Researcher:
Keleş, Güven Evren

Profile Picture
ORCID

Job Title

Faculty Member

First Name

Güven Evren

Last Name

Keleş

Name

Name Variants

Keleş, Güven Evren

Email Address

Birth Date

Filters

2011 - 201511

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.d1c22e98-31d7-431e-9ac2-3c0c07c7074d

Search Results

Now showing 1 - 10 of 11
  • Placeholder
    PublicationMetadata only
    Intradural communication between dorsal rootlets of spinal nerves: their clinical significance
    (Springer, 2015) Solmaz, Bilgehan; Tatarli, Necati; Ceylan, Davut; N/A; Keleş, Güven Evren; Çavdar, Safiye; Faculty Member; Faculty Member; School of Medicine; School of Medicine; N/A; 1995
    Background Anatomical and surgical textbooks give almost no attention to the intradural communications between dorsal rootlets of adjacent spinal nerves. These communications can be of significance in various neurosurgical procedures and clinical conditions of the region. Methods The spinal cord of six formaldehyde-fixed cadavers was dissected from C1–S5. The dorsal rootlets of the spinal nerves were exposed via a posterior approach and communications between adjacent spinal nerves were documented. Results The frequency of communication between adjacent dorsal rootlets of the spinal nerves showed variations among spinal levels. Thirty-eight dorsal rootlet communications were observed in six cadavers (12 sides) and 20 (52.6 %) were at cervical levels, 14 (36.8 %) at thoracic levels, and four (10.5 %) at lumbar levels. The majority of communications were observed on the left side (65.8 %). Communications were most frequently observed at cervical (C4–C5, C5–C6) and upper thoracic (T1–T2) levels and seen least frequently at lower thoracic and lumbar levels. No communications were observed at sacral levels. Five types of communication were observed: I. oblique ascending, II. oblique descending III. short Y, IV. long Y and V shaped. None of the communication extended beyond one segment at any spinal level. The occurrence of such dorsal rootlet communications ranged from 3 to 7 for each cadaver and the mean was 4.8±1.3. Histological sections from various levels of the dorsal rootlet communications showed that all consisted of myelinated fibers of varying diameters. Conclusions Such communications may lead to misinterpretation of the pathology on the basis of clinical signs and symptoms and also should be considered in rhizotomy.
  • Placeholder
    PublicationMetadata only
    A variation of the cords of the brachial plexus on the right and a communication between the musculocutaneous and median nerves on the left upper limb: a unique case
    (Thieme Medical Publishers, 2013) Tatarli, Necati; Ceylan, Davut; Hacioglu, Husniye; Uygun, Seda; Seker, Askin; Çavdar, Safiye; Keleş, Güven Evren; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 1995; N/A
    During routine anatomical dissection of the upper extremity of a 64-year-old cadaver for educational purposes, we observed variations in the brachial plexus on each side. On the right an anomaly of cord formation was present and on the left there was a communication between the musculocutaneous nerve (MCN) and median nerve (MN). On the right side the brachial plexus showed two trunks, superior (C5 and C6) and inferior (C7, C8, and T1); the middle trunk was absent. The superior trunk bifurcated into anterior and posterior divisions, the anterior division continued as the lateral cord forming the MCN. The posterior division gave off the subscapular branch. The inferior trunk trifurcated into radial, median, and ulnar nerves. The radial nerve gave off the axillary and thoracodorsal nerves. The ulnar nerve gave off the median cutaneous nerves of the arm and forearm. The median nerve received a small ascending branch from the MCN. On the right side, there was a communicating branch from the MCN to the MN in the lower third of the arm region. This communicating branch also gave rise to a muscular branch to the brachialis muscle and the lateral cutaneous nerve of forearm. No additional heads of the biceps brachii muscle were observed in either upper limb. Knowledge of the variations of the brachial plexus in humans can be valuable for operations of the shoulder joint and its repair for providing an effective block or treatment for anesthetists and also for explaining otherwise incomprehensible clinical signs for neurologists.
  • Placeholder
    PublicationMetadata only
    New missions for an old agent: granulocyte-colony stimulating factor in the treatment of stroke patients
