Researcher:
Genç, Herdem Aslan

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Herdem Aslan

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Genç

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Genç, Herdem Aslan

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2020 - 20228

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    Validity and reliability of the Turkish version of the adult adhd self-report screening scale for DSM-5
    (Galenos Yayınevi, 2021) Yorguner, Nese; Bulut, Serkut; Bulut, Gresa Carkaxhiu; Aydemir, Omer; Yazgan, Yanki; Genç, Herdem Aslan; Faculty Member; School of Medicine; 177866
    Background: Approximately half of the children with attention-deficit hyperactivity disorder continue to meet diagnostic criteria in adulthood. The prevalence of adult attention-deficit hyperactivity disorder is reported between 2.5% and 4.4% and is associated with significant impairment in quality of life and increased psychiatric comorbidity. Attention-deficit hyperactivity disorder in adults remains mostly undiagnosed and/or untreated despite the availability of effective treatments. The majority of people who do not receive necessary treatment are in the nonclinical or nonpsychiatric clinical population. Screening is an important step for diagnosing adults with attention-deficit hyperactivity disorder. Yet, there are no valid and reliable screening questionnaires calibrated for the Diagnostic and Statistical Manual for Mental Disorders-5 in Turkish. Aims: We aimed to test the reliability and the validity of the Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-5 screening questionnaire designed according to DSM-5 in the Turkish population. Study Design: Methodological and cross-sectional study. Methods: The translation was carried out according to the World Health Organization Composite International Diagnostic Interview translation guide using a linguistic adaptation approach. We used a convenience sampling method to recruit an individual with adult attention-deficit hyperactivity disorder (n = 68) and a control group (n = 68). The participants completed a sociodemographic form, 6-items Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-5, and the previous version 18-items Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-v1.1 for the concurrent validity analysis. For the diagnostic validity, clinical diagnosis made by psychiatrists according to the Diagnostic and Statistical Manual for Mental Disorders-5 criteria was used. Internal consistency and item-total correlation coefficients, exploratory factor analyses, correlation with Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-v1.1, and receiver operating characteristic curve analysis were conducted. Results: The internal consistency measured by Cronbach alpha was 0.869. Item-total correlation coefficients were calculated to be between 0.602 and 0.717, and the correlations were statistically significant (P < 0.0001). The Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-5 showed to have a unidimensional factor structure explaining 60.54% of the variance. The correlation between Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-5 and Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-v1.1 total score was calculated as 0.992 (P < 0.0001), and that between Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-5 and Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-v1.1 attention-deficit subdimension was 0.868 (P < 0.0001). In the receiver operating characteristic analysis of Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-5, the area under the curve was found to be 0.916. The cut-off score was calculated as 9 of 10 with a sensitivity of 85.2% and specificity of 89.7%. Conclusion: Adult Attention-Deficit Hyperactivity Disorder Self-Report Scale-5 is a valid and reliable self-report measure to assess and screen attention-deficit hyperactivity disorder in the Turkish population. It may be useful for both clinical and population studies.
