Researcher:
Solaroğlu, İhsan

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Faculty Member

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İhsan

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Solaroğlu

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Solaroğlu, İhsan

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2011 - 2019272020 - 202316

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    Neurotrophin-3 provides neuroprotection via TrkC receptor dependent pErk5 activation in a rat surgical brain injury model
    (Academic Press Inc Elsevier Science, 2018) Akyol, Onat; Sherchan, Prativa; Yilmaz, Gokce; Reis, Cesar; Ho, Wingi Man; Wang, Yuechun; Huang, Lei; Zhang, John H.; N/A; Solaroğlu, İhsan; Faculty Member; School of Medicine; 102059
    Background: Surgical brain injury (SBI) which occurs due to the inadvertent injury inflicted to surrounding brain tissue during neurosurgical procedures can potentiate blood brain barrier (BBB) permeability, brain edema and neurological deficits. This study investigated the role of neurotrophin 3 (NT-3) and tropomyosin related kinase receptor C (TrkC) against brain edema and neurological deficits in a rat SBI model. Methods: SBI was induced in male Sprague Dawley rats by partial right frontal lobe resection. Temporal expression of endogenous NT-3 and TrkC was evaluated at 6, 12, 24 and 72 h after SBI. SBI rats received recombinant NT-3 which was directly applied to the brain surgical injury site using gelfoam. Brain edema and neurological function was evaluated at 24 and 72 h after SBI. Small interfering RNA (siRNA) for TrkC and Rap1 was administered via intracerebroventricular injection 24 h before SBI. BBB permeability assay and western blot was performed at 24 h after SBI. Results: Endogenous NT-3 was decreased and TrkC expression increased after SBI. Topical administration of recombinant NT-3 reduced brain edema, BBB permeability and improved neurological function after SIR Recombinant NT-3 administration increased the expression of phosphorylated Rap1 and Erk5. The protective effect of NT-3 was reversed with TrkC siRNA but not Rap1 siRNA. Conclusions: Topical application of NT-3 reduced brain edema, BBB permeability and improved neurological function after SBI. The protective effect of NT-3 was possibly mediated via TrkC dependent activation of Erk5.
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    The history of neurosurgery in Anatolia and Turkey: the Turkish Neurosurgical Society Society
    (Elsevier, 2013) Acar, Feridun; Bavbek, Murad; Ture, Ugur; Beskonakli, Ethem; Solaroğlu, İhsan; Faculty Member; School of Medicine; 102059
    Although the history of neurosurgery in Anatolia goes back ten thousand years, modern surgery began in Turkey in 1890. Neurosurgery in Turkey began in the first half of the 20th century. However, general surgeons began applying neurosurgical techniques back in the late 19th century. Most of these applications included procedures for craniocerebral traumas and infections. Dr. Cemil Topuzlu (1868-1958) is the founder of modern surgery in Turkey. Dr. Abdulkadir Cahit Tuner became the first neurosurgeon with a degree in Turkey in 1923. The first neurosurgery department was established in Istanbul in 1923, and the first training program began in the late 1940s. Currently there are almost 1200 neurosurgeons in Turkey and 75 training clinics at university hospitals and Training and Research Hospitals of the Ministry of Health provide neurosurgery training. The current state of neurosurgery in Turkey is parallel to that of the advanced Western countries. Apart from the application of neurosurgical procedures, there have been many scientific studies from Turkish neurosurgeons contributing to the total body of literature in neurosurgery.
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    New missions for an old agent: granulocyte-colony stimulating factor in the treatment of stroke patients
    (Bentham Science Publ Ltd, 2015) Digiçaylıoğlu, Murat; Zhang, John H.; N/A; Solaroğlu, İhsan; Keleş, Güven Evren; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 102059; N/A
    Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, anti-oxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.
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    The role of pericytes in neurovascular unit: Emphasis on stroke
    (Bentham Science Publ Ltd, 2017) N/A; N/A; Çakmak, Özgür Öztop; Solaroğlu, İhsan; Özdemir, Yasemin Gürsoy; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; 299358; 102059; 170592
