Researcher:
Bilge, İlmay

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İlmay

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Bilge

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Bilge, İlmay

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2015 - 2019172020 - 202216

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Now showing 1 - 10 of 33
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    Improving the urine spot protein/creatinine ratio by the estimated creatinine excretion to predict proteinuria in pediatric kidney transplant recipients
    (Wiley, 2021) Palaoğlu, Kerim Erhan; N/A; İncir, Said; Taşdemir, Mehmet; Koçak, Burak; Yelken, Berna; Arpalı, Emre; Akyollu, Başak; Baygül, Arzu Eden; Bilge, İlmay; Türkmen, Aydın; Doctor; Faculty Member; Faculty Member; Doctor; Doctor; Doctor; Faculty Member; Faculty Member; Doctor; N/A; School of Medicine; School of Medicine; N/A; N/A; N/A; School of Medicine; School of Medicine; N/A; Koç University Hospital; N/A; N/A; Koç University Hospital; Koç University Hospital; Koç University Hospital; N/A; N/A; Koç University Hospital; 175430; 175867; 220671; N/A; N/A; N/A; 272290; 198907; N/A
    Background Since the daily creatinine excretion rate (CER) is directly affected by muscle mass, which varies with age, gender, and body weight, using the spot protein/creatinine ratio (Spot P/Cr) follow-up of proteinuria may not always be accurate. Estimated creatinine excretion rate (eCER) can be calculated from spot urine samples with formulas derived from anthropometric factors. Multiplying Spot P/Cr by eCER gives the estimated protein excretion rate (ePER). We aimed to determine the most applicable equation for predicting daily CER and examine whether ePER values acquired from different equations can anticipate measured 24 h urine protein (m24 h UP) better than Spot P/Cr in pediatric kidney transplant recipients. Methods This study enrolled 23 children with kidney transplantation. To estimate m24 h UP, we calculated eCER and ePER values with three formulas adapted to children (Cockcroft-Gault, Ghazali-Barratt, and Hellerstein). To evaluate the accuracy of the methods, Passing-Bablok and Bland-Altman analysis were used. Results A statistically significant correlation was found between m24 h UP and Spot P/Cr (p < .001, r = 0.850), and the correlation was enhanced by multiplying the Spot P/Cr by the eCER equations. The average bias of the ePER formulas adjusted by the Cockcroft-Gault, Ghazali-Barratt, and Hellerstein equations were -0.067, 0.031, and 0.064 g/day, respectively, whereas the average bias of Spot P/Cr was -0.270 g/day obtained by the Bland-Altman graphics. Conclusion Using equations to estimate eCER may improve the accuracy and reduce the spot urine samples' bias in pediatric kidney transplantation recipients. Further studies in larger populations are needed for ePER reporting to be ready for clinical practice.
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    Progress Study: progression of chronic kidney disease in children and heat shock proteins
    (SPRINGER, 2021) Yürük Yıldırım, Zeynep Nagehan; Usta Akgül, Sebahat; Alpay, Harika; Aksu, Bağdagül; Savran Oğuz, Fatma; Kıyak, Aysel; Akıncı, Nurver; Yavuz, Sevgi; Özçelik, Gül; Gedikbaşı, Asuman; Gökçe, İbrahim; Özkayın, Neşe; Yıldız, Nurdan; Pehlivanoğlu, Cemile; Göknar, Nilüfer; Saygılı, Seha; Tülpar, Sebahat; Küçük, Nuran; Ağbaş, Ayşe; Dirican, Ahmet; Emre, Sevinç; Nayir, Ahmet; Yolmaz, Alev; Bilge, İlmay; Taşdemir, Mehmet; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 198907; 175867
    Various molecular and cellular processes are involved in renal fibrosis, such as oxidative stress, inflammation, endothelial cell injury, and apoptosis. Heat shock proteins (HSPs) are implicated in the progression of chronic kidney disease (CKD). Our aim was to evaluate changes in urine and serum HSP levels over time and their relationships with the clinical parameters of CKD in children. In total, 117 children with CKD and 56 healthy children were examined. The CKD group was followed up prospectively for 24 months. Serum and urine HSP27, HSP40, HSP47, HSP60, HSP70, HSP72, and HSP90 levels and serum anti-HSP60 and anti-HSP70 levels