Researcher:
İliaz, Sinem

Profile Picture
ORCID

Job Title

Doctor

First Name

Sinem

Last Name

İliaz

Name

Name Variants

İliaz, Sinem

Email Address

Birth Date

Filters

2016 - 2019232020 - 202210

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.a40d9e10-c87d-418d-9fc5-f017d49eec53

Search Results

Now showing 1 - 10 of 33
  • Placeholder
    PublicationMetadata only
    A rare case of right sided pulmonary artery agenesis associated with congenital mitral valve prolapse
    (Turkish Assoc Tuberculosis & Thorax, 2016) N/A; N/A; İliaz, Sinem; Aslan, Gamze; Öztürk, Ayşe Bilge; Özyiğit, Sabiha Leyla Pur; Tabak, Levent; Doctor; Doctor; Faculty Member; Doctor; Faculty Member; N/A; N/A; School of Medicine; N/A; School of Medicine; Koç University Hospital; Koç University Hospital; N/A; Koç University Hospital; N/A; N/A; N/A; 147629; 214687; N/A
    N/A
  • Placeholder
    PublicationMetadata only
    The clinical use of impulse oscillometry in neuromuscular diseases
    (W. B. Saunders, 2022) Bayraktaroglu, Mesut; N/A; İliaz, Sinem; Yunisova, Gulshan; Çakmak, Özgür Öztop; Çelebi, Özlem; Buluş, Eser; Duman, Arda; Oflazer, Piraye; Doktor; Doktor; Faculty Member; Doktor; Doktor; Doktor; Faculty Member; N/A; N/A; School of Medicine; N/A; N/A; N/A; School of Medicine; Koç University Hospital; Koç University Hospital; N/A; Koç University Hospital; Koç University Hospital; Koç University Hospital; N/A; N/A; N/A; 299358; N/A; N/A; N/A; N/A
    Background: The patients with neuromuscular diseases (NMD) are very fragile and it is hard to evaluate respiratory involvement of the primary disease in this group. Therefore, our study aimed to reveal the relationship between pulmonary function tests (PFT) and impulse oscillometry (IOS) and their correlation with respiratory clinical findings in NMD. Material and methods: A total of 86 consecutive patients with NMD were included. The clinical findings of respiratory involvement, PFT, and IOS results of the patients were analyzed. Results: Forty patients out of 86 were female. There were 29 patients with amyotrophic lateral sclerosis, four patients with myasthenia gravis, and 53 patients with muscular dystrophies/myopathies. According to the PFT results, 47 patients had restrictive PFT. However, there was no difference in IOS parameters when we compared the patients according to restrictions in PFT. A positive correlation was found with FVC %pred and X-5. PEF % pred values were positively correlated with X-10, X-15, and X-20, and negatively correlated with A(X) and R5-20. The patients with worse swallowing capability had increased R-rs levels, and more negative X-rs levels. The shortness of breath led to lower FEV1 %pred., higher R-5, A(X) and R5-20, and also more negative X-10, X-15, and X-35. Conclusion: Clinically reported dysphagia, a decreased capability of coughing, and shortness of breath in patients with NMD make R-rs increase in general, but X-rs parameters, which mainly express rib cage elasticity, turn more negative. In patients with NMD, IOS monitoring may help in evaluating the regression in respiratory functions, however, future studies are needed to understand more.
  • Placeholder
    PublicationMetadata only
    Pneumonia in HIV-infected patients
    (Türk Solunum Araştırmaları Derneği, 2016) Önür, Seda Tural; Dalar, Levent; Yalçın, Arzu Didem; N/A; İliaz, Sinem; Doctor; N/A; Koç University Hospital; N/A
    Acquired immune deficiency syndrome (AIDS) is an immune system disease caused by the human immunodeficiency virus (HIV). The purpose of this review is to investigate the correlation between an immune system destroyed by HIV and the frequency of pneumonia. Observational studies show that respiratory diseases are among the most common infections observed in HIV-infected patients. In addition, pneumonia is the leading cause of morbidity and mortality in HIV-infected patients. According to articles in literature, in addition to antiretroviral therapy (ART) or highly active antiretroviral therapy (HAART), the use of prophylaxis provides favorable results for the treatment of pneumonia. Here we conduct a systematic literature review to determine the pathogenesis and causative agents of bacterial pneumonia, tuberculosis (TB), nontuberculous mycobacterial disease, fungal pneumonia, Pneumocystis pneumonia, viral pneumonia and parasitic infections and the prophylaxis in addition to ART and HAART for treatment. Pneumococcus-based polysaccharide vaccine is recommended to avoid some type of specific bacterial pneumonia.
