Researcher: Kılıç, Alparslan
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Kılıç, Alparslan
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Publication Metadata only Immature platelet fraction: Is a novel early predictive marker for disease severity in patients with Covid-19 pneumonia?(De Gruyter Open Ltd, 2021) Tasdemir, Z.A.; Palaoğlu, K.E.; N/A; İncir, Said; Komesli, Zeynep; Baygül, Arzu Eden; Çaltı, Hatice Kant; Kapmaz, Mahir; Tekin, Süda; Kılıç, Alparslan; Dağel, Tuncay; Okan, Ayşe; Somay, Kayra; Akpınar, Timur Selçuk; Doctor; Doctor; Faculty Member; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Faculty Member; N/A; N/A; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; N/A; School of Medicine; Koç University Hospital; Koç University Hospital; N/A; Koç University Hospital; Koç University Hospital; Koç University Hospital; Koç University Hospital; Koç University Hospital; Koç University Hospital; Koç University Hospital; N/A; 175430; N/A; 272290; N/A; N/A; 42146; N/A; N/A; N/A; N/A; 216646Objectives : In many diseases, immature platelet fraction (IPF%) is related to coagulopathy and poor outcome. This study aimed to investigate the predictive value of IPF% for the severity of pneumonia in patients with Coronavirus Disease 2019 (COVID-19). Methods : A total of 154 patients with COVID‐19 infections were included. The patients were divided into two groups according to the severity of pneumonia (severe and non-severe) regarding their oxygen demand. Results : Given laboratory parameters, the median IPF% was significantly higher in the severe group (11.9 vs. 3.9%, p<0.001). Mean platelet volume (p<0.001), platelet-large cell ratio (p=0.001), platelet distribution width (p=0.001), D-Dimer (p<0.001), INR (p=0.003), and aPTT (p=0.007) were also found to be significantly higher in the severe group. Moreover, IPF (p=0.014, Odds ratio = 2.000, 95%CI: 1.149-3.482) was an independent predictor for the severity. The curve value from receiver operating characteristics was 0.879 (p<0.001, 95%CI: 0.784-0.943) for determining the severity of pneumonia. IPF% had a sensitivity and specificity value of 69.5 and 92.4% to detect the disease’s severity. Conclusions : IPF% is an independent predictor for the severity of COVID-19 pneumonia. Assessment of IPF% may both help to early determine high-risk patients with COVID-19 and to alert the physicians. / Amaç : Pek çok hastalıkta, immatür platelet fraksiyonu (%İPF), koagülopati ve kötü sonuçla ilişkilidir. Bu çalışma, Coronavirus Hastalığı 2019 (COVID-19) olan hastalarda pnömoni şiddeti için %İPF’nin prediktif değerini araştırmayı amaçladı. Yöntem : COVID-19 enfeksiyonu olan toplam 154 hasta dahil edildi. Hastalar, oksijen ihtiyaçları göz önüne alınarak pnömoni şiddetine göre (ağır ve ağır olmayan) iki gruba ayrıldı. Bulgular : Laboratuvar parametrelerine bakıldığında, medyan İPF yüzdesi ağır grupta anlamlı olarak daha yüksekti (%11.9′a karşı %3.9, p<0.001). Ortalama trombosit hacmi (p<0.001), trombosit-büyük hücre oranı (p=0.001), trombosit dağılım genişliği (p=0.001), D-Dimer (p<0.001), İNR (p=0.003) ve aPTT (p=0.007) ağır grupta anlamlı olarak daha yüksek bulundu. Ayrıca, İPF (p=0.014, Odds oranı = 2.000, %95 CI: 1.149-3.482) hastalık şiddeti için bağımsız bir öngördürücü olarak bulundu. Algılayıcı işletim eğrisinden gelen eğri değeri, pnömoni şiddetini belirlemek için 0.879 (p<0.001, %95 CI: 0.784-0.943) idi. İPF, hastalığın şiddetini saptamak için %69.5′lik duyarlılık ve %92.4′lük özgüllük değerine sahipti. Sonuç : İPF, COVID-19 pnömonisinin şiddeti için bağımsız bir öngörücüdür. %İPF’nin