were measured by ELISA at baseline, 12 months, and 24 months. The urine levels of all HSPs and the serum levels of HSP40, HSP47, HSP60, HSP70, anti-HSP60, and anti-HSP70 were higher at baseline in the CKD group than in the control group. Over the months, serum HSP47 and HSP60 levels steadily decreased, whereas HSP90 and anti-HSP60 levels steadily increased. Urine HSP levels were elevated in children with CKD; however, with the exception of HSP90, they decreased over time. In conclusion, our study demonstrates that CKD progression is a complicated process that involves HSPs, but they do not predict CKD progression. The protective role of HSPs against CKD may weaken over time, and HSP90 may have a detrimental effect on the disease course.
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    A rare cause of chronic hyponatremia in an infant: aldosterone synthase type-2 deficiency
    (Springer, 2018) Güran, Tülay; Yeşiltepe Mutlu, Rahime Gül; Taşdemir, Mehmet; Kızılkan, Nuray Uslu; Börklü Yücel, Esra; Hatun, Şükrü; Kayserili, Hülya; Bilge, İlmay; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 153511; N/A; 221274; N/A; 153504; 7945; 198907
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    Metabolic acidosis with increased anion gap, oxaluria, and acute kidney injury: answers
    (Springer, 2021) Aksu, Bağdagül; Rahimov, Erkin; Yılmaz, Alev; Yıldırım, Zeynep Yürük; Emre, Sevinç; Şirin, Aydan; Bilge, İlmay; Faculty Member; School of Medicine; 198907
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    Is there a unique symptom in lower urinary tract dysfunction in children?
    (Wiley, 2021) N/A; N/A; Özen, Mehmet Ali; Taşdemir, Mehmet; Aygün, Murat Serhat; Necef, Işıl; Aydın, Emrah; Bilge, İlmay; Eroğlu, Egemen; Faculty Member; Faculty Member; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 293404; 175867; 291692; N/A; 32059; 198907; 214688
    Objectives Lower urinary tract symptoms (LUTS), particularly urgency, incontinence and intermittency are common in children and it is suggested that the specific symptoms may be used for definite diagnosis for LUT dysfunction (LUTD). This study was performed to investigate the relationship between each LUTD and its associated symptoms, using uroflowmetry/electromyography (UF/EMG) as a diagnostic tool. Methods Each patient was categorized into one of four LUT conditions which were overactive bladder (OAB), dysfunctional voiding (DV), underactive bladder and primary bladder neck dysfunction (PBND), according to UF/EMG results. Patients' complaints and findings were documented by using voiding dysfunction symptom score, bladder diary, urine analysis and ultrasonography. In addition, a detailed history of bowel habits (including use of Rome III criteria) was obtained. Results There were 189 children of which 106 were female. The OAB was the largest group including 91 patients, followed by the DV group which had 61 patients. The symptoms specific to any LUTD group were constipation and hesitancy (P < .05). Hesitancy was present in 89.4% with PBND and constipation was present in 78.6% of patients with DV. None of other symptoms were able to differentiate any LUTD group from the other. Conclusions While certain symptoms are often presumed by clinicians to imply specific diagnoses, the main outcome of this study is that there is a generally weak correlation between the specificity of symptoms and LUTD. Symptoms-based approach may lead to misdiagnosis in LUTD. Thus, it may be essential to focus on the underlying pathologies and UF/EMG test may help this.
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    Urinary NAG, KIM-1 and NGAL levels in childhood urolithiasis: are reliable markers of renal tubular injury?
    (Springer, 2016) Fuçucuoğlu, Dilara; Küçük, Suat Hayri; Erol, Meltem; Yiğit, Özgül; Çalışkan, Salim; Taşdemir, Mehmet; Bilge, İlmay; Faculty Member; Faculty Member; School of Medicine; School of Medicine; Koç University Hospital; 175867; 198907
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    A rare cause of AA amyloidosis and end-stage kidney failure: questions and answers
    (Springer, 2019) Baba, Zeliha Füsun; Taşdemir, Mehmet; Yılmaz, Sezen Güçlü; Bilge, İlmay; Faculty Member; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; 175867; N/A; 198907
