Researcher:
Kanıtez, Nilüfer Alpay

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Faculty Member

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Nilüfer Alpay

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Kanıtez

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Kanıtez, Nilüfer Alpay

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2019 - 2019102020 - 202316

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    Reply to: endovascular embolisation with Amplatzer vascular plug of ruptured pulmonary artery aneurism in Behçet's disease: a commentary
    (NLM (Medline), 2020) Bes, C.; Çelik, S.; N/A; Kanıtez, Nilüfer Alpay; Faculty Member; School of Medicine; 239432
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    Biological and targeted-synthetic disease-modifying antirheumatic drugs with concomitant methotrexate or leflunomide in rheumatoid arthritis: real-life treasure prospective data
    (Clinical and Experimental Rheumatology S.A.S., 2021) Kimyon G.; Kalyoncu U.; Kiraz S.; Bes C.; Coskun N.; Yagiz B.; Kucuksahin O.; Erden A.; Kilic L.; Bilgin E.; Kasifoglu T.; Emmungil H.; Koca S.S.; Akar S.; Cinar M.; Yazisiz V.; Ates A.; Ersozlu D.; Gonullu E.; Mercan R.; Ertenli I.; Karadag O.; Bolek E.C.; Farisogullari B.; Yakkan G.; Sari A.; Armagan B.; Dalkilic E.; Pehlivan Y.; Erten S.; Bilge S.Y.; Ilgen U.; Karatas A.; Yilmaz S.; Tekgoz E.; Colak S.; Terzioglu E.; Kelesoglu B.; N/A; Kanıtez, Nilüfer Alpay; Faculty Member; School of Medicine; 239432
    Objective To determine the real-life efficacy, safety, and drug-retention rates of leflunomide (LEF) or methotrexate (MTX) as a synthetic DMARD used in combination with biological DMARDs for rheumatoid arthritis (RA). Methods The TReasure database is a web-based, prospective, observational cohort of RA and spondyloarthritis patients from 17 centres in different regions of Turkey and data entry was enabled since December 2017. Until May 2019, 2556 RA patients on biologic treatment were recorded. Demographic and RA-related data of 1526 patient either received LEF or MTX were compared, efficacy of both drugs compared by RA-disease activity composite indices. Reasons fordrug discontinuation also recorded. Drug retention rates were compared with Kaplan-Meier curves (log-rank test). Results Of 2556 RA patients 1526 (59.7%) were receiving concomitant LEF (n=646, 42.3%; median follow up 35 months) or concomitant MTX (n=880, 57.3%; median follow-up 32 months) at the time of initiation to their first bDMARDs. The LEF group were older and had longer disease duration, proportion of females and seropositive patients was higher in this group. In the LEF group, non-anti-TNF agents were used in higher rate. Remission rates, changes in composite indices and rate of comorbidities and adverse events were similar in both groups. The retention rate of LEF + non-anti-TNF b/tsDMARDs was higher compared to MTX + anti–TNF bDMARDs (p=0.002, log-rank). Rates of adverse events were similar in both groups. Conclusion LEF in combination with either anti-TNF or non-anti-TNF drugs appears as an effective and safe therapeutic option at least as MTX.
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    Comparison of relapse rates in behcet's disease with venous involvement on different doses of azathioprine therapy, a retrospective observational study
    (Wiley, 2021) Girgin, Sinem; Yurumez, Seda; Omma, Ahmet; Celik, Selda; Icacan, Ozan Cemal; Bes, Cemal; N/A; Kanıtez, Nilüfer Alpay; Faculty Member; School of Medicine; 239432
    Aim The aim of this study was to investigate relapse rates in azathioprine (AZA) maintenance therapy at different doses in Behcet's disease (BD) with venous involvement. Method Clinical records of patients who met the diagnostic criteria of International Study Group (ISG) for BD, were diagnosed with venous involvement of BD for at least 6 months and sustained clinical remission with AZA for at least 3 months were analyzed retrospectively. The analysis cohort was divided into 2 groups based on AZA dose (Group A: >= 2 mg/kg/d and Group B: <2 mg/kg/d). Relapse was defined as requiring another antirheumatic/immunosuppressive drug or more than dose of 10 mg/d of prednisolone. Results of 78 patients who were included into the study, there was no significant difference between the 2 groups in terms of age, gender and clinical characteristics. Mean relapse-free survival time was found to be higher in group A compared to group B (111.6 +/- 11.2, 95% CI 89.5 +/- 133.8 versus 51.5 +/- 6.1, 95% CI 39.5 +/- 63.4 months). Conclusion Relapse-free survival rate was less in the group receiving low-dose AZA and shows the importance of effective dose of AZA in maintenance therapy.
