Researcher:
Karadana, Gökçe Akgül

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Doctor

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Gökçe Akgül

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Karadana

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Karadana, Gökçe Akgül

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2017 - 20184

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    Valsalva maneuver techniques for supraventricular tachycardias: Which and how?
    (Sage Publications Ltd, 2017) N/A; N/A; Ekinci, Salih; Karadana, Gökçe Akgül; Arş, Eda; Musalar, Ekrem; Aktaş, Can; Doctor; Doctor; Doctor; Doctor; Doctor; Faculty Member; N/A; N/A; N/A, N/A; N/A; School of Medicine; Koç University Hospital; Koç University Hospital; Koç University Hospital; Koç University Hospital; Koç University Hospital; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; 24297
    Study objective: While some research has been done on Valsalva maneuvers in treating supraventricular tachycardia, there is no standardized algorithm on which technique has been the most effective for the termination of supraventricular tachycardias. In this study, we compare different Valsalva maneuver techniques in order to determine the exact technique needed for maximal vagal response. Methods: This was a repeated measures clinical study, which enlisted a sample of healthy adult volunteers. Participants performed four different Valsalva maneuver techniques (40 mm Hg10 s, 40 mm Hg15 s, 50 mm Hg10 s, and 50 mm Hg15 s) while lying in a supine position. The maneuvers were repeated three times. An electrocardiography printout was obtained during each trial, and heart rate differences between pre-maneuver and post-maneuver were measured. Results: Among the 97 volunteers who participated in the study, 7 were excluded because the target Valsalva maneuver pressures were not reached, and 1 volunteer was excluded due to T-wave inversion that developed after Valsalva maneuver. We enrolled 89 participants. There was no significant difference in the heart rate decrease among the four techniques. In addition, there was no difference between the vagal responses in terms of age, gender, and body mass index. Conclusion: This study shows that the four different Valsalva maneuver techniques were not superior to one another in terms of decreased heart rate.
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    PublicationOpen Access
    Diagnostic value of signal peptide, CUB (Complement C1r/C1s, Uegf, and Bmp1), EGF (Epidermal Growth Factor)-like domain-containing Protein 1 (SCUBE1) and Chemerin in experimental testicular torsion
    (Aves, 2017) Yeniocak, Selman; Saraç, Fatma; Olgaç, Vakur; Kalkan, Asım; Düz, Muhammed Emin; Koldaş, Macit; Department of Emergency; Karadana, Gökçe Akgül; Faculty Member; Department of Emergency; School of Medicine
    Aim: The purpose of this experimental study was to investigate the potential diagnostic value of the platelet activation marker SCUBE1 [signal peptide, CUB (complement C1r/C1s, Uegf, and Bmp1), and EGF (epidermal growth factor)-like domain-containing protein 1] and the adipocytokine chemerin in a prepubertal rat model of testicular torsion (TT). Materials and Methods: Twenty-eight male rats were used for this study. They were randomly assigned into one of the four groups, each containing seven rats. No additional procedure other than a sham operation was performed on the control group (group IV). The other subjects comprised the torsion ischemia groups (groups I, II, and III). Blood specimens were collected after 30 min (group I), 2 h (group II), or 4 h (group III) using the intracardiac method. For group IV, which was the sham operation group, blood specimens were collected after 4 h, and testis tissue specimens were extracted by orchiectomy for histopathological examination. Results: No statistically significant change was determined in SCUBE1 levels of rats exposed to torsion. Also, no significant difference was observed between SCUBE1 levels of rats exposed to torsion and those of the control group. Statistically significant change was determined in chemerin levels during observation in rats exposed to torsion. This change was statistically significant between groups I and III. There was no statistically significant difference between chemerin levels of rats exposed to torsion (groups I, II, and III) and those of the control group (group IV). Conclusion: We observed no statistically significant differences when plasma SCUBE1 and chemerin levels of rats subjected to TT were compared with a control group in this study.
