Researcher:
Mamipour, Mina

Profile Picture
ORCID

Job Title

PhD Student

First Name

Mina

Last Name

Mamipour

Name

Name Variants

Mamipour, Mina

Email Address

Birth Date

Filters

2019 - 20202

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.c19bf149-0913-4588-9f01-4927c0ba6460

Search Results

Now showing 1 - 2 of 2
  • Placeholder
    PublicationMetadata only
    Cytoprotective and cytofunctional effect of polyanionic polysaccharide alginate and gelatin microspheres on rat cardiac cells
    (Elsevier, 2020) Amini, Hassan; Hashemzadeh, Shahriar; Saberianpour, Shirin; Rahbarghazi, Reza; Nouri, Mohammad; N/A; Heidarzadeh, Morteza; Mamipour, Mina; Yousefi, Mohammadreza; Sokullu, Emel; PhD Student; PhD Student; PhD Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; N/A; N/A; N/A; 163024
    This study investigated the cyto-functional effect of Alginate-Gelatin microspheres on rat cardiomyoblasts after 7 days. Rat cardiomyoblasts were encapsulated inside Alginate-Gelatin microspheres via application of high voltage rate and dropping in a stirring CaCl2 solution. The swelling rate, biodegradation, and mechanical features were measured. Cell viability was assessed using MTT. Cell membrane integrity was monitored via calculation supernatant SCOT, SGPT, CPK, and LDH. We also measured SOD, GPx, and anti-oxidant capacity. Protein levels of Nrl-2 and PCCG-1 alpha were detected via western blotting. The cyto-functional activity of encapsulated cells was monitored using real-time PCR assay targeting the expression of Connexin-43, alpha-actinin, and myosin light chain. Data showed suitable biodegradation and swelling rate in Alginate-gelatin microspheres by time. 7-day incubation of rat cells inside microspheres did not exert cytotoxicity compared to control cells (p> 0.05). The release of SGPT, SGOT, CPK, and LDH in encapsulated cells was significantly decreased compared to the control group (p < 0.05). We also found enhanced anti-oxidant capacity and SOD and GPx activity in cells after being-encapsulated inside Alginate-Gelatin microspheres (p < 0.05) coincided with increased Nrf-2 synthesis (p < 0.05) compared to control cells. The expression of Connexin-43, alpha-actinin, and myosin light chain was significantly up-regulated, showing cyto-functional effect of Alginate-Gelatin microspheres after 7-days
  • Placeholder
    PublicationMetadata only
    Toll-like receptors in the functional orientation of cardiac progenitor cells
    (Wiley, 2019) Sokullu, Sadiye E.; Ghaderi, Shahrooz; Amini, Hassan; Rahbarghazi, Reza; N/A; N/A; Yousefi, Mohammadreza; Mamipour, Mina; PhD Student; PhD Student; Graduate School of Health Sciences; Graduate School of Health Sciences; N/A; N/A
    Cardiac progenitor cells (CPCs) have the potential to differentiate into several cell lineages with the ability to restore in cardiac tissue. Multipotency and self-renewal activity are the crucial characteristics of CPCs. Also, CPCs have promising therapeutic roles in cardiac diseases such as valvular disease, thrombosis, atherosclerosis, congestive heart failure, and cardiac remodeling. Toll-like receptors (TLRs), as the main part of the innate immunity, have a key role in the development and differentiation of immune cells. Some reports are found regarding the effect of TLRs in the maturation of stem cells. This article tried to find the potential role of TLRs in the dynamics of CPCs. By showing possible crosstalk between the TLR signaling pathways and CPCs dynamics, we could achieve a better conception related to TLRs in the regeneration of cardiac tissue.