Researcher: Canda, Abdullah Erdem
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Canda, Abdullah Erdem
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Publication Metadata only Diagnostic value of serum and urine endocan levels in nonmuscle invasive bladder cancer: a prospective comparative study(Wiley-Hindawi, 2024) Aydin, Hasan Riza; Adanur, Senol; Ozkaya, Fatih; Utlu, Adem; Laloglu, Esra; Turgut, Hasan; Demirdogen, Saban Oguz; Akkas, Fatik; Canda, Abdullah Erdem; School of MedicineObjective. This prospective study aimed to explore the potential diagnostic value of endocan levels in bladder cancer by investigating a possible association of serum and urine endocan levels with the stage and grade of bladder tumors in patients with nonmuscle-invasive bladder cancer (NMIBC) in terms of risk stratification. Materials and Methods. Participants included 66 male patients with NMIBC. Patients with full pathology results, NMIBC stage T1, and healthy controls were categorized as groups 1, 2, and 3, respectively. Patients were further classified into high- and low-grade groups following their pathology results. Risk classification according to the European Association of Urology (EAU) was assigned to patients with NMIBC, and associations of risk groups with serum and urine endocan levels were analyzed. An enzyme-linked immunosorbent assay was used to identify serum and urine endocan concentrations. Results. Serum endocan levels according to pathological staging were significantly higher in groups 1 and 2 than in group 3. The urine endocan level was statistically significantly higher in group 2 than in group 3 (p < 0.001). The predictive power of the urine endocan level was evaluated for its ability to predict T1 disease, revealing an area under the curve of 0.735 and a threshold of 903. The EAU classification was evaluated according to risk groups, and the urine endpoint was statistically significantly higher in the univariate analysis for the high and very high-risk groups (p = 0.034). Conclusion. Our results indicate that endocan levels hold significant promise in prognostic feature evaluation in NMIBC, particularly in the context of screening patients with hematuria.Publication Metadata only Does presence of a median lobe affect perioperative complications, oncological outcomes and urinary continence following robotic-assisted radical prostatectomy?(Urology and Nephrology Research Centre, 2018) Hamidi, Nurullah; Atmaca, Ali Fuat; Keske, Murat; Gok, Bahri; Koc, Erdem; Asil, Erem; Ardicoglu, Arslan; Canda, Abdullah Erdem; Faculty Member; School of Medicine; 116202Purpose: To evaluate of the presence of a median lobe(ML) affect perioperative complications, positive surgical margins(PSM), biochemical recurrence(BCR) and urinary continence(UC) following robotic-assisted radical prostatectomy( RARP). Materials and Methods: Data of 924 consecutive patients who underwent RARP for prostate cancer (PCa) and who have at least 1-year follow-up were evaluated retrospectively. All patients were divided into two groups: Group 1(n=252) included patients with ML and Group 2 (n=672) included patients without ML. The primary endpoint of this study was to compare complication rates between two groups. The secondary endpoints were to compare PSM, BCR and UC rates. Result: Both groups were statistically similar in terms of demographics and variables about PCa. Mean prostate volume was higher in Group 1 vs. Group 2 (69 ± 31 vs. 56 ± 23 mL, p < .001). Total operative time was longer in Group 1 vs. Group 2 (144 ± 38 vs. 136 ± 44 min, p = .01). Biochemical recurrence, PSM, perioperative and postoperative complication rates of our population were 13.6%, 14.9%, 1.7% and 8.7%, respectively. There were no statistical differences in terms of perioperative complication, PSM and BCR rates between the groups(p > 0.05). At the first month after RARP, total continence rate was statistically significant lower in Group 1 vs. Group 2 (49.2% and 56.5%, p = .03), respectively. However, there were no significant differences in terms of continence rates at 3rd month, 6th month and 1st-year follow-up. Conclusion: Due to our experience, the presence of ML does not seem to affect perioperative complication, intraoperative blood loss, PSM and BCR