    (Bentham Science Publ Ltd, 2015) Digiçaylıoğlu, Murat; Zhang, John H.; N/A; Solaroğlu, İhsan; Keleş, Güven Evren; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 102059; N/A
    Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, anti-oxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.
  • Placeholder
    PublicationMetadata only
    Anatomy of the spinal dorsal root entry zone: its clinical significance
    (Springer, 2014) Kirazli, Ozlem; Tatarli, Necati; Guclu, Bulent; Ceylan, Davut; Ziyal, Ibrahim; N/A; Keleş, Güven Evren; Çavdar, Safiye; Faculty Member; Faculty Member; School of Medicine; School of Medicine; N/A; 1995
    The posterolateral sulcus (PLS) is an important surgical landmark, especially for DREZ (dorsal root entry zone) operations. The present study aimed to show the variations of the PLS using human spinal cord histological sections and report the variability in the number of dorsal rootlets of the spinal nerves in each the spinal cord segment. Further, measure the height and width of the dorsal horn on histological sections for cervical, thoracic, and lumbar levels. The results of the present study showed various patterns of PLS 1.clearly present PLS, 2. short PLS, 3. absent PLS or 4. irregular PLS. Height and width measurements of the dorsal horn showed that the average width was greatest at lower cervical (0.48 +/- 0.04 mm) and least at lower thoracic levels (0.41 +/- 0.04 mm), whereas the average height was greatest at upper cervical (3.0 +/- 0.06 mm) and smallest at lower lumbar levels (1.8 +/- 0.08 mm). The average number of rootlets varied considerably, at cervical level it was 7.6 +/- 1.4 mm, at thoracic 6.6 +/- 0.8 mm and at lumbar 6.1 +/- 0.4 mm. The detailed anatomy of the variations of the PLS and the average number of rootlets at each spinal level can increase the success of regional surgery. Further, fine measurements on histological sections can give detailed knowledge on the size necessary for lesioning in DREZ operations.
  • Placeholder
    PublicationMetadata only
    Falcine venous plexus within the falx cerebri: anatomical and scanning electron microscopic findings and clinical significance
    (Springer, 2013) Tatarlı, Necati; Ceylan, Davut; Canaz, Hüseyin; Tokmak, Mehmet; Bay, Hüsniye Hacıoğlu; Şeker, Aşkın; Kılıç, Türker; N/A; N/A; Keleş, Güven Evren; Çavdar, Safiye; Faculty Member; Faculty Member; School of Medicine; School of Medicine; N/A; 1995
    Only limited attention has been paid to the anatomy and clinical importance of the falcine venous plexus. The aim of this study was to evaluate the falcine venous plexus anatomically using scanning electron microscopy (SEM), and to provide guidance for neurosurgical approaches. Latex or ink was injected into the superior and inferior sagittal sinus. The falcine venous plexus lying within the connective tissue of the falx cerebri was observed by dividing the falx into thirds (anterior, middle and posterior). Further, the SEM appearance of the falcine venous plexus was evaluated. The anterior third of the falx cerebri consisted of small diameter falcine venous vessels. These vessels were localized close to either the superior or inferior sagittal sinus, and none extended as far as mid-falx cerebri levels in any of the 16 cases. They communicated with either superior or inferior sagittal sinuses, but not with both of these sinuses. In the middle third of the falx cerebri, the majority of the vessels of the falcine venous plexus had larger diameter compared to those of the anterior third. These vessels extended the length of the falx cerebri levels. They communicated with both superior and inferior sagittal sinuses. In the posterior third of the falx cerebri, the vessels of the falcine venous plexuses had the largest diameter and were located at the junction of the inferior sagittal sinus and the straight sinus. They were localized at the lower two-thirds of the falx cerebri. In all cases, the dense venous networks communicated with the inferior sagittal sinus but not with the superior sagittal sinus. The falcine venous plexus observed in the posterior third of the falx cerebri was denser than in the anterior and middle portions. The SEM revealed small vessels whose diameter ranged between 42 and 138 mu m. The vessels of the falcine venous plexus in the anterior third had a mean diameter of 0.42 +/- 0.1 mm, in the middle third a mean diameter of 0.87 +/- 0.17 mm, and in the posterior third, 1.38 +/- 0.21 mm. The falcine venous plexus is a network of venous channels that exists within the connective tissue of the falx; the sizes and patterns of communication of these structures showed regional differences. Neurosurgeons should be aware of the regional differences when making an incision or puncturing the falx during a surgical approach.
