Researcher:
Aydın, Emrah

Profile Picture
ORCID

Job Title

Faculty Member

First Name

Emrah

Last Name

Aydın

Name

Name Variants

Aydın, Emrah

Email Address

Birth Date

Filters

2018 - 201982020 - 20218

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.db68eaf8-128b-4be1-aa5d-f2099f270aa1

Search Results

Now showing 1 - 10 of 16
  • Placeholder
    PublicationMetadata only
    Proteomic profiling of tracheal fluid in ovine model of congenital diaphragmatic hernia with fetal tracheal occlusion identifies dysregulation of epithelial PI3K/AKT, WNT, and notch signaling
    (Amer Thoracic Soc, 2019) Varisco, B. M.; Oria, M.; Joshi, R.; Cabanas, N.; Schmidt, R.; Schroeder, C.; Marotta, M.; Peiro, J.; Aydın, Emrah; Faculty Member; School of Medicine; 32059
  • Placeholder
    PublicationMetadata only
    LSC-2021-reversible fetal tracheal occlusion in mice: a novel transuterine method
    (European Respiratory Soc Journals Ltd, 2021) N/A; N/A; Torlak, Nilhan; Yıldırım, Alkım; Eroğlu, Egemen; Aydın, Emrah; PhD Student; Undergraduate Student; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; 214688; 32059
    N/A
  • Placeholder
    PublicationMetadata only
    Long-term outcomes in pediatric appendiceal carcinoids: Turkey experience
    (Springer, 2018) Akova, Fatih; Eray, Y. Nur; Toksoy, Nurseli; Yalcin, Senay; Altinay, Serdar; Tetikkurt, Umit Seza; Aydın, Emrah; Faculty Member; School of Medicine; 32059
    The tendency of non-operative management of appendicitis let us explore the natural history of appendiceal carcinoids, compare them with appendicitis patients, and determine the possibility of deciding the extent of the surgery and post-operative follow-up on behalf of the intraoperative findings. A retrospective review was performed of patients with appendicitis between 2009 and 2017. of 2781 patients, 10 (0.36%) were diagnosed with appendiceal carcinoids. Sixty percent were female with an average age of 13.101.73. The mean tumor size was 0.97 +/- 0.34cm with 70% located at the tip. Majority had an insular pattern (n=9), six had subserosal fat tissue invasion, one had extension to mesoappendix, one had vascular invasion, and two had lymphatic invasion. The average mitotic index was 3.20 +/- 1.40/50HPF, and Ki 67 activity was 3 +/- 1.7%. The mean follow-up period was 66.40 +/- 25.92months. Patients were further evaluated with ultrasonography (n=10), CT (n=3), and MRI (n=10). Serum markers including chromogranin (n=9), NSE (n=6), and 5-HIAA (n=6) were normal. None required further treatment and had any symptoms of carcinoid syndromes or recurrences post-operatively.p id=Par2 Conclusion: Other than appendectomy, no additional surgery or follow-up is required in appendiceal carcinoids less than 1.5cm in size, regardless of the lymphoid or vascular invasion.
  • Placeholder
    PublicationMetadata only
    Comparing foreign body injuries patterns between Turkey and European countries: are female Turkish children more vulnerable?
    (Elsevier, 2021) Azzolina, Danila; Baldas, Solidea; French, Megan A.; Gregori, Dario; Lorenzoni, Giulia; Aydın, Emrah; Faculty Member; School of Medicine; 32059
    Objectives: The present study aimed at analyzing and comparing Foreign Body (FB) injuries patterns in children from Turkey and other European countries in order to assess any country and culturally specific aspects of FB risk. Methods: Data from Susy Safe register were included in the analysis. For this study, ICD-935 (mouth, esophagus and stomach) and ICD-934 (trachea, bronchus, and lung) cases from European countries and from a single center in the Istanbul Bahcelievler State Hospital, Turkey, were extracted from the Susy database. A Multiple Correspondence