Researcher:
Celaloğlu, Çağnur

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Undergraduate Student

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Çağnur

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Celaloğlu

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Celaloğlu, Çağnur

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20181

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Researcher Of Publications: search.filters.isAuthorOfPublication.c328f84e-5736-4acd-a1ef-8e4eb7a85912

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    pH and molecular weight dependence of auric acid reduction by polyethylenimine and the gene transfection efficiency of cationic gold nanoparticles thereof
    (Royal Society of Chemistry (RSC), 2018) N/A; N/A; N/A; N/A; Department of Chemistry; N/A; Department of Chemistry; Çavuşlar, Özge; Celaloğlu, Çağnur; Duman, Fatma Demir; Konca, Yeliz Utku; Yağcı, Mustafa Barış; Acar, Havva Funda Yağcı; PhD Student; Undergraduate Student; PhD Student; Teaching Faculty; Researcher; Faculty Member; Department of Chemistry; Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM); Graduate School of Sciences and Engineering; College of Sciences; Graduate School of Sciences and Engineering; N/A; College of Sciences; College of Sciences; N/A; N/A; N/A; N/A; 111280; N/A; 178902
    Small, cationic gold nanoparticles (GNP) are produced by the direct reduction of auric acid in a non-reducing solvent, water, with branched polyethylenimine (bPEI) in a broad pH range (3.0-9.0). Basic pH, which is studied for the first time, emerged as a favorable condition to achieve good reducing power and surface passivation simultaneously, providing smaller particles (hydrodynamic size ca. 6 nm) with enhanced long-term stability and a sharper surface plasmon peak (SPP). This synthetic method produces colloidal GNPs with bPEI in a broad molecular weight range (0.6, 1.8, 10 and 25 kDa). The molecular weight did not influence the crystal size much but did affect the hydrodynamic size and the stability. 0.6 kDa bPEI provides the largest GNPs (ca. 100 nm aggregates) which lack long term stability. 1.8 kDa bPEI provides small particles (hydrodynamic size ca. 7 nm) with the sharpest SPP. The GNPs prepared with 25 and 1.8 kDa bPEI show no significant cytotoxicity in HEK 293T cells and PEI25-Au transfects green fluorescent protein (GFP) into HEK 293T cells more efficiently (82%) than FuGENE (R) (50%). This simple one pot synthesis of cationic GNPs in water is a valuable, simple alternative for the generation of new cationic GNPs in water with even low molecular weight PEI.