Researcher:
Koç, İrem

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Master Student

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İrem

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Koç

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Koç, İrem
Koc, Irem

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20241

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    Selective antibacterial and antibiofilm activity of chlorinated hemicyanine against gram-positive bacteria
    (Elsevier B.V., 2024) Onbasli, Kubra; Department of Chemistry; Department of Physics; Department of Electrical and Electronics Engineering; Ataç, Nazlı; Gündüz, Hande; Koç, İrem; Khan, Minahil; Savani, Samira; Can, Füsun; Acar, Havva Funda Yağcı; Kölemen, Safacan; Koç University İşbank Center for Infectious Diseases (KU-IS CID); n2STAR-Koç University Nanofabrication and Nanocharacterization Center for Scientific and Technological Advanced Research; School of Medicine; College of Sciences; Graduate School of Sciences and Engineering; College of Engineering
    Antibiotic-free therapies are highly needed due to the limited success of conventional approaches especially against biofilm related infections. In this direction, antimicrobial phototherapy, either in the form of antimicrobial photothermal therapy (aPTT) or antimicrobial photodynamic therapy (aPDT), have appeared to be highly promising candidates in recent years. These are local and promising approaches for antibiotic resistant bacterial infections and biofilms. Organic small photosensitizers (PSs) are extensively preferred in antimicrobial phototherapy applications as they offer a great opportunity to combine therapeutic action (aPTT, aPDT or both) with fluorescence imaging on a single molecule. In this study, the bactericidal effect of cationic chlorinated hemicyanine (Cl-Hem)-based type I PS, which can function as a dual aPDT/aPTT agent, was investigated on both planktonic cells and biofilms of different gram-positive (E. faecalis and S. epidermidis) and gram-negative bacteria (P. aeruginosa and K. pneumoniae) with and without 640 nm laser irradiation. Cl-Hem was shown to induce a selective phototheranostic activity against gram-positive bacteria (E. faecalis and S. epidermidis). Cl-Hem exhibited both dose and laser irradiation time dependent bactericidal effect on planktonic and biofilms of S. epidermidis. These results clearly showed that highly potent Cl-Hem can treat resistant microbial infections, while allowing fluorescence detection at the same time. High biofilm reduction observed with combined aPDT/aPTT action of Cl-Hem together with its non-cytotoxic nature points out that Cl-Hem is a promising PS for antibacterial and antibiofilm treatments. © 2024 Elsevier B.V.