Researcher:
Aria, Mohammad Mohammadi

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Mohammad Mohammadi

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Aria

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Aria, Mohammad Mohammadi

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2018 - 201982020 - 20213

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Now showing 1 - 10 of 11
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    Electrophysiology measurements for studying neural interfaces
    (Elsevier, 2020) N/A; Aria, Mohammad Mohammadi; PhD Student; Graduate School of Sciences and Engineering; N/A
    Electrophysiology Measurements for Studying Neural Interfaces helps readers to choose a proper cell line and set-up for studying different bio-electronic interfaces before delving into the electrophysiology techniques available. Therefore, this book details the materials and devices needed for different types of neural stimulation such as photoelectrical and photothermal stimulations. Also, modern techniques like optical electrophysiology and calcium imaging in this book provides readers with more available approaches to monitor neural activities in addition to whole-cell patch-clamp technology.
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    Three-dimensional neuron-astrocyte construction on matrigel enhances establishment of functional voltage-gated sodium channels
    (Wiley-Blackwell, 2021) N/A; N/A; N/A; N/A; Department of Electrical and Electronics Engineering; N/A; N/A; Karahüseyinoğlu, Serçin; Şekerdağ, Emine; Aria, Mohammad Mohammadi; Taş, Yağmur Çetin; Nizamoğlu, Sedat; Solaroğlu, İhsan; Özdemir, Yasemin Gürsoy; Faculty Member; Researcher; PhD Student; Researcher; Faculty Member; Faculty Member; Faculty Member; Department of Electrical and Electronics Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; N/A; Graduate School of Sciences and Engineering; N/A; College of Engineering; School of Medicine; N/A; 110772; N/A; N/A; N/A; 130295; 102059; 170592
    This study aimed to investigate and compare cell growth manners and functional differences of primary cortical neurons cultured on either poly-d-lysine (PDL) and or Matrigel, to delineate the role of extracellular matrix on providing resemblance to in vivo cellular interactions in nervous tissue. Primary cortical neurons, obtained from embryonic day 15 mice pups, seeded either on PDL- or Matrigel-coated culture ware were investigated by DIC/bright field and fluorescence/confocal microscopy for their morphology, 2D and 3D structure, and distribution patterns. Patch clamp, western blot, and RT-PCR studies were performed to investigate neuronal firing thresholds and sodium channel subtypes Nav1.2 and Nav1.6 expression. Cortical neurons cultured on PDL coating possessed a 2D structure composed of a few numbers of branched and tortuous neurites that contacted with each other in one to one manner, however, neurons on Matrigel coating showed a more complicated dimensional network that depicted tight, linear axonal bundles forming a 3D interacted neuron-astrocyte construction. This difference in growth patterns also showed a significant alteration in neuronal firing threshold which was recorded between 80 < linj > 120 pA on PDL and 2 < linj > 160 pA on Matrigel. Neurons grown up on Matrigel showed increased levels of sodium channel protein expression of Nav1.2 and Nav1.6 compared to neurons on PDL. These results have demonstrated that a 3D interacted neuron-astrocyte construction on Matrigel enhances the development of Nav1.2 and Nav1.6 in vitro and decreases neuronal firing threshold by 40 times compared to conventional PDL, resembling in vivo neuronal networks and hence would be a better in vitro model of adult neurons.
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    Stokes-shift-engineered indium phosphide quantum dots for efficient luminescent solar concentrators
    (American Chemical Society (ACS), 2018) Ow-Yang, Cleva W.; N/A; N/A; N/A; Department of Electrical and Electronics Engineering; N/A; Department of Electrical and Electronics Engineering; Sadeghi, Sadra; Jalali, Houman Bahmani; Melikov, Rustamzhon; Kumar, Baskaran Ganesh; Aria, Mohammad Mohammadi; Nizamoğlu, Sedat; PhD Student; PhD Student; PhD Student; Other; PhD Student; Faculty Member; Department of Electrical and Electronics Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; N/A; N/A; N/A; N/A; 130295
    Luminescent solar concentrators (LSCs) show promise because of their potential for low-cost, large-area, and high-efficiency energy harvesting. Stokes shift engineering of luminescent quantum dots (QDs) is a favorable approach to suppress reabsorption losses in LSCs; however, the use of highly toxic heavy metals in QDs constitutes a serious concern for environmental sustainability. Here, we report LSCs based on cadmium-free InP/ZnO core/shell QDs with type-II band alignment that allow for the suppression of reabsorption by Stokes shift engineering. The spectral emission and absorption overlap was controlled by the growth of a ZnO shell on an InP core. At the same time, the ZnO layer also facilitates the photostability of the QDs within the host matrix. We analyzed the optical performance of indium-based LSCs and identified the optical efficiency as 1.45%. The transparency, flexibility, and cadmium-free content of the LSCs hold promise for solar window applications.