    Background: Among the central nervous system (CNS) disorders, diseases like ischemic and hemorrhagic stroke which are important health care problems as well as leading causes for emergency admissions, primarily affect neurovascular structure. Despite their high rate of mortality and morbidity, very few efficient treatment targets have been established until now. Objective: Blood-brain barrier (BBB) is the mostly effected structure in stroke as detected in both clinical studies and experimental settings. BBB is composed of endothelia, astrocyte end-foot, pericytes and basal lamina. Neurovascular unit, pericytes and BBB forming endothelia play significant pathophysiological roles in both ischemic and hemorrhagic stroke. Discussion: In this mini-review, the role of microcirculation and cells of blood-brain barrier in stroke pathophysiology will be discussed with a special emphasis based on pericytes. Pericytes are especially important for providing adequate microcirculatory supply according to needs of neuronal tissue and form one of the functionally important part of BBB and take role in neurovascular coupling. Understanding the role and disease producing mechanisms of neurovascular unit elements in different neurological conditions will provide novel targets for future treatments.
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    Spreading depolarization waves in neurological diseases: a short review about its pathophysiology and clinical relevance
    (Bentham Science Publ Ltd, 2019) Taş, Yağmur Çetin; Solaroğlu, İhsan; Özdemir, Yasemin Gürsoy; Researcher; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; School of Medicine; School of Medicine; N/A; 102059; 170592
    Lesion growth following acutely injured brain tissue after stroke, subarachnoid hemorrhage and traumatic brain injury is an important issue and a new target area for promising therapeutic interventions. Spreading depolarization or peri-lesion depolarization waves were demonstrated as one of the significant contributors of continued lesion growth. In this short review, we discuss the pathophysiology for SD forming events and try to list findings detected in neurological disorders like migraine, stroke, subarachnoid hemorrhage and traumatic brain injury in both human as well as experimental studies. Pharmacological and non-pharmacological treatment strategies are highlighted and future directions and research limitations are discussed.
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    Hematopoietic growth factor family for stroke drug development
    (Springer, 2012) Digiçaylıoğlu, Murat; N/A; Solaroğlu, İhsan; Faculty Member; School of Medicine; 102059
    Hematopoietic growth factors (HGFs) are a family of cytokines that play important roles in the survival, proliferation, and differentiation of hematopoietic progenitors, as well as in the functional activation of mature cells. However, there is a growing body evidences have suggested that HGFs have important non-hematopoietic functions in the central nervous system. Preclinical studies have demonstrated significant benefits from the use of these cytokines in the acute and chronic treatment of various neurological disorders. Unfortunately, the efficacy of these candidate neuroprotectants in animal experiments does not reliably predict efficacy in stroke patients. This chapter presents a broad overview of data from preclinical neuroprotection and clinical trial studies.
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    Observational studies in neurosurgery: structure, functioning, and uses
    (Elsevier, 2022) Esene, Ignatius Ngene; Negida, Ahmed; Ibe, Chidiebere S.; Kanmounye, Ulrick S.; Thango, Nqobile; Jokonya, Luxwell; Hoz, Samer S.; Dechambenoit, Gilbert; Kalangu, Kazadi K. N.; N/A; Solaroğlu, İhsan; Faculty Member; School of Medicine; 102059