  • Placeholder
    PublicationMetadata only
    Our experience on silicone y-stent for severe COPD complicated with expiratory central airway collapse
    (Lippincott Williams and Wilkins (LWW), 2017) Özgül, Mehmet A.; Cetinkaya, Erdogan; Cortuk, Mustafa; Tanriverdi, Elif; Gul, Sule; Özgül, Guler; Onaran, Hilal; Abbasli, Kenan; Dincer, Huseyin E.; N/A; İliaz, Sinem; Doctor; N/A; Koç University Hospital; N/A
    Background: Expiratory central airway collapse (ECAC) is abnormal central airway narrowing during expiration. ECAC involves 2 different pathophysiological entities as tracheobronchomalacia and excessive dynamic airway collapse (EDAC). Although the exact cause is unknown, chronic obstructive pulmonary disease (COPD) is frequently accompanied by ECAC. Although there are various publications on the relationship between COPD and ECAC, there are very few data for stent placement in patients with tracheobronchomalacia accompanied severe COPD. We share our results for stenting in ECAC among patients with severe COPD. Methods: The data in this case series were collected retrospectively. The ECAC diagnosis was made during flexible bronchoscopy with severe COPD. Silicone Y-stents were placed via rigid bronchoscopy under general anesthesia. Results: A total of 9 patients' (7 men) data were evaluated with an average age of 67 +/- 10.73 years. One patient experienced stent migration on the second day of stenting prompting stent removal. Another patient died 1 month after stenting. Consequently, we evaluated the follow-up data of remaining 7 patients. The changes in forced expiratory volume 1 was not significant for these 7 cases (P = 0.51). The modified Medical Research Council (mMRC) score improvement was statistically significant (P = 0.03). Functional status improvement was observed in 4 of 7 patients. of the 7 patients, mean additional follow-up bronchoscopic interventions requirement was 2.2 times. Conclusions: Our study showed significant decrease in mMRC score with stenting for ECAC in severe COPD. For 2 patients, we experienced severe complications during short-term follow-up period after stenting. Additional follow-up bronchoscopic interventions were required.
  • Placeholder
    PublicationMetadata only
    The neutrophil-lymphocyte ratio as an inflammatory marker in acute exacerbation of COPD
    (Springer Wien, 2016) İliaz, Raim; N/A; İliaz, Sinem; Doctor; N/A; Koç University Hospital; N/A
    N/A
  • Placeholder
    PublicationMetadata only
    Does gastroesophageal reflux increase chronic obstructive pulmonary disease exacerbations?
    (W B Saunders Co Ltd, 2016) Iliaz, Raim; Onur, Seda Tural; Arici, Serpil; Akyuz, Umit; Karaca, Cetin; Demir, Kadir; Besisik, Fatih; Kaymakoglu, Sabahattin; Akyuz, Filiz; N/A; İliaz, Sinem; Doctor; N/A; Koç University Hospital; N/A
    Background: The relationship between chronic obstructive pulmonary disease (COPD) exacerbations and gastroesophageal reflux (GER) has been investigated less than asthma-GER. We aimed to evaluate the presence of GER in patients with COPD and its impact on exacerbations. Methods: We included 24 patients with stable mild-moderate stage COPD and 19 volunteers as the control group. We conducted a gastroesophageal reflux disease (GERD) symptom questionnaire, gastroscopy, manometry, and an ambulatory 24-h pH-impedance study. Results: According to the GERD questionnaire, only 5 (20.8%) patients with COPD had typical GER symptoms. According to the 24-h pH-impedance study, the mean DeMeester score (DMS) was 38.1 ± 34.6 in the COPD group and 13.3 ± 16.8 in the control group (p = 0.01). The acid reflux (DMS > 14.7) rate was higher in patients with COPD than in controls (73.9% vs 26.3%, p = 0.01). The symptom association probability positivity rate was 17.4% (n = 4) in the COPD group, which was similar to the controls (p = 0.11). The mean proximal extension rate of reflux (Z 17 cm) was 26.4 ± 12.9% in the COPD group. The proximal extent of reflux was positively correlated with the number of COPD exacerbations per year (p = 0.03, r = 0.448). In the motility results, only 2 (20%) patients in the control group had a minor motility disorder. Seventeen (70.8%) patients in the COPD group had a minor motility disorder, and 4 (16.7%) had major motility disorders (p < 0.001). Conclusion: In our study, gastroesophageal reflux was frequent in patients with COPD, but only a quarter had typical reflux symptoms. The proximal extent of reflux may trigger frequent exacerbations of COPD.