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    Effective neural photostimulation using indium-based type-ii quantum dots
    (American Chemical Society (ACS), 2018) Şahin, Mehmet; Ow-Yang, Cleva W.; N/A; N/A; N/A; N/A; Department of Electrical and Electronics Engineering; Department of Chemical and Biological Engineering; Department of Electrical and Electronics Engineering; Jalali, Houman Bahmani; Aria, Mohammad Mohammadi; Dikbaş, Uğur Meriç; Sadeghi, Sadra; Kumar, Baskaran Ganesh; Kavaklı, İbrahim Halil; Nizamoğlu, Sedat; PhD Student; PhD Student; Master Student; PhD Student; Other; Faculty Member; Faculty Member; Department of Chemical and Biological Engineering; Department of Electrical and Electronics Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; College of Engineering; College of Engineering; N/A; N/A; N/A; N/A; N/A; 40319; 130295
    Light-induced stimulation of neurons via photoactive surfaces offers rich opportunities for the development of therapeutic methods and high-resolution retinal prosthetic devices. Quantum dots serve as an attractive building block for such surfaces, as they can be easily functionalized to match the biocompatibility and charge transport requirements of cell stimulation. Although indium based colloidal quantum dots with type-I band alignment have attracted significant attention as a nontoxic alternative to cadmium-based ones, little attention has been paid to their photovoltaic potential as type-II heterostructures. Herein, we demonstrate type-II indium phosphide/zinc oxide core/shell quantum dots that are incorporated into a photoelectrode structure for neural photostimulation. This induces a hyperpolarizing bioelectrical current that triggers the firing of a single neural cell at 4 mu W mm(-2), 26-fold lower than the ocular safety limit for continuous exposure to visible light. These findings show that nanomaterials can induce a biocompatible and effective biological junction and can introduce a route in the use of quantum dots in photoelectrode architectures for artificial retinal prostheses.
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    Quantum dot white leds with high luminous efficiency
    (Optical Soc Amer, 2018) N/A; Department of Electrical and Electronics Engineering; N/A; N/A; N/A; Department of Electrical and Electronics Engineering; Sadeghi, Sadra; Kumar, Baskaran Ganesh; Melikov, Rustamzhon; Aria, Mohammad Mohammadi; Jalali, Houman Bahmani; Nizamoğlu, Sedat; PhD Student; Other; PhD Student; PhD Student; PhD Student; Faculty Member; Department of Electrical and Electronics Engineering; Graduate School of Sciences and Engineering; College of Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; N/A; N/A; N/A; N/A; 130295
    Colloidal quantum dots (QDs) have attracted significant attention in the last three decades due to high quantum yield (QY) and tunable electronic properties via quantum confinement effect and material composition. However, their utilization for efficient solid-state lighting sources has remained a challenge due to the decrease of QY from the synthesis batch in the liquid state to the host matrix in the solid state, which is also known as the host material effect. Here, we suppress the host material effect by simple liquid-state integration in light-emitting diodes (LEDs) that lead to a luminous efficiency of 64 lm/W for red, green, blue (RGB)-based and 105 lm/W for green, blue (GB)-based white light generation. For that, we maximized the QY of red- and green-emitting QDs by optimizing synthesis parameters and integrated efficient QDs with QY up to 84% on blue LED dies in liquid form at appropriate injection amounts for high-efficiency white lighting. Liquid-state integration showed two-fold and six-fold enhancement of efficiency in comparison with incorporation of QDs in polydixnethylsiloxane film and close-packed formation, respectively. Our theoretical calculations predicted that the luminous efficiency of liquid QD-LEDs can reach over 200 lm/W. Therefore, this study paves the way toward ultra-high-efficiency QD-based lighting.
