Researcher:
Bilir, Esra

Profile Picture
ORCID

Job Title

Researcher

First Name

Esra

Last Name

Bilir

Name

Name Variants

Bilir, Esra

Email Address

Birth Date

Filters

2018 - 201962020 - 202313

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.d8c8dfc4-c90c-4e12-a614-a53edb816539

Search Results

Now showing 1 - 10 of 19
  • Placeholder
    PublicationMetadata only
    World Gynecologic Oncology Day: the use of Twitter to raise awareness of gynecologic cancers
    (Elsevier Inc., 2022) Uwins, Christina; Yılmaz, Yusuf; Bhandoria, Geetu P.; Bilir, Esra; Researcher; School of Medicine; N/A
    Background: Social media provides an opportunity for people to connect and form communities. This community architecture can help to disseminate health-related information in the form of an awareness campaign. The European Society of Gynaecological Oncology and the European Network of Gynaecological Cancer Advocacy Groups initiated a global campaign, World Gynecologic Oncology Day, on September 20, 2020. We studied and analyzed the impact and reach of this Twitter campaign. Objective: This study aimed to assess the impact and reach of the 2020 World Gynecologic Oncology Day Twitter campaign. Study Design: We analyzed gynecologic oncology–specific posts (tweets) between 12 am on September 17, 2020, to 11:59 pm on September 25, 2020 (Coordinated Universal Time), covering the days immediately before and after World Gynecological Oncology Day (September 20, 2020), using Tweepy. The European Network of Gynecological Cancer Advocacy Groups suggested hashtags (#GoForPurple, #WorldGODay, and #GoForCheckup) should be used for this social media campaign. We used these hashtags for our data (tweet) collection. Results: A total of 382 Twitter accounts participated in this campaign and 662 tweets, including retweets, were reported. Of those, 22% of participants were healthcare professionals. A total of 164 unique hashtags were identified, and #WorldGODay was the most frequently used among the Twitter accounts. #VaginalCancer, #CervicalCancer, and #VulvarCancer were used in relation to the campaign. We identified 5 significant communities that contributed to raising awareness. Conclusion: Twitter campaigns should be designed around a single, short, easy-to-spell hashtag and coordinated with previously identified influential accounts using timed tweets. #WorldGOday hashtag was relevant, easy to spell, memorable, and the most effective hashtag used in this campaign.
  • Placeholder
    PublicationMetadata only
    Call for implementation research: cross-continental partnership experiences from the Trans-African Digital e-Health Network (i-STARC Project)
    (BMJ Publishing Group, 2023) Nasser, Sara; Togo, Pierre Adegne; Elghanmi, Adil; Sehouli, Jalid; Bilir, Esra; Researcher; School of Medicine; N/A
    N/A
  • Placeholder
    PublicationMetadata only
    Letter from a young female physician, candidate
    (Galenos Yayincilik, 2018) Bilir, Esra; Researcher; School of Medicine; N/A
    N/A
  • Placeholder
    PublicationMetadata only
    Notes from young physician candidates on the primary health care system
    (Halk Sağlığı Uzmanları Derneği, 2019) N/A; N/A; Kaymaz, Kubilay; Bilir, Esra; Other; Researcher; N/A; School of Medicine; Koç University Hospital; N/A; N/A
    In this paper, we aim to share our experiences and observations made during the obligatory primary care internship at a Family Health Center and a Community Health Center. We noted our experiences in a systematic manner using the key characteristics of good primary care provision defined in World Health Organization Primary Care Evaluation Tool (access to the services, comprehensiveness, continuity and coordination of care). We also pointed out the importance of a medical education curriculum for Primary Health Care (PHC) focusing on the potential struggles of the new graduates. Eventually, we realized that PHC is an underestimated topic within medical education and stronger PHC in Turkey would greatly benefit the patients and the system. Demographic features of the district in which we have worked had both its unique advantages and disadvantages. We observed that most of the problems encountered during the provision of PHC in these centers were due to flawed coordination among primary and other level providers, suboptimal work environment and conditions including high number of patients per primary care physician, underestimation of certain preventive services such as family planning and a need for better health information systems. We believe that undergraduate training at PHC level should be emphasized and undertaken through an effective partnership between stakeholders. / Bu yazıda, Aile Sağlığı Merkezi ve Toplum Sağlığı Merkezi'nde zorunlu temel sağlık hizmetleri stajımız sırasında edindiğimiz tecrübe ve gözlemlerimizi paylaşmayı amaçlıyoruz. Dünya Sağlık Örgütü Birinci Basamak Değerlendirme Aracı'nda tanımlanan iyi bir birinci basamak sağlık hizmetleri sunumunun temel özelliklerini (hizmete erişim, kapsamlılık, süreklilik ve bakımın koordinasyonu) kullanarak tecrübemizi sistematik bir şekilde not ettik. Ayrıca yeni mezunların potansiyel sorunlarına odaklanarak Temel Sağlık Hizmetleri (TSH) için tıp eğitimi müfredatının önemine de dikkat çektik. Nihayetinde TSH’nin tıp eğitiminde ihmal edilen bir konu olduğunu ve Türkiye’de daha güçlü bir TSH’nin hastalara ve sisteme büyük fayda sağlayacağını gördük. Çalıştığımız ilçenin demografik özelliklerinin kendine özgü avantaj ve dezavantajları vardı. Bu merkezlerde TSH sunumu sırasında karşılaşılan sorunların çoğunun, birinci basamak ve diğer seviye sağlayıcılar arasındaki kusurlu koordinasyondan, doktor başına düşen yüksek hasta sayısı da dahil uygun olmayan çalışma ortamı ve koşullarından, aile planlaması gibi bazı önleyici hizmetlere gereken önemin verilmemesi ve daha iyi bir sağlık bilgi sistemine ihtiyaç duyulmasından kaynaklandığını gözlemledik. TSH eğitimine ağırlık verilmesi ve bunun paydaşlar arasında etkin bir ortaklık ile yapılması gerektiğine inanıyoruz.
