Researcher:
Durmaz Çetin, Birsen

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Birsen

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Durmaz Çetin

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Durmaz Çetin, Birsen

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2015 - 201942020 - 20222

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    Sexual dysfunction in women with human papilloma virus infection in the turkish population
    (Taylor & Francis, 2019) Mercan, Sibel; Sur, Haydar; Kilciksiz, Can Misel; Apaydin, Zuhal; Ayhan, Cem; N/A; Mercan, Ramazan; Durmaz Çetin, Birsen; Kaçar, Anıl Şafak; Ata, Mustafa Barış; Faculty Member; Faculty Member; PhD Student; Faculty Member; School of Medicine; School of Medicine; Graduate School of Health Sciences; School of Medicine; 125526; 111719; N/A; 182910
    Human papilloma virus infection (HPV) is the most common sexually transmitted disease. It may increase the risk of several cancers, including those of the cervix, vulva, vagina, head and neck. HPV is usually transmitted during sexual intercourse; there are limited data about sexual dysfunction (SD) after infection with this virus. We aimed to measure the incidence of SD in women with HPV. In this study, we evaluated 67 HPV-infected female patients and 66 healthy controls. The Arizona Sexual Experience Scale (ASEX), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Socio Demographic Form were used for evaluation. Gynaecologists and psychiatrists evaluated the participants. Women with HPV were found to have significantly higher Arizona Sexual Experience Scale (ASEX) total scores and ASEX sub scores than the control group in the domains of sexual desire, arousal, genital response, orgasmic experience and their satisfaction from orgasm (p.05). The study group shows a statistically significant difference in the Beck Depression Inventory (BDI), but Beck Anxiety Inventory (BAI) scores show no significant differences between the experimental and control groups. Our study shows that HPV positivity in female patients is associated with a significant impairment in sexual function and that this impairment is not related to depression or anxiety.Impact statementWhat is already known on this subject? There are only a few studies concerned with sexual dysfunction in HPV patients. These studies have methodological problems, as they do not rule out the effect of depression on sexual dysfunction. It is very difficult to perform studies on sexual dysfunction and sexually transmitted diseases, because both physicians and patients are reluctant to talk about sexual problems. In the present study, only 6 out of 15 physicians accepted to contribute to the study. Although the physicians gave a questionnaire to more than 400 patients, only 133 of them completed that questionnaire. The most important difficulties in this study was to find enough patients.What do the results of this study add? Depression and sexual dysfunction are frequently seen in HPV patients. Although depression is one of the most common causes of sexual dysfunction, an HPV infection may lead to sexual dysfunction even in the patients without depression.What are the implications of these findings for clinical practice and/or further research? HPV infections may be associated with mental health problems and sexual dysfunction. The gynaecologists and other clinicians working with HPV patients should also evaluate patients psychologically and refer patients to psychiatry if required. The psychiatric problems associated with an HPV infection do not only impair sexual functions, but also may lead to difficulties in social life.
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    Urinary tuberculosis: a cohort of 79 adult cases
    (TAYLOR & FRANCIS LTD, 2015) Altıparmak, Mehmet Rıza; Trabulus, Sinan; Balkan, ilker İnanç; Yalın, Serkan Feyyaz; Denizli, Nazım; Aslan, Gönül; Doruk, Hasan Erdal; Engin, Aynur; Tekin, Recep; Birengel, Serhat; Arslan, Ferhat; Turhan, Vedat; Mert, Ali; N/A; Durmaz Çetin, Birsen; Faculty Member; N/A; School of Medicine; N/A; 111719
    We aimed to investigate the demographic, clinical, diagnostic, treatment and outcome features of patients with urinary tuberculosis (UTB). Patients with UTB admitted to seven separate centers across Turkey between 1995 and 2013 were retrospectively evaluated. The diagnosis of UTB was made by the presence of any clinical finding plus positivity of one of the following: (1) acid-fast bacilli (AFB) in urine, (2) isolation of Mycobacterium tuberculosis, (3) polymerase chain reaction (PCR) for M. tuberculosis, (4) histopathological evidence for TB. Seventy-nine patients (49.36% male, mean age 50.1 +/- 17.4 years) were included. Mean time between onset of symptoms and clinical diagnosis was 9.7 +/- 8.9 months. The most common signs and symptoms were hematuria (79.7%), sterile pyuria (67.1%), dysuria (51.9%), weakness (51.9%), fever (43%) and costovertebral tenderness (38%). Cystoscopy was performed in 59 (74.6%), bladder biopsy in 18 (22.8%), kidney biopsy in 1 (1.26%) and nephrectomy in 12 (15.2%) patients. Histopathological verification of UTB was achieved in 12 (63.1%) patients who undergone biopsy and in 100% of those undergone nephrectomy. Mycobacterium tuberculosis was isolated in the urine of 50 (63.3%) cases. Four-drug standard anti-TB treatment was the preferred regimen for 87.3% of the patients. Mean treatment duration was 10.5 +/- 2.7 months. Deterioration of renal function occurred in 15 (18.9%) patients two of whom progressed to end-stage renal disease and received hemodialysis. Only one patient died after 74-day medical treatment period. Cases with UTB may present with non-specific clinical features. All diagnostic studies including radiology, cyctoscopy and histopathology are of great importance to exclude UTB and prevent renal failure.
