Researcher:
Tatar, Sedat

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Doctor

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Sedat

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Tatar

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Tatar, Sedat

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2018 - 201962020 - 20218

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Now showing 1 - 10 of 14
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    The repairing of the recto-neovaginal fistula in a male-to-female transgender through perineal graciloplasty
    (Cureus Inc, 2021) N/A; N/A; Omarov, Nail; Tatar, Sedat; Doctor; Faculty Member; N/A; School of Medicine; Koç University Hospital; N/A; N/A; N/A
    Rectovaginal fistulas, which are abnormal epithelial-lined connections between the rectum and vagina, are challenging to treat. Treatment of recto-neovaginal fistulas is more complicated due to the altered perineal anatomy in individuals undergoing gender reassignment surgery. We present a recto-neovaginal fistula that occurred after reassignment surgery male-to-female transgender case of a was successfully treated with restorative perinea! grad loplasty.
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    Bilateral rhomboid block may provide complete pain relief following bilateral breast surgery
    (Elsevier Science Inc, 2021) N/A; N/A; N/A; N/A; N/A; N/A; N/A; Gürkan, Yavuz; Manici, Mete; Salgın, Belitsu; Dilege, Ece; Ağcaoğlu, Orhan; Tatar, Sedat; Erçelen, Ömür; Faculty Member; Faculty Member; Researcher; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 154129; 113502; 327625; 218050; 175476; N/A; 12305
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    The effects of oral mucosa-derived heterotopic fibroblasts on cutaneous wound healing
    (Elsevier Sci Ltd, 2021) N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Sezgin, Billur; Tatar, Sedat; Karahüseyinoğlu, Serçin; Şahin, Gizem Nur; Ergün, Yağmur; Meriç, Gizem; Ersoy, Kaan; Faculty Member; Faculty Member; Faculty Member; PhD Student; Master Student; Undergraduate Student; Undergraduate Student; School of Medicine; N/A; School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; 133762; N/A; 110772; N/A; N/A; N/A; N/A
    An intriguing observation that has recently found support through clinical and experimental studies is that wounds of the oral mucosa tend to display faster healing and result in less scarring than in the skin. We aimed to investigate the potential of heterotopic oral mucosal fibroblasts in cutaneous wounds while determining the main differences between wounds conditioned with either the oral mucosa or dermis-derived human fibroblasts. A total of 48 nude mice were divided into four groups: control, sham, dermal fibroblast (DF), and oral fibroblast (OF). Fibroblasts were isolated, cultured, and seeded onto fibrin scaffolds for transfer to full-thickness dorsal wounds. Cell viability, wound area, healing rate, vascularization, cellular proliferation, dermal thickness, collagen architecture, and subtypes were evaluated. Both cell groups had a viability of 95% in fibrin gel prior to transfer. None of the wounds fully epithelialized on day 10, while all were epithelialized by day 21, which resulted in scars of different sizes and quality. Healing rate and scars were similar between the control and sham groups, whereas fastest healing and least scarring were noted in the OF group. Dermal thickness was highest in the DF group, which was also supported by highest levels of collagen types I and III. Proliferative cells and vascular density were highest in the OF group. DF result in healing through a thick dermal component, while oral fibroblasts result in faster healing and less scarring through potentially privileged angiogenic and regenerative gene expression.
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    Defining a new variable that may impact long-term postoperative nasal tip support the biomechanical properties of the columellar strut graft
    (Lippincott Williams and Wilkins (LWW), 2019) Layegh, Ehsan; N/A; N/A; Department of Mechanical Engineering; N/A; N/A; N/A; N/A; Sezgin, Billur; Güney, Kırdar; Lazoğlu, İsmail; Tatar, Sedat; Özel, Melis; Özmen, Selahattin; Yavuzer, Cahit Reha; Faculty Member; Doctor; Faculty Member; N/A; Undergraduate Student; Faculty Member; Other; Department of Mechanical Engineering; School of Medicine; N/A; College of Engineering; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 133762; N/A; 179391; N/A; N/A; 125951; N/A