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    Structural control of InP/ZnS core/shell quantum dots enables high-quality white LEDs
    (Iop Publishing Ltd, 2018) Ow-Yang, Cleva W; Department of Electrical and Electronics Engineering; N/A; N/A; N/A; N/A; Department of Electrical and Electronics Engineering; Kumar, Baskaran Ganesh; Sadeghi, Sadra; Melikov, Rustamzhon; Aria, Mohammad Mohammadi; Jalali, Houman Bahmani; Nizamoğlu, Sedat; Other; PhD Student; PhD Student; PhD Student; PhD Student; Faculty Member; Department of Electrical and Electronics Engineering; College of Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; N/A; N/A; N/A; N/A; 130295
    Herein, we demonstrate that the structural and optical control of InP-based quantum dots (QDs) can lead to high-performance light-emitting diodes (LEDs). Zinc sulphide (ZnS) shells passivate the InP QD core and increase the quantum yield in green-emitting QDs by 13-fold and redemitting QDs by 8-fold. The optimised QDs are integrated in the liquid state to eliminate aggregation-induced emission quenching and we fabricated white LEDs with a warm, neutral and cool-white appearance by the down-conversion mechanism The QD-functionalized white LEDs achieve luminous efficiency (LE) up to 14.7 lm W-1 and colour-rendering index up to 80. The structural and optical control of InP/ZnS core/shell QDs enable 23-fold enhancement in LE of white LEDs compared to ones containing only QDs of InP core.
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    Perovskite-based optoelectronic biointerfaces for non-bias-assisted photostimulation of cells
    (Wiley, 2019) Cameron, Petra J.; Pering, Samuel R; N/A; Department of Electrical and Electronics Engineering; N/A; N/A; N/A; N/A; Department of Chemical and Biological Engineering; Department of Electrical and Electronics Engineering; Aria, Mohammad Mohammadi; Srivastava, Shashi Bhushan; Şekerdağ, Emine; Dikbaş, Uğur Meriç; Sadeghi, Sadra; Özdemir, Yasemin Gürsoy; Kavaklı, İbrahim Halil; Nizamoğlu, Sedat; PhD Student; Researcher; Researcher; Master Student; PhD Student; Faculty Member; Faculty Member; Faculty Member; Department of Chemical and Biological Engineering; Department of Electrical and Electronics Engineering; Graduate School of Sciences and Engineering; College of Engineering; Graduate School of Health Sciences; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; School of Medicine; College of Engineering; College of Engineering; N/A; N/A; N/A; N/A; N/A; 170592; 40319; 130295
    Organohalide perovskites have attracted significant attention for efficient solar energy harvesting. They boost the photoelectrical conversion efficiency of the solution-processable solar cells because of having a nearly 100% internal quantum efficiency, operating in both narrow- and broadband spectral regimes, near-infrared sub-bandgap absorption, and high diffusion length. At the same time, these optoelectronic properties make it an ideal candidate for photostimulation of neurons. However, the biocompatibility of perovskite and its longevity in a cell medium constitute a major limitation to use it for biological interfaces. Here, high-level perovskite stability and biocompatibility are shown by forming hydrophobic perovskite microcrystals and encapsulating them within a polydimethylsiloxane layer. For effective and safe photostimulation of cells perovskite microcrystals are interfaced with poly(3-hexylthiophene-2,5-diyl) (P3HT) polymer for dissociation of the photogenerated charge carriers, which leads to non-bias-assisted cell stimulation. The results point out a new direction for the use of perovskite for photomedicine.