  • Placeholder
    PublicationMetadata only
    Posttraumatic brachial plexitis
    (Lippincott Williams & Wilkins, 2011) Aydın, Sabri; Abuzayed, Bashar; Bozkuş, Hakan; Boyacıyan, Arı; Sarıoğlu, Ali Çetin; N/A; Keleş, Güven Evren; Faculty Member; School of Medicine; N/A
    N/A
  • Placeholder
    PublicationMetadata only
    Diagnosis of brain death by orbital Doppler ultrasound: a comparative research study
    (Turkish Neurosurgery Society, 2015) Algın, Oktay; Gündoğdu, Gökhan; İzdeş, Seval; Keleş, Güven Evren; Solaroğlu, İhsan; Faculty Member; Faculty Member; School of Medicine; School of Medicine; N/A; 102059
    Aim: It remains unknown whether orbital Doppler-ultrasound (ODUS) could be an alternative to other established ancillary tests for the diagnosis of brain death. We investigated the effectiveness of ODUS in the diagnosis of brain death and compared data obtained from ODUS with transcranial Doppler-ultrasound (TDUS) and carotid Doppler-ultrasound (CDUS) findings. MaterIal and Methods: ODUS, CDUS and TDUS examinations were performed on 22 consecutive patients who had clinical examination and confirmatory test findings consistent with brain death. The compatibility of resistive indices (RI) from ODUS, TDUS and CDUS examinations were analyzed. Results: In ODUS examinations, the RI values were equal to or greater than one in 15 patients (68%). In the remaining 7 patients, the RI values were ≥0.75. RI values were ≥ 1 in 16 (72%) and 18 (82%) patients in CDUS and TDUS examinations, respectively. RI values of CDUS and TDUS were ≥0.76 in the remaining patients. ConclusIon: ODUS is an easily applicable technique that is safer, cheaper and faster when compared with the other confirmatory tests. False results could be prevented by evaluating patients with an ODUS RI value of <1 together with the TDUS and/or CDUS results. / AMAÇ: Orbital Doppler-ultrasonografi (ODUS)’un; beyin ölümü tanısında, diğer doğrulayıcı testlere alternatif bir yöntem olup olamayacağı henüz bilinmemektedir. Çalışmanın amacı beyin ölümü tanısında ODUS’un etkinliğini araştırmak ve transkraniyal Doppler-ultrasonografi (TDUS) ve karotid Doppler-ultrasonografi (CDUS) bulgularıyla karşılaştırmaktır. YÖNTEM ve GEREÇLER: Klinik muayene ve doğrulayıcı testler ile beyin ölümü tanısı alan ardışık 22 hastaya ODUS, CDUS ve TDUS uygulandı. ODUS, CDUS ve TDUS rezistif indeks (RI) değerlerinin beyin ölümü tanısı ile uyumluluğu analiz edildi. BULGULAR: Çalışmadaki hastalardan on beşinin (%68) ODUS incelemesinde; RI değeri 1’den büyük ya da eşit, geriye kalan 7 hastada ise 0,75 veya üstüydü. CDUS ve TDUS değerlendirmelerinde RI değerleri; CDUS incelemelerinde 16 hastada (%72) RI değeri 1’den büyük veya eşit iken TDUS incelemelerin de ise 18 hastada (%82) RI 1’den büyük ya da eşitti. Geriye kalan hastaların tümünün CDUS ve TDUS incelemelerinde RI değeri 0,75’ten büyüktü. SONUÇ: ODUS; anjiyografi gibi diğer doğrulayıcı testler ile karşılaştırıldığında kolay uygulanabilinen, zararsız, güvenli ve hızlı bir tekniktir. ODUS incelemede RI değeri 1 ve üstü ise beyin ölümü tanısı güvenle konulabilir. ODUS’ta RI<1 ise TDUS ve/veya CDUS ile tanının kesinleştirilmesi gerekmektedir. Hatalı sonuçlar, ODUS, TDUS ve/veya CDUS sonuçlarının birlikte değerlendirilmesi ile engellenebilir.
  • Placeholder
    PublicationMetadata only
    Bronchogenic cyst of the craniocervical junction a case report
    (Turkish Neurosurgery Society, 2014) Çaylak, Berrin; Algın, Oktay; Solaroğlu, İhsan; Keleş, Güven Evren; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 102059; N/A
    Intracranial bronchogenic cysts (BCs) are uncommon, and BCs at the craniocervical junction are extremely rare. These lesions are most frequently encountered in the cervico-thoracic region of the spine. Their pathogenesis is still poorly understood. Regardless of the surgical approach, the aim of surgery should be total removal of the cyst and its content, whenever feasible. In this case report, a 50-year-old patient with a BC of the craniocervical junction is presented. The patient was operated on through a right-sided suboccipital retrosigmoid approach. The uniform layer of pseudostratified, ciliated and mucus-secreting columnar cells was seen on histological examination. The clinical manifestations, diagnosis, and treatment of this unusual condition are discussed. / İntrakraniyal bronkojenik kistler nadir patolojilerdir ve kraniyoservikal bileşkede oldukça az görülürler. Omurganın genellikle servikotorasik bileşke bölgesinde yerleşirler. Patogenezleri tam olarak anlaşılamamıştır. Tedavilerinde genel kabul gören yol, cerrahi yaklaşım tipine bakılmaksızın uygun olan her olgulara kist ve içeriğinin total çıkarılmasıdır. Bu makalede, 50 yaşında kraniyoservikal bileşkede bronkojenik kisti olan bir olgu sunulmuştur. Olgu sağ suboksipital retrosigmoid yaklaşımla ameliyat edilmiştir. Histolojik incelemede psödostratifiye, silialı, mukus sekrete eden kolumnar hücreler görülmüştür. Bu nadir patolojinin klinik bulguları, tanı ve tedavisi tartışılmıştır.
