Researcher:
Elbüken, Çağlar

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Çağlar

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Elbüken

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Elbüken, Çağlar

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2012 - 20143

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Researcher Of Publications: search.filters.isAuthorOfPublication.a654435e-f70f-471a-acf4-c2a1177499b5

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    MEMS biosensor for blood plasma viscosity measurements
    (Elsevier Science Bv, 2012) N/A; Department of Electrical and Electronics Engineering; Department of Mechanical Engineering; N/A; N/A; Department of Molecular Biology and Genetics; Department of Chemical and Biological Engineering; Department of Mechanical Engineering; Department of Electrical and Electronics Engineering; Çakmak, Onur; Elbüken, Çağlar; Ermek, Erhan; Bulut, Selma; Kılınç, Yasin; Barış, İbrahim; Kavaklı, İbrahim Halil; Alaca, Burhanettin Erdem; Ürey, Hakan; PhD Student; Researcher; Other; PhD Student; PhD Student; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; Department of Molecular Biology and Genetics; Department of Chemical and Biological Engineering; Department of Mechanical Engineering; Department of Electrical and Electronics Engineering; Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM); Graduate School of Sciences and Engineering; College of Engineering; College of Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Sciences; College of Engineering; College of Engineering; College of Engineering; N/A; N/A; N/A; N/A; N/A; 111629; 40319; 115108; 8579
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    LoC sensor array platform for real-time coagulation measurements
    (Institute of Electrical and Electronics Engineers (IEEE), 2014) Yaralıoğlu, Göksenin G.; N/A; Department of Electrical and Electronics Engineering; Department of Mechanical Engineering; Department of Electrical and Electronics Engineering; Department of Electrical and Electronics Engineering; Department of Electrical and Electronics Engineering; Çakmak, Onur; Kılınç, Necmettin; Ermek, Erhan; Mostafazadeh, Aref; Elbüken, Çağlar; Ürey, Hakan; PhD Student; Researcher; Other; Researcher; Researcher; Faculty Member; Department of Mechanical Engineering; Department of Electrical and Electronics Engineering; Graduate School of Sciences and Engineering; College of Engineering; College of Sciences; College of Engineering; College of Engineering; College of Engineering; N/A; 59959; N/A; N/A; N/A; 8579
    This paper reports a MEMS-based sensor array enabling multiple clot-time tests in one disposable microfluidic cartridge using plasma. The versatile LoC (Lab-on-Chip) platform technology is demonstrated here for real-time coagulation tests (activated Partial Thrompoblastin Time (aPTT) and Prothrombin Time (PT)). The system has a reader unit and a disposable cartridge. The reader has no electrical connections to the cartridge, which consists of multiple microfluidic channels and MEMS microcantilevers placed in each channel. Microcantilevers are made of electro-plated nickel and actuated remotely using an external electro-coil. The read-out is also conducted remotely by a laser and the phase of the MEMS oscillator is monitored real-time. The system is capable of monitoring coagulation time with a precision estimated at 0.1sec.
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    Microcantilever based disposable viscosity sensor for serum and blood plasma measurements
    (Academic Press Inc Elsevier Science, 2013) N/A; Department of Mechanical Engineering; Department of Mechanical Engineering; Department of Electrical and Electronics Engineering; Department of Molecular Biology and Genetics; Department of Mechanical Engineering; Department of Chemical and Biological Engineering; Çakmak, Onur; Elbüken, Çağlar; Ermek, Erhan; Mostafazadeh, Aref; Barış, İbrahim; Alaca, Burhanettin Erdem; Kavaklı, İbrahim Halil; Ürey, Hakan; PhD Student; Researcher; Faculty Member; Researcher; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; Department of Electrical and Electronics Engineering; Department of Molecular Biology and Genetics; Department of Mechanical Engineering; Department of Chemical and Biological Engineering; Graduate School of Sciences and Engineering; College of Engineering; College of Engineering; Graduate School of Sciences and Engineering; College of Sciences; College of Engineering; College of Engineering; N/A; N/A; N/A; N/A; 111629; 115108; 40319; 8579
    This paper proposes a novel method for measuring blood plasma and serum viscosity with a microcantilever-based MEMS sensor. MEMS cantilevers are made of electroplated nickel and actuated remotely with magnetic field using an electro-coil. Real-time monitoring of cantilever resonant frequency is performed remotely using diffraction gratings fabricated at the tip of the dynamic cantilevers. Only few nanometer cantilever deflection is sufficient due to interferometric sensitivity of the readout. The resonant frequency of the cantilever is tracked with a phase lock loop (PLL) control circuit. The viscosities of liquid samples are obtained through the measurement of the cantilever's frequency change with respect to a reference measurement taken within a liquid of known viscosity. We performed measurements with glycerol solutions at different temperatures and validated the repeatability of the system by comparing with a reference commercial viscometer. Experimental results are compared with the theoretical predictions based on Sader's theory and agreed reasonably well. Afterwards viscosities of different Fetal Bovine Serum and Bovine Serum Albumin mixtures are measured both at 23 degrees C and 37 degrees C, body temperature. Finally the viscosities of human blood plasma samples taken from healthy donors are measured. The proposed method is capable of measuring viscosities from 0.86 cP to 3.02 cP, which covers human blood plasma viscosity range, with a resolution better than 0.04 cP. The sample volume requirement is less than 150 mu l and can be reduced significantly with optimized cartridge design. Both the actuation and sensing are carried out remotely, which allows for disposable sensor cartridges. (C) 2013 Published by Elsevier Inc.