Analysis (MCA) approach was employed to identify differences or similarities between the groups of FB injuries. Results: The Turkey dataset has a larger proportion of females in comparison to the European data (p-value 0.002). According to the MCA analysis, the first two dimensions are explaining 48.11% of the variability (dimension 1, 37.44%; dimension 2, 10.67%). The three largest contributions to dimension 1 are via naturalis removal, not hospitalized, and ICD-935. The greatest contributions to dimension 2 are FB type, and consistency. Conclusion: The most interesting study finding is the higher incidence of females suffering a FB injury in ICD-934-935 in the Turkey dataset compared to that seen in the European dataset and also higher than that for all ICD locations within the Susy Safe register. The higher incidence of females tends to go against the belief that boys suffer higher FB injuries and needs to be further investigated.
  • Placeholder
    PublicationMetadata only
    Is there a unique symptom in lower urinary tract dysfunction in children?
    (Wiley, 2021) N/A; N/A; Özen, Mehmet Ali; Taşdemir, Mehmet; Aygün, Murat Serhat; Necef, Işıl; Aydın, Emrah; Bilge, İlmay; Eroğlu, Egemen; Faculty Member; Faculty Member; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 293404; 175867; 291692; N/A; 32059; 198907; 214688
    Objectives Lower urinary tract symptoms (LUTS), particularly urgency, incontinence and intermittency are common in children and it is suggested that the specific symptoms may be used for definite diagnosis for LUT dysfunction (LUTD). This study was performed to investigate the relationship between each LUTD and its associated symptoms, using uroflowmetry/electromyography (UF/EMG) as a diagnostic tool. Methods Each patient was categorized into one of four LUT conditions which were overactive bladder (OAB), dysfunctional voiding (DV), underactive bladder and primary bladder neck dysfunction (PBND), according to UF/EMG results. Patients' complaints and findings were documented by using voiding dysfunction symptom score, bladder diary, urine analysis and ultrasonography. In addition, a detailed history of bowel habits (including use of Rome III criteria) was obtained. Results There were 189 children of which 106 were female. The OAB was the largest group including 91 patients, followed by the DV group which had 61 patients. The symptoms specific to any LUTD group were constipation and hesitancy (P < .05). Hesitancy was present in 89.4% with PBND and constipation was present in 78.6% of patients with DV. None of other symptoms were able to differentiate any LUTD group from the other. Conclusions While certain symptoms are often presumed by clinicians to imply specific diagnoses, the main outcome of this study is that there is a generally weak correlation between the specificity of symptoms and LUTD. Symptoms-based approach may lead to misdiagnosis in LUTD. Thus, it may be essential to focus on the underlying pathologies and UF/EMG test may help this.
  • Placeholder
    PublicationMetadata only
    Manual separation, topical vaseline and estrogen in labial adhesions
    (Logos Medical Publishing, 2019) N/A; N/A; Özen, Mehmet Ali; Aydın, Emrah; Eroğlu, Egemen; Shabsog, Mohammed Kamal Yahya; Oğuzkurt, Nigar Pelin; Faculty Member; Faculty Member; Faculty Member; Undergraduate Student; Doctor; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; Koç University Hospital; 293404; 32059; 214688; N/A; N/A
