Researcher:
Timurdoğan, Erman

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PhD Student

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Erman

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Timurdoğan

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Timurdoğan, Erman

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2010 - 20125

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    MEMS biosensor for parallel and highly sensitive and specific detection of hepatitis
    (IEEE, 2011) Kavaklı, I.H.; Department of Electrical and Electronics Engineering; N/A; Department of Electrical and Electronics Engineering; Ürey, Hakan; Ermek, Erhan; Timurdoğan, Erman; Alaca, Burhanettin Erdem; Faculty Member; Other; Undergraduate Student; Faculty Member; Department of Electrical and Electronics Engineering; College of Engineering; College of Sciences; College of Engineering; College of Engineering; 8579; N/A; N/A; 115108
    A label-free biosensor array that offers highly sensitive, high-dynamic-range and highly specific detection of Hepatitis A antigen is reported. Sensor array consists of Ni cantilevers with surfaces functionalized with Hepatitis A antibody. Cantilevers are self-actuated at resonance using a single electromagnetic drive coil. Detection of resonance frequency is optical and facilitated by diffraction gratings embedded on cantilevers. All antibody-antigen interactions take place within undiluted bovine serum providing a high background noise due to unspecific molecules. A minimum detection limit of less than 0.1 ng/ml target molecule concentration is demonstrated. A high dynamic range is achieved, which is greater than 1000:1 concentration range. The proposed sensor array is shown to be compatible with most of the requirements of a hand-held biosensor including label-free, robust and real-time measurement with well integrated components.
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    Magnetic actuated moems resonant biosensor array
    (IEEE, 2010) Department of Electrical and Electronics Engineering; N/A; Department of Chemical and Biological Engineering; N/A; Ürey, Hakan; Timurdoğan, Erman; Kavaklı, İbrahim Halil; Alaca, Burhanettin Erdem; Nargül, Sezin; Faculty Member; Undergraduate Student; Faculty Member; Faculty Member; PhD Student; Department of Electrical and Electronics Engineering; Department of Chemical and Biological Engineering; College of Engineering; College of Engineering; College of Engineering; College of Engineering; Graduate School of Sciences and Engineering; 8579; N/A; 40319; 115108; N/A
    A biosensor platform is utilized in liquid for detection of His protein. T-shaped thin film nickel cantilevers are actuated magnetically using self-oscillation principle and the sensing is based on embedded diffraction gratings on the cantilevers with interferometric sensitivity. Experiments are performed in a custom 1ml liquid chamber and 5.7ng/ml detection sensitivity is demonstrated. Method is label-free, robust and allows mu ltip lexing. It also doesn't require any electrical connections to the MEMS sensor chip. Therefore, it is suitable for real-time multi analyte screening using a disposable chip in a portable device.
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    MEMS biosensor for detection of Hepatitis A and C viruses in serum
    (Elsevier Advanced Technology, 2011) N/A; N/A; Department of Mechanical Engineering; Department of Chemical and Biological Engineering; Department of Electrical and Electronics Engineering; Timurdoğan, Erman; Alaca, Burhanettin Erdem; Kavaklı, İbrahim Halil; Ürey, Hakan; PhD Student; Faculty Member; Faculty Member; Faculty Member; Department of Mechanical Engineering; Department of Chemical and Biological Engineering; Department of Electrical and Electronics Engineering; Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM); Graduate School of Sciences and Engineering; College of Engineering; College of Engineering; College of Engineering; N/A; 115108; 40319; 8579