  • Placeholder
    PublicationMetadata only
    The denticulate ligament: anatomical properties, functional and clinical significance
    (Springer, 2012) Ceylan, Davut; Tatarh, Necati; Abdullaev, Tuychiboy; Seker, Askin; Yildiz, Sercan D.; Konya, Deniz; Bayri, Yasar; Kilic, Turker; N/A; Keleş, Güven Evren; Çavdar, Safiye; Faculty Member; Faculty Member; School of Medicine; School of Medicine; N/A; 1995
    It is widely believed that the main function of denticulate ligaments (DLs) is to stabilize the spinal cord within the vertebral canal. The aim of this study was to assess the anatomical and histological structure of the DLs and to document any regional differences. Five formalin-fixed adult cadavers were used. The DLs were exposed via the posterior approach, and detailed anatomy and histology of these structures were documented. The main findings were: (1) each DL is composed of a single narrow fibrous strip that extends from the craniovertebral junction to T12, and each also features 18-20 triangular extensions that attach to the dura at their apices; (2) the triangular extensions are smaller and more numerous at the cervical levels, and are larger and less numerous at the thoracic levels; (3) the apices of the extensions attach to the dura via fibrous bands at cervical levels (each band 3-5 mm long) and lower thoracic levels (21-26 mm long), whereas they attach directly to the dura at upper thoracic levels; (4) the narrow fibrous strip of the DL features longitudinally oriented collagen fibers, whereas the triangular extensions are composed of transverse and obliquely oriented collagen fibers. The collagen fibers are thicker and more abundant at the cervical than at the thoracic levels. DL histology and anatomy are strongly correlated with the function of this structure at different spinal levels. It is important to have accurate knowledge about DLs as these structures are relevant for clinical procedures that involve the spinal cord or craniovertebral junction.
  • Placeholder
    PublicationMetadata only
    A unique case of intradural communicating branches between the accessory nerve and the dorsal roots of the cervical spinal nerves
    (Thieme Medical Publ Inc, 2013) Şeker, Aşkın; Ceylan, Davut; Tatarlı, Necati; Abdullaev, Tuychiboy; Gülbar, Seda; Konya, Deniz; Bayri, Yaşar; Kılıç, Türker; N/A; Keleş, Güven Evren; Çavdar, Safiye; Faculty Member; Faculty Member; School of Medicine; School of Medicine; N/A; 1995
    Objective The accessory nerve has cranial and spinal roots. The cranial roots emerge from the medulla, whereas the spinal roots arise from motor cells within the ventral horn of C1-C7 segments of the spinal cord. Communications have been described between the spinal accessory nerve rootlets and the dorsal rootlets of cervical spinal nerves. In the present case, we report a communication that has not been reported before and discuss the functional anatomy. Materials and Methods During the dissection of the craniovertebral junction of a 67-year-old formalin-fixed adult male cadaver, a connection between the spinal accessory nerve rootlets and the dorsal rootlets of the cervical spinal nerves was observed. Results A communication between the spinal rootlets of the accessory nerve and the dorsal roots of cervical spinal nerves was present on the right and left side. On the right, a communication between the accessory nerve spinal rootlet and the dorsal rootlet of the fourth cervical spinal nerve existed. On the left, there were two branches from the lowest accessory nerve spinal rootlet, one run ventrally and the other dorsally to the spinal rootlet and reached the dorsal root of third cervical spinal nerve. The dorsal root of C1 did not exist on either the right or the left side. Further, an unusual spinal accessory nerve formation was also observed. Discussion This case does not fit into any of the previously described classifications in the literature. Therefore, the different variations concerning the communications between the spinal rootlets of the accessory nerve and the cervical spinal nerves should be kept in mind during both surgical, especially radical neck dissections, and nonsurgical evaluations.