Researcher: Armutlu, Ayşe
Loading...
Name Variants
Armutlu, Ayşe
Email Address
Birth Date
33 results
Search Results
Now showing 1 - 10 of 33
Publication Metadata only Fluorescence-guided extended pelvic lymphadenectomy during robotic radical prostatectomy(Springernature) N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Özkan, Arif; Köseoğlu, Ersin; Canda, Abdullah Erdem; Çil, Barbaros Erhan; Aykanat, İbrahim Can; Sarıkaya, Ahmet Furkan; Tarım, Kayhan; Armutlu, Ayşe; Kulaç, İbrahim; Barçın, Erinç; Falay, Fikri Okan; Kordan, Yakup; Baydar, Dilek Ertoy; Balbay, Mevlana Derya; Esen, Tarık; Doctor; Faculty Member; Faculty Member; Faculty Member; Doctor; Researcher; Researcher; Teaching Faculty; Faculty Member; Undergraduate Student; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 350876; 116202; 169993; N/A; 327615; 327605; 133567; 170305; N/A; 246484; 157552; 8025; 153320; 50536We evaluated and described the impact of prostatic indocyanine green (ICG) injection on extended pelvic lymph node (LN) dissection (ePLND) in robotic-assisted radical prostatectomy (RARP). Between January 2019 and December 2021, we included consecutive 50 PCa patients who underwent ePLND during RARP with (n = 25) or without (n = 25) prostatic ICG injection. ICG injection was performed during abdominal port placement and robot docking. Pelvic LNs reflecting green color were initially excised and then the template was completed. The outcomes of two groups were compared. Overall, nine (36%) and five (20%) of the patients had metastatic LN involvement in the ICG and non-ICG groups, respectively. Of the 509 dissected LNs in the ICG group, 122 (23.9%) were fluorescence active. 20 LNs (3.9%) were metastatic in this group, 9 (45%) of which were ICG+. 408 LNs were resected on the non-ICG group with 8(1.9%) being metastatic. Eight (88.9%) of nine pN+ patients were florescent positive in the ICG group. Out of six patients with pN+ disease, Ga68 PSMA-PET/CT detected positive LNs preoperatively. In addition to preoperative Ga68 PSMA-PET/CT investigation, ICG-guided ePLND might increase identification and removal of metastatic LNs duirng RARP. Improvements in staging and oncologic outcomes may also be seen in intermediate- and high-risk patients.Publication Metadata only Rapid on-site evaluation by imprint cytology for liver core-needle biopsies, is it really needed?(Springer, 2019) N/A; N/A; N/A; N/A; N/A; Armutlu, Ayşe; Taşkın, Orhun Çığ; Oğuzkurt, Levent; Fırat, Pınar Arıkan; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; 133567; 166686: 13559; 207545Publication Metadata only A practical method for accurate coordination between the plastic surgeon and the pathologist: the clockwork technique(Korean Soc Plastic & Reconstructive Surgery, 2018) N/A; N/A; N/A; N/A; N/A; N/A; N/A; Sezgin, Billur; Kapucu, İrem; Yenidünya, Bahar Güliz; Bulutay, Pınar; Armutlu, Ayşe; Özmen, Selahattin; Yavuzer, Cahit Reha; Faculty Member; Researcher; Undergraduate Student; Teaching Faculty; Teaching Faculty; Faculty Member; Other; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 133762; 327602; N/A; N/A; 133565; 133567; 125951; N/ACooperation between the surgeon and the pathologist is essential for the correct diagnosis and treatment of skin tumors [1]. Precise communication between these two specialties allows for the precise evaluation of the tumor borders by the pathologist, which in turn reduces the amount of unnecessary tissue removed, thereby improving functional preservation and the aesthetic outcomes of surgery. Although not every skin tumor excision requires a high level of interdisciplinary interaction, the location and the type of tumor are key elements that can make such a collaboration necessary. This is especially true for tumors located near critical facial aesthetic subunits such as the eyelids, nostrils, and mouth, and for locally aggressive tumors that spread in unpredictable patterns. Mohs micrographic surgery (MMS) is an alternative to conventional surgery in such cases, and allows tissue preservation to be maximized without compromising adequate surgical excision of the tumor [2]. MMS remains an effective, yet not commonly accessible option, as it can only be performed by pathologically trained surgeons. Nevertheless, regardless of the surgical method, establishing the orientation of the specimen is always critical, and accuracy in this regard can be achieved by various techniques, such as using sutures in different lengths or color codes for each side. Surgeons may use hand-drawn pictures, printed maps of the areas in question, and photographs to guide the patholoCOMMUNICATION A practical method for accurate coordination between the plastic surgeon and the pathologist: The clockwork technique Billur Sezgin1 , Irem Kapucu1 , Guliz Yenidunya1 , Pinar Bulutay2 , Ayse Armutlu2 , Selahattin