  • Placeholder
    PublicationMetadata only
    The role of hysteroscopy in fertility preservation in endometrial cancer and atypical endometrial hyperplasia: a semi-systematic literature review
    (Springer Science and Business Media Deutschland GmbH, 2023) Kahramanoğlu İ.; Bilir, Esra; Researcher; School of Medicine; N/A
    Purpose: Endometrial premalignancies are among the common reasons for outpatient gynecology visits among women in reproductive ages. Due to the continued increase in global obesity incidence among them, endometrial malignancies are expected to become even further prevalent. Hence, fertility-sparing interventions are essential and needed. In this semi-systematic literature review, we aimed to investigate the role of hysteroscopy in fertility preservation in endometrial cancer and atypical endometrial hyperplasia. Our secondary goal is to analyze the pregnancy outcomes following fertility preservation. Methods: We conducted a computed search in PubMed. We included original research articles including hysteroscopic interventions in pre-menopausal patients with endometrial malignancies and premalignancies who underwent fertility-preserving treatments. We collected data on medical treatment, response, pregnancy outcomes, and hysteroscopy. Results: Of the query results (n = 364), our final analysis included 24 studies. Overall, 1186 patients with endometrial premalignancies and endometrial cancer (EC) were included. More than half of the studies were retrospective design. They included almost ten different forms of progestins. Of the reported pregnancies (n = 392), the overall pregnancy rate was 33.1%. The majority of the studies used operative hysteroscopy (87.5%). Only three (12.5%) reported their hysteroscopy technique in detail. Although more than half of the studies did not provide any information on adverse effects due to hysteroscopy, there were no serious adverse effects among the reported ones. Conclusion: Hysteroscopic resection may increase the success rate of fertility-preserving treatment of EC and atypical endometrial hyperplasia. The clinical significance of the theoretical concern of the dissemination of cancer is not known. Standardization of the use of hysteroscopy in fertility-preserving treatment is needed. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
  • Placeholder
    PublicationMetadata only
    Blastocyst morphology grading: what is the most important predictor of live birth when accounting for endometrial receptivity?
    (Oxford Univ Press, 2018) Storr, A.; Cooke, S.; Garrett, D.; Venetis, C.; N/A; Bilir, Esra; Researcher; School of Medicine; N/A
    N/A
  • Placeholder
    PublicationMetadata only
    Pre-participation screening of the athletes in Turkey: approach of primary care physicians
    (Oxford Univ Press, 2019) N/A; N/A; Dursun, Merve; Bilir, Esra; Kaymaz, Kubilay; Sakarya, Sibel; Undergraduate Student; Researcher; Other; Faculty Member; School of Medicine; School of Medicine; Koç University Hospital; School of Medicine; N/A; N/A; N/A; 172028
    N/A
  • Placeholder
    PublicationMetadata only
    A comparative molecular analysis of DNA damage response, cell cycle progression, viability and apoptosis of malignant granulosa cells exposed to gemcitabine and cisplatin
    (Springer, 2020) Bildik, Gamze; Esmaeilian, Yashar; Vatansever, Doğan; Bilir, Esra; Taşkıran, Çağatay; Öktem, Özgür; Teaching Faculty; Researcher; Faculty Member; Researcher; Faculty Member; Faculty Member; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; 193687; N/A; 134190; 102627
    We aimed to provide a comparative characterization of DNA damage response elements, survival/apoptosis and cell cycle progression of the malignant granulosa cells exposed to gemcitabine and cisplatin. Malignant granulosa tumor cell lines COV434 and KGN were used for the experiments. Cell viability, proliferation, DNA damage response and apoptosis were investigated. Cell cycle progression was assessed. In vitro estradiol (E-2) and AMH productions of the cells were measured. Exposure of asynchronous malignant granulosa cells to gemcitabine caused growth arrest, induced DNA damage and activated cellular stress pathways, cell cycle checkpoint sensors and triggered apoptosis as evidenced by increased expression of phospho-p38, gamma-histone H2AX, phospho-Chk-1/phospho-Chk-2, and cleaved forms of PARP and caspase-3 in a dose dependent manner. In vitro E-2 and AMH productions of the cells were decreased along with reduction in viable cell mass. Cisplatin treatment produced a similar response but it was associated with JNK activation rather than p38. When the cells were synchronized and treated with gemcitabine at G(2)/M transition, the degradation of cyclin B1 and dephosphorylation of cdc-2 at Tyr 15 residue did not occur, resulting in cycle arrest. Similar effects on cell cycle progression was also observed in cisplatin. However, it was associated with JNK activation and higher expression of gamma-histone H2AX and cleaved forms of caspase-3 and PARP, indicative of more extensive DNA damage and apoptosis in the cells. This descriptive study provides evidence that gemcitabine exerts cytotoxic effects and causes perturbations in cell cycle progression of malignant granulosa cells.