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    Continuous venovenous hemodiafiltration in the treatment of maple syrup urine disease
    (Karger, 2016) Sık, Güntülü; Topal, Nilüfer; Çitak, Agop; Zeybek, Çiğdem; Tüten, Abdulhamit; N/A; N/A; Demirkol, Demet; Bilge, İlmay; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 108964; 198907
    Background: The study aims to define the efficacy of continuous renal replacement therapy in acute metabolic decompensation treatment of maple syrup urine disease (MSUD). Methods: All the neonates, infants and children who have had life threatening conditions due to MSUD and were treated with continuous venovenous hemodiafiltration (CVVHDF) were analyzed retrospectively. Results: Fourteen patients underwent 15 sessions of CVVHDF (age range 15 days to 87 months, mean 40.8 +/- 31.4 months). One patient required additional CVVHDF 1 week after cessation of CVVHDF. Twenty seven percent (n = 4) of the patients were intubated and mechanically ventilated. Twelve patients responded to treatment and dramatic neurological improvement was observed within 24 h. Two of the 14 patients required 36 h of CVVHDF for neurological improvement. The mean duration of CVVHDF was 20.2 +/- 8.6 (9-36) h. The mean leucine level was 1,648 +/- 623.8 (714-2,768) mu mol/l before and was 256.5 +/- 150.6 (117-646) mu mol/l at the end of treatment. No mortality was observed. Conclusion: Continuous hemodiafiltration is an effective and safe method in correcting metabolic disturbances in MSUD. (C) 2016 S. Karger AG, Basel
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    Ambulatory arterial stiffness index (AASI), a surrogate marker of arterial stiffness, is increased in obese children
    (Springer, 2017) Gayret, Özlem Bostan; Taşdemir, Mehmet; Erginöz, Ergin; Bilge, İlmay; Faculty Member; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 175867; 307256; 198907
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    Can immature granulocyte count and hemogram indices begood predictors of urinary tract infection in children?
    (Association of Clinical Biochemistry Specialists, 2021) Palaoğlu, Kerim Erhan; N/A; N/A; N/A; N/A; N/A; İncir, Said; Taşdemir, Mehmet; Çaltı, Hatice Kant; Baygül, Arzu Eden; Bilge, İlmay; Faculty Member; Faculty Member; Doctor; Faculty Member; Faculty Member; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; N/A; N/A; Koç University Hospital; N/A; N/A; 175430; 175867; N/A; 272290; 198907
    Objectives: A left shift in a complete blood count (CBC) indicates the presence of immature granulocytes (IGs), and an elevated count is associated with a bacterial infection. The aim of this study was to evaluate the role of the IG count and inflammatory CBC parameters and indices in children with a urinary tract infection (UTI). Methods: In this retrospective study, 55 children with a UTI (patient group) and 47 children with no infection matched for age and sex (control group) were enrolled. The symptoms, clinical findings, CBC parameters, and platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammatory index (SII), and urinalysis findings were recorded. The C-reactive protein (CRP) level, urine culture results, and radiological data for the UTI group were also noted and analyzed. Results: The IG count; leukocyte, platelet, and neutrophil counts; and the CRP value were higher in the patient group than in the control group (p=0.001, 0.001, 0.035, 0.001, and < 0.001, respectively). The NLR, PLR, SII, and mean platelet volume were not significantly different between the groups. The median hemoglobin level was significantly lower in the patient group than in the control group (10.9 g/dL vs. 12.2 g/dL; p=0.004). The area under the curve values for CRP, and counts of IG, leukocytes, and neutrophils were 0.851 (95% confidence interval [CI]: 0.761-0.917), 0.736 (95% CI: 0.633-0.823), 0.714 (95% CI: 0.609-0.804), and 0.670 (95% CI: 0.564-0.765), respectively. Conclusion: The IG count is an easily obtained measurement that can be utilized alongside the CRP value and other indicators to create better predictive value in the management of UTI.