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    Predictors of ADHD persistence in elementary school children who were assessed in earlier grades: a prospective cohort study from Istanbul, Turkey
    (Elsevier, 2021) Gokce, Sebla; Yazgan, Yanki; Bulut, Gresa Carkaxhiu; Kayan, Esengul; Findik, Onur Tugce Poyraz; Ayaz, Ayse Burcu; Yusufoglu, Canan; Ayyildiz, Didem; Budak, Burcu; Atabay, Ender; Yilmaz, Sultan Seval; Kaytanli, Umut; Akin, Elif; N/A; Genç, Herdem Aslan; Faculty Member; School of Medicine; Koç University Hospital; 177866
    Background: Attention-deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorders among school-age children worldwide. In a more recent follow-up study, Biederman et al. found that 78% of children diagnosed with ADHD between the ages of 6-17 years continued to have a full (35%) or a partial persistence after eleven years. Objective: In this study, it was aimed to identify the factors contributing to the persistence of ADHD symptoms in elemantary school children who were prospectively assessed both in their earlier and upper grades. Methods: The sample was drawn from a previous community-based study where ADHD symptoms in 3696 first/or second graders were examined in regard to their school entry age. Two years after, the families of the children that participated in the initial study were called by phone and invited to a re-evaluation session. Among those who were reached, 154 were consequently eligible and were assessed with Swanson, Nolan and Pelham questionnaire (SNAP-IV), Conners' rating scales (CRS) and the Kiddie schedule for affective disorders and schizophrenia (K-SADS). Results: of the 154 children, 81 had been evaluated to have "probable ADHD" by the initial interview. Among these 81 children, 50 (61.7%) were indeed diagnosed with ADHD after two years. Initial scores of the teacher reported SNAP-IV inattention subscale predicted the ADHD diagnosis after two years, with an odds ratio of 1.0761 (p = 0.032, Wald: 4.595). Conclusions: Our results suggest that high inattention symptom scores reported by the teacher in the earlier grades, might predict an ADHD diagnosis in upper grades.
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    The impact of the arts on hospital adaptation and treatment cooperation for pediatric patients with cancer
    (Wiley, 2022) Huzmeli, Hazal; Kebudi, Rejin; N/A; N/A; Genç, Herdem Aslan; Özcan, Aslıhan; Faculty Member; Other; School of Medicine; N/A; N/A; School of Medicine; Koç University Hospital; 177866; N/A
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    PublicationOpen Access
    Children with supracondylar humerus fractures have an increased risk of attention deficit hyperactivity disorder
    (Universa Press, 2021) Genç, Erdinç; Bulut, Gresa Carkaxhiu; Genç, Herdem Aslan; Faculty Member; Koç University Hospital
    Children with attention deficit hyperactivity disorder (ADHD) have an increased risk of sustaining fractures during their preschool years. Supracondylar humerus fractures (SHFs) comprise the majority of fracture surgeries in the pediatric age range. We hypothesized that ADHD symptoms would be present in children with SHFs, and this characteristic trauma may be associated with an ADHD diagnosis. Thus, we compared the ADHD symptoms of children with and without SHFs. Further, we compared the trauma characteristics, gender, proneness to injury, and presence of prior trauma history of children diagnosed with and without ADHD. We recruited 41 children who were admitted to emergency service with an SHF and 41 age- and gender-matched children without a fracture history. A semi-structured diagnostic interview and a Swanson Nolan Pelham questionnaire were used to obtain data about ADHD symptoms. A clinical intake form was utilized for further clinical data. ADHD symptoms were significantly higher in the fracture group; male gender, parent- reported proneness to injury, and prior history of trauma were significantly associated with ADHD. Orthopedic surgeons may provide early detection of ADHD by using screening tools or asking questions to caregivers and making referrals when needed. This may lead to prevention of further injuries.