following RARP. However, the presence of ML seems to be a disadvantage in gaining early UC following RARP.Publication Metadata only Fluorescence-guided extended pelvic lymphadenectomy during robotic radical prostatectomy(Springernature) N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Özkan, Arif; Köseoğlu, Ersin; Canda, Abdullah Erdem; Çil, Barbaros Erhan; Aykanat, İbrahim Can; Sarıkaya, Ahmet Furkan; Tarım, Kayhan; Armutlu, Ayşe; Kulaç, İbrahim; Barçın, Erinç; Falay, Fikri Okan; Kordan, Yakup; Baydar, Dilek Ertoy; Balbay, Mevlana Derya; Esen, Tarık; Doctor; Faculty Member; Faculty Member; Faculty Member; Doctor; Researcher; Researcher; Teaching Faculty; Faculty Member; Undergraduate Student; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 350876; 116202; 169993; N/A; 327615; 327605; 133567; 170305; N/A; 246484; 157552; 8025; 153320; 50536We evaluated and described the impact of prostatic indocyanine green (ICG) injection on extended pelvic lymph node (LN) dissection (ePLND) in robotic-assisted radical prostatectomy (RARP). Between January 2019 and December 2021, we included consecutive 50 PCa patients who underwent ePLND during RARP with (n = 25) or without (n = 25) prostatic ICG injection. ICG injection was performed during abdominal port placement and robot docking. Pelvic LNs reflecting green color were initially excised and then the template was completed. The outcomes of two groups were compared. Overall, nine (36%) and five (20%) of the patients had metastatic LN involvement in the ICG and non-ICG groups, respectively. Of the 509 dissected LNs in the ICG group, 122 (23.9%) were fluorescence active. 20 LNs (3.9%) were metastatic in this group, 9 (45%) of which were ICG+. 408 LNs were resected on the non-ICG group with 8(1.9%) being metastatic. Eight (88.9%) of nine pN+ patients were florescent positive in the ICG group. Out of six patients with pN+ disease, Ga68 PSMA-PET/CT detected positive LNs preoperatively. In addition to preoperative Ga68 PSMA-PET/CT investigation, ICG-guided ePLND might increase identification and removal of metastatic LNs duirng RARP. Improvements in staging and oncologic outcomes may also be seen in intermediate- and high-risk patients.Publication Metadata only A risk grouping algorithm for predicting factors of persistently elevated prostate-specific antigen in patients following robot-assisted radical prostatectomy(Wiley, 2021) Micoogullari, Uygar; Cakici, Mehmet Caglar; Kisa, Erdem; Kilic, Furkan Umut; Ardicoglu, Arslan; Altinova, Serkan; Atmaca, Ali Fuat; Akbulut, Ziya; N/A; Balbay, Mevlana Derya; Canda, Abdullah Erdem; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 153320; 116202Objective: After radical prostatectomy, prostate-specific antigen(PSA) value measuring >= 0.1 ng/mL is defined as persistent PSA(pPSA) and in many studies, it was found to be associated with aggressive disease and poor prognosis. Our aim in this study is to point out the pathological and clinical factors affecting pPSA among the patients who underwent robot-assisted radical prostatectomy(RARP) in an experienced academic centre and to make a useful risk grouping algorithm that can predict pPSA value based on operative data. Methods: We examined records of 1273 patients who underwent RARP retrospectively. Preoperative, operative and postoperative data were collected. Based on the PSA values (ng/mL) measured after 4-to-8 weeks of RARP, patients were divided into two groups as pPSA group (Group1)(n = 97) with PSA values >= 0.1 ng/mL and undetectable PSA group (Group2)(n = 778) with PSA values <0.1 ng/mL. Later on, Group1 was further divided into Group1a (PSA:0.1-0.2 ng/mL) and Group 1b (PSA >= 0.2 ng/mL) to evaluate biochemical recurrence(BCR). Results: Multivariate logistic regression analyses of the collected data revealed that preoperative PSA >= 20 ng/mL, operation time, a postoperative international society of urological pathology (ISUP) grade of >= 4, pT 3-4 and pN were independently associated with pPSA. Based on these results, a risk grouping algorithm predicting pPSA was developed. By looking at the risk grouping algorithm pPSA was found in 98.9% of the cases with a preoperative PSA value of >= 20 ng/mL, an operation time of 150 min, a postoperative ISUP grade of 4-5, a positive