Ozmen1 , Reha Yavuzer1 Departments of 1 Plastic, Reconstructive, and Aesthetic Surgery and 2 Pathology, Koc University School of Medicine, Istanbul, Turkey Correspondence: Billur Sezgin Department of Plastic, Reconstructive, and Aesthetic Surgery, Koç University Hospital, Maltepe Mh., Davutpasa cad. No 4, Topkapı, 34010 Zeytinburnu, Istanbul, Turkey Tel: +90-850-250-8250–20201, Fax: +90-0442-232-5300, E-mail: bsezgin@ku.edu.tr This article was presented as a poster at the 38th Congress of the Turkish Society of Plastic, Reconstructive and Aesthetic Surgeons on 27–30 October, 2016 in Antalya,Turkey. gist. Tissue nicks or poly-angulated drawings can also be used to improve the orientation [3]. These markings are especially useful when determining the need for re-excision; thus, precision is key for minimizing further tissue loss while obtaining tumor-free margins. We present an easily applicable technique that has been developed to increase the precision of surgical margin evaluation in various skin tumors. The ‘clockwork technique’ uses a clock face template for the orientation of the specimen. This method ensures accurate coordination between the surgeon excising the tumor and the pathologist who guides the surgeon in re-excision until tumor-free margins are achieved. The first step is to determine the type of the lesion via biopsies if necessary, as the safety margin will be adjusted according to the characteristics of the primary tumor. Lesions involving facial subunits may be an exception, as the required margin may not be planned accordingly in certain critical locations. The second step is to outline the approximate borders of the visually apparent tumor and to draw a safety margin that will serve as the clock face for the orientation of the specimen. Then, the periphery of the circle is numbered through 12 as in a clock (Fig. 1). The hourly markings go through both the excised specimen and the healthy tissue, so that the surgeon knows which part of the excised tissue corresponds to which ‘hour.’ The lesion is excised as a complete circle and a single suture is placed at a pre-determined hourly interval as a guide if the marking is disrupted. After microscopic examination, the pathologist can state which hour slice corresponds to a tumor-positive margin, and further excision can be carried out only in the area of that hour slice. Plastic surgeons need to work very meticulously alongside pathologists, as every millimeter of skin preserved can be used to achieve better aesthetic and functional outcomes. The clockwork technique can be applied to any type and size of lesion. It is also beneficial for tumors that have unpredictable growth patterns, where it is not possible to agree on a standard optimal safety margin, such as dermatofibrosarcoma protuberans. Moreover, in areas where aesthetic and functional preservation are concerns, it helps to preserve more healthy tissue, as further re-excision can be carried out in only onetwelfth of the excisional border. In conclusion, this technique is advantageous because it is an easily applicable and fast method that facilitates optimal communication between the surgeon and pathologist regarding specimen borders, allowing precise re-excisions that can be limited to intervals corresponding to one-twelfth of the surgical margin.Publication Metadata only Histopathologic infiltration pattern predicts metastasis and progression better than pT-Stage and grade in well-differentiated pancreatic neuroendocrine tumors: a proposal for an infiltration-based morphologic grading system(SPRINGERNATURE, 2021) Reid, Michelle; Culci, Pelin Bağcı; Balcı, Serdar; Demirtaş, Deniz; Pehlivanoğlu, Burçin; Saka, Burcu; Memiş, Bahar; Bozkurtlar, Emine; Leblebici, Can Berk; Corobea, Adelina Birceanu; Xue, Yue; Sökmensüer, Cenk; Scarpa, Aldo; Luchini, Claudio; Baştürk, Olca; Taşkın, Orhun Çığ; Armutlu, Ayşe; Erkan, Murat Mert; Kapran, Yersu; Adsay, Nazmi Volkan; Faculty Member; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 166686; 133567; 214689; 168101; 286248N/APublication Metadata only Vulvar inflammatory linear verrucous epidermal nevus: remission with nonsteroidal antiinflammatory cream: case report(Türkiye Klinikleri, 2017) N/A; N/A; Gökalp, Hilal; Armutlu, Ayşe; Doctor; Teaching Faculty; Koç University Hospital; School of Medicine; N/A; 133567Inflammatory linear verrucous epidermal nevus (ILVEN) is usually accompanied by persistent and severe pruritus. It is mostly located in the lower left limb as hyperpigmented or erythematous hyperkeratotic linear papules and/or plaques. Genital/perigenital involvement is extremely rare. It varies in size from very small lesions to the involvement of the whole extremity. The differential diagnosis is broad, including but not limited to lineer psoriasis, lichen striatus, verrucous