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    Central nervous system infections in the absence of cerebrospinal fluid pleocytosis
    (Elsevier, 2017) Erdem, H.; Ozturk-Engin, D.; Cag, Y.; Senbayrak, S.; Inan, A.; Kazak, E.; Savasci, U.; Elaldi, N.; Vahaboglu, H.; Hasbun, R.; Nechifor, M.; Tireli, H.; Kilicoglu, G.; Defres, S.; Gulsun, S.; Ceran, N.; Crisan, A.; Johansen, I.S.; Namiduru, M.; Dayan, S.; Kayabas, U.; Parlak, E.; Khalifa, A.; Kursun, E.; Sipahi, O.R.; Yemisen, M.; Akbulut, A.; Bitirgen, M.; Popovic, N.; Kandemir, B.; Luca, C.; Parlak, M.; Stahl, J.P.; Pehlivanoglu, F.; Simeon, S.; Ulu-Kilic, A.; Yasar, K.; Yilmaz, G.; Yilmaz, E.; Beovic, B.; Catroux, M.; Lakatos, B.; Sunbul, M.; Oncul, O.; Alabay, S.; Sahin-Horasan, E.; Kose, S.; Shehata, G.; Andre, K.; Dragovac, G.; Gul, H.C.; Karakas, A.; Chadapaud, S.; Hansmann, Y.; Harxhi, A.; Kirova, V.; Masse-Chabredier, I.; Oncu, S.; Sener, A.; Tekin, R.; Deveci, O.; Ozkaya, H.D.; Karabay, O.; Agalar, C.; Gencer, S.; Karahocagil, M.K.; Karsen, H.; Kaya, S.; Pekok, A.U.; Celen, M.K.; Deniz, S.; Ulug, M.; Demirdal, T.; Guven, T.; Bolukcu, S.; Avci, M.; Nayman-Alpat, S.; Yaşar, K.; Pehlivanoglu, F.; Ates-Guler, S.; Mutlu-Yilmaz, E.; Tosun, S.; Sirmatel, F.; Batirel, A.; Öztoprak, N.; Kadanali, A.; Turgut, H.; Baran, A.I.; Karaahmetoglu, G.; Sunnetcioglu, M.; Haykir-Solay, A.; Denk, A.; Ayaz, C.; Gorenek, L.; Larsen, L.; Poljak, M.; Barsic, B.; Argemi, X.; Sørensen, S.M.; Bohr, A.L.; Tattevin, P.; Gunst, J.D.; Baštáková, L.; Jereb, M.; Johansen, I.S.; Chehri, M.; Beraud, G.; Del Vecchio, R.F.; Maresca, M.; Yilmaz, H.; Sharif-Yakan, A.; Kanj, S.S.; Korkmaz, F.; Komur, S.; Coskuner, S.A.; Ince, N.; Akkoyunlu, Y.; Halac, G.; Nemli, S.A.; Ak, O.; Kaya, S.; Gunduz, A.; Gozel, M.G.; Hatipoglu, M.; Cicek-Senturk, G.; Akcam, F.Z.; Inkaya, A.C.; Sagmak-Tartar, A.; Ersoy, Y.; Tuncer-Ertem, G.; Balkan, I.I.; Ersoz, G.; Ozgunes, N.; Yesilkaya, A.; Erturk, A.; Gundes, S.; Turhan, V.; Yalci, A.; Aydin, E.; Diktas, H.; Ulcay, A.; Seyman, D.; Leblebicioglu, H.; Durmaz Çetin, Birsen; Faculty Member; School of Medicine; 111719
    Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated.