değerlendirilmesi, hem COVID-19′lu yüksek riskli hastaları erken belirlemeye hem de hekimleri uyarmaya yardımcı olabilir.Publication Metadata only Relationship between fasting glucose, HbA1c levels, and the SYNTAX Score 2 in patients with non-ST-elevation myocardial infarction(Sage, 2022) N/A; N/A; Kılıç, Alparslan; Baydar, Onur; Doctor; Doctor; N/A; N/A; Koç University Hospital; Koç University HospitalWe evaluated if admission glycosylated hemoglobin (HbA(1c)) and fasting glucose levels are correlated with the severity of coronary artery disease (CAD) in non-ST-elevation myocardial infarction (NSTEMI), nondiabetic, patients. Coronary artery disease severity, according to the anatomical synergy between percutaneous coronary intervention (PCI) with taxus and cardiac surgery (SYNTAX) score 2 (SSII), was retrospectively evaluated in 359 nondiabetic patients hospitalized with NSTEMI who underwent coronary angiography. Glucose intolerance was assessed by serum fasting glucose and HbA(1c) levels. We stratified patients according to tertiles of SSII (<= 21.5, 21.5-30.6, and >= 30.6). These score ranges were defined as SSII low, SSII mid, and SSII high, respectively. The average age of the patients was 57.1 +/- 10.9 years; 189 (52.1%) patients were males. The average fasting glucose was 114 +/- 52 mg/dL, HbA(1c) was 5.8% +/- 0.9%, and SSII was 18.9 +/- 10.3. A stronger correlation was found between HbA(1c) and SSII than fasting glucose and SSII (r1 = 0.901, P < .001, r2 = 0.378, P < .001, respectively), and HbA(1c) level and hypertension were independent risk factors for SSII high (odds ratio [OR]: 2.2 (95% CI: 0.5-9.0, P < .001; OR: 1.1 (1.0-1.3), P = .007, respectively). In conclusion, in nondiabetic patients with NSTEMI, HbA(1c) levels correlated with CAD severity as measured by the SSII.Publication Metadata only Relationship between the triglyceride-glucose index and the SYNTAX score 2 in patients with non-ST elevation myocardial infarction(Lippincott Williams and Wilkins (LWW), 2023) N/A; Baydar, Onur; Kılıç, Alparslan; Gürsoy, Erol; Doctor; Doctor; Doctor; N/A; N/A; N/A; Koç University Hospital; N/A; N/A; N/AObjective: We evaluated if admissiontriglyceride-glucose index (TyG index) correlated with the anatomical synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score 2 in non-ST elevation myocardial infarction (NSTEMI), nondiabetic patients. Methods: SYNTAX score 2 (SSII) was retrospectively evaluated in 260 nondiabetic patients hospitalized with NSTEMI who underwent coronary angiography. The TyG index was calculated using the following equation: log [fasting triglycerides (mg/dl) × fasting glucose (mg/dl)/2]. We stratified patients according to tertiles of SSII (≤21.5, 21.5-30.6, and ≥30.6). These score ranges were defined as SSII low, SSII mid, and SSII high, respectively. Results: the average age of the patients was 57.2 ± 10.9 years; 135 patients (52.2%) were males. The average TyG index was 8.68 ± 0.12, and SSII was 18.9 ± 9.9. A moderate correlation was found between TyG index and SSII (r = 0.347; P < 0.001) and TyG index was independent risk factors for SSII high [odds ratio (OR), 6.0; 95% CI, 2.7-17.0; P < 0.001]. Conclusion: in nondiabetic patients with NSTEMI, TyG index correlated with the SSII.Publication Metadata only Mitral annular calcification and its severity predict high risk for cardio-embolic stroke in elderly patients with first diagnosed atrial fibrillation(Taylor & Francis, 2021) Öksuz, Fatih; Yarlioglues, Mikail; Duran, Mustafa; Elcik, Deniz; Özturk, Selçuk; Çelik, İbrahim Etem; Murat, Sani