Researcher:
Aygün, Murat Serhat

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Murat Serhat

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Aygün

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Aygün, Murat Serhat

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2015 - 201952020 - 202315

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    The angiographic and clinical follow-up outcomes of the wide-necked and complex intracranial aneurysms treated with LVIS EVO-assisted coiling
    (NLM (Medline), 2023) Puthuran, Mani; Onal, Yilmaz; Barburoglu, Mehmet; Chandran, Arun; Berdikhojayev, Mynzhylky; Gravino, Gilbert; Velioglu, Murat; Sencer, Serra; Aygün, Murat Serhat; Aydın, Kubilay; Şentürk, Yunus Emre; Teaching Faculty; Doctor; Doctor; School of Medicine; N/A; N/A; Koç University Hospital; 291692; N/A; N/A
    Background: The Low Profile Visible Intraluminal Support EVO (LVIS EVO) is a self-expandable braided stent, which was recently introduced for the treatment of intracranial aneurysms. Full visibility of the stent and a relatively high metal coverage ratio are the unique features of the LVIS EVO. Objective: To assess the safety, efficacy, and midterm durability of LVIS EVO stent-assisted coiling for the treatment of wide-necked intracranial aneurysms. Methods: The endovascular databases were reviewed to identify patients treated with LVIS EVO-assisted coiling. The technical success and immediate clinical/angiographic outcomes were assessed. Periprocedural and delayed complications were evaluated. The follow-up angiographic/clinical outcomes were investigated. The preprocedural/follow-up neurological statuses were assessed with the modified Rankin Scale. Results: One hundred three aneurysms in 103 patients (63 females) with a mean age of 54.9 ± 11.3 years were included. The mean maximum sac diameter was 6.2 ± 2.9 mm. The procedural technical success rate was 100%. Immediate postprocedural angiography showed complete occlusion in 77.7%. The mean duration of the angiographic follow-up was 8.8 ± 3.6 months. Follow-up angiography showed complete aneurysm occlusion in 89% of the 82 patients with angiographic follow-up. Recanalization was observed in 7.3% of 82 patients. Two patients (2.4%) required retreatment. In addition, 8.7% of the patients had at least 1 complication, and 2.9% of the patients developed a permanent morbidity. All patients had mRS scores ≤2. Conclusion: The results of this study demonstrate that SAC with LVIS EVO is a relatively safe, efficient, and durable treatment for wide-necked and complex intracranial aneurysms. Copyright © Congress of Neurological Surgeons 2022. All rights reserved.
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    Intrathyroidal ectopic thymus and sonoelastographic findings
    (Bentham Science Publ Ltd, 2021) Sağtaş, Ergin; Çolakoğlu, Bülent; Güneyli, Serkan; Aygün, Murat Serhat; Taşkın, Orhun Çığ; Faculty Member; Teaching Faculty; Faculty Member; School of Medicine; School of Medicine; School of Medicine; 36622; 291692; 166686
    Background: Intrathyroidal ectopic thymus (IET) can be misdiagnosed as thyroid nod-ules. Purpose: The purpose of this study is to evaluate the sonoelastographic findings of IET in pediatric population. Methods: Twelve children who had been examined with ultrasound (US) and strain elastography between December 2012 and December 2019 were included in this retrospective study. The pa-tients' demographics and ultrasonographic findings, including the location, margin, shape, diame-ters, volume, structure, vascularity, and elastography values of the lesions were evaluated. Results: Twelve lesions were detected in 12 asymptomatic patients (3 females and 9 males) with a mean age of 4.67 +/- 2.27 years. The most common location of the IET was in posterior part and mid-dle third of thyroid, and the most common appearance on US was a well-defined, ovoid-shaped, and predominantly hypoechoic solid lesion with punctate/linear branching hyperechogenities. The lesions were mostly hypovascular on Doppler US. The mean strain ratio on elastography was found to be 1.10 +/- 0.04. In the follow-up of 7 patients with available information, there was no sig-nificant change in size or appearance of IET on US. Conclusion: IET should be considered in the differential diagnosis of the lesions within the thy-roid. The first step to accurately diagnose an IET is to consider it in the differential diagnosis. In ad-dition to US, strain elastography findings can be used to distinguish IETs from papillary thyroid cancers which can have similar US appearance, and help avoid unnecessary biopsies.
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    Is there a unique symptom in lower urinary tract dysfunction in children?
    (Wiley, 2021) N/A; N/A; Özen, Mehmet Ali; Taşdemir, Mehmet; Aygün, Murat Serhat; Necef, Işıl; Aydın, Emrah; Bilge, İlmay; Eroğlu, Egemen; Faculty Member; Faculty Member; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 293404; 175867; 291692; N/A; 32059; 198907; 214688
