Researcher:
Bulut, Selma

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PhD Student

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Selma

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Bulut

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Bulut, Selma

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2012 - 20173

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Researcher Of Publications: search.filters.isAuthorOfPublication.b19acef8-55ae-4cd5-947c-1c500f87e4a1

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Now showing 1 - 3 of 3
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    MEMS biosensor for blood plasma viscosity measurements
    (Elsevier Science Bv, 2012) N/A; Department of Electrical and Electronics Engineering; Department of Mechanical Engineering; N/A; N/A; Department of Molecular Biology and Genetics; Department of Chemical and Biological Engineering; Department of Mechanical Engineering; Department of Electrical and Electronics Engineering; Çakmak, Onur; Elbüken, Çağlar; Ermek, Erhan; Bulut, Selma; Kılınç, Yasin; Barış, İbrahim; Kavaklı, İbrahim Halil; Alaca, Burhanettin Erdem; Ürey, Hakan; PhD Student; Researcher; Other; PhD Student; PhD Student; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; Department of Molecular Biology and Genetics; Department of Chemical and Biological Engineering; Department of Mechanical Engineering; Department of Electrical and Electronics Engineering; Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM); Graduate School of Sciences and Engineering; College of Engineering; College of Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Sciences; College of Engineering; College of Engineering; College of Engineering; N/A; N/A; N/A; N/A; N/A; 111629; 40319; 115108; 8579
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    PublicationOpen Access
    MerR and ChrR mediate blue light induced photo-oxidative stress response at the transcriptional level in Vibrio cholerae
    (Nature Publishing Group (NPG), 2017) Department of Chemical and Biological Engineering; Tardu, Mehmet; Bulut, Selma; Kavaklı, İbrahim Halil; PhD Student; Department of Chemical and Biological Engineering; College of Engineering; N/A; N/A; 40319
    Blue light (BL) is a major environmental factor that affects the physiology, behavior, and infectivity of bacteria as it contributes to the generation of reactive oxygen species (ROS) while increasing photo-oxidative stress in cells. However, precise photo-oxidative response mechanism in non-phototrophic bacteria is yet to be elucidated. In this study, we investigated the effect of BL in Vibrio cholerae by using genetics and transcriptome profiling. Genome-wide analysis revealed that transcription of 6.3% of V. cholerae genes were regulated by BL. We further showed that BL enhances ROS production, which is generated through the oxidative phosphorylation. To understand signaling mechanisms, we generated several knockouts and analyzed their transcriptome under BL exposure. Studies with a double-knockout confirm an anti-sigma factor (ChrR) and putative metalloregulatory-like protein (MerR) are responsible for the genome-wide regulation to BL response in V. cholerae. Collectively, these results demonstrate that MerR-like proteins, in addition to ChrR, are required for V. cholerae to mount an appropriate response against photo-oxidative stress induced by BL. Outside its natural host, V. cholerae can survive for extended periods in natural aquatic environments. Therefore, the regulation of light response for V. cholerae may be a critical cellular process for its survival in these environments.
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    PublicationOpen Access
    The photolyase/cryptochrome family of proteins as DNA repair enzymes and transcriptional repressors
    (Wiley, 2017) Aydın, Cihan; Department of Chemical and Biological Engineering; Department of Molecular Biology and Genetics; Kavaklı, İbrahim Halil; Barış, İbrahim; Tardu, Mehmet; Gül, Şeref; Öner, Haşimcan; Bulut, Selma; Yarparvar, Darya; Ustaoğlu, Pınar; Teaching Faculty; PhD Student; Researcher; Department of Chemical and Biological Engineering; Department of Molecular Biology and Genetics; College of Engineering; College of Sciences; 40319; 111629; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A
    Light is a very important environmental factor that governs many cellular responses in organisms. As a consequence, organisms possess different kinds of light-sensing photoreceptors to regulate their physiological variables and adapt to a given habitat. The cryptochrome/photolyase family (CPF) includes photoreceptors that perform different functions in different organisms. Photolyases repair ultraviolet-induced DNA damage by a process known as photoreactivation using photons absorbed from the blue end of the light spectrum. On the other hand, cryptochromes act as blue light circadian photoreceptors in plants and Drosophila to regulate growth and development. In mammals, cryptochromes have light-independent functions and are very important transcriptional regulators that act at the molecular level as negative transcriptional regulators of the circadian clock. In this review, we highlight current knowledge concerning the structural and functional relationships of CPF members.