Researcher:
Asarcıklı, Fikret

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Doctor

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Fikret

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Asarcıklı

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Asarcıklı, Fikret

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2021 - 20226

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Now showing 1 - 6 of 6
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    Predictive factors for response to a standard dose of intravenous immunoglobulin therapy in children with immune thrombocytopenia
    (Kartal Eğitim ve Araştırma Hastanesi, 2022) Yıldırım, Ülkü Miray; Tekkeşin, Funda; Koç, Begüm Şirin; Kılıç, Suar Çakı; N/A; Asarcıklı, Fikret; Doctor; N/A; Koç University Hospital; N/A
    Objective: Acute immune thrombocytopenic purpura (ITP) is a common acquired bleeding disorder. Intravenous immunoglobulin (IVIG) therapy is commonly given as initial treatment to pediatric patients with ITP. Factors that can predict the response to IVIG have not been fully determined. We retrospectively evaluated whether the clinical and laboratory findings of pediatric patients with ITP at the time of diagnosis could predict the response to IVIG and progression to chronic ITP. Methods: A total of 45 patients with newly diagnosed ITP who were initially treated with IVIG were evaluated between January 2016 and December 2019. Short-term response was estimated by platelet counts 2 weeks after IVIG, and long- term response was assessed by thrombocytopenia-free survival (TFS). TFS was defined as the probability of survival without treatment failure after initial IVIG, such as relapse, requiring additional therapeutic interventions, or progression to chronic ITP. Results: In univariate analysis, age ≥25 months (p=0.002), platelet count ≤6.9x109 /L (p=0.034), and hemoglobin (Hb) level >12.4 g/dl (p=0.001) were considered to be unfavourable factors for short-term response. Univariate analysis of unfavourable factors for longterm response showed that age ≥25 months (p=0.002), platelet count ≤6.9x109 /L (p=0.034), and Hb level >12.4 g/dl (p=0.001) were significant factors. Conclusion: These results suggest that in newly diagnosed ITP patients older than 25 months and/or with platelet count < 6.9x109 /L, other therapeutic options such as corticosteroids alone or in combination with IVIG may be considered as initial therapy.
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    Larotrectinib in NTRK fusion-positive locally advanced or metastatic soft tissue sarcomas in children: a case series
    (Wiley, 2021) Buyukkapu, S. Bay; Kebudi, R.; Asarcıklı, Fikret; Sözmen, Banu Oflaz; Erbey, Mehmet Fatih; Doctor; Faculty Member; Faculty Member; N/A; School of Medicine; School of Medicine; Koç University Hospital; N/A; 198711; 206213
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    Comparative analysis of autophagy in drug responses and aggressive behavior of adult versus pediatric glioma cell lines
    (Wiley, 2022) Aygun, Bera; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Yenidoğan, İrem; Peker, Nesibe; Deveci, Gamze; Kırmızı, Döndü; Asarcıklı, Fikret; Sözmen, Banu Oflaz; Akyoldaş, Göktuğ; Kulaç, İbrahim; Solaroğlu, İhsan; Erbey, Mehmet Fatih; Gözüaçık, Devrim; Researcher; Researcher; PhD Student; Other; Doctor; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; N/A; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; School of Medicine; N/A; Graduate School of Health Sciences; N/A; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; 327591; N/A; N/A; N/A; N/A; 198711; 203677; 102059; 206213; 40248
    Central nervous system tumors are the most common solid cancer and a leading cause of cancer-related deaths in children. Glioma is the most challenging pediatric CNS tumor with therapy resistance and poor prognosis in pediatric patients. Although histopathological analyses revealed similarities with adult brain glioma, emerging evidence suggests that the deregulated molecular pathways in pediatric glioma (p-GM) are different from that of adults. Autophagy, a cellular clearance system and a drug resistance mechanism, has been implicated in glioma progression, invasion, and relapse, yet its role in pediatric patients is not well documented. In this study, we compared the autophagic capacity of adult versus p-GM cell lines and evaluated the effect of autophagy manipulation on drug responses. In addition, migration, extracellular matrix invasion ability, and the metabolism of pediatric and adult gliomas were compared and the contribution of autophagy to the aggressive phenotype was evaluated.
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    Roseola infantum during the COVID-19 pandemic
    (Lippincott Williams and Wilkins, 2022) N/A; Aktürk, Hacer; Bağcı, Mihrimah Selcen; Yiğit, Murat Hüseyin; Khalilova, Fidan; Ünlügedik, Özlem; Asarcıklı, Fikret; Faculty Member; Other; Researcher; Doctor; Other; Doctor; School of Medicine; N/A; School of Medicine; N/A; N/A; N/A; N/A; Koç University Hospital; N/A; Koç University Hospital; Koç University Hospital; 162936; N/A; 327599; N/A; N/A; N/A
    introduction: Roseola infantum is always considered to be among the differential diagnosis of young patients with fever and leukopenia whom to be strictly isolated with the preliminary diagnosis of COVID-19 until otherwise proven during the pandemic. Results: Human herpes virus-6 (HHV-6) polymerase chain reaction (PCR) blood test was performed in 4 of 7 patients with a clinical diagnosis of roseola infantum and all found to be HHV-6 PCR positive. the most striking laboratory finding in all patients was leukopenia. HHV-6 PCR tests were found to be positive. Severe acute respiratory syndrome coronavirus-2 testing were found to be negative in all patients. Conclusion: During the peak of the pandemic, children continued to present with fever because of viral infections other than COVID-19.
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    Cytomegalovirus-related hemophagocytosis in childhood acute lymphoblastic leukemia
    (Lippincott Williams and Wilkins (LWW), 2021) N/A; N/A; N/A; N/A; N/A; Bağcı, Mihrimah Selcen; Erbey, Mehmet Fatih; Sözmen, Banu Oflaz; Asarcıklı, Fikret; Doctor, Faculty Member; Faculty Member; Doctor; N/A; School of Medicine; School of Medicine; N/A; Koç University Hospital; N/A; N/A; Koç University Hospital; N/A; 206213; 198711; N/A
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    PublicationOpen Access
    Catheter-related bloodstream infection caused by Burkholderia cepacia in a pediatric oncology patient
    (Association for Increasing the Visibility of Scientific Research (ACVCS), 2022) Özen, Mehmet Ali; Aktürk, Hacer; Sözmen, Banu Oflaz; Asarcıklı, Fikret; Erbey, Mehmet Fatih; Kandemir, Oğuzhan; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; Koç University Hospital; 293404; N/A; N/A; N/A; 206213; N/A
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