    Objectives Lower urinary tract symptoms (LUTS), particularly urgency, incontinence and intermittency are common in children and it is suggested that the specific symptoms may be used for definite diagnosis for LUT dysfunction (LUTD). This study was performed to investigate the relationship between each LUTD and its associated symptoms, using uroflowmetry/electromyography (UF/EMG) as a diagnostic tool. Methods Each patient was categorized into one of four LUT conditions which were overactive bladder (OAB), dysfunctional voiding (DV), underactive bladder and primary bladder neck dysfunction (PBND), according to UF/EMG results. Patients' complaints and findings were documented by using voiding dysfunction symptom score, bladder diary, urine analysis and ultrasonography. In addition, a detailed history of bowel habits (including use of Rome III criteria) was obtained. Results There were 189 children of which 106 were female. The OAB was the largest group including 91 patients, followed by the DV group which had 61 patients. The symptoms specific to any LUTD group were constipation and hesitancy (P < .05). Hesitancy was present in 89.4% with PBND and constipation was present in 78.6% of patients with DV. None of other symptoms were able to differentiate any LUTD group from the other. Conclusions While certain symptoms are often presumed by clinicians to imply specific diagnoses, the main outcome of this study is that there is a generally weak correlation between the specificity of symptoms and LUTD. Symptoms-based approach may lead to misdiagnosis in LUTD. Thus, it may be essential to focus on the underlying pathologies and UF/EMG test may help this.
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    A 52-year-old man with progressive weakness and incontinence
    (Sage, 2022) Danyeli, Ayca Ersen; Bozkurt, Subutay Berke; Uysal, Sanem Pinar; Akpek, Sergin; Kahyaoglu, Bulent; Peker, Selcuk; Altıntaş, Ayşe; Aygün, Murat Serhat; Akay, Olga Meltem; Üre, Ümit Barbaros; Ferhanoğlu, Ahmet Burhan; Faculty Member; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 11611; 291692; 170966; N/A; 18320
    Here we report a challenging case of a 52-year-old man presenting with subacute constipation, urinary retention, impotence, absent Achilles reflexes, and hypoesthesia in S2-S5 dermatomes. We review the clinical decision-making as the symptoms evolved and diagnostic testing changed over time. Once the diagnosis is settled, we discuss the sign and symptoms, additional diagnostic tools, treatment options and prognosis.
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    Jumping stump
    (N/A, 2020) N/A; N/A; Çakmak, Özgür Öztop; Eren, İlker; Aygün, Murat Serhat; Özer, Fahriye Feriha; Ertan, Fatoş Sibel; Faculty Member; Faculty Member; Teaching Faculty; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 299358; 168021; 291692; N/A; 112829
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    Cerebellar cognitive-affective syndrome preceding ataxia associated with complex extrapyramidal features in a Turkish SCA48 family
    (Springer, 2020) Kaya-Güleç, Zeynep Ece; Genç, Gencer; N/A; Palvadeau, Robin Jerome; Şimşir, Gülşah; Vural, Atay; Çakmak, Özgür Öztop; Aygün, Murat Serhat; Falay, Fikri Okan; Başak, Ayşe Nazlı; Ertan, Fatoş Sibel; Researcher; Master Student; Faculty Member; Faculty Member; Teaching Faculty; Teaching Faculty; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Sciences and Engineering; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; 182369; 299358; 291692; 246484; 1512; 112829
    SCA48 is a novel spinocerebellar ataxia (SCA) originally and recently characterized by prominent cerebellar cognitive-affective syndrome (CCAS) and late-onset ataxia caused by mutations on the STUB1 gene. Here, we report the first SCA48 case from Turkey with novel clinical features and diffusion tensor imaging (DTI) findings, used for the first time to evaluate a SCA48 patient. A 65-year-old female patient with slowly progressive cerebellar ataxia, cognitive impairment, behavioral changes, and a vertical family history was evaluated. Following the exclusion of repeat expansion ataxias, whole exome sequencing (WES) was performed. Brain magnetic resonance imaging (MRI), including DTI, and single-photon emission computed tomography (SPECT) were used to study the primarily affected tracts and regions. WES revealed the previously reported heterozygous truncating mutation in ubiquitin ligase domain of STUB1 (ENST00000219548:c.823_824delCT, ENSP00000219548:p.L275Dfs*16) leading to a frameshift. Patient's cognitive status was compatible with CCAS. Novel clinical features different from the original report include later onset chorea, dystonia, general slowness of movements, apraxia, and palilalia, some of which have been recently reported in two families with different STUB1 mutations. CCAS is a prominent and often early feature of SCA48 which may be followed years after the onset of the disease by other complex neurological signs and symptoms. DTI may be helpful for demonstrating the cerebello-frontal tracts, involved in CCAS-associated SCA48, the differential diagnosis of which may be challenging especially in its early years.
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    Ultrasound-guided retrograde tibial access through chronically occluded tibial arteries: a last resort recanalization technique