Namik; Kılıç, Alparslan; Doctor; Koç University Hospital; N/ABackground: Atrial fibrillation (AF) is the most common arrhythmia worldwide and a large proportion of patients with AF are older than 75 years of age. Mitral annular calcification (MAC), which is usually observed in advanced age, is associated with increased risk of AF and cardio-embolic stroke in the general population. Objectives: This study was performed to assess whether presence of MAC and its severity predict cardio-embolic stroke in elderly patients with first diagnosed AF. Methods: In this cross-sectional study, 72 elderly patients suffering from acute cardio-embolic stroke with first diagnosed AF and 79 elderly control group patients with first diagnosed AF and without stroke were investigated. A parasternal short-axis view at the level of the mitral annulus was used for MAC measurements. The severity of MAC was measured from the anterior to posterior edge at its greatest width. Results: MAC thicknesses were significantly higher in the stroke group. ROC curve analysis showed that a cut point of 2.5 mm for the value of MAC thickness exhibited 68.1% sensitivity and 77.2% specificity for detecting cardio-embolic stroke in elderly patients with AF. In multivariate logistic regression analysis, MAC thickness (OR = 1.173, 95% CI 1.083-1.270; p < 0.001) was found to be independent predictor of cardio-embolic stroke in elderly patients with AF. Conclusion: MAC thickness may provide useful information for the relevant risk evaluation of elderly patients with AF. Pre-stroke MAC presence and its severity appear to have better clinical value for predicting cardio-embolic stroke in elderly patients with AF, independent from traditional risk factors for stroke.Publication Metadata only The triglyceride-glucose index, a predictor of insulin resistance, is associated with subclinical atherosclerosis(Sage, 2021) Okçuoğlu, John; Apaydın, Ziya; Can, Mehmet Mustafa; N/A; Baydar, Onur; Kılıç, Alparslan; Other; Other; N/A; N/A; Koç University Hospital; Koç University Hospital; N/A; N/AInsulin resistance is one of the most important risk factors that accelerate atherosclerosis. The goal of this study is to investigate the relationship between the triglyceride glucose (TyG) index and functional vessel disease measured using pulse wave velocity (PWV), in a nondiabetic asymptomatic Turkish population. Nondiabetic, healthy patients (n = 1095) with no previous history of coronary heart disease were enrolled. Functional vessel disease was detected by measuring PWV. The TyG index was calculated using the following equation: log [fasting triglycerides (mg/dL) x fasting glucose (mg/dL)/2]. The study population was divided into 2 groups based on their TyG index. The high TyG index group had higher PWV, corrected PWV, left ventricular mass index, body mass index, rates of hypertension, and was predominately male. Age, gender, blood urea nitrogen level, and TyG index were detected as independent risk factors of PWV in linear regression analysis. Triglyceride glucose index and age were also independent risk factors of the corrected PWV in logistic regression analysis. These findings show a relationship between TyG index and subclinical vessel disease, even in patients without a history of atherosclerotic cardiovascular disease or diabetes.Publication Metadata only Monocyte to high-density lipoprotein ratio and high sensitive c-reactive protein levels in patients with isolated coronary artery ectasia(DNT Ortadoğu Yayıncılık, 2020) N/A; N/A; Kılıç, Alparslan; Baydar, Onur; Doctor; Doctor; N/A; N/A; Koç University