    Resonant microcantilever arrays are developed for the purpose of label-free and real-time analyte monitoring and biomolecule detection. MEMS cantilevers made of electroplated nickel are functionalized with Hepatitis antibodies. Hepatitis A and C antigens at different concentrations are introduced in undiluted bovine serum. All preparation and measurement steps are carried out in the liquid within a specifically designed flowcell without ever drying the cantilevers throughout the experiment. Both actuation and sensing are done remotely and therefore the MEMS cantilevers have no electrical connections, allowing for easily disposable sensor chips. Actuation is achieved using an electromagnet and the interferometric optical sensing is achieved using laser illumination and embedded diffraction gratings at the tip of each cantilever. Resonant frequency of the cantilevers in dynamic motion is monitored using a self-sustaining closed-loop control circuit and a frequency counter. Specificity is demonstrated by detecting both Hepatitis A and Hepatitis C antigens and their negative controls. This is the first report of Hepatitis antigen detection by resonant cantilevers exposed to undiluted serum. A dynamic range in excess of 1000 and with a minimum detectable concentration limit of 0.1 ng/ml (1.66 pM) is achieved for both Hepatitis A and C. This result is comparable to labeled detection methods such as ELISA.
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    Simultaneous self-sustained actuation and parallel readout with mems cantilever sensor array
    (IEEE, 2012) Leblebici, Yusuf; Department of Electrical and Electronics Engineering; Department of Mathematics; N/A; Department of Electrical and Electronics Engineering; N/A; N/A; Ürey, Hakan; Mostafazadeh, Ali; Ermek, Erhan; Sağıroğlu, Cem; Timurdoğan, Erman; Lüleç, Sevil Zeynep; Faculty Member; Faculty Member; Other; Undergraduate Student; PhD Student; Other; Department of Mathematics; Department of Electrical and Electronics Engineering; College of Engineering; College of Sciences; College of Sciences; College of Engineering; Graduate School of Sciences and Engineering; N/A; 8579; 4231; N/A; N/A; N/A; N/A
    Parallel readout of a microcantilever array using single magnetic actuator and a single photo detector for concurrent detection is reported. The system includes MEMS cantilever array designed for different resonance frequencies, optical elements for laser beam shaping and focusing, one detector and feedback electronics, and single broadband actuator for parallel excitation. The cantilevers are made using a simple one-mask fabrication process with embedded amplitude gratings at the tips. A line shaped laser beam is used to illuminate the cantilevers. A single readout photodiode is placed at the first order diffraction beam location on the Fourier plane. The amplified photodiode signal is fed back into the magnetic actuation using a preamplifier and a broadband current amplifier. In this paper, we report for the first time parallel monitoring of the thermal resonance peaks of inherently frequency-multiplexed MEMS cantilevers. We demonstrated simultaneous self-sustained oscillations of seven cantilevers by using a single actuator and detector in air environment. The method is suitable for low-cost multiplexed portable biosensors.
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    Detection of human kappa-opioid antibody using microresonators with integrated optical readout
    (Elsevier advanced Technology, 2010) N/A; N/A; N/A; N/A; Department of Mechanical Engineering; Department of Chemical and Biological Engineering; Department of Electrical and Electronics Engineering; Department of Mechanical Engineering; Timurdoğan, Erman; Özber, Natali; Nargül, Sezin; Yavuz, Serhat; Kılıç, M. Salih; Kavaklı, İbrahim Halil; Ürey, Hakan; Alaca, Burhanettin Erdem; PhD Student; Master Student; PhD Student; Master Student; Resercher; Faculty Member; Faculty Member; Faculty Member; Department of Chemical and Biological Engineering; Department of Electrical and Electronics Engineering; Department of Mechanical Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; College of Engineering; College of Engineering; College of Engineering; N/A; N/A; N/A; N/A; N/A; 40319; 8579; 115108
    Label-free detection of the interaction between hexahistidine-tagged human kappa-opioid receptor membrane protein and anti-His antibody is demonstrated in liquid by an optical microelectromechanical system utilizing electromagnetically actuated microresonators Shift in resonance frequency due to accretion of mass on the sensitive surface of microresonators is monitored via an integrated optical readout a frequency resolution of 2 Hz is obtained Together with a sensitivity of 7 ppm/(ng/ml)) this leads to a minimum detectable antibody concentration of 57 ng/ml for a 50-kHz device the measurement principle is shown to impart immunity to environmental noise, facilitate operation in liquid media and bring about the prospect for further miniaturization of actuator and readout leading to a portable biochemical sensor.