  • Placeholder
    PublicationMetadata only
    A cause of pleural effusion is familial mediterranean fever
    (Look Us Scientific, 2016) Chousein, Efsun Gonca Uğur; Abalı, Hülya; Öztürk, Sakine; Çağlar, Emel; N/A; İliaz, Sinem; Doctor; N/A; Koç University Hospital; N/A
    Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by recurrent abdominal pain and fever episodes. Pleural pain and effusion can also be seen, but rarely in the absence of abdominal pain. FMF is treated with colchicine to control symptoms and to prevent amyloidosis and renal failure. A 41-year-old woman was admitted to our hospital due to recurrent fever, chest pain, and dyspnea. She had an exudative pleural effusion and responded to antibiotic therapy with partial radiographic resolution. She had recurrence of her symptoms three weeks after the completion of therapy. Pleural biopsy by video-assisted thoracoscopy revealed chronic non-specific pleuritis. The patient disclosed that two of her offspring had FMF. Gene analysis showed she was heterozygous carrier of M680I (G/C) mutation. Treatment with colchicine led to resolution of her symptoms and of the pleural effusion. Turkey has a high prevalence of FMF. Pulmonologists should consider FMF in the differential diagnosis of patients with recurrent pleural effusions. / Kırk bir yaşında kadın hasta tekrarlayan ateş, sol yan ağrısı, nefes darlığı yakınmalarıyla başvurdu. Arka-ön akciğer grafisinde solda plevral efüzyon ile uyumlu görünüm saptandı. Torasentez ile alınan plevral sıvı örnekleri eksuda özelliğinde olup nötrofil hâkimiyeti mevcuttu. Hastaya plöropnömoni tanısıyla antibiyoterapi uygulandı. Kısmi klinik ve radyolojik iyileşme ile taburcu edildi. Üç hafta sonra aynı şikâyetlerle tekrar kliniğimize müracaat etti. Hastaya Video Assisted Torakoskopi uygulandı. Biyopsi sonucu kronik nonspesifik plörit olarak geldi. Anamnez derinleştirildiğinde iki çocuğunda Ailevi Akdeniz Ateşi (AAA) olduğu ve hastanın M680I (G/C) heterojen taşıyıcısı olduğu öğrenildi. Romatoloji bölümüyle konsülte edilerek hastaya oral kolşisin 0,5 mg 2x1 başlandı. Bu tedaviden sonra hastanın kliniği düzeldi, plevral sıvısı geriledi. AAA tanısı olan hastalarının %95 'inde ana yakınma abdominal ağrıdır. Abdominal ağrı olmaksızın plevral ağrı nadirdir. Plevral sıvı daha da nadirdir. Plevral efüzyonların etiyolojisini araştırırken Akdeniz bölgesinde yer alan ülkemizde, AAA’nin de plevral sıvı nedeni olabileceğini aklımızda tutmamız gerekmektedir.
  • Placeholder
    PublicationMetadata only
    Correlation of final pathology with the ROSE used during the EBUS-TBNA
    (European Respiratory Soc Journals Ltd, 2018) N/A; N/A; İliaz, Sinem; Çağlayan, Benan Niku; Bulutay, Pınar; Armutlu, Ayşe; Uzel, Fatma Işıl; Öztürk, Ayşe Bilge; Özyiğit, Sabiha Leyla Pur; Doctor; Faculty Member; Teaching Faculty; Teaching Faculty; Doctor; Faculty Member; Doctor; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; N/A; Koç University Hospital; N/A; N/A; N/A; Koç University Hospital; N/A; N/A; Koç University Hospital; N/A; 230719; 133565; 133567; N/A; N/A; 147629; 214687
    Introduction: When using EBUS-TBNA, the use of rapid onsite evaluation(ROSE) reduces the overall cost by reducing the duration of operation and the amount of unnecessary biopsy. The aim of this study was to determine correlation of ROSE used during EBUS-TBNA with the final pathologic diagnosis and the cellular subgroup in malignant group. Methods: This prospective study involved 449 lymphadenomegaly (LAM)/mass lesion belonging to 219 consecutive patients who experienced EBUS-TBNA under ROSE. Patient demographic data, morphologic features of mediastinal/hilar lesions (lymphadenopathy/mass), diameter, number of samples, ROSE results, and