    (2022) Türeli, Derya; Deniz, Sinan; Oğuzkurt, Levent; N/A; Aygün, Murat Serhat; Teaching Faculty; School of Medicine; Koç University Hospital; 291692
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    Terminal osseous dysplasia with pigmentary defects (TODPD) in a Turkish girl with new skin findings
    (Wiley, 2019) Demirkesen, Cuyan; N/A; N/A; N/A; N/A; N/A; Azaklı, Hülya; Akkaya, Ayşe Deniz; Aygün, Murat Serhat; Eraslan, Serpil; Kayserili, Hülya; PhD Student; Doctor; Teaching Faculty; Researcher; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; 274199; 291692; N/A; 7945
    Terminal osseous dysplasia with pigmentary defects (TODPD; MIM #300244) is an extremely rare, X-linked dominant, in utero male-lethal disease, characterized by skeletal dysplasia of the limbs, pigmentary defects of the skin, and recurrent digital fibromatosis of childhood. Delayed/abnormal ossification of bones of the hands and feet, joint contractures, and dysmorphic facial features may accompany. A single recurrent mutation (c.5217 G>A) of the FLNA gene which causes cryptic splicing was identified as the cause of the disease. We here present the first TODPD case from Turkey with full-blown phenotype who exhibit unique additional findings, hypopigmented patch on the lower extremity following Blaschko's lines and smooth muscle hamartoma of the scalp in review of all the previously reported TODPD cases.
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    Isolated hypoglossal nerve palsy due to a jugular foramen schwannoma
    (Literatura Medica, 2019) Egemen, Emrah; Solaroğlu, İhsan; N/A; Çakmak, Özgür Öztop; Vanlı-Yavuz, Ebru Nur; Aygün, Murat Serhat; Baştan, Birgül; Özdemir, Yasemin Gürsoy; Faculty Member; Doctor; Teaching Faculty; Doctor; Faculty Member; School of Medicine; N/A; School of Medicine; N/A; School of Medicine; Koç University Hospital; Koç University Hospital; Koç University Hospital; Koç University Hospital; Koç University Hospital; 299358; N/A; 291692; N/A; 170592
    Introduction - Although the involvement of the hypoglossal nerve together with other cranial nerves is common in several pathological conditions of the brain, particularly the brainstem, isolated hypoglossal nerve palsy is a rare condition and a diagnostic challenge. Case presentation - The presented patient arrived to the hospital with a history of slurred speech and an uncomfortable sensation on his tongue. Neurological examination showed left-sided hemiatrophy of the tongue with fasciculations and deviation towards the left side during protrusion. Based on the clinical and MRI findings, a diagnosis of hypoglossal nerve schwannoma was made. Discussion - Hypoglossal nerve palsy may arise from multiple causes such as trauma, infections, neoplasms, and endocrine, autoimmune and vascular pathologies. In our case, the isolated involvement of the hypoglossal nerve was at the skull base segment, where the damage to the hypoglossal nerve may occur mostly due to metastasis, nasopharyngeal carcinomas, nerve sheath tumors and glomus tumors. Conclusion - Because of the complexity of the region's anatomy, the patient diagnosed with hypoglossal nerve schwannoma was referred for gamma knife radiosurgery.
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    Radiological evaluation of the localization of sympathetic ganglia in the cervical region
    (Springer France, 2021) Şentürk, Salim; Ünsal, Ülkün Ünlü; Aygün, Murat Serhat; Doctor; Teaching Faculty; School of Medicine; School of Medicine; Koç University Hospital; N/A; 291692
    Purpose: To determine local variations of cervical sympathetic ganglia (CSG) according to vertebral levels on preoperative neck magnetic resonance imaging (MRI) by designating carotid artery (CA) as the standard landmark at the center, in attempts to prevent injury to CSG in the anterior-anterolateral approaches performed in the cervical spinal region. Materials and Methods: The retrospective study reviewed neck MRI images of 281 patients, of which the images of 231 patients were excluded from the study based on the exclusion criteria. As a result, the MRI images of the remaining 50 patients were included in the study. The circumference of carotid artery (CA) was divided into eight equal zones with CA defined as the standard landmark at the center. High-risk zones were determined based on the anterior-anterolateral approaches. Results: At C1 level, a superior ganglion was located on the right side in 32 (64%) and on the left side in 30 (60%) patients. At this level, it was most commonly located in Zone 6. Middle ganglion was observed most frequently at C3 level, which was detected on the right side in 17 (34%) and on the left side in 17 (34%) patients. At this level, it was most commonly located in Zone 2. Conclusion: Variations in the localizations of superior and middle cervical ganglia should be taken into consideration prior to surgical procedures planned for this region. This study sheds light on high-risk zones in the surgical site and could guide surgeons to better understand the location of cervical sympathetic ganglia before surgical planning.