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    Helicobacter pylori infection in family members of patients with gastroduodenal symptoms. a cross-sectional analytical study
    (Associacao Paulista Medicina, 2018) Palanduz, Ayse; Erdem, Levent; Ozcan, Nuran Gulgun; N/A; Durmaz Çetin, Birsen; Faculty Member; School of Medicine; 111719
    BACKGROUND: Primary Helicobacter pylori (H. pylori) infection is acquired predominantly in childhood in the family setting. We aimed to investigate the presence of intrafamilial concurrent H. pylori infection. DESIGN and SETTING: Cross sectional analytical study with a control group, conducted in a tertiary care hospital. METEIODS: Fifty adult patients with gastroduodenal symptoms who underwent gastroscopy (index par ents), their spouses and their children were enrolled in the study. Blood samples were collected from all of the study subjects to test for immunoglobulin G (IgG) antibody response. H. pylori antigen was investigat ed in the stool specimens of children only. RESULTS: The participants were divided into two groups: Group 1 consisted of the 40 patients in whom H. pylori infection was demonstrated via endoscopy, their spouses and their children. Group 2 included the remaining 10 patients who underwent endoscopy revealing negative results for H. pylori, their spouses and their children IgG antibodies were present in all of the index parents, 95% of their spouses and 93% of their children in group 1;13 of the children (9%) were also positive for H. pylori stool antigen (HpSA). However, IgG antibodies were present in only 2 of the 10 index parents in group 2. One of their spouses and one of their children had a positive antibody response All of their children had negative stool antigen test results. CONCLUSION: H. pylori infections exhibit intrafamilial clustering Parental infection, age >= 7 years and having three or more siblings are the major risk factors for H. pylori infection in children.
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    Evaluation of culture results in pediatric clinics of the training and research hospital
    (Tekirdağ Namık Kemal Üniversitesi, 2022) Günaydın, Nurşen Ciğerci; Bayraktar, Banu; Çetinkaya, Feyzullah; N/A; Durmaz Çetin, Birsen; Faculty Member; School of Medicine; 111719
    Aim: Infections due to drug resistant microorganisms are increasing and it is important to evaluate culture specimens for early recognition, fast and effective therapy, epidemiological and prognosis of the infections. The aim of the study is to evaluate the results of blood and urine cultures taken from patients hospitalized in pediatric services outside the neonatal intensive care unit. Materials and Methods: In this study, 2277 blood cultures and 857 urine cultures taken between the years of 2007 and 2008 were evaluated retrospectively. 6.8% (n=156) positive blood cultures and 6% (n=52) positive urine cultures were included in the study. Blood cultures were put onto Bact-Alert 3D automotized blood culture systems and urine cultures were put onto MacConkey and 5% sheep blood agar plates. Microorganisms were identified with routine bacteriological procedures and antibiotic sensitivity tests were performed.Results: In pediatrics clinics, 79.4% gram positive microorganisms (69% coagulase-negative staphylococcus CNS) among positive blood cultures 86.5% gram negative microorganisms (61.5% Escherichia coli) among positive urine cultures were produced. Microorganisms grew in blood cultures were as follows: 48% (n=75) Methicillin-resistant CNS, 21% (n=33) Methicillin-sensitive CNS, 7.5% (n=12) Klebsiella species (4.5% ESBL positive), 2.6% (n=4) Streptococcus pneumoniae, 2.6% (n=4) Methicillin-sensitive staphylococci 2% (n=3) Acinetobacter, 2.6% (n=4) Candida tropicalis, 2% (n=3) Escherichia coli, 2% (n=3) Enterobacter, 1.3% (n=2) Haemophilus influenzae, 0.6% (n=1) Brucella spp. Microorganisms detected in urine cultures are as follows: 61.5% (n=32) Escherichia coli (40% ESBL positive), 11.5% (n=6) Enterococcus spp., 5.8% (n=3) Proteus spp., 3.8% (n=2) Pseudomonas spp., 3.8% (n=2) Stenotrophomonas maltophilia, 2% (n=1) Methicillin-sensitive staphylococci, 2% (n=1) Acinetobacter baumannii, 2% (n=1) Klebsiella spp. Conclusion: Identifying the infectious agents and their antibiotic susceptibility and resistance rates is important for adequate and effective initial empiric antimicrobial therapy and treatment of infections. /Öz: Amaç: Çoklu ilaç direnci olan mikroorganizmalar ile enfeksiyon sıklığı giderek artmakta olup; enfeksiyonların erken tanınması, etkili tedavisi ve prognoz açısından kültür örneklerinin değerlendirilmesi önemlidir. Bu çalışmanın amacı, yenidoğan yoğun