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    Pregnancy in Takayasu's arteritis has a high risk of hypertension-related fetomaternal complications: a retrospective study of a Turkish cohort
    (Wiley, 2022) Tahra, Sema Kaymaz; Kara, Mete; Keser, Gokhan; Yazici, Ayten; Erden, Abdulsamet; Omma, Ahmet; Gercik, Onay; Akar, Servet; Aksu, Kenan; Kenar, Gokce; Kocaer, Sinem Burcu; Onen, Fatos; Ersozlu, Duygu; Alibaz-Oner, Fatma; Bayramlar, Osman Faruk; Direskeneli, Haner; N/A; Gönenli, Mehmet Gökhan; Kanıtez, Nilüfer Alpay; Teaching Faculty; Faculty Member; School of Medicine; School of Medicine; 350445; 239432
    Background This study aimed to examine fetomaternal outcomes in pregnant women in a large Turkish Takayasu arteritis (TAK) cohort and to evaluate the effects of pregnancy on the disease in those patients. Methods This is a cohort study involving 296 pregnancies of 112 TAK patients from 8 tertiary rheumatology centers in Turkey. Pregnancies were divided into 2 groups as pre-d (before disease onset) and post-d (after disease onset). In addition, post-d pregnancies were further divided into 2 subgroups according to fetomaternal complications (FMC) development status. Finally, patients were grouped into those with and without a history of pregnancy after disease onset. Results In post-d pregnancies, rates of worsening hypertension, new-onset hypertension, and preeclampsia were higher than in pre-d pregnancies (0.9% vs 16%, P < .001, 0.5% vs 5.3%, P = .012, and 0% vs 4%, P = .013, respectively). Patients with FMC were more likely to have renal artery involvement (65% vs 21%, P = .003). The patients who had post-d were younger, had longer disease duration, and had more relapses number than other patients (P < .001, P = .028, P = .016, respectively). Vasculitis Damage Index (VDI) results were similar in patients with or without post-d pregnancies. Conclusion Pregnancies after disease onset were found to be associated with HT and preeclampsia/eclampsia. HT-related FMCs are increased in TAK, and patients with renal artery involvement are at higher risk. The number of relapses increases in patients who become pregnant after disease onset, but pregnancy was not an independent risk factor for relapse. Pregnancy after the onset of disease had no negative effect on VDI.
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    Endovascular embolisation with Amplatzer vascular plug of ruptured pulmonary artery aneurism in Behçet's disease
    (Clinical and Experimental Rheumatology, 2019) N/A; N/A; Kanıtez, Nilüfer Alpay; Faculty Member; School of Medicine; 239432
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    The impact of the COVID-19 pandemic on internal medicine clerkship by comparing exam results and feedback
    (Routledge Journals, Taylor and Francis Ltd) N/A; N/A; Kanıtez, Nilüfer Alpay; Yaşlı, Mert; Algül, Serra Koçak; Faculty Member; Undergraduate Student; Other; School of Medicine; School of Medicine; N/A; N/A; N/A; Koç University Hospital; 239432; N/A; N/A
    COVID-19 pandemic affected the world in many ways. internal medicine education needed to be shaped according to the requirements of this pandemic. the aim of this study is to understand the effect of COVID-19 pandemic on internal medicine education and evaluate the newly introduced methods for education. Fourth-year medical students of 2019-2020 and 2020-2021 academic terms are evaluated in this study. Exam results and feedback scores of students are obtained. assessment methods in pre-pandemic group are face-to-face written exam and OSCE exam, whereas in post-pandemic group, online written exam and OSCE exam are used. Feedback forms are the same in both groups. the