    Objective: Although labial adhesions are frequently seen in childhood, debates are continuing about its pathophysiology and management. Despite topical estrogen is the most preferred treatment option, there are different opinions about its efficacy and side effects. Herein, we aimed to compare the effectiveness of combined treatments and manual separation and their long-term recurrence rates. Method: All primary cases diagnosed with complete labial adhesion between 2014 and 2019 and followed up for at least 6 months were analyzed per age, admission complaints, recurrence and side effects. Study groups were determined as; MS (Group 1); MS and pure vaseline (Group 2); MS and topical estrogen (Group 3). Results: Ninety-eight patients with median age of 2.6 years (range 4 to 108 months) who met the study criteria were included in the study. While itching, erythema, post-void dripping and urinary infection were the most common symptoms at presentation, 28.5% of the patients were diagnosed during routine examination and 17.3% of the cases diagnosed by the families as closed vagina. Group 1 had 30 (30.61%), Group 2, 39 (39.80%) and Group 3 29 (29.60%) patients. The recurrence rates were 23.3%, 2.5%, and 6.8%, respectively. Side effects were seen only in MS and topical estrogen-treated group (4 children). Conclusion: Treatment with MS and pure vaseline has a lower recurrence rate without any side effects compared to the other two groups. It can be preferred safely in the treatment of complete labial adhesions.  / GİRİŞ ve AMAÇ: Labial adezyon çocukluk çağında sık görülmesine rağmen, patofizyolojisi ve yönetimi hakkında tartışmalar mevcuttur. En sık tercih edilen tedavi seçeneği topikal östrojen olmakla beraber etkinliği ve yan etkileri hakkında farklı görüşler mevcuttur. Bu çalışmada manuel separasyon (MS) ile kombine yapılan tedavilerin etkinliğini ve uzun süredeki nüks oranlarını karşılaştırmayı amaçladık. YÖNTEM ve GEREÇLER: 2014 ve 2019 yılları arasında tam labial adezyon tanısı alan ve en az 6 ay süre ile takip edilen tüm birincil vakalar yaş, başvuru yakınması, nüks ve yan etkiler bakımından analiz edildi. Çalışma grupları; MS (Grup 1); MS ve saf vazelin (Grup 2); MS ve topikal östrojen (Grup 3), olarak belirlendi. BULGULAR: Kriterleri karşılayan 98 hasta çalışmaya dahil edildi. Hastaların ortanca yaşı 2,6 yıldı ( 4-108 ay). Grup 1 de 30 (%30,6), grup 2 de 39 (%39,8) ve grup 3 de 29 (%29,6) hasta mevcuttu. Kaşıntı, kızarıklık, işeme sonrası damlama, üriner enfeksiyon en sık başvuru semptomları iken, hastaların %28,5 inde tanı semptom olmadan rutin muayene esnasında, %17,3 ünde ise aileler tarafından tespit edilen vajen kapalılığı sonrasında konulmuştu. Nüks oranları grup 1 de %23,3, grup 2 de %2,5 ve grup 3 de ise %6,8 olarak tespit edildi. Sadece MS ve topikal östrojen uygulanan grupta, 4 çocukta yan etki görülmüştü. TARTIŞMA ve SONUÇ: MS ve saf vazelin tedavisi, diğer iki gruba göre herhangi bir yan etkisi olmadan daha düşük nüks oranına sahiptir. Bu sebeplerden dolayı labial adezyonların tedavisinde bu uygulamanın güvenle tercih edilebileceğini düşünmekteyiz.
  • Placeholder
    PublicationMetadata only
    Yap activation and basal cell expansion in mouse and rabbit models of fetal tracheal occlusion
    (Amer Thoracic Soc, 2019) Varisco, B. M.; Stephens, C.; Cabanas, N.; Oria, M.; Peiro, J.; Aydın, Emrah; Faculty Member; School of Medicine; 32059
  • Placeholder
    PublicationMetadata only
    The effectiveness of skin anchoring technique for the treatment of isolated buried penis
    (Türkiye Klinikleri, 2020) N/A; Aydın, Emrah; Özen, Mehmet Ali; Oğuzkurt, Nigar Pelin; Eroğlu, Egemen; Faculty Member; Faculty Member; Doctor; Faculty Member; School of Medicine; School of Medicine; N/A; School of Medicine; Koç University Hospital; 32059; 293404; N/A; N/A
