Researcher:
İspir, Pelin

Profile Picture
ORCID

Job Title

Master Student

First Name

Pelin

Last Name

İspir

Name

Name Variants

İspir, Pelin

Email Address

Birth Date

Filters

2016 - 20183

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.d550602b-b735-464d-8bfe-749b80066d06

Search Results

Now showing 1 - 3 of 3
  • Placeholder
    PublicationMetadata only
    The clinical impact of ST131 H30-Rx subclone in urinary tract infections due to multidrug-resistant Escherichia coli
    (Elsevier, 2016) Kurt-Azap, Özlem; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Can, Füsun; İspir, Pelin; Nurtop, Elif; Şeref, Ceren; Loçlar, İlayda; Aktaş, Özge Nur; Orhan, Yelda Ceren; Ergönül, Önder; Faculty Member; Master Student; Master Student; PhD Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 103165; N/A; N/A; N/A; N/A; N/A; N/A; 110398
    In this study, risk factors for ST131 H30 and H30-Rx subclones among urinary tract infections (UTIs) caused by multidrug-resistant (MDR) Escherichia coli were described. Urine samples were collected from consecutive outpatients registered to the outpatient clinics of Bas, kent University Hospital (Ankara, Turkey) with complaints of acute cystitis in 2011. A total of 107 MDR E. coli isolates were included in the study. of the 107 isolates studied, 26 (24.3%) were typed as ST131 clone. Extended-spectrum beta-lactamase (ESBL)-producers accounted for 59 (55.1%) of the 107 isolates. Among the 59 ESBL-positive isolates, 18 (31%) were found to belong to the ST131 clone. of the 18 ESBL-positive ST131 isolates, 17 (94%) were defined as H30 subclone, among which 16 (94%) represented the H30-Rx subclone. Among the 48 ESBL-negative isolates, 8 (17%) ST131 isolates were detected, 7 (88%) of which belonged to H30 subclone; 5 (71%) of the H30 subclone isolates were classified under H30-Rx subclone. In multivariate analysis, hospitalisation within last year was the only host risk factor associated with MDR E. coli ST131 H30-Rx subclone UTI (OR = 3.5, 95% CI 1.04-12.17; P = 0.042). CTX-M-15 production was found to be highly associated with the presence of ST131 H30-Rx subclone (OR = 4.8, 95% CI 1.54-15.32; P = 0.007). In conclusion, urinary MDR E. coli ST131 H30-Rx subclone was found to be important in the dissemination of MDR UTIs in the community. Approximately 20% of the MDR isolates were H30-Rx subclone. Infection with this subclone was found to be healthcare-associated. (C) 2015 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.
  • Placeholder
    PublicationMetadata only
    Impact of the ST101 clone on fatality among patients with colistin-resistant Klebsiella pneumoniae infection
    (Oxford University Press (OUP), 2018) Menekse, Şirin; Karahan, Salih Nafiz; Azap, Oztem Kurt; Timurkaynak, Funda; Yavuz, Serap Şimşek; Basaran, Seniha; Yörük, Fugen; Azap, Alpay; Koculu, Safiye; Benzonana, Nur; N/A; N/A; N/A; N/A; N/A; N/A; Department of Industrial Engineering; N/A; N/A; N/A; Can, Füsun; İspir, Pelin; Ataç, Nazlı; Albayrak, Özgür; Demir, Tuana; Karaaslan, Doruk Can; Gönen, Mehmet; Lack, Nathan Alan; Ergönül, Önder; Kapmaz, Mahir; Faculty Member; Master Student; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Faculty Member; Faculty Member; Faculty Member; Doctor; Department of Industrial Engineering; Koç Üniversitesi İş Bankası Enfeksiyon Hastalıkları Uygulama ve Araştırma Merkezi (EHAM) / Koç University İşbank Center for Infectious Diseases (KU-IS CID); School of Medicine; Graduate School of Health Sciences; N/A; N/A; School of Medicine; School of Medicine; College of Engineering; School of Medicine; School of Medicine; N/A; Koç University Hospital; 103165; N/A; N/A; N/A; N/A; N/A; 237468; 120842; 110398; N/A