bakım ünitesi dışındaki çocuk servislerinde yatan hastalardan alınan kan ve idrar kültürü sonuçlarının değerlendirilmesidir. Gereç ve Yöntem: Bu çalışmada 2007-2008 yılları arasında bakılan 2277 kan kültürü ve 857 idrar kültürü retrospektif olarak değerlendirilmiştir. Kan kültüründe %6,8 (n=156), idrar kültüründe ise %6 (n=52) üreme anlamlı görülerek çalışmaya dahil edilmiştir. Alınan kan kültürleri Bact-Alert 3D otomatize kan kültür sistemlerinde, idrar örnekleri MacConkey ve %5 koyun kanlı agar besiyerlerine ekimi yapılarak üreyen mikroorganizmalar tanımlanmış, antibiyotik duyarlılık testleri yapılmıştır. Bulgular: Çocuk kliniklerinde bakteriyemi saptanan hastalarda %79,4 gram pozitif (%69’u Koagülaz-negatif stafilokok, KNS), idrar kültüründe ise %86,5 gram negatif (%61,5 Escherichia coli, %11,5 Enterokoklar) mikroorganizma üremiştir. Kan kültürlerinde üreyen mikroorganizmalar: %48 (n=75) Metisilin-dirençli KNS, %21(n=33) Metisilin-hassas KNS, %7,5 (n=12) Klebsiella pneumoniae (%4,5 genişlemiş spektrumlu beta-laktamaz, GSBL pozitif), %4,5 (n=7) Pseudomonas suşları, %3,2 (n=5) Enterococcus spp., %2,6 (n=4) Streptococcus pneumoniae, %2,6 (n=4) Metisilin-hassas Staphylococcus aureus, %2 (n=3) Acinetobacter, %2,6 (n=4) Candida tropicalis, %2 (n=3) Escherichia coli, %2 (n=3) Enterobacter, %1,3 (n=2) Hemofilus influenza, %0,6 (n=1) Brucella spp. idi. İdrar kültürlerinde saptanan mikroorganizmalar; %61,5 (n=32) E. coli, (%40 genişlemiş spektrumlu beta-laktamaz, GSBL pozitif), %11,5 (n=6) Enterococcus spp., %5,8 (n=3) Proteus spp., %3,8 (n=2) Pseudomonas spp., %3,8 (n=2) Stenotrophomonas maltophilia, %2 (n=1) Metisilin-hassas Staphylococcus aureus, %2 (n=1) Acinetobacter baumannii, %2 (n=1) Klebsiella spp. idi. Sonuç: Enfeksiyon etkeni mikroorganizmaların ve antibiyotik duyarlılıkları ile direnç oranlarının belirlenmesi uygun ve etkili ampirik antimikrobiyal tedavi başlanmasında ve enfeksiyonların tedavisinde önemlidir.
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    PublicationOpen Access
    Effect of high-risk Obstructive sleep apnea on clinical outcomes in adults with Coronavirus Disease 2019: a multicenter, prospective, observational cohort study
    (American Thoracic Society (ATS), 2021) Işık, Sacide Rana; Balcan, Baran; Çetin, Betül; OSACOVID-19 Study Collaborators; Ertuğ, Elif; Peker, Yüksel; Çelik, Yeliz; Arbatlı, Semih; Baygül, Arzu Eden; Yazıcı, Duygu; Bayram, Hasan; Karataş, Ferhan; Uzel, Fatma Işıl; İliaz, Sinem; Tabak, Levent; Öztürk, Ayşe Bilge; Atasoy, Kayhan Çetin; Kapmaz, Mahir; Durmaz Çetin, Birsen; Çağlayan, Benan Niku; Faculty Member; Researcher; PhD Student; PhD Student; Faculty Member; Doctor; Doctor; Doctor; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health Sciences; Koç University Hospital; 234103; N/A; N/A; 272290; N/A; 4890; N/A; N/A; 168584; N/A; 147629; N/A; N/A; 111719; 230719
    Rationale: obstructive sleep apnea (OSA) may contribute to poor outcomes in adults with Coronavirus Disease 2019 (COVID-19). Objective: to determine the effect of OSA on clinical outcomes in patients with COVID-19. Methods: the current prospective observational study was conducted in three hospitals in Istanbul, Turkey from March 10 to June 22, 2020. The participants were categorized as modified high-risk (mHR), or low-risk (mLR)-OSA according to a modified version of the Berlin questionnaire. Snoring patterns (intensity and/or frequency), breathing pauses and morning/daytime sleepiness, without taking obesity and hypertension into account, were used in the regression models. Results: the primary outcome was clinical improvement defined as a decline of 2 categories from admission on a 7-category ordinal scale. Secondary outcomes included worsening (increase of 1 category), need for hospitalization, supplemental oxygen and intensive care. In total, 320 eligible patients were enrolled. According to the modified scoring, 70 (21.9%) had mHR-OSA. Among 242 patients requiring hospitalization, clinical improvement within 2 weeks occurred in 75.4 % of the mHR-OSA group compared to 88.4 % of the modified low-risk (mLR-OSA) group (P = 0.014). In multivariate regression analyses, mHR-OSA (adjusted OR 0.42; 95% CI 0.19-0.92) predicted the delayed clinical improvement. In the entire study population (n=320), mHR-OSA was associated with clinical worsening and need for supplemental oxygen. Snoring patterns, especially louder snoring, were significantly predicted delayed clinical improvement, worsening, need for hospitalization, supplemental oxygen, and intensive care. Conclusions: adults with mHR-OSA in our Covid-19 cohort had poorer clinical outcomes than those with mLR OSA independent of age, sex and comorbidities.