    Objective: Buried penis has long been a problem not only for its causes but also for diversity in the techniques of surgical correction sometimes with unsatisfactory outcomes. The aim of the current study is to evaluate the effectiveness of a simple skin anchoring technique. Material and Methods: Buried penis repair patients between 2016 and 2018 were analyzed and those are younger than 1 year old, have accompanying congenital anomalies and a body mass index over 25 were excluded. The technique involves a complete degloving of penile shaft skin followed by two fixation sutures (5/0 polydioxanone) at 5 and 7 directions between Buck’s fascia at the penile base and the skin dermis at the base of the degloved penis and trimming the redundant prepuce per the skin length with resultant circumcision. Results: There were 12 patients whose mean age was 4.67±2.84 years and the mean follow up was 15.83±7.84 months. One (8.3%) patient had dissatisfaction who was lost to follow up but reached out by phone. Rest of the patients had satisfactory cosmetic outcomes. Conclusions: When treating patients with an isolated buried penis; degloving and skin anchoring technique is a simple and functionally and cosmetically satisfactory surgical technique. / Amaç: Gömülü penis sadece meydana getiren sebepler nedeni ile değil aynı zamanda çok farklı tedavi yöntemlerine rağmen başarısız sonuçlar nedeni ile de güncel bir problemdir. Çalışmanın amacı izole gömülü penis cerrahisinde cilt sabitleme tekniğinin sonuçlarını bildirmektir. Gereç ve Yöntemler: Çalışmada 2016-2018 yılları arasında gömülü penis nedeni ile opere edilen yaşı birden büyük, eşlik eden anomalisi olmayan ve vücut kitle indeksi 25’in altında olan olgular irdelendi. Penis tam deglovingi takiben penis kökünde Buck fasyası ile dermis arasına saat 5 ve 7 yönlerinde iki adet fiksasyon dikişi ile sabitlendi ve sünnet yapıldı. Bulgular: Çalışmaya dahil edilen 12 hastanın yaş ortalaması 4,67±2,84 yıl ve ortalama takip süresi 15,83±7,84 aydı. Estetik memnuniyetsizlik nedeni ile takipten çıkan 1 (8,3%) olgu dışında bütün hastalar sorunsuzdu. Sonuç: İzole gömülü penis cerrahisinde uygun hasta grubunda cilt asma tekniği basit ve işlevsel ve kozmetik olarak tatminkar bir cerrahi tekniktir.
  • Placeholder
    PublicationMetadata only
    Reversible fetal tracheal occlusion in mice: a novel minimal invasive technique
    (Elsevier, 2021) N/A; N/A; N/A; N/A; Aydın, Emrah; Torlak, Nilhan; Yıldırım, Alkım; Bozkurt, Elif Gökçen; Faculty Member; PhD Student; Undergraduate Student; Undergraduate Student; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; N/A; N/A; School of Medicine; Graduate School of Health Sciences; School of Medicine; School of Medicine; 32059; N/A; N/A; N/A
    Background: There is a certain need for reversible, cheap, and reproducible animal models for understanding the impact of tracheal occlusion (TO) in the congenital diaphragmatic hernia and pathophysiology. We aimed to present an easy, reversible, and minimally invasive murine TO model with optimized time points for introduction and removal of TO. Methods: Time-mated C57BL/6 mice underwent laparotomy at embryonic day 16.5 (E16.5) with transuterine TO performed on two fetuses in each uterine horn. In the TO group, the fetuses were harvested at E18.5 without suture removal; the suture was released at E17.5 in the TO-R group, and all fetuses were harvested at E18.5. The lungs of the fetuses were compared by morphometric and histologic analysis. Results: Successful TO was confirmed in 34 of 37 fetuses. Twenty-nine of them survived to E18.5 (90.6%), six of the fetuses had a spontaneous vaginal delivery. Fetal weights were comparable, but there was significant difference in lung weights and lung-to-body weight ratios (0.020 ? 0.006 [control] versus 0.026 ? 0.002 [TO] versus 0.023 ? 0.005 [TO-R]; P = 0.013). DNA/protein and DNA/lung weight ratios were elevated, whereas protein/lung weight ratio was lower in TO compared with the control group. Conclusions: Reversal of fetal transuterine TO at E17.5, which was put at E16.5 in mice, is feasible with comparable outcomes to other current animal models with certain advantages and potential to translate the studies to the human. ? 2020 Elsevier Inc. All rights reserved.