    Objectives: We describe the molecular characteristics of colistin resistance and its impact on patient mortality. Methods: A prospective cohort study was performed in seven different Turkish hospitals. The genotype of each isolate was determined by MLST and repetitive extragenic palindromic PCR (rep-PCR). Alterations in mgrB were detected by sequencing. Upregulation of pmrCAB, phoQ and pmrK was quantified by RT-PCR. mcr-1 and the genes encoding OXA-48, NDM-1 and KPC were amplified by PCR. Results: A total of 115 patients diagnosed with colistin-resistant K. pneumoniae (ColR-Kp) infection were included. Patients were predominantly males (55%) with a median age of 63 (IQR 46-74) and the 30 day mortality rate was 61%. ST101 was the most common ST and accounted for 68 (59%) of the ColR-Kp. The 30 day mortality rate in patients with these isolates was 72%. In ST101, 94% (64/68) of the isolates had an altered mgrB gene, whereas the alteration occurred in 40% (19/47) of non-ST101 isolates. The OXA-48 and NDM-1 carbapenemases were found in 93 (81%) and 22 (19%) of the total 115 isolates, respectively. In multivariate analysis for the prediction of 30 day mortality, ST101 (OR 3.4, CI 1.46-8.15, P = 0.005) and ICU stay (OR 7.4, CI 2.23-29.61, P = 0.002) were found to be significantly associated covariates. Conclusions: Besides ICU stay, ST101 was found to be a significant independent predictor of patient mortality among those infected with ColR-Kp. A significant association was detected between ST101 and OXA-48. ST101 may become a global threat in the dissemination of colistin resistance and the increased morbidity and mortality of K. pneumoniae infection.
  • Placeholder
    PublicationMetadata only
    Molecular epidemiology of bloodstream-associated Escherichia coli ST131 H30-Rx subclone infection in a region with high quinolone resistance
    (Microbiology Society, 2016) Kurt-Azap, Özlem; N/A; N/A; N/A; N/A; N/A; Can, Füsun; Nurtop, Elif; İspir, Pelin; Şeref, Ceren; Ergönül, Önder; Faculty Member; Master Student; Master Student; PhD Student; Faculty Member; School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; 103165; N/A; N/A; N/A; 110398
    Bloodstream infections caused by Escherichia coli ST131 and ST131 H30-Rx subclones have emerged worldwide. This study was carried out to evaluate the prevalence of the ST131-Rx subclone and characterize the virulence properties of the Rx isolates among the bloodstream E. coli isolates. A total of 297 non-duplicated E. coli bloodstream isolates were studied. Antibiotic susceptibilities were tested using the disc diffusion method. PCR amplification and sequencing was used to identify ST131 and H30-Rx, the virulence gene, the beta-lactamase and virotype. Quinolone resistance among bacteraemic E. coli strains was 51 %, and it was 98% among E. coli ST131 isolates. The ST131 isolates accounted for 16% (49) of all isolates and all ST131 isolates belonged to the extraintestinal pathogenic E. coli. The proportion of H30 subclone among the ST131 isolates was 98%, and 75 % of H30 isolates belonged to the H30-Rx subclone. The prevalence of ST131 increased from 13 to 23 % in 4 years; however, there was a decrease in the ratio of H30-Rx infections. CTX-M-15 was detected in 85% of ST131 and all of the H30-Rx isolates. The virulence genes associated with adhesion, cell protection, iron uptake and toxins (papA, iha, kpsMTII, iut and sat) were more common in ST131 than in non-ST131 isolates. Most of the ST131 and H30-Rx isolates were of the C virotype. All papA-positive isolates were in virotype C. The E. coli ST131 clone has increased rapidly among bloodstream isolates. However, a decrease in the proportion of the H30-Rx subclone in the quinolone-resistant population suggests the possibility of dissemination of other virulent and quinolone-resistant subclones in hospital settings.