lymphovascular invasion (LVI) status, pT3-T4, and pN+; while pPSA was found in 25.5% of the cases with a preoperative PSA value of <20 ng/mL, an operation time of 100 min, a postoperative ISUP grade of <4-5, a negative LVI status, pT<3-4 and pN-. The estimated BCR-free survival time was 16.3 months in Group 1a and 57.0 months in Group2 (P < .001). Adjuvant treatment ratio was 64.9% in Group1 and 7.1% in Group2 (P < .001). Conclusion: For the patients who underwent RARP, factors associated with aggressive disease can predict the PSA persistence. To plan our treatment modalities accurately, an applicable risk grouping algorithm in daily practice would be useful.Publication Metadata only Endopelvic fascia sparing robotic radical cystectomy with intracorporeal studer pouch with Balbay's technique(Society of Laparoscopic and Robotic Surgeons, 2022) Kilic, Mert; Musaoglu, Ahmet; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Balbay, Mevlana Derya; Köseoğlu, Ersin; Canda, Abdullah Erdem; Özkan, Arif; Kiremit, Murat Can; Tarım, Kayhan; Sarıkaya, Ahmet Furkan; Faculty Member; Faculty Member; Faculty Member; Doctor; Faculty Member; Researcher; Researcher; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 153320; 350876; 116202; 289255; 222920; 327605; 327615Background and Objectives: Robotic radical cystec-tomy (RARC) with intracorporeal urinary diversion is a technically complicated, time-consuming procedure. The aim of this study was to present the operative, pathologi-cal, oncological, and functional outcomes of patients who underwent endopelvic fascia sparing (EPFS) RARC with intracorporeal Studer pouch formation. To the best of our knowledge, this is first series in the literature that includes EPFS RARC.Methods: Between October 1, 2019 and April 30, 2022, 10 bladder cancer patients underwent EPFS RARC, bilat-eral extended pelvic lymph node dissection with intra-corporeal Studer pouch reconstruction with Balbay's technique. Patient demographics, operative, and post-operative parameters were recorded.Results: Among 10 patients, 8 were male and 2 were female. Mean operative time, median estimated blood loss, and median duration of hospital stay was 530 minutes, 316 ml, and 8 days, respectively. One month postoperatively, the mean maximum flow, average flow rate, mean voided, and post-voided urine volume were 20.2 ml/sec, 4.4 ml/sec, 273.6 ml, and 3.5 ml, respectively. All of the patients were fully continent during day-time, three had mild night-time incontinence requiring pad use (both patients 1 pad per night). During a mean 11.5 months of follow up, zero patients died. One patient with a pathological, stage 4 tumor, had nodal recurrence at six months postoperatively. No distant metastasis were detected. Conclusion: Endopelvic fascia sparing RARC has very promising early functional results with safe oncological outcomes and low complication rates.Publication Metadata only We investigated the impact of transurethral resection of the prostate (TUR-P) on perioperative outcomes in patients who underwent robot assisted radical prostatectomy (RARP)(Avrasya Üroonkoloji Derneği, 2019) Keske, Murat; Atmaca, Ali Fuat; Hamidi, Nurullah; N/A; N/A; Canda, Abdullah Erdem; Balbay, Mevlana Derya; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 116202; 153320We investigated the impact of transurethral resection of the prostate (TUR-P) on perioperative outcomes in patients who underwent robot assisted radical prostatectomy (RARP). Material and Methods: A total of 752 cases performed by 3 surgeons between February 2009 and December 2017 were reviewed retrospectively. First 100 cases of each surgeon were not included to exclude the learning curve effect. All patients (n = 452) were divided into two groups according to having a previous TUR-P history as Group 1 = patients with TUR-P history (n = 38), Group 2 = patients without TUR-P history (n = 414). Results: Mean patient age was 68.3± 5.9 versus 63.3±6.8 years p=0.00; mean console time was 144.3±37.1 versus 124.6±24.0 minutes, p=0.02; bladder neck reconstruction was 31.6% versus 16.7%, p=0.02; transurethral catheter removal time was 11.3±5.1 versus 8.6±2.7 days, p=0.00; for groups 1 and 2, respectively. Positive surgical margin rates were 26.3% versus 