Hospital; Koç University Hospital; N/A; N/AAim: Isolated coronary artery ectasia (ICAE) is a rare form of coronary artery disease and has almost same mortality and morbidity rate to atherosclerotic coronary artery disease. Monocyte to HDL-cholesterol ratio (MHR) has been entered the literature as a new inflammatory indicator in various cardiovascular disease. In this study we want to investigate relationship between inflammatory and oxidative markers that high sensitive C reactive protein (Hs-Crp), MHR and ICAE. Material and Methods: We retrospectively observed patients who underwent elective coronary angiography. Patients with ICAE and normal coronary arteries included in the study. MHR and Hs-Crp levels were observed just before the coronary angiography procedure. Results: A total of 98 patients (61, 62 % men) patients were included in this study and 28 (28.6%) of them had DM. 68 (69.3%) of patients had ICAE. MHR was significantly higher in patients with ICAE (0.0153 (0.007-0.130)ve 0.0111 (0.005- 0.020), p< 0.001). Hs-Crp was also significantly higher in patients with ICAE (Yd-Crp: 6 (0.2-33)ve 1(0.2-14), p < 0.001). MHR was also significantly correlated with Hs-crp levels (r:0,338, p: 0.001). Additionally; DM, smoking, HT, MHR and Hs-crp were detected as independent risk factors of ICAE in logistic regression analysis. In receiver operating characteristic curve analysis, the area under the curve for predicting CAE was 0.744 (p<0.01, 95% confidence interval [CI] 0.64 to 0.84) and cut- off value was 0.013 (sensitivity 69.1%, specificity 63.3%, ) for the number of MHR. Conclusion: MHO and Hs-Crp are markers of inflammation that can be easily and inexpensively examined and found high in patients with ICAE. These markers may be useful explaining the pathogenesis of ICAE and guiding treatment. / Amaç: Izole koroner arter ektazisi (İKAE), koroner arter hastalığının az görülen bir formu olup, aterosklerotik koroner arter hastalığna benzer mortalite ve morbidite oranına sahiptir. Monosit yüksek dansiteli lipoprotein (HDL) oranı ( MHO) klinikte yeni tanımlanan inflamasyon belirteçlerinden biridir. Çalışamızda MHO ve klinikte inflamasyon belirteci olarak sıkça kullanılan yüksek duyarlıklı C-reaktif protein (Yd-Crp) ile İKAE arasıdaki ilişki araştırılmıştır. Gereç ve Yöntemler: Çalışmamızda retrospektif olarak elektif koroner yapılan hastalar incelenmiştir. Hastaneye başvuruşunda koroner anjiografi hemen öncesinde alınan örneklerden Yd-Crp ve MHO oranı hesaplanmıştır. Bulgular: Toplam 98 (61, %62 erkek ) hasta geriye dönük incelenmiş, 28 (%28.6) hastada Diabetes Mellitus saptamıştır. İKAE hasta sayısı 68 (%69.8) olarak bulunmuştur. MHO ve Yd-Crp ; İKAE grubunda normal koroner arterlere sahip gruba göre anlamlı olarak yüksek saptandı (Sırasıyla; MHO: 0.0153 (0.007-0.130)ve 0.0111 (0.005-0.020), p< 0.001, Yd-Crp: 6 (0.2- 33)ve 1(0.2-14), p < 0.001). Ek olarak MHO ile Yd- Crp değeri arasında pozitif korelasyon saptandı (r:0,338, p: 0.001). Ayrıca; hipertansiyon , Diabetes Mellitus, sigara kullanımı, Yd-Crp ve MHO değerleri İKAE’ nin bağımsız risk faktörleri olarak bulundu. ROC analizinde MHO için eğri altında kalan alan 0.744 (p<0.01, 95% [CI] 0.64 - 0.84) ve cut- off değeri 0.013 (%69.1 sensivite , % 63.3 spesifite ) saptandı. Sonuç: Sonuç olarak MHO ve Hs-Crp basit ve ucuz şekilde bakılabilen inflamasyon belirteçleri olup, İKAE hastalarında yüksek saptanmıştır. Bu beliteçler, İKAE hastalığının patogenezinin aydınlatılmasında ve tedavinin yönlendirilmesinde faydalı olabilir.Publication Metadata only Evaluation of pulmonary arterial stiffness and