    Background: Although columellar strut grafts (CSGs) are considered among the fundamental steps for providing nasal tip support, a downward rotation of the nasal tip in patients with strut grafts can still be encountered. Patient-related factors such as nasal skin thickness can allow the plastic surgeon to anticipate certain drawbacks that can be encountered in the healing phase, but patient-based differences of nasal cartilage and the resulting impact have yet to be investigated. The purpose of this study was to evaluate the effect of the biomechanical properties of CSGs on late postoperative nasal tip position and support. Methods: The study was undertaken with the participation of 20 patients undergoing closed-technique primary rhinoplasty with CSGs. Each cartilage specimen was biomechanically analyzed to calculate the modulus of elasticity. Preoperative and postoperative images were obtained to determine nasal tip position and rotation with quantitative measurements. Postoperative 3- and 12-month measurements were evaluated according to their relationship with the elasticity modulus of the utilized cartilages. Results The evaluation demonstrated that the elasticity modulus can impact the long-term support of the nasolabial angle in which an increase in the coefficient of elasticity can result in a decrease in long-term nasal tip support. Conclusion: The results of the study reveal a new objective variable that can impact nasal tip dynamics and patient-related differences following rhinoplasty. This study not only brings forth a different perspective in the evaluation of nasal tip dynamics but can also provide data for determining ideal values for cartilage prefabrication.
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    Aesthetically thriving through coronavirus disease 2019 (COVID-19): an evaluation of patient motivation and perception on aesthetic surgery and minimally invasive procedures
    (Thieme Medical Publ Inc, 2021) N/A; N/A; N/A; N/A; N/A; Sezgin, Billur; Tatar, Sedat; Kara, Başak Selin; Özmen, Selahattin; Yavuzer, Cahit Reha; Faculty Member; Faculty Member; N/A; Faculty Member; Other; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 133762; N/A; N/A; 125951; N/A
    Although the cancellation of elective procedures due to the COVID-19 outbreak has been a vital precaution, it has resulted in the suspension of aesthetic procedures and surgeries worldwide. Consequently, this postponement and other factors might have a negative impact on patients planning to undergo aesthetic procedures. Understanding the changes in patient motivation and perception in comparison to the prepandemic period is imperative for proper adjustment of plastic surgery clinics. A prospective questionnaire study was conducted on patients with cancelled aesthetic surgeries or procedures to determine the effects that coronavirus disease 2019 (COVID-19) had on patient motivation regarding cosmetic surgery and procedures and to establish a relationship between patient characteristics and the overall effect of pandemia on the perception of cosmetic surgery. Although most patients felt angry or frustrated due to the cancellation of their surgeries or procedures, the majority accepted that it was a necessary precaution. Patients with a history of previous minimally invasive procedures had a significantly higher ratio of acceptance for cancellations, whereas single patients were more likely to want to have their treatments done if the decision were left up to them. A subset of patients considered undergoing additional cosmetic procedures in the setting of self-isolation, and all patients stated that they would reschedule once the pandemia was under control. Patients with established motivation for plastic surgery and minimally invasive procedures ultimately plan to resume their normal treatments alongside others after the pandemia subsides. Plastic surgeons must actively communicate with their patient population during this time to properly educate, embrace, and direct them under scientific guidelines.
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    The effect of minocycline on fat graft survival and apoptotic pathway
    (2019) Güney, Kırdar; Özel, Bora; Seymen, Cemile; Elmas, Çiğdem; Tuncer, Serhan; Cenetoğlu, Seyhan; N/A; Tatar, Sedat; Doctor; School of Medicine; Koç University Hospital; N/A
    Variable absorption rate is one of the biggest problems of fat grafting and one of the most important causes of fat graft volume loss is apoptosis. Minocycline is a tetracycline derivative and besides its antibacterial capacity, it has been widely using for anti-apoptotic effects. This study was designed to investigate the effect of minocycline on fat graft survival and adipocyte apoptosis. A total of two main and eight subgroups were designed and a total of 48 experimental animals, 6 in each group, were used. Fat grafts are obtained from Wistar albino rats and implanted to dorsal area of rats. Local and systemic minocycline was applied in the study groups. On the 9th day, apoptotic cells were detected by the terminal deoxynucleotidyl transferase dUTP nick end labeling method and on the 90th day morphologic characteristics and viability of adipocytes were evaluated using histologic and immunohistochemical methods and statistically compared. This study revealed that the fat grafts were bigger, and they kept their structures better and they were more vascular in the minocycline groups and apoptosis was significantly lower in the minocycline groups. The authors demonstrated that minocycline increases fat graft survival and statistical improvement in apoptosis inhibition via using minocycline therapy has been shown.
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    Effect of oral mucosa-derived heterotopic fibroblasts on cutaneous wound healing