    INTRODUCTION: Although randomized interventional studies are the gold standard of clinical study designs, they are not always feasible or necessary. In such cases, observational studies can bring insights into critical questions while minimizing harm and cost. There are numerous observational study designs, each with strengths and demerits. Unfortunately, it is not uncommon for observational study designs to be poorly designed or reported. In this article, the authors discuss similarities and differences between observational study designs, their application, and tenets of good use and proper reporting focusing on neurosurgery. METHODS: The authors illustrated neurosurgical case scenarios to describe case reports, case series, and cohort, cross-sectional, and case-control studies. The study design definitions and applications are taken from seminal research methodology readings and updated observational study reporting guidelines. RESULTS: The authors have given a succinct account of the structure, functioning, and uses of common observational study designs in Neurosurgery. Specifically, they discussed the concepts of study direction, temporal sequence, advantages, and disadvantages. Also, they highlighted the differences between case reports and case series; case series and descriptive cohort studies; and cohort and case-control studies. Also, they discussed their impacts on internal validity, external validity, and relevance. CONCLUSION: This paper disambiguates widely held misconceptions on the different observational study designs. In addition, it uses case-based scenarios to facilitate comprehension and relevance to the academic neurosurgery audience.
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    XENON in medical area: emphasis on neuroprotection in hypoxia and anesthesia
    (Wolters Kluwer Medknow Publications, 2013) Robinot, Alexander; Zhang, John H.; N/A; Esencan, Ecem; Yüksel, Simge; Tosun, Yusuf Berk; Solaroğlu, İhsan; Undergraduate Student; Undergraduated Student; Undergraduated Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; 102059
    Xenon is a medical gas capable of establishing neuroprotection, inducing anesthesia as well as serving in modern laser technology and nuclear medicine as a contrast agent. In spite of its high cost, its lack of side effects, safe cardiovascular and organoprotective profile and effective neuroprotective role after hypoxic-ischemic injury (HI) favor its applications in clinics. Xenon performs its anesthetic and neuroprotective functions through binding to glycine site of glutamatergic N-methyl-D-aspartate (NMDA) receptor competitively and blocking it. This blockage inhibits the overstimulation of NMDA receptors, thus preventing their following downstream calcium accumulating cascades. Xenon is also used in combination therapies together with hypothermia or sevoflurane. The neuroprotective effects of xenon and hypothermia cooperate synergistically whether they are applied synchronously or asynchronously. Distinguishing properties of Xenon promise for innovations in medical gas field once further studies are fulfilled and Xenon's high cost is overcome.
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    Tenosynovial giant cell tumor in the cervico- thoracic junction
    (Turkish Neurosurgery Society, 2012) Okutan, Özerk; Özen, Özlem; Saygılı, Barış; Beşkonaklı, Ethem; Solaroğlu, İhsan; Faculty Member; School of Medicine; 102059
    Tenosynovial giant cell tumor (TGT) rarely arises from the posterior coloumn of the cervical spine. Most lesions of TGT involve the tendon sheath and joint lining of the small joints of the fingers and hands, and consecutively the knee, ankles and feet, and hips. Rate of extra-articular presentation is about 5-15% in all cases. In this report, a case with paraparesis caused by TGT in the cervico-thoracic junction is presented. The clinical manifestations, diagnosis, and treatment of this unusual condition are discussed. In the treatment of TGT of the vertebral column, the main aim should be total surgical excision of the tumor. / Tenosinovyal dev hücreli tümör (TDHT) nadiren servikal omurganın arka elemanlarından nadiren köken alır. TDHT en çok el ve parmakların küçük eklemlerinin tendon kılıfı ile eklem kapsülünde ve sırasıyla diz, ayak bileği, ayak ve kalça eklemlerinde görülür. Tüm vakaların yaklaşık % 5-15’i eklem dışı yerleşimlidir. Bu raporda, parapareziye neden olan servikotorasik bileşkedeki tenosinovyal dev hücreli tümör olgusu sunulmuştur. Hastanın klinik, radyolojik ve tedavi şekli tartışılmıştır. Servikal omurgadaki tenosinovyal dev hücreli tümör tedavisinde, ana amaç tümörün total eksizyonu olmalıdır.
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    Comprehensive analysis of miRNA-mRNA regulatory modules and their association with survival in diffuse lower grade gliomas
    (2016) Tihan, Tarık; Keleş, Güven Evren; Department of Industrial Engineering; N/A; Gönen, Mehmet; Solaroğlu, İhsan; Faculty Member; Faculty Member; Department of Industrial Engineering; College of Engineering; School of Medicine; Koç University Hospital; 237468; 102059
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