comparison with right ventricular functions in patients with cirrhosis preparing for liver transplantation(Wiley, 2022) Elçioğlu, Betül Cengiz; Baydar, Onur; Helvacı, Füsun; Karataş, Cihan; Aslan, Gamze; Kılıç, Alparslan; Tefik, Nihal; Demir, Barış; Gürsoy, Erol; Demirci, Yasemin; Ural, Dilek; Kanmaz, Turan; Aytekin, Vedat; Aytekin, Saide; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Doctor; Faculty Member; Faculty Member; Faculty Member; Doctor; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; NA; N/A; N/A; 1057; 275799; 140946; N/AObjective Pulmonary complications are common in patients with liver cirrhosis. Devolopment of pulmonary hypertension (PH) is associated with a poor prognosis in these patients. Pulmonary arterial stiffness (PAS) is considered an early sign of pulmonary vascular remodeling. The aim of this study is to investigate PAS and compare it with right ventricular (RV) functions in patients with cirrhosis who are scheduled for liver transplantation. Methods The study included 52 cirrhosis patients (mean age 51.01 +/- 12.18 years, male gender 76.9%) who were prepared for liver transplantation and 59 age and sex matched (mean age 51.28 +/- 13.63 years, male gender 62.7%) healthy individuals. Patients with left ventricular ejection fraction (LVEF) less than 55%, ischemic heart disease, more than mild valvular heart disease, chronic pulmonary disease, congenital heart disease, rheumatic disease, moderate to high echocardiographic PH probability, rhythm or conduction disorders on electrocardiography were excluded from the study. In addition to conventional echocardiographic parameters, PAS value, pulmonary vascular resistance (PVR) and RV ejection efficiency was calculated by the related formulas with transthoracic echocardiography (TTE). Results Demographic characteristics and cardiovascular risk factors of the groups were similar. PAS, PVR, and sPAP values were found to be significantly higher in the patient group (20.52 +/- 6.52 and 13.73 +/- 2.05; 1.43 +/- 0.15 and 1.27 +/- 0.14; 27.69 +/- 3.91 and 23.37 +/- 3.81 p < 0.001, respectively). RV FAC and RV Ee were significantly lower and RV MPI was significantly higher in the patient group (45.31 +/- 3.85 and 49.66 +/- 3.62, p < 0.001; 1.69 +/- 0.35 and 1.85 +/- 0.23, p = 0.005; 0.39 +/- 0.07 and 0.33 +/- 0.09, p = 0.001, respectively). PAS was significantly correlated with RV FAC and MPI (r = -0.423, p < 0.001; r = 0.301, p = 0.001, respectively). Conclusions Increased PAS in cirrhosis patients may be associated with early pulmonary vascular involvement. Evaluation of RV functions is important to determine the prognosis in these patients. FAC, MPI, and RV Ee measurements instead of TAPSE or RV S ' may be more useful in demonstrating subclinical dysfunction. The correlation of PAS with RV FAC and MPI may indicate that RV subclinical dysfunction is associated with early pulmonary vascular remodeling in patients with liver cirrhosis.Publication Metadata only CHA2DS2-VASC score predicts risk of contrasttrast-induced nephropathy in non-st elevation myocardial infarction patients undergoing percutaneous coronary interventions(Karger, 2019) N/A; N/A; Baydar, Onur; Kılıç, Alparslan; Doctor; Doctor; N/A; N/A; Koç University Hospital; N/A; N/ABackround: The CHA2DS2-VASC score, used for embolic risk stratification in atrial fibrillation, has been reported recently to predict adverse clinical outcomes in patients with coronary artery disease. We investigated the correlation between the CHA2DS2-VASC score and contrast-induced nephropathy (CIN) in patients with non-ST elevation