  • Placeholder
    PublicationMetadata only
    Çocuklarda nadir boyun ve koltuk altı lipoblastomlarının yönetimi
    (Türkiye Klinikleri, 2021) Akova, Fatih; Binar, Murat; N/A; Aydın, Emrah; Faculty Member; School of Medicine; N/A
    Objective: Lipoblastomas are benign tumors developing from embryonic fat tissue with few cases reported in the head and neck region. Herein, we aim to present the management of a rare type of lipoblastoma in childhood. Material and Methods: A retrospective chart review was performed on all patients who were admitted due to a mass in the neck and axillary region between January 2015 and December 2019. Data were collected on demographics, comorbidities, preoperative characteristics, operative interventions, and postoperative complications and outcomes. The patients with lipoblastoma were further analyzed. Results: There were 52 patients operated on due to a mass in the neck or axillary region during the study time. The mean age was 5.42±4.16. The majority of the patients (40/52) were diagnosed with enlarged lymph nodes of which 32 (80%) were diagnosed with lymphoma. Among these populations, only two (3.8%) of them were diagnosed with lipoblastoma. Both cases were asymptomatic other than a painless mass. The histopathological examination confirmed the diagnosis of lipoblastoma after surgical excision. Both cases have been uneventful for four years postoperatively. Conclusion: In conclusion, lipoblastomas emerge as a slowly growing mass in early childhood and are mostly seen on the trunk and extremities. Although benign, they have the potential to increase in size and invade adjacent tissues. The gold standard treatment is complete surgical excision. Due to the possibility of recurrence, regular follow-up is strongly recommended after surgery. / Amaç: Lipoblastom, embriyonik yağ hücrelerinden köken alan iyi huylu bir tümördür. Baş-boyun bölgesinde bildirilen vaka sayıları sınırlıdır. Bu çalışmada, nadir yerleşimli lipoblastoma yaklaşımı literatür ışığında sunmayı amaçladık. Gereç ve Yöntemler: Kliniğimize Ocak 2015 ve Aralık 2019 yılları arasında boyun ve koltuk altı bölgesinde şişlik ile başvuran hastaların dosyaları geriye dönük olarak incelendi. Olguların demografik özellikleri, eşlik eden hastalıkları, ameliyat bulguları, komplikasyonları ve son durumları belirlendi. Bu olgular arasında lipoblastom tanısı alanlar detaylı olarak analiz edildi. Bulgular: Belirtilen dönemde boyun ve koltuk altı bölgesinde şüpheli lezyon ile yaş ortalaması 5,42±4,16 yıl olan 52 hasta başvurdu. Hastaların büyük çoğunluğunda (40/52) büyümüş lenf nodu mevcuttu ve bu hastaların 32 (%80)’si lenfoma tanısı aldı. Bu hastalardan sadece 2 tanesi (%3,8) lipoblastom tanısı aldı. Her 2 olguda da başvuru anında ana şikâyet ağrısız büyüyen şişlik idi. Cerrahi eksizyon sonrası yapılan histopatolojik inceleme ile lipoblastom tanısı doğrulandı. Erken dönemde komplikasyon gözlenmeyen her 2 olgu da postoperatif 4. yılda sorunsuz takip edilmektedir. Sonuç: Lipoblastom, çocukluk çağında ağrısız büyüyen, çoğunlukla gövde ve ekstremiteleri tutan bir lezyondur. İyi huylu olmasına rağmen büyüme ve çevre dokulara invaze olma eğilimindedir. Cerrahi olarak çıkarılması tedavide altın standarttır. Nüks etme ihtimali nedeni ile uzun süreli takip önerilmektedir.