    (Elsevier Science inc, 2020) N/A; N/A; N/A; N/A; N/A; N/A; N/A; Sezgin, Billur; Tatar, Sedat; Karahüseyinoğlu, Serçin; Şahin, Gizem Nur; Ergün, Yağmur; Meriç, Gizem; Ersoy, Kaan; Faculty Member; Faculty Member; Faculty Member; PhD Student; Master Student; Undergraduate Student; Undergraduate Student; School of Medicine; N/A; School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; 133762; N/A; 110772; N/A; N/A; N/A; N/A
    An intriguing observation that has recently found support through clinical and experimental studies is that wounds of the oral mucosa tend to display faster healing and result in less scarring than in the skin. We aimed to investigate the potential of heterotopic oral mucosal fibroblasts in cutaneous wounds while determining the main differences between wounds conditioned with either the oral mucosa or dermis-derived human fibroblasts. A total of 48 nude mice were divided into four groups: control, sham, dermal fibroblast (DF), and oral fibroblast (OF). Fibroblasts were isolated, cultured, and seeded onto fibrin scaffolds for transfer to full-thickness dorsal wounds. Cell viability, wound area, healing rate, vascularization, cellular proliferation, dermal thickness, collagen architecture, and subtypes were evaluated. Both cell groups had a viability of 95% in fibrin gel prior to transfer. None of the wounds fully epithelialized on day 10, while all were epithelialized by day 21, which resulted in scars of different sizes and quality. Healing rate and scars were similar between the control and sham groups, whereas fastest healing and least scarring were noted in the OF group. Dermal thickness was highest in the DF group, which was also supported by highest levels of collagen types I and III. Proliferative cells and vascular density were highest in the OF group. DF result in healing through a thick dermal component, while oral fibroblasts result in faster healing and less scarring through potentially privileged angiogenic and regenerative gene expression.
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    PublicationOpen Access
    Capecitabine-induced bilateral ectropion: a rare ocular manifestation requiring surgical intervention
    (Medknow Publications, 2018) N/A; N/A; Tatar, Sedat; Yalçın, Can Ege; Sezgin, Billur; Taş, Ayşe Yıldız; Müftüoğlu, Orkun; Özmen, Selahattin; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine
    It has been established that many chemotherapeutic agents are associated with a variety of ocular side effects. As an antineoplastic agent, 5-fluorouracil (5-FU) is the chemotherapeutic agent that is frequently linked with cicatricial ectropion. Capecitabine is a prodrug of 5-FU and has a more favorable side effect profile than 5-FU. Frequent side effects of capecitabine include gastrointestinal events and hand-foot-mouth syndrome; cicatricial ectropion is rather uncommon. Enzyme deficiencies affecting the capecitabine metabolism have been reported to be associated with exaggerated generalized systemic and cutaneous side effects; however, there are no cases in the literature reporting capecitabine-induced isolated bilateral-progressive ectropion. Although cessation of the agent is frequently sufficient for the treatment of ectropion, close follow-up is indicated in such patients as permanent damage may occur if the problem is left untreated. We report a case of capecitabine-induced bilateral cicatricial ectropion refractory to treatment cessation, ultimately requiring surgical treatment.
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    PublicationOpen Access
    Response to "Clarification needed for case presented in 'the excision of the buccal fat pad for cheek refinement: volumetric considerations'"
    (Oxford University Press (OUP), 2019) N/A; N/A; Sezgin, Billur; Tatar, Sedat; Böge, Medine; Özmen, Selahattin; Yavuzer, Cahit Reha; Faculty Member; Faculty Member; School of Medicine
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    PublicationOpen Access
    Far from luck's way: a concurrence of Kaposi sarcoma and cutaneous angiosarcoma in the setting of chronic lymphocytic leukemia
    (Medknow Publications, 2020) Sezgin, Billur; Yiğit, Yeşim Esen; Tatar, Sedat; Selçukbiricik, Fatih; Durankuş, Nilüfer Kılıç; Kulaç, İbrahim; Atasoy, Pınar; Faculty Member; Faculty Member; Faculty Member; School of Medicine; Koç University Hospital; 133762; N/A; N/A; 202015; N/A; 170305; N/A
    Kaposi sarcoma and cutaneous angiosarcoma are rare forms of skin malignancies that are vascular in nature and are frequently encountered in the immunosuppressed population. Although synchronous angiosarcoma and Kaposi sarcoma have been documented, to our knowledge, the coexistence of these vascular malignancies with underlying chronic lymphocytic leukemia has not been previously reported. A 51-year-old male patient with chronic lymphocytic leukemia presented with Kaposi sarcoma located on his left ankle. Shortly after, the patient presented with de novo lesions located on the plantar region of the right foot, reported as angiosarcoma. Following a multidisciplinary decision, treatment with adjuvant chemotherapy consisting of paclitaxel and carboplatin with consolidation radiotherapy was planned. The patient's Kaposi sarcoma has remained unchanged throughout this period.In such cases, the treatment is advised to be planned around the more aggressive malignancy. These patients should also be followed-up by dermatology due to the higher risk of secondary cutaneous malignancies.