myocardial infarction (NSTEMI) who underwent percutaneous coronary intervention (PCI). Methods: We retrospectively enrolled 363 (191; 52.6% men) NSTEMI patients undergoing PCI. The CHA2 DS2-VASC score was calculated for each patient, and the study population was divided into 2 groups: CHA2DS2-VASC score <2 group (low score; n = 259, 71.3%) and CHA2DS2-VASC score >= 2 group (high score; n = 104, 28.6%). Patients were then reallocated to 2 groups according to the presence or absence of CIN. CIN was defined as a rise in serum creatinine >0.5 mg/dL or >25% increase in baseline within 72 h after PCI. Results: Overall, 56 cases (15.4%) of CIN were diagnosed. When patients with a CHA2DS2-VASC score of <2 were compared with those with a CHA2DS2-VASC score of >= 2, patients with a high score had a higher frequency of CIN (33) 31.7% versus (23) 8.9%; p < 0.001. Also patients with CIN had higher CHADS2 VASC score (3.94 +/- 1.13 vs. 1.68 +/- 0.46, p < 0.001). Additionally, in-hospital mortality, length of hospital stay, major bleeding, requirement of mechanical ventilation, and dialysis were observed significantly higher in patients with CHA2DS2-VASC score of >= 2 (p = 0.001, p = 0.002, p = 0.006, p = 0.001, p = 0.001, respectively). In receiver operating characteristic curve analysis, the area under the curve for predicting CIN was 0.702 (p < 0.001, 95% CI 0.617-0.787) and cutoff value was 2.5 (sensitivity 58.9%, specificity 76.9%) for the number of CHA2DS2-VASC score. Conclusion: In NSTEMI patients undergoing PCI, CHADS2 VASC score is associated with an increased risk for CIN and in-hospital morbidity and mortality. (C) 2019 S. Karger AG, BaselPublication Metadata only The relationship between diurnal blood pressure abnormalities and target organ damage in normotensive subjects. Which is more important? Increased blood pressure levels or circadian blood pressure abnormalities(Taylor and Francis inc, 2020) N/A; N/A; N/A; Kılıç, Alparslan; Baydar, Onur; Doctor; Doctor; N/A; N/A; Koç University Hospital; Koç University Hospital; N/A; N/AObjective: Circadian blood pressure (CBP) abnormalities are well-known risk factors for many diseases such as cardiovascular, cerebrovascular, and chronic kidney disease. the object of this study was to evaluate the relationship between abnormalities in CBP rhythm and target organ damage (TOD) in normotensive non-dipper (non-DP) subjects. Methods: the 24-h ambulatory BP monitoring (aBPM) and echocardiography were performed and urinary albumin excretion (UaE) was measured in 127 normotensive dipper (DP) (42 males, 85 females) and 337 (89 males, 248 females) normotensive non-DP subjects. Results: When we compared DP and non-DP subjects; Pulse wave velocity (PWV) (7.12 +/- 1.72 vs 7.57 +/- 1.87 m/s, p = 0.02), the percentile of corrected PWV (cPWV) (7.1 vs. 20.2, p= 0.001) and the percentile of corrected augmentation index (caIx) (23.5 vs. 33.9, p = 0.03), left ventricle mass index (LVMI) (78.00 +/- 23.27 vs. 95.59 +/- 18.29 g/m(2), p = 0.01), relative wall thickness (RWT)(0.36 +/- 0.13 vs 0.46 +/- 0.09, p = 0.01), percentile of proteinuria (8.6 vs 29.2%, p = 0.00) were higher in non-DP group. in the correlation analyses, the PWV, LVMI, RWT were negatively correlated with the rate of systolic fall in nighttime (%)(-0.15, p = 0.01 vs. -0.23, p = 0.02 vs. -0.27, p = 0.00). It was observed that cPWV, caIx, and UaE were independently associated with age and non-DP status (NDS), in logistic regression analysis. Conclusions: Our results suggested that normotensive persons with CBP abnormalities had TOD. in light of the data