27.3%, p=0.897; erectile function (IIEF≥17) rates on postoperative 12th-month were 60% versus 67%, p=0.644 for groups 1 and 2, respectively. First 3 months continence rates were 52.6% versus 72%, p=0.035 for groups 1 and group 2, respectively. Postoperative 12. month continence rates were similar for group 1 and 2(94.7% vs 97.3% ; p=0.562). Conclusion: RARP after TUR-P has similar oncological outcomes, longer operative time, worse postoperative early continence acquisition rates and longer urethral catheter removal time. / Öz: Bu çalışmada robot yardımlı radikal prostatektomi (RYRP) yapılan hastalarda geçirilmiş transüretral prostat rezeksiyonu (TUR-P) cerrahisinin perioperatif sonuçlar üzerine etkisi araştırılmıştır. Gereç ve Yöntemler: Şubat 2009-Aralık 2017 arasında 3 cerrah tarafından gerçekleştirilen toplam 752 vakanın verileri retrospektif olarak incelendi. Her bir cerrahın ilk 100 vakası öğrenme eğrisi nedeniyle çalışma dışı bırakıldı. Tüm hastalar (n=452) RYRP öncesinde TUR-P öyküsü olup olmamasına göre iki gruba ayrıldı. Grup 1=TUR-P öyküsü olanlar (n=38), Grup 2=TUR-P öyküsü olmayanlar, (n=414). Bulgular: Sırasıyla grup 1 ve 2’de ortalama hasta yaşı 68.3± 5.9 ve 63.3±6.8 yıl p=0.00; ortalama konsol süresi 144.3±37.1 ve 124.6±24.0 dakika, p=0.02; mesane boynu rekonstrüksiyon gereksinim oranı %31.6 ve %16.7, p=0.02; ortalama transüretral kateter kalış süresi 11.3±5.1 ve 8.6±2.7 gün, p=0.00 saptanmıştır. Sırasıyla grup 1 ve 2’de, pozitif cerrahi sınır, grup 1’de %26.3, grup 2’de %27.3, p=0.897 ve erektil fonksiyon oranları (IIEF≥17) (postoperatif 12. ay grup 1’de %60, grup 2’de %67, p=0.644) benzer saptanmıştır. Erken dönemde (3. ay) kontinans oranları grup 1 ve grup 2 de sırasıyla %52.6 ve %72 olarak bulunmuştur (p=0.035). 12. ay sonunda kontinans oranları açısından iki grupta %94.7 ve %97.3 olarak birbirine benzer sonuçlar elde edilmiştir (p=0.562). Sonuç: TUR-P sonrası RYRP ameliyatı yapılması, TUR-P geçirmeyen hastalara göre benzer onkolojik sonuçları olan, daha uzun ameliyat süresi olan, postoperatif erken kontinans kazanılması oranları daha az olan ve daha uzun süre idrar sondası takılması gerektiren bir ameliyattır.Publication Metadata only The results of patients undergoing partial nephrectomy for renal mass: robotic versus laparoscopic(Kuwait Medical Assoc, 2022) Asil, Erem; Gok, Bahri; Koc, Erdem; Ener, Kemal; Atmaca, Ali Fuat; N/A; Canda, Abdullah Erdem; Faculty Member; School of Medicine; 116202Objective: Robotic surgery is an emerging trend nowadays, but when the costs are considered, there are question marks associated with preferring it to laparoscopic surgery. In this study, we examined the results of both approaches by comparing the intraoperative, postoperative and oncological outcomes of the patients who underwent robotic partial nephrectomy (RPN) and laparoscopic partial nephrectomy (LPN) for renal cell carcinoma in our clinic. Design: Retrospective study Setting: Ankara City Hospital, Turkey Subject: A total of 96 patients who underwent LPN and RPN for renal mass between 2011 and 2018 and followed up for at least three months were included in the study. Interventions: Preoperative patient data included age, gender, body mass index, smoking cessation, American Society of Anaesthesia physical status score, Padua score and renal nephrometry score. Main Outcome Measure: Perioperative and postoperative data included duration of operation, warm ischemia time, blood loss, perioperative and post-operative complications (1-30 days) according to Clavien-Dindo classification. Results: There was a significant difference between the groups in terms of hospital stay (3.6 +/- 1.1 days in the RPN group and 5.32 +/- 2.2 days in the LPN group). In the RPN group, renal artery clamp placement reduced the amount of bleeding compared to non-clamped patients, which was statistically significant. Conclusion: Despite concerns about the higher cost of RPN in comparison to LPN, RPN is a safe and feasible approach in clinical T1 tumors with similar morbidity and oncologic outcomes and shorter hospital stay.Publication Metadata only Which is the best radiological imaging method for predicting actual prostate weight?