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    Nanoengineering InP quantum dot-based photoactive biointerfaces for optical control of neurons
    (Frontiers, 2021) Ulgut, Burak; Department of Electrical and Electronics Engineering; Department of Chemical and Biological Engineering; N/A; Nizamoğlu, Sedat; Kavaklı, İbrahim Halil; Şahin, Afsun; Karatüm, Onuralp; Aria, Mohammad Mohammadi; Eren, Güncem Özgün; Yıldız, Erdost; Melikov, Rustamzhon; Srivastava, Shashi Bhushan; Sürme, Saliha; Doğru-Yüksel, Itır Bakış; Jalali, Houman Bahmani; Faculty Member; Faculty Member; Faculty Member; PhD Student; Researcher; Teaching Faculty; PhD Student; Department of Electrical and Electronics Engineering; Department of Chemical and Biological Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); College of Engineering; School of Medicine; Graduate School of Sciences and Engineering; Graduate School of Health Sciences; 130295; 40319; 171267; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A
    Light-activated biointerfaces provide a non-genetic route for effective control of neural activity. InP quantum dots (QDs) have a high potential for such biomedical applications due to their uniquely tunable electronic properties, photostability, toxic-heavy-metal-free content, heterostructuring, and solution-processing ability. However, the effect of QD nanostructure and biointerface architecture on the photoelectrical cellular interfacing remained unexplored. Here, we unravel the control of the photoelectrical response of InP QD-based biointerfaces via nanoengineering from QD to device-level. At QD level, thin ZnS shell growth (similar to 0.65 nm) enhances the current level of biointerfaces over an order of magnitude with respect to only InP core QDs. At device-level, band alignment engineering allows for the bidirectional photoelectrochemical current generation, which enables light-induced temporally precise and rapidly reversible action potential generation and hyperpolarization on primary hippocampal neurons. Our findings show that nanoengineering QD-based biointerfaces hold great promise for next-generation neurostimulation devices.
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    Silk-based aqueous microcontact printing
    (American Chemical Society (ACS), 2018) Department of Electrical and Electronics Engineering; N/A; Department of Physics; Department of Molecular Biology and Genetics; Kumar, Baskaran Ganesh; Melikov, Rustamzhon; Aria, Mohammad Mohammadi; Yalçın, Aybike Ural; Begar, Efe; Sadeghi, Sadra; Güven, Kaan; Nizamoğlu, Sedat; PhD Student; PhD Student; Faculty Member; Faculty Member; Department of Electrical and Electronics Engineering; Department of Physics; Department of Molecular Biology and Genetics; College of Engineering; Graduate School of Sciences and Engineering; N/A; N/A; N/A; N/A; N/A; N/A; 52290; 130295
    Lithography, the transfer of patterns to a film or substrate, is the basis by which many modern technological devices and components are produced. However, established lithographic approaches generally use complex techniques, expensive equipment, and advanced materials. Here, we introduce a water-based microcontact printing method using silk that is simple, inexpensive, ecofriendly, and recyclable. Whereas the traditional microcontact printing technique facilitates only negative lithography, the synergetic interaction of the silk, water, and common chemicals in our technique enables both positive and negative patterning using a single stamp. Among diverse application possibilities, we exemplify a proof of concept of the method through optimizing its metal lift-off process and demonstrate the fabrication of electromagnetic metamaterial elements on both solid and flexible substrates. The results indicate that the method demonstrated herein is universally applicable to device production and technology development.
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    PublicationOpen Access
    Technology advancements in blood coagulation measurements for point-of-care diagnostic testing
    (Frontiers, 2019) Erten, Ahmet; N/A; N/A; Yalçın, Özlem; Aria, Mohammad Mohammadi; Faculty Member; School of Medicine; Graduate School of Sciences and Engineering; 218440; N/A
    In recent years, blood coagulation monitoring has become crucial to diagnosing causes of hemorrhages, developing anticoagulant drugs, assessing bleeding risk in extensive surgery procedures and dialysis, and investigating the efficacy of hemostatic therapies. In this regard, advanced technologies such as microfluidics, fluorescent microscopy, electrochemical sensing, photoacoustic detection, and micro/nano electromechanical systems (MEMS/NEMS) have been employed to develop highly accurate, robust, and cost-effective point of care (POC) devices. These devices measure electrochemical, optical, and mechanical parameters of clotting blood. Which can be correlated to light transmission/scattering, electrical impedance, and viscoelastic properties. In this regard, this paper discusses the working principles of blood coagulation monitoring, physical and sensing parameters in different technologies. In addition, we discussed the recent progress in developing nanomaterials for blood coagulation detection and treatments which opens up new area of controlling and monitoring of coagulation at the same time in the future. Moreover, commercial products, future trends/challenges in blood coagulation monitoring including novel anticoagulant therapies, multiplexed sensing platforms, and the application of artificial intelligence in diagnosis and monitoring have been included.