of this article, non-dipper status is detected in the early period and if the provision of diurnal blood pressure rhythm may reduce the incidence of future adverse events in nondipper normotensive subjects.Publication Metadata only Relationship between monocyte to high-density lipoprotein ratioand contrast-induced nephropathy in patients with non-st elevationmyocardial infarction(DNT Ortadoğu Yayıncılık, 2020) N/A; N/A; Kılıç, Alparslan; Baydar, Onur; Doctor; Doctor; N/A; N/A; Koç University Hospital; Koç University Hospital; N/A; N/AAim: Contrast-induced nephropathy (CIN) is associated with worse prognosis in patients with non-ST-elevation myocardial infarction (NSTEMI). Early identification patients with a high risk of CIN are very crucial to improve outcomes. The monocyte to high-density lipoprotein ratio (MHR) is a novel inflammatory marker. We aimed to investigate the MHR had a predictive role for CIN development in patients with NSTEMI. Material and Methods: NSTEMI who underwent percutaneous coronary intervention (PCI) were included in the study. MHR was calculated and CIN was defined as an increase in serum creatinine 25% or 0.5 mg/dl from baseline in the first 48- 72 hours. Results: A total of 370(200, 54.1% men) patients were included in this study and 104 (28.1%) of them had DM. 25 (6.7%) of patients had CIN.MHR was significantly higher in patients with CIN (0.014± 0.004 vs 0.011± 0.006-respectively, p: 0.017). MHR was also significantly correlated with creatinine levels after PCI (r:0,104, p: 0.047). CIN group also experienced a more complicated in-hospital clinical course. Additionally; weight and MHR were detected as independent risk factors of CIN in logistic regression analysis. Conclusion: Preprocedural MHR may be used as cheap, easy and simple marker of CIN. It may help with the early identification of patients with NSTEMIwho are at high risk of CIN. / Amaç: Kontrast madde kullanımına bağlı nefropati (KBN) gelişimi perkutan koroner girişim (PKG) yapılan ST elevasyonu olmayan miyokard enfarktüsü (NON-STEMI) geçiren hastalarda sık görülmekte olup artmış mortalite ve morbidite ile ilişklidir. KBN açısından yüksek riskli hastaların önceden tespiti ve tedavisi, klinik sonuçların iyileşmesinde etkili olacaktır. Monosit yüksek dansiteli lipoprotein (HDL) oranı ( MHO) klinikte yeni tanımlanan inflamasyon belirteçlerinden biridir. Çalışamızda işlem öncesi MHO’ nın PKG yapılmış NON-STMI hastalarında KBN gelişimi arasıdaki ilişki araştırılmıştır. Gereç ve Yöntemler: Çalışmamızda retrospektif olarak NON-STEMI tanısıyla PKG yapılanhastalar incelenmiştir. Hastaneye başvuruşunda alınan örneklerden MHO oranın hesaplanmış ve KBN; işlemden 48-72 saat sonra bakılan serum kreatininde bazal değere göre % 25 ya da 0,5 mg/dl artış olarak tanımlanmıştır. Bulgular: Toplam 370(200, %54.1 erkek ) hasta geriye dönük incelenmiş, 25 (%6.7) hastada KBN geliştiği saptanmıştır. Ayrıca hastaların 104’ünde (%28.1) Diabetes Mellitus (DM) olduğu görülmiştür. MHO; KBN gelilşen grupta gelişmeyen gruba göre anlamlı olarak yüksek saptandı (sırasıyla 0.014± 0.004 ve 0.011± 0.006, p: 0.017). Ek olarak MHO ile PKG sonrası kreatinin değerleri arasında pozitif korelasyon saptandı (r:0,104, p: 0.047). Beklendiği gibi KBN gelişen hastların yatışları sırasında daha çok komplikasyon olduğu görüldü. Ayrıca; kiloveMHO değerleri KBN gelişimi için bağımsız risk faktörleri olarak bulundu. Sonuç: MHO ucuz, basit ve kolay şekilde saptanabilen inflamasyon belirteci olup, PKG yapılan NON-STEMI hastlarında KBN’nin saptanmasında ve tedavinin yönlendirilmesinde faydalı olabilir.