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    PublicationOpen Access
    Validity and reliability of the Turkish version of the adult ADHD self-report screening scale for DSM-5
    (Galenos Yayınevi, 2020) Yorguner, Neşe; Bulut, Serkut; Bulut, Gresa Carkaxhiu; Aydemir, Ömer; Yazgan, Yankı; Genç, Herdem Aslan; Faculty Member
    Background: Approximately half of the children with Attention-deficit/hyperactivity disorder (ADHD) continue to meet diagnostic criteria in adulthood. The prevalence of adult ADHD is reported between 2.5% and 4.4% and is associated with significant impairment in quality of life and increased psychiatric comorbidity. ADHD in adults remains mostly undiagnosed and/or untreated despite the availability of effective treatments. Majority of people who do not receive necessary treatment are in the non-clinical, or non-psychiatric clinical population. Screening is an important step for diagnosing adults with ADHD. Yet there are no valid and reliable screening questionnaires calibrated for DSM-5 in Turkish. Aims: we aimed to test the reliability and the validity of the ASRS-5 screening questionnaire designed according to DSM-5 in the Turkish population. Study design: methodological and cross-sectional study Methods: The translation was carried on according to the WHO-CIDI translation guide using a linguistic adaptation approach. We used a convenience sampling method to recruit an adult ADHD group (n=68) and a control group (n=68). The participants completed a sociodemographic form, six items ASRS-5 and a previous version 18 items ASRS v1.1 for the concurrent validity analysis. For the diagnostic validity clinical diagnosis made by psychiatrists according to DSM-5 criteria was used. Internal consistency and item-total correlation coefficients, exploratory factor analyses, correlation with ASRS v1.1 and ROC curve analysis were conducted. Results: the internal consistency measured by Cronbach alpha was 0.869. Item-total correlation coefficients were calculated to be between 0.602 and 0.717 and the correlations were statistically significant (p<0.0001). The ASRS-5 showed to have a unidimensional factor structure explaining the 60.54% of the variance. The correlation between ASRS-5 and ASRS v1.1 total score was calculated as 0.992 (p<0.0001), between ASRS-5 and ASRS v1.1 attention deficit sub-dimension as 0.868 (p<0.0001). In the ROC analysis of ASRS-5, the area under the curve was found to be 0.916. The cut-off score was calculated as 9/10 with a sensitivity of 85.2% and specificity as 89.7%. Conclusion: our data suggests that ASRS-5 is a valid and reliable self-report measure to assess and screen ADHD in Turkish population. It may be useful for both clinical and population studies.
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    PublicationOpen Access
    Behavioral implications of the Covid-19 process for autism spectrum disorder, and individuals' comprehension of and reactions to the pandemic conditions
    (Frontiers, 2020) Mutluer, Tuba; Doenyas, Ceymi; Genç, Herdem Aslan; Faculty Member; PhD Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Koç University Hospital; 305311; N/A; N/A
    During disasters and pandemics, vulnerable populations such as patients with mental conditions are known to be overly influenced. Yet, not much is known about how the individuals with autism spectrum disorder (ASD), one of the most common neurodevelopmental conditions globally with a prevalence of 1%, are affected from health-related disasters, especially the current Covid-19 pandemic. Therefore, we conducted an investigation of how individuals with ASD responded to Covid-19 in terms of comprehension and adherence to implemented measures; changes in their behavioral problems; and how their caregivers' anxiety levels relate with these behavioral changes. Our sample consisted of 87 individuals with ASD (15 girls; ages ranged from 3-29, with an average of 13.96 +/- 6.1). The majority of our sample had problems understanding what Covid-19 is and the measures it requires. They also had challenges in implementing social distance and hygiene-related regulations of the pandemic. The majority stopped receiving special education during this period. We observed a Covid-19-related clinical presentation that resembled PTSD in individuals with ASD in terms of increased stereotypies, aggression, hypersensitivity, behavioral problems, and sleep and appetite alterations. All subscales of Aberrant Behavior Checklist (ABC) differed significantly between before and after the pandemic conditions. The number of hours the children slept significantly decreased from before to during Covid-19. The anxiety levels of caregivers were high and correlated with the current behavioral problem levels of their children, but not with the level of their behavioral problems before the pandemic. The difference in ABC total score and specifically the lethargy/social withdrawal subscale score predicted parents' anxiety score. Our results suggest that the Covid-19 period inflicts specific challenges to individuals with ASD and their caregivers, underlining the need for targeted, distance special education interventions and other support services for this population.