epidermal nevus, lichen simplex chronicus, linear lichen planus and linear Darier disease and, prognosis is poor. In this report, we present a case of vulvar ILVEN that responded to topical nonsteroidal anti-inflammatory cream.Publication Metadata only Primary peritoneal mesothelioma with clear cell morphology presenting with multiple liver masses: report of a case with a unique VHL Y98fs*24 mutation and indolent clinical course(Lippincott Williams & Wilkins, 2020) Saeed, Ömer A. M.; Zhang, Xin; Saxena, Romil; Armutlu, Ayşe; Teaching Faculty; School of Medicine; 133567Malignant: Peritoneal mesothelioma represents less than a quarter of all malignant mesothelioma cases. Malignant mesothelioma can be classified based on morphology into epithelioid, sarcomatoid, or mixed types. Peritoneal epithelioid mesotheliomawith predominant clear cell features is very rare and mimics various malignancies posing a diagnostic challenge. Here we report a rare case of primary peritoneal mesothelioma with clear cell features presenting with liver masses. A 68-year-old man who had multiple liver nodules on imaging was admitted for worsening abdominal pain. He complained of intermittent abdominal pain for more than 10 years. Longitudinal follow-up of the patients' abdominal images over 10 years showed slowly progressive liver lesions. Microscopic examination of resected tumors revealed pleomorphic epithelioid neoplasm with clear cytoplasm, distinct cell borders, optically clear chromatin, and prominent nucleoli embedded in a vascular stroma. Immunostaining showed that the tumor cells were positive for AE1/3, vimentin, carbonic anhydrase IX, TFE1/33, and Gata3, whereas they were negative for PAX-8, arginase-1, hepatocyte specific antigen, inhibin, S100, DOG1, CD117, CD31, TTF-1, p63, smooth muscle actin, and HMB45. CancerType ID testing favored the diagnosis of mesothelioma with 90% probability, a diagnosis that was further confirmed by calretinin and WT1 positivity. Foundation genomic testing showed VHL Y98fs*24 mutation, a unique genetic mutation that, to our knowledge, was never described before. In summary, this is a rare case of primary peritoneal mesothelioma with clear cell features presenting as liver masses. The tumor had a unique genetic mutation and behaved in an indolent manner in contrast to what is commonly seen in mesotheliomas.Publication Metadata only A difficult diagnosis in a child with renal mass: desmoplastic small round cell tumour of the kidney(Springer, 2018) Aydin, Özkan; N/A; N/A; Armutlu, Ayşe; Baydar, Dilek Ertoy; Teaching Faculty; Faculty Member; School of Medicine; School of Medicine; 133567; 8025N/APublication Metadata only Clinicopathologic and immunohistochemical characteristics of upper gastrointestinal leiomyomas harboring interstitial cells of Cajal: a potential mimicker of gastrointestinal stromal tumor(Elsevier Science inc, 2020) Taşkın, Orhun Çığ; Armutlu, Ayşe; Adsay, Nazmi Volkan; Aslan, Fatih; Kapran, Yersu; Faculty Member; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 166686; 133567; 286248; 219202; 168101Objective: To analyze clinicopathologic characteristics of upper gastrointestinal leiomyomas and to determine the distribution and immunohistochemical features of interstitial cells of Cajal, in order to designate whether they can cause diagnostic challenges. Materials and Methods: Twenty-four upper gastrointestinal leiomyomas (14 esophagus, 10 stomach) were retrieved. CD117, DOG-1 and muscle markers were performed. the staining was analyzed based on the distribution and percentage. interstitial cells of Cajal were distinguished based on their positivity for both CD117 and DOG-1 immunohistochemistry, Along with their morphological features. Results: Mean age of patients was 49 years, M/F ratio was 2.4. Patients with gastric leiomyomas were significantly younger than those with esophageal leiomyomas (41.5 vs. 54.3, p = 0.012). Histologically, leiomyomas were similar to their endometrial counterpart. Immunohistochemically, All tumors had strong/diffuse positivity for muscle markers. CD117 highlighted mast cells in all cases. Three cases had prominently increased mast cells. Both CD117 and DOG-1 also highlighted interstitial cells of Cajal in 24/24 (100%) of cases. interstitial cells of Cajal were distributed in variable proportions, from focal to homogenous. in one case, they constituted 50% of tumor cells. in 16 cases, the distribution was homogenous. Superficial leiomyomas (n = 3) had only focal CD117 and DOG-1 positivity. Conclusion: Upper gastrointestinal leiomyomas harbor expression of CD117 and DOG-1 in entrapped/colonized interstitial cells of Cajal, which can cause a potential pitfall in the differential diagnosis, especially in cases that show prominent immunohistochemical positivity. Evaluation of the immunohistochemistry can