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    PublicationOpen Access
    The diagnostic value of irisin in patients with acute abdominal pain: a preliminary study
    (Kare Yayıncılık, 2018) Yeniocak, Selman; Karcıoğlu, Özgür; Kalkan, Asım; Saraç, Fatma; Keklikkıran, Zehra Zeynep; Gümüş, Alper; Koldaş, Macit; Korkut, Semih; N/A; Karadana, Gökçe Akgül; Doctor; School of Medicine
    Background: the aim of this study was to investigate the prognostic value of irisin by examining the serum level of this smooth muscle protein in patients presenting at the emergency department (ED) with acute abdominal pain. Methods: this research was performed as a single-center, prospective, cross-sectional study. In all, 213 adult patients presenting at the ED with acute abdominal pain and 140 healthy controls were enrolled. The serum irisin level was correlated with the leukocyte, C-reactive protein, amylase, and creatine kinase values. The irisin level was compared between groups of those who were admitted or discharged, and those who received surgical or medical treatment. Results: the mean irisin level of the 213 patients and the 140 controls was 6.81 +/- 3.17 mcg/mL vs. 5.69 +/- 2.08 mcg/mL. The mean irisin value of the hospitalized patients (7.98 +/- 3.1 1 mcg/mL) was significantly higher than that of the discharged patient group (6.38 +/- 3.09 mcg/mL) and the controls (control vs. discharged: p=0.202; control vs. hospitalized: p<0.001; discharged vs. hospitalized: p=0.001). When compared with that of the control group, the irisin level was significantly higher in patients with gall bladder diseases, urolithiasis, and acute appendicitis (p=0.001, p=0.007, p=0.007). Conclusion: the serum irisin level in patients with abdominal pain may serve as a guide in diagnostic decision-making and determining the prognosis for cases of acute abdominal pain involving luminal obstruction in tubular intra-abdominal organs.
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    PublicationOpen Access
    Demographic and clinical characteristics among Turkish homeless patients presenting to the emergency department
    (Elsevier, 2017) Gökmen, Necati; Barış, İbrahim; Öçmen, Elvan; Yılmaz, Osman; Günerli, Ali; Karadana, Gökçe Akgül; Doctor; Koç University Hospital
    Objective: Since the homeless are at greater risk of encountering health problems than the general population, the reasons for and incidence of their presentations to emergency departments also vary. The purpose of this study was to determine the sociodemographic and clinical characteristics of Turkish homeless patients who brought to the emergency department by ambulance. Materials and methods: The records of homeless adult patients brought to the ED by 112 emergency service ambulance teams over a 1-year period from January to December, 2014, were examined retrospectively.Results: Thirty-six (21.56%) of the homeless patients enrolled in the study presented due to trauma, and 131 (78.44%) due to non-traumatic causes. One hundred thirty-seven (82.04%) of the total patient group were male. The mean age of the non-trauma patients was 47.3 +/- 15.2 years (range, 18-81 years), and the mean age of the trauma patients was 36.9 +/- 14.4 years (range, 18-63 years). The most common reason for presentation among patients prese nting to the emergency department for non-trauma reasons was clouded consciousness (n = 39, 23.35%), followed by general impaired condition (n = 26, 15.57%), respiratory difficulty (n = 25 14.97%) and abdominal pain (n = 21, 12.57%). The most common reason for presentation among trauma cases was traffic accidents (n = 13, 7.78%), followed by sharp implement injury (n = 9, 5.39%). Four (2.4%) homeless patients died in the emergency department, three (%1.8) homeless patients discharged from the emergency department, and the remaining 160 (95.8%) were admitted to the hospital. Conclusion: Homeless patients may present to the emergency department due to traumatic or non-traumatic causes. Admission levels are high among these patients, who may have many acute and chronic problems, and appropriate precautions must be taken in the management of these subjects in the emergency department. Copyright (C) 2017 The Emergency Medicine Association of Turkey. Production and hosting by Elsevier B.V. on behalf of the Owner. This is an open access article under the CC BY-NC-ND license.