final pathology results were recorded. Comparisons of ROSE and final pathology results were compared. Results: In total of 219 patients, 133 were male(60.7%). The mean age was 62±14 years. The mean diameter of the sampled LAM/masses was 14.8±1.0mm. The mean number of needle pass in a LAM was 3.1±1.3 and the mean number of pass leading to a ROSE diagnosis was 1.5±0.9. According to ROSE results, 54.3% of the lesions were lymphoid material/reactive, 4.5% were inadequate, 5.8% were granulomatous inflammation, and the remaining 35.4% were malignant pathology. As a result of the definite pathology, 2.4% of lesions were inadequate, 58.1% were benign pathologies, and 39.4% were malignant. The diagnostic success rate for ROSE in malignancies was 93.5% and false negativity was 4%. Regarding whether ROSE detected the malignant cell type/subtype assignment correctly in 145 lesions reported as lung cancer in final pathology, ROSE was correct 64.1%. Conclusion: Despite the high correlation of ROSE with the final pathology, ROSE could moderately predict tm subtype/cell type in lung ca.
  • Placeholder
    PublicationMetadata only
    Comorbidities in elderly patients with pulmonary disease
    (Wiley-Blackwell, 2016) İliaz, Raim; N/A; İliaz, Sinem; Doctor; N/A; Koç University Hospital; N/A
    N/A
  • Placeholder
    PublicationMetadata only
    Streptococcus constellatus'a bağlı torasik ampiyem olgusu
    (Look Us Scientific, 2016) Chousein, Efsun Gonca Uğur; Öztürk, Sakine Yılmaz; Bahadır, Ayşe; Ortaköylü, Mediha Gönenç; Bağcı, Belma Akbaba; Çağlar, Emel; N/A; İliaz, Sinem; Doctor; N/A; Koç University Hospital; N/A
    A 61–year-old mentally retarded man with congenital neurological disability presented with cough, wheezing, fever, and agitation for one week. The preliminary diagnosis was bronchopneumonia and respiratory failure and a treatment consisted of empiric antibiotics, bronchodilators, mucolytics and oxygen therapy was initiated. Thoracentesis revealed empyema and a closed tube thoracotomy was placed. Streptococcus constellatus was isolated from the pleural fluid. The patient was not on an oral care. Our microbiology laboratory reported the isolation of Streptococcus constellatus. According to the published literature on the resistance to the first-line antibiotics such as beta-lactam inhibitors, macrolides, and metronidazole, antibiotics were changed accordingly. The patient's overall condition improved, the markers of infection normalized, the amount of pleural effusion regressed, and culture of pleural effusion became sterile. After the removal of the thoracic tube, he was discharged from the hospital. Patients with neurological disabilities lacking proper oral hygiene are at high-risk for mortality-bearing diseases such as empyema secondary to non-pathogenic bacteria, including Streptococcus constellatus. Isolating the causative microorganism can guide the antibiotic therapy where the antibiotic susceptibility testing is not available. / Atmış bir yaşında konjenital nörolojik defisitli, mental retarde erkek hasta, bir haftadır olan öksürük, hırıltılı solunum, ateş, ajitasyonla başvurdu. Yatırılarak plöropnömoni ve solunum yetmezliği tanıları ile ampirik antibiyotik, bronkodilatör ve oksijen tedavisi başlandı. Torasentez ile ampiyem niteliğinde sıvı alındı, kapalı tüp torakostomi uygulandı. Ağız bakımının yapılmadığı öğrenilen hastada sıvıda Streptococcus constellatus izole edildi. O güne kadar kliniği ve enfeksiyon göstergeleri düzelmeyen hastanın tedavisinin değiştirilmesi planlandı. Literatürler ışığında etkenin betalaktam inhibitörleri, makrolidler ve metronidazol gibi ajanlara dirençli olabileceği göz önüne alınarak antibiyoterapisi değiştirildi. Olgu; genel durumunun düzelmesi, enfeksiyon göstergelerinin düşmesi, sıvının azaldığının görülmesi, kültürünün negatifleşmesi, tüpünün çekilmesi sonrasında kontrole gelmek üzere taburcu edildi. Nörolojik defisitli hastalarda ağız hijyeni yapılmadığında; normalde patojen olmayan Streptococcus constellatus gibi mikroorganizmaların mortal seyreden ampiyem gibi tablolara yol açabileceğini, elimizde bir antibiyogram olmasa da etkenin izolasyonunun uygun antibiyotik seçimi konusunda bize yol gösterebileceğini hatırlatmak amacı ile olgumuzu sunmaktayız.