be exceptionally challenging in small biopsy/cytology specimens. Careful histologic evaluation of the tumor as well as the recognition of interstitial cells of Cajal will help the pathologist render the accurate diagnosis.Publication Metadata only Tumor genomic profiling to determine tissue origin of cancers of unknown primary: a single institute experience with its utility and impact on patient management(Lippincott Williams and Wilkins (LWW), 2022) Saeed, Omer A. M.; Cheng, Liang; Longe, Harold O.; Saxena, Romil; Armutlu, Ayşe; Teaching Faculty; School of Medicine; 133567Tumor genomic profiling represents a promising tool in diagnosis and management of cancer of unknown primary. We report our experience on the impact of genomic profiling in elucidating primary tumor site, correlation with pathologic findings and patient management. Tissue or cytology specimens from 22 cancers of unknown primary were referred for genomic profiling. Reports were available to review in 18 cases; 3 samples were inadequate for analysis. of the remaining 15 cases, primary tumor site was suggested in 12 cases (80%), whereas it remained indeterminate in 3 (20%). of the 12 cases, molecular profiling was concordant with light microscopy findings in 3 patients, whereas in 2 cases molecular testing identified a sarcoma, contradicting light microscopy and immunohistochemistry findings. The suggested primary was confirmed by additional immunohistochemistry in 1 case and by endoscopic biopsy in another. In 5 cases, follow-up biopsy or additional testing were not considered necessary for patient management. Three patients received palliative care and 12 received various chemotherapy regimens. Five patients died within a year, whereas 9 were alive more than a year after diagnosis, 3 of who were alive >3 years after diagnosis. In conclusion, genomic profiling helped confirm the original diagnosis and suggested primary sites in two third of our cases. Although many patients may be at a disease stage too advanced to withstand further investigations or underg aggressive therapy, molecular testing improves diagnostic accuracy and may thus assist in selection of the most appropriate therapy.Publication Metadata only Infiltration pattern predicts metastasis and progression better than the T-stage and grade in pancreatic neuroendocrine tumors: a proposal for a novel infiltration-based morphologic grading(Elsevier, 2022) Reid, Michelle D.; Bağcı, Pelin; Balcı, Serdar; Pehlivanoğlu, Burçin; Memiş, Bahar; Bozkurtlar, Emine; Leblebici, Can Berk; Birceanu, Adelina; Xue, Yue; Sökmensüer, Cenk; Scarpa, Aldo; Luchini, Claudio; Baştürk, Olca; Taşkın, Orhun Çığ; Armutlu, Ayşe; Demirtaş, Deniz; Saka, Burcu; Erkan, Murat Mert; Kapran, Yersu; Baygül, Arzu Eden; Adsay, Nazmi Volkan; Faculty Member; Teaching Faculty; Undergraduate Student; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 166686; 133567; 371572; 222921; 214689; 168101; 272290; 286248The advancing edge profile is a powerful determinant of tumor behavior in many organs. In this study, a grading system assessing the tumor-host interface was developed and tested in 181 pancreatic neuroendocrine tumors (PanNETs), 63 of which were <=2 cm. Three tumor slides representative of the spectrum (least, medium, and most) of invasiveness at the advancing edge of the tumor were selected, and then each slide was scored as follows. Well-demarcated/encapsulated, 1 point; Mildly irregular borders and/or minimal infiltration into adjacent tissue, 2 points; Infiltrative edges with several clusters beyond the main tumor but still relatively close, and/or satellite demarcated nodules, 3 points; No demarcation, several cellular clusters away from the tumor, 4 points; Exuberantly infiltrative pattern, scirrhous growth, dissecting the normal parenchymal elements, 5 points. The sum of the rankings on the three slides was obtained. Cases with scores of 3-6 were defined as "non/minimally infiltrative" (NI; n = 77), 7-9 as "moderately infiltrative" (MI; n = 68), and 10-15 as "highly infiltrative" (HI; n = 36). In addition to showing a statistically significant correlation with all the established signs of aggressiveness (grade, size, T-stage), this grading system was found to be the most significant predictor of adverse outcomes (metastasis, progression, and death) on multivariate analysis, more strongly than T-stage, while Ki-67 index did not stand the multivariate test. As importantly, cases <=2 cm were also stratified by this grading system rendering it applicable also to this group that is currently placed in "watchful waiting" protocols. In conclusion, the proposed grading system has a strong, independent prognostic value and therefore should be considered for integration into routine pathology practice after being evaluated in validation studies with larger series.