanmıştır. Gereç ve yöntem: MIPPO ile tedavi edilen 20 hastanın 21 humerus cisim kırığına ait verileri retrospektif olarak değerlendirildi. Hastaların demografik verileri, yaralanma şekilleri, AO sınıflaması ve bölgesine göre kırık sınıflaması, sigara kullanımı, radial sinir yaralanması kaydedildi. Radyografik olarak 6. ayda kaynama durumu ve dizilim değerlendirildi. Hastaların son kontrollerinde omuz ve dirsek hareket açıklığı ile objektif, Amerikan Omuz ve Dirsek Derneği (ASES) skoru, California Üniversitesi Los Angeles (UCLA) skoru, Mayo dirsek performans indeksi (MEPI), Kol Omuz El Engellilik (DASH) skoru ve Constant omuz skoru ile subjektif değerlendirme yapıldı. Bulgular: hastaların ortalama omuz fleksiyonu 169,5°±26,4°, abdüksiyonu 169,5°±26,4° idi. Ortalama dirsek hareket arkı 131,4°±19,8° bulundu. Ortalama ASES ve UCLA skorları sırasıyla 88,5±16,4 ve 32,1±5,2, MEPI ve DASH skoru sırasıyla 93,1±11,3 ve 11,8±20,0, ortalama Constant skoru 9,1±15,3 bulundu. İki hastada 6. ayda kaynamama gözlendi. Sonuç: MIPPO yöntemi humerus cisim kırıklarının tedavisinde; minimal yumuşak doku hasarı, korunmuş omuz ve dirsek fonksiyonları ile başarılı bir tekniktir.
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    PublicationOpen Access
    Retrorectal tumor: a single-center 10-years' experience
    (Korean Surgical Society, 2020) Yalav, Orçun; Topal, Uğur; Eray, İsmail Cem; Gencel, Eyüphan; Rencüzoğulları, Ahmet; Deveci, Mehmet Ali; Faculty Member; School of Medicine
    Purpose: retrorectal tumors [RTs] are a rare incidence and recommendations on the ideal surgical approaches are lacking. This study aimed to evaluate outcomes and follow-up results of patients undergoing excision of RTs at our institution. Methods: a retrospective review was conducted for undergoing surgery for RT between January 2009 and January 2019. Demographic characteristics, presenting symptoms, preoperative diagnostic tests, surgical procedures, histopathological results, intraoperative and postoperative complications, postoperative hospital stay, postoperative 30-day mortality, 90-day unplanned readmission rate, and long-term outcomes were evaluated. Results: twenty patients with a mean age of 48.3 +/- 14.2 were analyzed. The most common presenting complaint was perineal pain (35.0%). Magnetic resonance imaging and computed tomography was preferred in 18 and 2 patients, respectively. Tumor localization was below the level of the third sacral vertebrae in 14 patients for whom the posterior surgical approach was used. No postoperative mortality was recorded at the end of follow-up of 53.8 +/- 40 months. Mean length of postoperative hospital stay was 8.6 +/- 9.4 days. Ten percent of the patients had unplanned hospital readmission within 90 days after discharge. Recurrence developed in 1 patient, for whom pathology were reported as chordoma. conclusion: RT should be managed by a multidisciplinary team given the complexity and heterogeneity of these tumors despite the fact that the majority are benign. A good understanding of pelvic anatomy and characterization of lesions through detailed radiological imaging is crucial to optimize surgical planning. Complete surgical resection is key for prolonged disease-free and overall survival of patients diagnosed with RTs.
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    PublicationOpen Access
    Clinical and radiological outcomes of Salter versus Pemberton osteotomies in the management of developmental dysplasia of the hip: a retrospective comparative study
    (Aves, 2022) Mirioğlu, A.; Biçer, Ö.S.; Tekin, M.; Özkan, C.; Bağır, M.; Deveci, Mehmet Ali; Faculty Member; School of Medicine; 206311
    Objective: the aim of this study was to investigate whether there is a relationship between Salter and Pemberton pelvic osteotomies and avascular necrosis of femoral head in the management of developmental dysplasia of the hip (DDH). Methods: This retrospective study included 69 hips of 52 patients aged between 12-36 months, diagnosed as DDH who had undergone either Salter or Pemberton pelvic osteotomy with Smith Petersen approach. There were 35 patients in Salter Pelvic Osteotomy and 34 patients in Pemberton Pelvic Osteotomy groups. Before the treatment of DDH, Tönnis classification was used, preoperative and 24th month postoperative Acetabular Index (AI) angles were measured. Kalamchi-MacEwen grades of avascular necrosis were determined in terms of presence of avascular necrosis of the femoral head. Results: There were no significant differences between two osteotomy groups at the end of mid-term follow up in terms of the radiological parameters and avascular necrosis of femoral head. However it was found that the increased avascular necrosis incidence was significantly associated with Tönnis grade 4 hips. Conclusion: Salter and Pemberton osteotomies can be both used safely in the treatment of DDH regarding their effect on the femoral head. Level of evidence: Level III, Therapeutic Study.