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    PublicationOpen Access
    Population-based psychiatric comorbidity in children and adolescents with autism spectrum disorder: a meta-analysis
    (Frontiers, 2022) Can, Merve; Münir, Kerim; Mutluer, Tuba; Genç, Herdem Aslan; Eser, Hale Yapıcı; Ertınmaz, Beliz; Faculty Member; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Koç University Hospital; 305311; 177866; N/A; 134359; N/A
    Psychiatric comorbidity in autism spectrum disorder (ASD) is a subject of critical scientific importance, affecting the quality of life, prognosis, and functional outcomes. The prevalence of psychiatric disorders vary considerably according to variables such as index subject characteristics, study setting, sampling frame, diagnostic methods used, as well as country of geographic origin. To date, most studies comprise clinical or treatment referral samples in tertiary care or subjects enrolled in clinical trials and genetic cohort collections. Such samples carry the potential for overestimation of both the frequency and severity of psychiatric comorbidity. A systematic literature search was performed using PubMed and Web of Science databases restricted to population-based study publications in the English between May 1, 2015, and May 31, 2020. A comprehensive keyword list was generated to investigate co-occurrence of psychiatric disorders in children and adolescents with ASD. A wide range of DSM-5 based disorders such as anxiety, mood, ADHD, intellectual disability/intellectual developmental disorder, eating/feeding, gender dysphoria and sleep-wake disorders were assessed. Initial search revealed a total of 1674 articles after removal of duplicates. Two independent researchers conducted a parallel-blinded screening process to identify the eligible studies based on titles and abstracts; 39 studies were analyzed in the current review. The main findings show prevalence estimates of 22.9% (95% CI: 17.7- 29.2) for intellectual disability; 26.2% (22-31) for attention-deficit hyperactivity disorder; 11.1% (8.6-14.1) for anxiety disorders; 19.7% (11.9-30.7) for sleep disorders; 7% (5.2- 9.3) for disruptive disorders; 2% (1.3- 3.1) for bipolar disorders; 2.7% (1.8- 4.2) for depression; 1.8% (0.4-8.7) for obsessive-compulsive disorder; and 0.6% (0.3-1.1) for psychosis. Psychiatric comorbidity in population-based studies is lower than in clinical and referred samples. However, our results also indicate that the frequency of psychiatric comorbidity in children and adolescents with ASD in the population context is considerable, without the influence of referral bias implicit in clinical and treatment samples. There is a need for better targeted diagnostic tools to detect psychiatric comorbidity in children and youth in future population-based studies, as an essential component in providing care as well as new insights into the nature and mechanisms of its underlying associations.
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    PublicationOpen Access
    Attention-deficit hyperactivity disorder symptoms in a group of children receiving orthodontic treatment in Turkey
    (Aves, 2020) Kılıçoğlu, Hülya; Okutan, Serhan; Sabuncuoğlu, Osman; Genç, Herdem Aslan; Faculty Member; Koç University Hospital
    Objective: children with attention-deficit hyperactivity disorder (ADHD) are known to have several oral health problems, particularly traumatic dental injuries, decayed or filled teeth, and poor oral hygiene. The objective of the present study was to determine the ADHD symptoms in a group of patients with malocclusion and receiving orthodontic treatment. Methods: a total of 88 subjects with a diagnosis of malocclusion between aged 8 and 17 years were included in the study. Socio-demographic characteristics, breastfeeding history, oral habits, and dental trauma history of the subjects were acquired by a detailed questionnaire. Subjects and their parents completed questionnaires addressing ADHD, other psychiatric problems, and dental health impact on the quality of life. During the orthodontic examination, the Index of Complexity, Outcome, and Need was applied to confirm the diagnosis of malocclusion. Results: parent-reported psychiatric complaint occurred in almost half of the patients (n=38, 43.2%); the most frequent psychiatric complaints were inattention (n=22, 25%), opposition (n=13,14.8%), and hyperactivity (n=11, 12.5%).The estimated ADHD prevalence according to parent measure was 15.9% (n=14). Self-report measures revealed that 18.4% (n=16) had behavioral symptoms.The most affected quality of life domain was psychological discomfort. Conclusion: the findings indicate that ADHD prevalence in children with malocclusion is high. The orthodontists should have a keen eye on behavioral problems.