  • Placeholder
    PublicationMetadata only
    Can a morphological description of the peritoneal carcinomatosis in advanced ovarian cancer add prognostic information? analysis of 1686 patients of the tumor bank ovarian cancer
    (Frontiers Media Sa, 2022) Nasser, Sara; Babayeva, Aygun; Braicu, Ioana; Richter, Rolf; Chekerov, Radoslav; Muallem, Mustafa-Zelal; Pietzner, Klaus; Inci, Melissa-Guelhan; Sehouli, Jalid; N/A; Bilir, Esra; Researcher; School of Medicine; N/A
    Background:Peritoneal carcinomatosis in ovarian cancer is frequent and generally associated with higher stage and poorer outcome. The clinical features of peritoneal carcinomatosis are diverse and their relevance for surgical and long-term outcome remains unclear. We conducted this prospective study to describe intraoperatively the different features of peritoneal carcinomatosis(PC) and correlate them with clinicopathological features, progression-free(PFS) and overall survival (OS),. Methods: We performed a systematic analysis of all patients with documented intraoperative PC and a primary diagnosis of epithelial ovarian, tubal, or peritoneal cancer from January 2001 to September 2018. All data were evaluated by using the systematic tumor bank tool. Specific PC features included texture(soft-hard), consistency(coarse-fine or both), wet vs dry(PC with ascites vs. PC without ascites), and localization(diffuse-local). PC characteristics were then evaluated for correlation with age, FIGO-stage, histology, lymph-node involvement, grade, and presence of residual tumor at primary surgery. Moreover, the influence of PC characteristics on OS and PFS was analyzed. Results: A total of 1686 patients with PC and primary epithelial ovarian cancer were included. Majority of the patients were characterized by diffuse PC(73.9%). The majority of peritoneal nodules were fine in texture (55.3%) and hard in consistency (87.4%). Moreover, 27.6% of patients had dry PC. Diffuse PC localization was significantly associated with higher FIGO-stage (p<0.001), high-grade (p=0.003) and serous tumors (p=0.006) as well as residual tumor as compared to local PC (p<0.001). Wet PC also significantly correlated with diffuse localization (p <0.001) and residual tumor as compared to dry PC (p<0.001). Coarse PC was significantly associated with residual tumor as compared to fine PC (p=0.044). All other PC features didn ' t correlate with clinicopathological features. As for survival outcomes, diffuse peritoneal localization (p<0.001), wet PC (p<0.001), and additional lymph node involvement (p<0.001) were associated with lower OS and PFS rates. Other PC features did not significantly impact survival. Conclusion: Diffuse localization of peritoneal carcinomatosis was significant predictor of recurrence. Lower OS and PFS were associated with diffuse peritoneal localization, wet PC, and additional lymph node involvement. Further prospective trials are warranted with the inclusion of translational research aspects to better understand the different peritoneal carcinomatosis patterns.
  • Placeholder
    PublicationMetadata only
    Painful catamenial vulvar lesions misleading gynecologist
    (Sage Publications Ltd, 2022) Dikmen, Bahar Yılmaz; Yıldız, Şule; Bilir, Esra; Bulutay, Pınar; Türkgeldi, Engin; Ata, Mustafa Barış; Faculty Member; Researcher; Teaching Faculty; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 134205; N/A; 133565; 329649; 182910
    Endometriosis usually presents as cyclical pain in the pelvis but may also present as painful cutaneous lesions. Many diseases may mimic hidradenitis suppurativa (HS) since HS, a chronic inflammatory painful skin disease, is a clinical diagnosis. A 32-year-old woman presented with painful lumps on her vulva and groin accompanied with bloody discharge during menstruation. She was followed up with preliminary diagnosis of endometriosis. Previous excision without definitive diagnosis resulted in temporary relief. She was prescribed oral contraceptive pills that alleviated her symptoms but quitted due to headache. Surgical excision was performed for definitive diagnosis and therapeutic relief. Pathology report revealed HS. She was prescribed oral doxycycline. She responded well to the therapy and has symptom-free for the last 2 years. She delivered one healthy girl via cesarian section 2 years after the treatment. Endometriosis and HS should be included in the differential diagnosis when women present with menstrual painful lesions around external genitalia for diagnosis and treatment.