median written exam score was higher in the post-pandemic group than in the pre-pandemic group (84 vs 80, respectively, p = 0.003). there is no statistical significance among OSCE exam grades of the two groups. Feedback scores for bedsides were slightly higher in the post-pandemic group, and there is no statistical significance. Written and OSCE exam results in the post-pandemic group were as good as in the pre-pandemic group. We realized that the learning objectives in classical lecture can also be achieved from video recordings. although not statistically proven, we claim that increasing the time spent in clinical practice will yield more experience to the students.
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    Biologic treatments in Takayasu's Arteritis: a comparative study of tumor necrosis factor inhibitors and tocilizumab
    (W B SAUNDERS CO-ELSEVIER INC, 2021) Alibaz-Oner, Fatma; Kaymaz-Tahra, Sema; Bayindir, Ozun; Yazici, Ayten; Ince, Burak; Kalkan, Kubra; Kocaer, Sinem Burcu; Bilge, Nazife Sule Yasar; Omma, Ahmet; Durak, Elif; Ilgin, Can; Akar, Servet; Kasifoglu, Timucin; Onen, Fatos; Emmungil, Hakan; Inanc, Murat; Cefle, Ayse; Aksu, Kenan; Keser, Gokhan; Direskeneli, Haner; N/A; Kanıtez, Nilüfer Alpay; Faculty Member; School of Medicine; 239432
    Objective: To compare the treatment outcomes of TNF inhibitors and tocilizumab (TCZ) in patients with Takayasu arteritis. Methods: Takayasu arteritis patients who were refractory to conventional immunosuppressive (IS) drugs and received biologic treatment were included in this multicenter retrospective cohort study. Clinical, laboratory and imaging data during follow-up were recorded. Remission, glucocorticoid (GC) sparing effect, drug survival was compared between TNF inhibitor and TCZ treatments. Also, a subgroup matched comparison was performed between groups. Results: One hundred and eleven (F/M: 98/13) patients were enrolled. A total of 173 biologic treatment courses (77 infliximab, 49 TCZ, 33 adalimumab, 9 certolizumab, 3 rituximab, 1 ustekinumab and 1 anakinra) were given. Tocilizumab was chosen in 23 patients and TNF inhibitors were chosen in 88 patients as first line biologic agent. Complete/partial remission rates between TCZ and TNF inhibitors were similar at 3rd month and at the end of the follow-up. GC dose decrease (<4 mg) or discontinuation of GCs was achieved in a similar rate in both groups (TNF inhibitors vs TCZ: 78% vs 59%, p = 0.125). Drug survival rate was 56% in TNF inhibitors and 57% in TCZ group (p = 0.22). The use of concomitant conventional ISs did not affect the drug survival (HR =0.78, 95% CI =0.42-1.43, p = 0.42). The match analysis showed similar results between groups in terms of relapse, decrease in GC dose, surgery need and mortality. Conclusion: The efficacy and safety outcomes and drug survival rates seem to be similar for TNF inhibitors and tocilizumab in patients with Takayasu arteritis. (c) 2021 Elsevier Inc. .
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    Endovascular embolisation with amplatzer vascular plug of ruptured pulmonary artery aneurism in behcet's disease: a commentary
    (Clinical Exper Rheumatology, 2020) N.; Beş, C.; Çelik, S.; N/A; Kanıtez, Nilüfer Alpay; Faculty Member; School of Medicine; Koç University Hospital; 239432
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    Pregnancy outcome in patients with Takayasu arteritis: the results of Turkish Takayasu Study Group
    (Wiley, 2019) Kaymaz-Tahra, Sema; Yazici, Ayten; Cefle, Ayse; Kara, Mete; Yarkan-Tugsal, Handan; Gercik, Onay; Akar, Servet; Onen, Fatos; Aksu, Kenan; Keser, Gokhan; Bes, Cemal; Kamali, Sevil; Alibaz-Oner, Fatma; Direskeneli, Haner; N/A; Kanıtez, Nilüfer Alpay; Faculty Member; School of Medicine; 239432
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    An unusual case of extrapulmonary tuberculosis in rheumatology consultation
    (Aves, 2022) Somay, Kayra; Eren, İlker; Kapmaz, Mahir; Çağlayan, Benan Niku; Karakaya, Afak Durur; Kanıtez, Nilüfer Alpay; Researcher; Faculty Member; Doctor; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; 168021; N/A; 230719; 269567; 239432
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