(Wiley, 2020) Gok, Bahri; Hajiyev, Elchin; Hamidi, Nurullah; Koc, Erdem; Asil, Erem; Ardicoglu, Arslan; Atmaca, Ali Fuat; Keseroglu, Bugra Bilge; N/A; Canda, Abdullah Erdem; Faculty Member; School of Medicine; 116202In this study, we compared the weight of the prostate specimen removed after robotic radical prostatectomy with the prostate weight measured pre-operatively by four different imaging modalities. Pre-operative prostate weight before robotic radical prostatectomy was measured by Transabdominal Ultrasonography (TAUS), Transrectal Ultrasonography (TRUS), Abdominal Tomography (CT) and MultiparametricProstate Magnetic Resonance imaging (mpMRI). of the 170 patients enrolled in the study, the mean age was 65.2 +/- 7.08 (46-84) years and mean prostate-specific antigen (PSA) 9.6 +/- 7.7 (1.8-50). The mean post-operative actual prostate weight was 63.1 +/- 30 gr. The mean pre-operative prostate volumes measured by TAUS, TRUS, CT and MPMRI were 64.5 +/- 28.5, 49.1 +/- 30.6, 54.5 +/- 30.5 and 68.7 +/- 31.7 ml, respectively (p < .001). Post-operative actual prostate weight correlated with prostate weight measured by TAUS, TRUS, CT and mpMRI (r coefficient 0.776, 0.802, 0.768 and 0.825 respectively). The best of these was mpMRI. Although prostate weight measured by different imaging methods has a high correlation to predict actual prostate weight, actual prostate weight is best predicted by measurements with mpMRI. However, errors and deviations that may occur with these imaging methods should be taken into consideration.Publication Metadata only Concurrent repair of inguinal hernias with mesh application during transperitoneal robotic-assisted radical prostatectomy: is it safe?(Urology and Nephrology Research Centre, 2018) Atmaca, Ali Fuat; Hamidi, Nurullah; Keske, Murat; Ardicoglu, Arslan; Canda, Abdullah Erdem; Faculty Member; School of Medicine; 116202Purpose: To assessment the safety of concurrent repair of inguinal hernia (IH) with mesh application during transperitoneal robotic-assisted radical prostatectomy(RARP). Materials and Methods: Data of 20 patients (totally 25 procedures) who performed concurrent IH repair with mesh application during RARP were retrospectively enrolled in this study. Preoperative patient characteristics, intra and postoperative parameters (pathological Gleason grade, prostate volume at surgical specimen, operative time, herniorrhaphy time, estimated blood loss, complications, time of hospitalization, catheterization, and drainage) were evaluated. Standard PSA control and postoperative complications of mesh application such as hernia recurrence, mesh infection, seroma formation and groin pain were evaluated at every follow-up visits (every three in the first year, then every 6 months in years 2 to 5 and annually thereafter. Result: The mean age was 66 ± 8 years in our population. Fifteen (60 %) patients had a unilateral hernia and 5 (40 %) patients had bilateral hernias. The mean operative time was 139 ± 21minutes and estimated mean blood loss was 108 ± 76 mL. The mean duration of IH repair in patients which was 27 ± 5 (range: 17- 40) minutes. The mean time of drainage, hospitalization, and catheterization were 2.5 ± 0.8 days (range: 2-6), 4 ± 0.9 days (range: 2-7) and 8.2 ± 1.9 days (range: 7-14), respectively. We did not observe any intra-operative complication due to RARP or IH repair. Wound evisceration at camera port site developed in only a patient on postoperative day 20. Our median follow-up time was 13 months and we did not observe mesh infection or hernia recurrence during follow-up. Conclusion: Concurrent IH repair with RARP procedure seem to be easy to perform, effective and safe procedure.Publication Metadata only Is robotic transperitoneal partial nephrectomy safe in the management of cystic renal cell masses? Outcomes of an ERUS multicenter study including 216 patients(ELSEVIER, 2021) Mottrie, A.; Challacombe, B.; Montorsi, F.; Ener, K.; Ploumidis, A.; Larcher, A.; Decaestecker, K.; De Luyk, N.; Buffi, N.; Uleri, A.; Gallina, A.; De Naeyer, G.; Guazzoni, G.; Fernando, A.; Briganti, A.; Cestari, A.; Catterwell, R.; Van Praet, C.; Capitanio, U.; Pappas, A.; N/A; Canda, Abdullah Erdem; Kordan, Yakup; Esen, Tarık; Balbay, Mevlana Derya; Faculty Member; Faculty Member; Faculty Member; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; 116202; 157552; 50536; 153320N/A